School of Biomedical Sciences
The Chinese University of Hong Kong 香港中文大學

CHENG Hon Ki ChristopherResearch Professor

B.Sc., Ph.D.

Telephone:   39436801

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.


  Rm 604A, 6/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK


  1. Genomics and gene knockout studies in zebrafish.
  2. Molecular endocrinology and hormone action.
  3. Identification and development of drugs from natural and synthetic sources.
  4. Novel functional molecules.
  1. Tang, H., Liu, Y., Li, J., Yin, Y., Li G., Chen, Y., Li, S., Zhang, Y., Lin, H., Liu, X. and Cheng, C. H. K. (2016) Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish. Scientific Reports 6, 28545.
  2. Hao, Y., Chow, A. W., Yip, W. C., Chi, H., Wan, T. F., Tong, B. C., Cheung, K. H., Chan, W. Y., Chen, Y., Cheng, C. H. K. and Ko, W. H. (2016) G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca2+ signaling pathway in human airway epithelia. Pflügers Archiv - European Journal of Physiology 468(8), 1489-503.
  3. Liu, Y., Zhao, H. and Cheng, C. H. K. (2016) Mutagenesis in Xenopus and Zebrafish using TALENs. In R. Kühn, W. Wurst & B. Wefers (Eds), TALENs: Methods and Protocols, Methods in Molecular Biology (Vol. 1338, pp. 207-27). New Jersey, USA: Humana Press Inc.
  4. Chu, L., Li, J., Liu, Y. and Cheng, C. H. K. (2015) Gonadotropin signaling in zebrafish ovary and testis development: Insights from gene knockout study. Molecular Endocrinology 29(12), 1743-58.
  5. Luo, D., Liu, Y., Chen, J., Xia, X., Cao, M., Cheng, B., Wang, X., Gong, W., Qiu, C., Zhang, Y., Cheng, C. H. K., Zhu, Z. and Hu, W. (2015) Direct production of XYDMY− sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs. Scientific Reports 5, 14057.
  6. Li, J., Chu, L., Sun, X., Liu, Y. and Cheng, C. H. K. (2015) Igfs mediate the action of luteinizing hormone on oocyte maturation in zebrafish. Molecular Endocrinology 29(3), 373-83.
  7. Tang, H., Liu, Y., Luo, D., Ogawa, S., Yin, Y., Li, S., Zhang, Y., Hu, W., Parhar, I. S., Lin, H., Liu, X. and Cheng, C. H. K. (2015) The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies. Endocrinology 156(2), 589-99.
  8. Chu, L., Li, J., Liu, Y., Hu, W. and Cheng, C. H. K. (2014) Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular Endocrinology 28(11), 1785-95.
  9. Xiao, Z., Li, C. H., Chan, S. L., Xu, F., Feng, L., Wang, Y., Jiang, J., Sung, J. J. Y, Cheng, C. H. K. and Chen, Y. (2014) A small molecule modulator of the tumor suppressor miRNA-34a inhibits the growth of hepatocellular carcinoma. Cancer Research 74(21), 6236-47.
  10. Liu, Y., Luo, D., Lei, Y., Hu, W., Zhao, H. and Cheng, C. H. K. (2014) A highly effective TALEN-mediated approach for targeted gene disruption in Xenopus tropicalis and zebrafish. METHODS 69(1), 58-66.
  11. Xie, C., Liu, X., Sham, K. W. Y., Lai, J. M. Y. and Cheng, C. H. K. (2014) Silencing of elongation factor-2 kinase reveals AMPK-ULK1 dependent autophagy in colon cancer cells. Autophagy 10(9), 1495-508.
  12. Liu, Y., Luo, D., Zhao, H., Zhu, Z., Hu, W. and Cheng, C. H. K. (2013) Inheritable and precise large genomic deletions of non-coding RNA genes in zebrafish using TALENs. PLoS ONE 8(10), e76387.
  13. Xie, C., Liu, X., Yu, S. B. S and Cheng, C. H. K. (2013) Cardiac Glycosides Block Cancer Growth through HIF-1a and NF-kB Mediated Plk1. Carcinogenesis 34(8), 1870-80.
  14. Leung, K. C. F., Chak, C. P., Lee, S. F., Lai, J. M. Y., Zhu, X., Wang, Y., Sham, K. W. Y. and Cheng, C. H. K. (2013) Enhanced Cellular Uptake and Gene Delivery of Glioblastoma with Deferoxamine-coated Magnetic Nanoparticle/Plasmid DNA/Branched Polyethylenimine Composites. Chemical Communications 49(6), 549-51.
  15. Lei, Y., Guo, X., Liu, Y., Cao, Y., Deng, Y., Chen, X., Cheng, C. H. K., Dawid, I. B., Chen, Y. and Zhao, H. (2012) Efficient Targeted Gene Disruption in Xenopus Embryos Using Engineered Transcription Activator-like Effector Nucleases (TALENs). PNAS 109(43), 17484-9.
  16. Zhou, W., Li, S., Liu, Y., Qi, X., Chen, H., Cheng, C. H. K., Liu, X., Zhang, Y. and Lin, H. (2012) The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio). Molecular and Cellular Endocrinology 361(1-2), 202-12.
  17. Xie, C., Chan, W. Y., Yu, S. S. B., Zhao, J. and Cheng, C. H. K. (2011) Bufalin Induces Autophagy-mediated Cell Death in Human Colon Cancer Cells through Reactive Oxygen Species Generation and JNK Activation. Free Radical Biology and Medicine 51(7), 1365-75.
  18. Gao, J., Wang, Y., Xing, Q., Yan, J., Senthil, M., Akmal, Y., Kowolik, C. M., Kang, J., Lu, D. M., Zhao, M., Lin Z., Cheng, C. H. K., Yip, R. M. and Yim, J. H. (2011) Identification of a Natural Compound by Cell-based Screening that Enhances Interferon Regulatory Factor-1 Activity and Causes Tumor Suppression. Molecular Cancer Therapeutics 10(10), 1174-83.
  19. Chen, M., Huang, X., Yuen, D. S. H. and Cheng, C. H. K. (2011) A study on the functional interaction between the GH/PRL family of polypeptides with their receptors in zebrafish: evidence against GHR1 being the receptor for somatolactin. Molecular and Cellular Endocrinology 337(1-2), 114-21.
  20. Li, J., Liu, Z., Wang, D. and Cheng, C. H. K. (2011) Insulin-like growth factor 3 is involved in oocyte maturation in zebrafish. Biology of Reproduction 84(3), 476-86.