School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


Associate Professor

BSc, MPhil, PhD

Telephone:  39436104

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 404A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Antibody engineering and design
  2. G protein-coupled receptors
  3. Non-coding RNAs and repetitive sequences
  4. Lipids in signaling and diseases
  5. Cancer Biology
  1. Leung, S.O., Gao, K., Wang, G.Y., Cheung, B.K.W., Lee, K.Y., Zhao, Q., Cheung, W.T. and Wang, J.Z. (2015). Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody. mAbs, 7, 66-76. PMID: 25427174 DOI:10.4161/19420862.2014.985519
  2. Zhao, Q., Wong, P.F., Lee, S.S.T., Leung, S.O., Cheung, W.T.* and Wang, J.Z.* (2014). Generation of anti-idiotype scFv for pharmacokinetic measurement in lymphoma patients treated with chimera anti-CD22 antibody SM03 PLoS One, 9, e96697. PMID: 24816427 DOI:10.1371/journal.pone.0096697
  3. Jiang, L.L., Teng, G.M.K., Chan, E.Y.M., Au, S.W.N., Wise, H., Lee, S.S.T., and Cheung, W.T. (2012). Impact of cell type and epitope tagging on heterologous expression of G protein-coupled receptor: A systematic study on angiotensin type II receptor. PLoS One, 7, e47016. PMID: 23056563 DOI:10.1371/journal.pone.0047016
  4. Cheng, M., Chan, S.Y.W., Zhao, Q., Chan, E.Y.M., Au, S.W.N., Lee, S.S.T. and Cheung, W.T. (2011). Construction and characterization of single-chain variable fragment (scFv) antibody library derived from germline rearranged immunoglobulin variable genes. PLoS One, 6, e27406. PMID: 22096568 DOI:10.1371/journal.pone.0027406
  5. Lin, W.Z., Li, Z.F., Tsang, S.Y., Lung, L.K.W., Zhu, Y.K., Cheng, M., Chan, W.Y., Lee, S.S.T. and Cheung, W.T. (2009). Identification and characterization of a novel CXC chemokine in xenograft tumor induced by mas over-expressing cells. Int J Cancer, 125, 1316-1327. PMID: 19408311 DOI:10.1002/ijc.24440
  6. Sun, Y., Ng, L., Lam, W., Lo, C.K.C., Chan, P.T., Yuen, Y.L. Wong, P.F., Tsang, D.S.T., Cheung, W.T. and Lee, S.S.T. (2008). Identification and characterization of a novel mouse peroxisome proliferator-activated receptor α-regulated and starvation-induced gene. Ppsig, Int. J. Biochem. Cell Biol., 40, 1775-1791. PMID: 18289917 DOI: 10.1016/j.biocel.2008.01.006
  7. Cheng, M., Lee, S.S.T., and Cheung, W.T. (2007), Dual effect of endothelin I on angiotensin II-potentiated purinergic neurotransmission in prostatic rat vas deferens. Eur. J. Pharmacol., 557, 204-211. PMID: 17196586 DOI:10.1016/j.ejphar.2006.11.035.
  8. Cheung, W.T. and Cheng, M. (2007). Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering. US Patent No, 7241598
  9. Bikkavilli, R.K., Tsang, S.Y., Tang, W.M., Sun, J.X., Ngai, S.M., Lee, S.S.T., Ko, W.H., Wise, H. and Cheung, W.T. (2006), Identification and characterization of surrogate peptide ligand for orphan G protein-coupled receptor mas using phage-displayed peptide library. Biochem. Pharmacol., 71, 319-337. PMID: 16336942 DOI: 10.1016/j.bcp.2005.10.050
  10. Cheng, M., Chan, C.W.L., Cheung, R.C.F., Bikkavilli, R.K., Zhao, Q., Au, S.W.N., Chan, P.K.S., Lee, S.S.T., Cheng, G., Ho, W.K.K., and Cheung, W.T. (2005). Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11. Biochem. Biophys. Res. Commun., 338, 1654-1660. PMID: 16263078 DOI:10.1016/j.bbrc.2005.10.088
  11. Lee, S.S.T., Chan, W.Y., Lo, C.K.C., Wan, D.C.C., Tsang, D.S.C. and Cheung, W.T. (2004). Requirement of PPARα in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation. J. Lipid Res., 45, 2025-2037. PMID: 15342691 DOI:10.1194/jlr.M400078-JLR200.
  12. Wong, P.F., Lee, S.S.T. and Cheung, W.T. (2004). Immunohistochemical colocalization of type II angiotensin receptors with somatostatin in rat pancreas. Regul. Peptid., 117, 195-205. PMID: 14749040 DOI:10.1016/j.regpep.2003.10.019
  13. Lee, S.S.T., Li, T., Lee, W.S. and Cheung, W.T. (2002). Application of fluorescent differential display and PPARα-null mice to analyse PPAR target genes. Method Enzymol., 357, 214-240. PMID: 12424913.
  14. Cooper, A.C., Robinson, G., Vinson, G.P., Cheung, W.T. and Broughton, Pipkin F. (1999). The localization and expression of the renin-angiotensin system in the human placenta throughout pregnancy. Placenta, 20, 467-474. PMID: 10419812 DOI:10.1053/plac.1999.0404.
  15. Cheung, W.T., Yeung, S.Y., Yiu, A.K.L., Ip, T.M., Wan, D.C.C., Luk, S.K.S. and Ho, W.K.K. (1999). Characterization of a functional AT1A angiotensin receptor in pancreatoma AR4-2J cells. Peptides, 20, 829-836. PMID: 10477083 DOI:10.1016/S0196-9781(99)00069-8.
  16. Sum, C.S., Wan, C.C. and Cheung, W.T. (1996). Potentiation of purinergic transmission by angiotensin in prostatic rat vas deferens. Br. J. Pharmacol. 118, 1523-1529. PMID: 8832081.
  17. Cheung, W.T., Richards, D.E. and Rogers, J.H. (1993). Calcium binding by chick calretinin and rat calbindin-D28K synthesized in bacteria. Eur. J. Biochem., 215, 401-410. PMID: 8344307 DOI:10.1111/j.1432-1033.1993.tb18047.x.
  18. Hanley, M.R., Cheung, W.T., Hawkins, P., Poyner, D., Benton, H.P., Blair, L., Jackson, T.R. and Goedert, M. (1990). The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action. Ciba Foundation Symposium 150, 23-46. PMID: 2197067.
  19. Cheung, W.T., Lee, C.M. and Ng, T.B. (1988). Potentiation of the anti-lipolytic effect of 2-chloroadenosine after chronic caffeine treatment. Pharmacol., 36, 331-339. PMID: 3406045 DOI:10.1159/000138403.
  20. Cheung, W.T., Shi, M.M., Young, J.D. and Lee, C.M. (1987). Inhibition of radioligand binding to A1 adenosine receptors by bay K8644 and nifedipine. Biochem. Pharmacol., 36, 2183-2186. PMID: 2440436 DOI: 10.1016/0006-2952(87)90148-1.