School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


CHO Chi HinResearch Professor

B.Pharm., Ph.D.

Telephone:  39436886

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 521A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Gastrointestinal cancer and inflammation
  2. Peptides for cancer diagnosis and therapy
  1. Zhang, L., Wu, W.W.K., Gallo, R.L., Fang, E.F., Hu, W., Ling, T.K., Shen, J., Chan R.L., Lu L., Luo, X.M., Li M.X., Chan, K.M., Yu, J., Wong, V.W., Ng, S.C., Wong, S.H., Chan, F.K., Sung, J.J., Chan, M.T. & Cho, C.H. (2016). Critical role of antimicrobial peptide cathelicidin for controlling Helicobacter pylori survival and infection. J. Immunol., 196(4), 1799-1809.
  2. Lu, L., Li, Z.J., Li, L.F., Wu, W.K.K., Shen, J., Zhang, L., Chan, R.L.Y., Yu, L., Liu, Y.W., Ren, S.X., Chan, K.M. & Cho, C.H. (2015). Vascular-targeted TNFα enhances vascular function and benefits antitumor immunotherapy in colorectal cancer. J. Controlled Release 210, 134-146.
  3. Shen, J., Xiao, Z.G., Wang, M.H.,To. K.F., Che, Y.C., Li, M.S., Tong, J.H., Kang W., Zhang L., Wang, L., Lu, L., Chan, R.L.Y., Yu, J., Chan, F.K.L., Sung, J.J.Y., Cheng, A.S. & Cho, C.H. (2015). MiR-490-3p targeting SMARCD1, a member of the SWI/SNF chromatin remodeling family, was epigenetically silenced in H. pylori-induced gastric carcinogenesis. Cancer Res. 75, 754-765.
  4. Ren S.X., Cheng, A.S.L., To, K.F., Tong, J.H.M., Li, M.S., Wong, C.C.M., Shen, J., Zhang, L., Chan, R.L.Y., Wang, X.J., Ng, S.S.M., Chiu, L.C.M., Marquez, V.E., Gallo, R.L., Chan, F.K.L., Yu, J., Sung, J.J.Y., Wu, W.K.K. & Cho, C.H. (2012). Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res. 72, 6512-6523.
  5. Li, Z.J., Wu, W.K.K., Ng, S.S.M., Yu, L., Li, H.T., Wong C.C.M., Wu, Y.C., Zhang, L., Ren S.X., Sun, X.G., Chan, K.M. & Cho, C.H. (2010). A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. J. Controlled Release 148, 292-302.
  6. Wu, W.K.K., C.H. Cho, Lee, C., Wu, Y.C., Yu, L., Li, Z.J., Wong, C.C.M., Li, H.T., Zhang, L., Ren, S.X., Che, C.T., Yu, J. & Sung, J.J.Y. (2010). Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy, 6, 1-11.
  7. Liu, X., Wu, W.K.K., Sung, J.J.Y., Yu, L., Li, Z.J., Zhang, S.T., & Cho, C.H. (2008). Epidermal growth factor stimulates esophageal cancer cell growth via transactivation of β-adrenoceptor. J. Pharmacol. Exp. Therap, 326, 69-75.
  8. Yang, Y.H., Wu, W.K.K., Tai, E.K.K., Wong, H.P.S., Lam, E.K.Y., Shin, V.Y. & Cho, C.H. (2006). The cationic host defence peptide rCRAMP promotes gastric ulcer healing in rats. J. Pharmacol. Exp. Therap., 318, 547-554.
  9. Wu, W.K.K., Wong, H.P.S., Luo, S.W., Chan K., Huang, F.Y., Hui, M.K.C., Lam, E.K.Y., Shin, V.Y., Ye, Y.N., Yang, Y.H. & Cho C.H. (2005). 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via b-adrencoceptors. Cancer Res. 65, 5272-5277.
  10. Ye, Y.N., Wu, W.K.K., Shin, V.Y., Bruce, I.C., Wong, B.C.Y. & Cho, C.H. (2005).  Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis 26, 827-834.
  11. Liu, E.S.L., Ye, Y.N., Shin, V.Y., Yuen, S.T. Leung, S.Y., Wong, B.C.Y. & Cho, C.H. (2003). Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice. Carcinogenesis 24, 1407-1413.
  12. Wang, W.P., Guo, X., Koo, M.W.L., Wong, B.C.Y., Lam, S.K., Ye, Y.N. & Cho, C.H. (2001). Protective effect of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats. Am. J. Physiol. Gastrointest. Liver Physiol., 281, G586-G594.
  13. Ma, L., Wang, W.P., Chow, J.Y.C., Lam, S.K. & Cho, C.H. (2000). The role of polyamine in gastric mucus synthesis inhibited by cigarette smoke or its extracts. Gut 47, 170-177.
  14. Guo, X., Wang, W.P., Ko, J.K.S. & Cho, C.H. (1999). Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on experimental inflammatory bowel disease in rats. Gastroenterology, 117, 884-892.
  15. Li, Y., Wang, H.Y. & Cho, C.H. (1999). Association of heparin with basic fibroblast growth factor, epidermal growth factor and constitutive nitric oxide synthase on the healing of gastric ulcers in rats. J. Pharmacol. & Exp. Therap. 290, 789-796.
  16. Chow, J.Y.C., Ma, L. & Cho, C.H. (1997). The potentiating action of cigarette smoke on ethanol-induced gastric mucosal damage in rats. Gastroenterology 113, 1188-1197.
  17. Chow, J.Y.C., L. Ma & Cho, C.H. (1996). An experimental model for studying passive cigarette smoking: effects on gastric ulceration. Life Sci. 58, 2415-2422.
  18. Hui, W.M., Chen, B.W., Kung, A.W.C., Cho, C.H., Luk, C.T. & Lam, S.K. (1993). Effect of epidermal growth factor on gastric blood flow in rats - possible role in mucosal protection. Gastroenterology, 104, 1605-1610.
  19. Chen, B.W., Hui, W.M., Lam, S.K., Cho, C.H., Ng, M.M.T. & Luk, C.T. (1989). Effect of sucralfate on gastric mucosal blood flow in rats. Gut, 30, 1544-1551.
  20. Cho, C.H., Ogle, C.W. & Dai, S. (1976). Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats. Eur. J. Pharmacol., 38, 337-341.