School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


HUANG Yu Professor

B.Sc. (Fudan University Shanghai Medical School, China); M.Phil., Ph.D. (University of Cambridge, UK)

Telephone:  39436787

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 223A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Website:   http://www.cuhk.edu.hk/proj/HuangLab/

 

  1. Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency
  2. Endothelium-derived Contracting Factors in the Regulation of Vascular Tone
  3. Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension
  4. Ischemic Stroke and Neuronal Damage
  5. Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs. Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides
  1. Zhang H, Liu J, Dan Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe, GL Lee, Ng CF, Ma RCW, Yao X & *Huang Y (2016) Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 2016 Jan 28. pii: db151067. [Epub ahead of print]
  2. Hu W, Zhang Y, Wang L, Lau CW, Xu J, Luo JY, Gou L, Yao XY, Chen ZY, Ma RCW, Tain XY & *Huang Y (2016) Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology 2016 Jan 14. pii: ATVBAHA.115.306302. [Epub ahead of print]
  3. Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang Li, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & *Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.
  4. Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X & *Huang Y (2015) Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 64(5):1654-1575 with commentary 64(5):1506-1508.
  5. Liu L, Liu J, Tian XY, Wong WT, Lau CW, Xu A, XU G, Ng CF, Yao X, Gao Y & *Huang Y (2014) Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling 21(11):1571-1581.
  6. Cheang WS, Tian XY, Wong WT, Lau CW, Lee ST; Chen ZY, Yao X, Wang N & *Huang Y (2014) Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor d pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6.
  7. Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & *Huang Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159.
  8. Dong J, Wong SL, Lau CW, Liu J, He ZD, Ng CF, Yao X, Chen ZY, Ni X, Wang H & *Huang Y (2013) Calcitriol restores renovascular function in estrogen-deficient rats through the downregulation of cyclooxygenase-2 and thromboxane-prostanoid receptor. Kidney International 84(1):54-63 with commentary 2013;84(1):9-11.
  9. Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SST, Chen ZY, Cooke JP, Yao X & *Huang Y (2012) PPARd activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-3293.
  10. Dong J, Wong SL, Lau CW, Lee, HK, Ng CF, Zhang L, Yao X, Chen ZY, Vanhoutte PM & *Huang Y (2012) Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. European Heart Journal 33(23):2980-2990.
  11. Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu Z, Xu A, Lam KS, Chen ZY, Ng CF, Yao X, *Huang Y (2012) Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 60(3):833-841.
  12. Yuen CY, Wong SL, Lau CW, Tsang SY, Xu A, Zhu Z, Ng CF, Kong SK, Lee HK, Yao X & *Huang Y (2012) From skeleton to cytoskeleton: Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circulation Research 111:e55-e66.
  13. Tian XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X & *Huang Y (2012) Uncoupling protein-2 protects endothelial function in diet-Induced obese mice. Circulation Research 110(9):1211-1216.
  14. Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP & *Huang Y (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling 16(4):363-373.
  15. Tian XY, Yung LH, Wong WT, Leung FP, Liu L, Chen YC, Kong SK, Kwan KM, Ng SSM, LaiPB, Yung LM, Yao X & *Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-244.
  16. Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RLC, Wang Y, Lee VWY, Lam KSL, Vanhoutte PM & *Huang Y (2011) Adiponectin is required for PPARg-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 14(1):104-115.
  17. Wong SL, Lau CW, Wong WT, Xu A, Au CL, Ng CF, Ng SSM, Yao X & *Huang Y (2011) Pivotal role of PKCd in angiotensin II-induced endothelial cyclooxygenase-2 expression: A link to vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biology 31(5):1169-1176.
  18. Wong WT, Tian XY, Chen YC, Leung FP, Liu L, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL & *Huang Y (2010) Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circulation Research 107(5):984-991.
  19. Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Au CL, Chen ZY, Yao X & *Huang Y (2010) Angiotensin II type 1 receptor-dependent oxidative stress modulates endothelial dysfunction in aortas of diabetes mice and humans. Antioxidants & Redox Signaling 16(3):757-768.
  20. Wong SL, Leung FP, Au CL, Yung LM, Lau CW, Yao X, Chen ZY, Vanhoutte PM & *Huang Y (2009) Cyclooxygenase-2-derived PGF2a mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during ageing. Circulation Research 104(2):228-235 with editorial commentary (104(2):141-143)