HUANG Yu Professor

B.Sc. (Fudan University Shanghai Medical School, China); M.Phil., Ph.D. (University of Cambridge, UK)

Telephone:  3943 6787

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 223A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Website:   http://www.cuhk.edu.hk/proj/HuangLab/

 

 

Biography

HUANG Yu (黃聿) is the Professor of Biomedical Sciences and the founding Director (Basic Sciences) of Heart and Vascular Institute (formerly named Institute of Vascular Medicine), CUHK.He was the past President of Asian Society for Vascular Biology (2010-2018) and currently the Vice-President for both Chinese Society for Vascular Medicine and the Chinese Section of International Society for Heart Research. He is the newly elected Fellow of the International Society for Heart Research (2019) (http://www.cuhk.edu.hk/proj/HuangLab/).


Huang Yu serves as the Grant Review Panel Member for Hong Kong Research Grants Council, Hong Kong Government’s Health and Medical Research Fund, and Natural Science Foundation of China. He has so far served (past and present) as the editor, guest editor, associate editor, and editorial board member for 18 SCI-indexed journals including British Journal of Pharmacology (editor) and Circulation Research (associate editor). He has reviewed grant proposals for 27 granting agencies of 11 countries and regions. He is also the visiting or guest professor of 11 universities and institutes.

The research focus of Huang’s team is to elucidate cellular and molecular events in initiation and progression of endothelial cell dysfunction in hypertension, obesity, and diabetes, to uncover novel biomarkers for vascular pathogenesis, and to develop venues to reverse vascular dysfunction in animal models of cardio-metabolic disorders. He has co-authored 423 peer-reviewed publications in SCI-indexed journals including Nature, Science, Cell Metabolism, Circulation Research, European Heart Journal, PNAS, Diabetes, Hypertension, ATVB, Stroke with >21928 Google scholar citations (H-index of 75). Huang Yu received Croucher Senior Research Fellowship in 2014 and several other awards. He was the recipient of The Asian Lecture on Vascular Biology (2018), The Robert F. Furchgott Lecture (2013), and The Office of Life Sciences Distinguished Lecture, National University of Singapore (2007).

  1. Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency.
  2. Endothelium-derived Contracting Factors in the Regulation of Vascular Tone.
  3. Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension.
  4. Mechanobiology and Atherosclerosis.
  5. Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs. Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides.
  1. Zhang, H., Liu, J., Qu, D., Wang, L., Wong, C.M., Lau, C.W., Huang, Y., Wang, Y.F., Huang, H., Xia, Y., Xiang, L., Cai, Z., Liu, P., Wei, Y., Yao, X., Ma, R. C. W., Huang, Y.* (2018). Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes. Proceedings of The National Academy of Sciences of The United States of America, 115(29), E6927-E6936.
  2. Gou, L., Zhao, L., Song, W., Wang, L., Liu, J., Zhang, H., Huang, Y., Lau, C. W., Yao, X.Q., Tian, X. Y., Wong, W. T., Luo, J. Y., Huang, Y.* (2018). Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling, 28(5), 358-370. 
  3. Cheang, W. S., Wong, W. T., Zhao, L., Xu, J., Wang, L., Lau, C. W., Chen, Z. Y., Ma, R. C. W., Xu, A., Wang, N., Tian, X. Y.*, Huang, Y.* (2017). PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes, 66(2), 519-528.
  4. Wang, L., Luo, J.Y., Li, B., Tian, X. Y., Chen, L. J., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., Ai, D., Mak, K. L., Tong, K. K., Kwan, K. M., Wang, N., Chiu, J. J., Zhu, Y.*, Huang, Y.* (2016). Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature, 540, 579-581. Commented in Nature News and Views, Nature, 540, 531-532.
  5. Zhang, H., Liu, J., Qu, D., Wang, L., Luo, J.Y., Lau, C. W., Liu, P., Gao, Z., Tipoe, G. L., Lee, H. K., Ng, C. F., Ma, R. C. W., Yao, X., Huang, Y.* (2016). Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes, 65(5), 1196-1207 with Commentary Diabetes, 65(5), 1152-1154.
  6. Hu, W., Zhang, Y., Wang, L., Lau, C. W., Xu, J., Luo, J.Y., Gou, L., Yao, X. Y., Chen, Z. Y., Ma, R. C. W., Tian, X. Y., Huang, Y.* (2016). Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology, 36(3), 553-560.
  7. Zhang, Y., Liu, J., Luo, J.Y., Tian, X. Y., Cheang, W. S., Xu, J., Lau, C. W., Wang, L., Wong, W. T., Wong, C. M., Lan, H. Y., Yao, X. Q., Raizada, M. K., Huang, Y.* (2015). Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling, 23(11), 880-892 with Cover Image of the Issue.
  8. Liu, J., Wang, L., Tian, X. Y., Liu, L. M., Wong, W. T., Zhang, Y., Han, Q., Ho, H. M., Wang, N., Wong, S. L., Chen, Z. Y., Yu, J., Ng, C. F., Yao, X., Huang, Y.* (2015). Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes, 64(5), 1654-1575 with commentary 64(5), 1506-1508.
  9. Liu, L., Liu, J., Tian, X. Y., Wong, W. T., Lau, C. W., Xu, A., XU, G., Ng, C. F., Yao, X., Gao, Y., Huang, Y.* (2014). Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling, 21(11), 1571-1581.
  10. Wong, C. M., Zhang, Y., Huang, Y.* (2014). Bone morphogenic protein-4-induced oxidant signaling via protein carbonylation for endothelial dysfunction. Free Radical Biology and Medicine, 75C, 178-190.
  11. Cheang, W. S., Tian, X. Y., Wong, W. T., Lau, C. W., Lee, S. T., Chen, Z. Y., Yao, X., Wang, N., Huang, Y.* (2014). Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis and Vascular Biology, 34(4), 830-6.
  12. Zhang, Y., Liu, J., Tian, X. Y., Wong, W. T., Chen, Y., Wang, L., Luo, J. Y., Cheang, W. S., Lau, C. W., Kwan, K. M., Wang, N., Yao, X., Huang, Y.* (2014). Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology, 34(1), 152-159.
  13. Dong, J., Wong, S. L., Lau, C. W., Liu, J., He, Z. D., Ng, C. F., Yao, X., Chen, Z. Y., Ni, X., Wang, H., Huang, Y.* (2013). Calcitriol restores renovascular function in estrogen-deficient rats through the downregulation of cyclooxygenase-2 and thromboxane-prostanoid receptor. Kidney International, 84(1), 54-63 with commentary, 2013, 84(1), 9-11.
  14. Tian, X. Y., Wong, W. T., Wang, N., Lu, Y., Cheang, W. S., Liu, J., Liu, L., Liu, Y., Lee, S. S. T., Chen, Z. Y., Cooke, J. P., Yao, X., Huang, Y.* (2012). PPARδ activation protects endothelial function in diabetic mice. Diabetes, 61(12), 3285-3293.
  15. Dong, J., Wong, S. L., Lau, C. W., Lee, H. K., Ng, C. F., Zhang, L., Yao, X., Chen, Z. Y., Vanhoutte, P. M., Huang, Y.* (2012). Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. European Heart Journal, 33(23), 2980-2990.
  16. Liu, Y., Tian, X. Y., Mao, G., Fang, X., Fung, M. L., Shyy, J. Y. J., Huang, Y.*, Wang, N.* (2012). Peroxisome proliferator-activated receptor γ ameliorates pulmonary arterial hypertension by inhibiting 5-HT2B receptor. Hypertension, 60(6), 1471-1478.
  17. Liu, L., Liu, J., Wong, W. T., Tian, X. Y., Lau, C. W., Wang, Y. X., Xu, G., Pu, Y., Zhu, Z., Xu, A., Lam, K. S., Chen, Z. Y., Ng, C. F., Yao, X., Huang, Y.* (2012). Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension, 60(3), 833-841.
  18. Yuen, C. Y., Wong, S. L., Lau, C. W., Tsang, S. Y., Xu, A., Zhu, Z., Ng, C. F., Kong, S .K., Lee, H. K., Yao, X., Huang, Y.* (2012). From skeleton to cytoskeleton: Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circulation Research, 111, e55-e66.
  19. Tian, X. Y., Wong, W. T., Xu, A., Lu, Y., Zhang, Y., Wang, L., Cheang, W. S., Wang, Y., Yao, X., Huang, Y.* (2012). Uncoupling protein-2 protects endothelial function in diet-Induced obese mice. Circulation Research, 110(9), 1211-1216.
  20. Tian, X. Y., Wong, W. T., Leung, F. P., Zhang, Y., Wang, Y. X., Lee, H. K., Ng, C. F., Chen, Z. Y., Yao, X., Au, C. L., Lau, C. W., Vanhoutte, P. M., Cooke, J. P., Huang, Y.* (2012). Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling, 16(4), 363-373.
  21. Tian, X. Y., Yung, L. H., Wong, W. T., Leung, F. P., Liu, L., Chen, Y. C., Kong, S. K., Kwan, K. M., Ng, S. S. M., Lai, P. B., Yung, L. M., Yao, X., Huang, Y.* (2012). Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology, 52(1), 237-244.
  22. Cheang, W. S., Wong, W. T., Tian, X. Y., Yang, Q., Lee, H. K., He, G. W., Yao, X., Huang, Y.* (2011). Endothelial nitric oxide synthase enhancer AVE3085 restores endothelial function and reduces oxidative stress in type 2 diabetic db/db mice. Cardiovascular Research, 92(2), 267-275.
  23. Wong, W. T., Tian, X. Y., Xu, A., Yu, J., Lau, C. W., Hoo, R. L. C., Wang, Y., Lee, V. W. Y., Lam, K. S. L., Vanhoutte, P. M., Huang, Y.* (2011). Adiponectin is required for PPARg-mediated improvement of endothelial function in diabetic mice. Cell Metabolism, 14(1), 104-115.
  24. Wong, S. L., Lau, C. W., Wong, W. T., Xu, A., Au, C. L., Ng, C. F., Ng, S. S. M., Yao, X., Huang, Y.* (2011). Pivotal role of PKδ in angiotensin II-induced endothelial cyclooxygenase-2 expression: A link to vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biology, 31(5), 1169-1176.
  25. Yuen, C. Y., Wong, W. T., Tian, X. Y., Wong, S. L., Lau, C. W., Yu, J., Tomlinson, B., Yao, X., Huang, Y.* (2011). Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research, 90(1), 122-129.
  26. Wong, W. T., Tian, X. Y., Chen, Y. C., Leung, F. P., Liu, L., Lee, H.K., Ng, C. F., Xu, A., Yao, X., Vanhoutte, P. M., Tipoe, G. L., Huang, Y.* (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circulation Research, 107(5), 984-991.
  27. Wong, W. T., Tian, X. Y., Xu, A., Ng, C. F., Lee, H. K., Au, C. L., Chen, Z. Y., Yao, X., Huang, Y.* (2010). Angiotensin II type 1 receptor-dependent oxidative stress modulates endothelial dysfunction in aortas of diabetes mice and humans. Antioxidants & Redox Signaling, 16(3), 757-768.
  28. Tian, J., Wong, W. T., Tian, X. Y., Zhang, P., Huang, Y.*, Wang, N.* (2010). Rosiglitazone attenuates endothelin-1-induced vasoconstriction by up-regulating endothelial expression of ETB receptor. Hypertension, 56(1), 129-135.
  29. Chan, Y. C., Leung, F. P., Wong, W. T., Tian, X. Y., Yung, L. M., Lau, C. W., Tsang, S. Y., Yao, Y, Chen, Z. Y., Huang, Y.* (2010). Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation. Arteriosclerosis, Thrombosis and Vascular Biology, 30(5), 992-999.
  30. Wong, S. L., Leung, F. P., Au, C. L., Yung, L. M., Lau, C. W., Yao, X., Chen, Z. Y., Vanhoutte, P. M., Huang, Y.* (2009). Cyclooxygenase-2-derived PGF2a mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during ageing. Circulation Research, 104(2), 228-235 with editorial commentary 104(2), 141-143.

    * Corresponding / Co-corresponding author
  1. RGC - General Research Fund [PI; 01-Jan-20]: "Scavenging mitochondrial ROS by UCP2 attenuates atherosclerosis through suppression of endoplasmic reticulum stress" (HK$1,517,507).
  2. Ministry of Science and Technology of China (MOST) [PI; 29-Jul-19]: "篩選慢性腎病致心腦血管病早期診斷和預後標誌物;研究其致心腦血管損害的發病機制和防治新手段" (RMB1,030,000).
  3. Health and Medical Research Fund [PI; 08-May-19]: "Artificial Sweeteners Improve Vascular Function and Reduce Oxidative Stress in Diabetes and Obesity" (HK$1,500,000).
  4. RGC-Germany/Hong Kong Joint Research Scheme [PI; 08-Jan-19]: "Elementary Calcium Release in Vascular Adaptation, Hypertension and Ageing" (HK$58,100).
  5. RGC - General Research Fund [PI; 01-Jan-19]: "Suppression of Hippo pathway mediates endothelial dysfunction through activating the BMP4-SMAD axis in metabolic disorder" (HK$868,956).
  6. Health and Medical Research Fund [PI; 23-Apr-18]: "Hippo Pathway Mediates the Beneficial Effect Hippo Pathway Mediates the Beneficial Effect of Metformin against Diabetic Vascular Dysfunction and Insulin Resistance" (HK$1,200,000).
  7. RGC - General Research Fund [PI; 01-Jan-18 to 31-Dec-20]: "Targeting YAP/TAZ activation ameliorates endothelial dysfunction in diabetic mice" (HK$1,126,512).
  8. Health and Medical Research Fund [PI; 18-Jul-17 to 17-Jul-19]: "Novel Lipid-lowering-independent Benefits of Statins against Vascular Dysfunction in Metabolic Syndrome" (HK$1,199,176).
  9. RGC - Collaborative Research Fund (CRF) [PI; 30-Jun-17 to 29-Jun-20]: "A Multi-disciplinary Study on the Beneficial Effects of PPARD in Physical Exercise Against Diabetic Vascular Complications: Cellular Crosstalk and Energy Metabolism" (HK$6,817,834).
  10. RGC - General Research Fund [PI; 01-Jan-17 to 31-Dec-19]: "Targeting TFEB to reverse endothelial dysfunction in diabetic mice through induction of autophagy" (HK$1,317,102).
  11. Health and Medical Research Fund [PI; 15-Aug-16 to 14-Aug-18]: "Molecular Mechanisms of Red Wine Resveratrol against Metabolic Vascular Dysfunction" (HK$1,199,696).
  12. Natural Science Foundation of China (NSFC) - National Health and Medical Science Council, Australia (NHMRC) Joint Research Scheme [PI; 25-Jan-16 to 31-Dec-20]: "Identifying the Epigenomic Fingerprint of Coronary Heart Disease in Chinese Adults with Type 2 Diabetes (Project Awarded received by SZRI: RMB 3,500,000; no funding transferred to Hong Kong)" (RMB3,500,000).
  13. Health and Medical Research Fund [PI; 01-Jun-15 to 31-May-17]: "Cellular Mechanisms Underlying the Benefits of Danshen-derived Salvianolic Acid B against Vascular Inflammation and Dysfunction in Diabetes" (HK$999,916).
  14. RGC - General Research Fund [PI; 01-Jan-15 to 31-Dec-17]: "Critical Role of Smad Signaling in Mediating Vascular Inflammation and Dysfunction in Diabetes and Obesity" (HK$959,868).
  15. Germany/Hong Kong Joint Research Scheme [PI; 01-Jan-15 to 31-Dec-16]: "Vascular TRPV1 and TRPV4 Channels: Implications for Hemodynamic Mechanisms of Acute Ischemic Kidney Failure and Paracrine Regulation of Arterial Tone by Perivascular Adipose Tissue" (HK$82,600).
  16. Health and Medical Research Fund [PI; 01-Apr-14 to 31-Mar-16]: "Investigation of In Vivo and In Vitro Vascular Benefits of Vitamin D in Mouse Models of Obesity and Diabetes" (HK$993,920).
  17. National Natural Science Foundation of China [PI; 01-Jan-14 to 31-Dec-16]: "Cross-talk of the Toll-like Receptor and Bone Morphogenic Protein Signaling and its Function in Metabolic Vascular Dysfunction (Project Awarded: RMB 1,600,000; no funding transferred to Hong Kong)" (RMB1,600,000).