School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


HUANG Yu Professor

B.Sc. (Fudan University Shanghai Medical School, China); M.Phil., Ph.D. (University of Cambridge, UK)

Telephone:  39436787

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 223A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Website:   http://www.cuhk.edu.hk/proj/HuangLab/

 

  1. Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency
  2. Endothelium-derived Contracting Factors in the Regulation of Vascular Tone
  3. Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension
  4. Ischemic Stroke and Neuronal Damage
  5. Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs. Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides
  1. Gong, Y., Luo, J.Y., Wang, L. & *Huang, Y. (2017). MicroRNAs regulating reactive oxygen species in cardiovascular diseases. Antioxidants & Redox Signaling 2017 Oct 2. doi: 10.1089/ars.2017.7328. [Epub ahead of print]
  2. Gou, L., Zhao, L., Song, W., Wang, L., Liu, J., Zhang, H., Huang, Y., Lau, C.W., Yao, X.Q., Tian, X.Y., Wong, W.T., Luo, J.Y. & *Huang, Y. (2017). Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 2017 Jul 6. doi: 10.1089/ars.2017.7005. [Epub ahead of print]
  3. Cheang, W.S., Wong, W.T., Zhao, L., Xu, J., Wang, L., Lau, C.W., Chen, Z.Y., Ma, R.C.W., Xu, A., Wang, N., *Tian, X.Y. & *Huang, Y. (2017). PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes 66(2):519-528.
  4. Wang, L., Luo, J.Y., Li, B., Tian, X.Y., Chen, L.J., Huang, Y., Liu, J., Deng, D., Lau, C.W., Wan, S., Ai, D., Mak, K.L., Tong, K.K., Kwan, K.M., Wang, N., Chiu, J.J., *Zhu, Y. & *Huang, Y. (2016).Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540:579-581. Commented in Nature News and Views, Nature 540:531-532.
  5. Zhang, H., Liu, J., Qu, D., Wang, L., Luo, J.Y., Lau, C.W., Liu, P., Gao, Z., Tipoe, G.L., Lee, H.K., Ng, C.F., Ma, R.C.W., Yao, X., & *Huang, Y. (2016). Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 65(5):1196-1207 with Commentary Diabetes 65(5):1152-1154.
  6. Hu, W., Zhang, Y., Wang, L., Lau, C.W., Xu, J., Luo, J.Y., Gou, L., Yao, X.Y., Chen, Z.Y., Ma, R.C.W., Tian, X.Y., & *Huang, Y. (2016). Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology 36(3):553-560.
  7. Zhang, Y., Liu, J., Luo, J.Y., Tian, X.Y., Cheang, W.S., Xu, J., Lau, C.W., Wang, L., Wong, W.T., Wong, C.M., Lan, H.Y., Yao, X.Q., Raizada, M.K., & *Huang, Y. (2015). Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling, 23(11), 880-892 with Cover Image of the Issue.
  8. Liu, J., Wang, L., Tian, X.Y., Liu, L.M., Wong, W.T., Zhang, Y., Han, Q., Ho, H.M., Wang, N., Wong, S.L., Chen, Z.Y., Yu, J., Ng, C.F., Yao, X., & *Huang, Y. (2015). Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes, 64(5), 1654-1575 with commentary 64(5), 1506-1508.
  9. Liu, L., Liu, J., Tian, X.Y., Wong, W.T., Lau, C.W., Xu, A., XU, G., Ng, C.F., Yao, X., Gao, Y., & *Huang, Y. (2014). Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling, 21(11), 1571-1581.
  10. Wong, C.M., Zhang, Y. & *Huang, Y. (2014). Bone morphogenic protein-4-induced oxidant signaling via protein carbonylation for endothelial dysfunction. Free Radical Biology and Medicine 75C:178-190
  11. Cheang, W.S., Tian, X.Y., Wong, W.T., Lau, C.W., Lee, S.T., Chen, Z.Y., Yao, X., Wang, N., & *Huang, Y. (2014). Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4), 830-6.
  12. Zhang, Y., Liu, J., Tian, X.Y., Wong, W.T., Chen, Y., Wang, L., Luo, J.Y., Cheang, W.S., Lau, C.W., Kwan, K.M., Wang, N., Yao, X., & *Huang, Y. (2014). Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology, 34(1), 152-159.
  13. Dong, J., Wong, S.L., Lau, C.W., Liu, J., He, Z.D., Ng, C.F., Yao, X., Chen, Z.Y., Ni, X., Wang, H., & *Huang, Y. (2013). Calcitriol restores renovascular function in estrogen-deficient rats through the downregulation of cyclooxygenase-2 and thromboxane-prostanoid receptor. Kidney International, 84(1), 54-63 with commentary 2013, 84(1), 9-11.
  14. Tian, X.Y., Wong, W.T., Wang, N., Lu, Y., Cheang, W.S., Liu, J., Liu, L., Liu, Y., Lee, S.S.T., Chen, Z.Y., Cooke, J.P., Yao, X., & *Huang, Y. (2012). PPARδ activation protects endothelial function in diabetic mice. Diabetes, 61(12), 3285-3293.
  15. Dong, J., Wong, S.L., Lau, C.W., Lee, H.K., Ng, C.F., Zhang, L., Yao, X., Chen, Z.Y., Vanhoutte, P.M., & *Huang, Y. (2012). Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. European Heart Journal, 33(23), 2980-2990.
  16. Liu, Y., Tian, X.Y., Mao, G., Fang, X., Fung, M.L., Shyy, J.Y.J., *Huang, Y. & *Wang, N. (2012). Peroxisome proliferator-activated receptor γ ameliorates pulmonary arterial hypertension by inhibiting 5-HT2B receptor. Hypertension 60(6):1471-1478.
  17. Liu, L., Liu, J., Wong, W.T., Tian, X.Y., Lau, C.W., Wang, Y.X., Xu, G., Pu, Y., Zhu, Z., Xu, A., Lam, K.S., Chen, Z.Y., Ng, C.F., Yao, X., *Huang, Y. (2012). Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension, 60(3), 833-841.
  18. Yuen, C.Y., Wong, S.L., Lau, C.W., Tsang, S.Y., Xu, A., Zhu, Z., Ng, C.F., Kong, S.K., Lee, H.K., Yao, X., & *Huang, Y. (2012). From skeleton to cytoskeleton: Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circulation Research, 111, e55-e66.
  19. Tian, X.Y., Wong, W.T., Xu, A., Lu, Y., Zhang, Y., Wang, L., Cheang, W.S., Wang, Y., Yao, X., & *Huang, Y. (2012). Uncoupling protein-2 protects endothelial function in diet-Induced obese mice. Circulation Research, 110(9), 1211-1216.
  20. Tian, X.Y., Wong, W.T., Leung, F.P., Zhang, Y., Wang, Y.X., Lee, H.K., Ng, C.F., Chen, Z.Y., Yao, X., Au, C.L., Lau, C.W., Vanhoutte, P.M., Cooke, J.P., & *Huang, Y. (2012). Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling, 16(4), 363-373.
  21. Tian, X.Y., Yung, L.H., Wong, W.T., Leung, F.P., Liu, L., Chen, Y.C., Kong, S.K., Kwan, K.M., Ng, S.S.M., Lai, P.B., Yung, L.M., Yao, X., & *Huang, Y. (2012). Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology, 52(1), 237-244.
  22. Cheang, W.S., Wong, W.T., Tian, X.Y., Yang, Q., Lee, H.K., He, G.W., Yao, X. & *Huang, Y. (2011). Endothelial nitric oxide synthase enhancer AVE3085 restores endothelial function and reduces oxidative stress in type 2 diabetic db/db mice. Cardiovascular Research 92(2):267-275.Cardiovascular Research 92(2):267-275.
  23. Wong, W.T., Tian, X.Y., Xu, A., Yu, J., Lau, C.W., Hoo, R.L.C., Wang, Y., Lee, V.W.Y., Lam, K.S.L., Vanhoutte, P.M., & *Huang, Y. (2011). Adiponectin is required for PPARg-mediated improvement of endothelial function in diabetic mice. Cell Metabolism, 14(1), 104-115.
  24. Wong, S.L., Lau, C.W., Wong, W.T., Xu, A., Au, C.L., Ng, C.F., Ng, S.S.M., Yao, X., & *Huang, Y. (2011). Pivotal role of PKδ in angiotensin II-induced endothelial cyclooxygenase-2 expression: A link to vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biology, 31(5), 1169-1176.
  25. Yuen, C.Y., Wong, W.T., Tian, X.Y., Wong, S.L., Lau, C.W., Yu, J., Tomlinson, B., Yao, X. & *Huang, Y. (2011). Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research 90(1):122-129.
  26. Wong, W.T., Tian, X.Y., Chen, Y.C., Leung, F.P., Liu, L., Lee, H.K., Ng, C.F., Xu, A., Yao, X., Vanhoutte, P.M., Tipoe, G.L., & *Huang, Y. (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circulation Research, 107(5), 984-991.
  27. Wong, W.T., Tian, X.Y., Xu, A., Ng, C.F., Lee, H.K., Au, C.L., Chen, Z.Y., Yao, X. & *Huang, Y. (2010). Angiotensin II type 1 receptor-dependent oxidative stress modulates endothelial dysfunction in aortas of diabetes mice and humans. Antioxidants & Redox Signaling 16(3):757-768
  28. Tian, J., Wong, W.T., Tian, X.Y., Zhang, P., *Huang, Y. & *Wang, N.(2010). Rosiglitazone attenuates endothelin-1-induced vasoconstriction by up-regulating endothelial expression of ETB receptor. Hypertension 56(1):129-135.
  29. Chan, Y.C., Leung, F.P., Wong, W.T., Tian, X.Y., Yung, L.M., Lau, C.W., Tsang, S.Y., Yao, Y, Chen, Z.Y. & *Huang, Y. (2010). Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation.Arteriosclerosis, Thrombosis and Vascular Biology 30(5):992-999.
  30. Wong, S.L., Leung, F.P., Au, C.L., Yung, L.M., Lau, C.W., Yao, X., Chen, Z.Y., Vanhoutte, P.M., & *Huang, Y. (2009). Cyclooxygenase-2-derived PGF2a mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during ageing. Circulation Research, 104(2), 228-235 with editorial commentary, (104(2), 141-143).