School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

LEE Ka Ho Kenneth

Professor

B.Sc., PhD., C.Biol., M.I.Biol.

Telephone:  39436785

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Rm 126A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, CUHK

 

  1. Application of Small Molecules in Stem Cell Biology
  2. Use of Small Molecules in the treatment of Liver fibrosis and heart diseases
  3. Role of BRE gene in HUCPV stem cell biology
  1. Milani, R., Brognara, E., Fabbri, E., Finotti, A., Borgatti, M., Lampronti, I, Marzaro, G., Chilin, A., Lee, K.K.H., Kok, S.H., Chui, C.H. and Gambari, R. (2017). Corilagin induces high levels of apoptosis in the temorzolomide-resistant T98G glioma cell line. Oncology Research, doi.org/10.3727/096504017X14928634401187.
  2. Zhang, P., Wang, G., Lin, Z.-L., Wu, Y., Zhang, J., Liu, M., Lee, K.K.H., Chuai, M., and Yang, X. (2017). Alcohol exposure induces chick crainiofacial bone defects by negatively affecting cranial neural crest development.  Toxicology Letters, 281, 53-64.
  3. Jin, Y.-M., Zhao, S.-Z., Zhang, Z.-L., Chen, Y., Cheng, X., Chuai, M., Liu, G.-S., Lee, K.K.H. and Yang, X. (2017). High glucose level induces cardiovascular dysplasia during early embryo development.  Experimental and Clincial Endocrinology & Diabetes, doi: 10.1055/s-0043-109696.
  4. He, Y.Q., Li, Y., Wang, X.Y., He, X.D., Li, J., Chuai, M., Lee, K.K.H., Wang, J., Wang, L.J. and Yang, X. (2014). Dimethyl phenyl piperazine iodide (DMPP) induces glioma regression by inhibiting angiogenesis, Experimental Cell Research, 320 (2), 354-364.
  5. Lam, K.H., Gambari, R., Lee, K.K.H., Chen, Y.X., Kok, S.H.L., Wong, R.S.M., Lau, F.Y.L., Cheng, C.H., Wong, W.Y., Bian, Z.A., Chan, S.C., Tang, J.O.C. and Chui, C.H. (2014). Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus, Bioorganic & Medicinal Chemistry Letters, 24(1), 367-370.
  6. Chui, Y.L., Ma, C.H., Li, W., Xu, Z., Yao, Y., Lin, K.Y., Chan, J.Y.H. and Lee, K.K.H. (2014). Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells, Apoptosis, 19(5), 829-840.
  7. Lam, P.L., Lu, G.L., Hon, K.M., Lee, K.W., Ho, C.L., Wang, X., Tang, J.C.O., Lam, K.H., Wong, R.S.M., Kok, S.H.L., Bian, Z., Li, H., Lee, K.K.H., Gambari, R., Chui, C.H. and Wong, R.W.Y. (2014). Development of ruthenium (II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus, Dalton Transactions, 43,3949-3957.
  8. Wang, X.Y., Li, Y., Wang, G., Wang, L.J., Münsterberg, A., Chuai, M., Lee, K.K.H., Geng, J.G. and Yang, X. (2014), Combinational electroporation and transplantation approach of studying gene functions in avian embryos, Chinese Science Bulletin, 59(7), 616-624.
  9. Lam, K.H., Lee, K.K.H., Gambari, R., Kok, S.H.L., Kok, T.W., Chan, A SC, Bian, Z.X., Wong, W.Y., Wong, R.S.M., Lau, F.Y., Tong, S.W., Chan, K.W., Cheng, C.H. and Chui, C.H. (2014). Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue, Phytomedicine, 21, 877-882.
  10. Lam, P.L., Lee, K.K.H., Ho, Y.W., Wong, R.S.M., Tong, -W., Cheng, C.H., Lam, K.H., Tang, J.C.O., Bain, Z.-X., Gambari, R., Kok, S.H.L. and Chui, C.H. (2014). Development of chitosan based microcapsules as a delivery vehicle for orally administered daunorubicin, RSC Advances, 4, 14109-14114.
  11. Cheng, X., Wang, G., Lee, K.K.H. and Yang, X. (2014). Dexamethasone use during pregnancy: potential adverse effects on embryonic skeletogenesis, Current Pharmaceutical Design, DOI: 10.2174/1381612820666140205144534 [Epub ahead of print].
  12. Li, Y., Pang, I., Wang, X.-Y., Chuai, M., Münsterberg, A., Lee, K.K.H. and Yang, X. (2014). Endoderm contributes to endocardial composition during cardiogenesis, Chinese Science Bulletin, 59(22), 2749–2755.
  13. Zhao, B.Y., Liao, Z.F., Chen, S., Yuan, Z.Q., Chen, Y.L., Lee, K.K.H., Qi, X.F., Shen, X.T., Zheng, X., Quinn, T. and Cai, D.Q. (2014). Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rat, Journal of Cellular and Molecular Medicine, 8(5), 780-789.
  14. Ma, Z.L., Wang, G., Cheng, X., Chuai, M., Kurihara, H., Lee, K.K.H. and Yang, X. (2014). Excess caffeine exposure impairs eye development during chick embryogenesis, Journal of Cellular and Molecular Medicine, 18(6), 1134-1143.
  15. Lam, P.L., Kok, S.H.L., Bian, Z.X., Lam, K.H., Tang, J.C.O., Lee, K.K.H.*, Gambari, R.* and Chui, C.H.* (2014), D-glucose as a modifying agent in gelatin/collagen matrix and reservoir nanoparticles for Calendula officinalis delivery, Colloids and Surfaces B: Biointerfaces, 117, 277-283 (*co-corresponding author)
  16. Chan, R.Y.K., Lee, K.K.H., Wong, W.Y., Tang, J.C.O., Lam, K.H., Cheng, C.H., Lau, F.Y., Kok, S.H.L., Gambari, R. and Chui, C.H. (2014). The puzzling issue of “vehicle-treated control” when using ethanol as drug carrier for MCF-7 cells. Phytotherapy Research, 28(11):1735-1736
  17. Tang, M.K., Lo, L.M., Shi, W.T., Yao, Y., Lee, H.S.S. and Lee, K.K.H. (2014). Transient acid treatment cannot induce neonatal somatic cells to become pluripotent stem cells, F1000Research, 3,102 (DOI: 10.12688/f1000research.4382).
  18. Chen, Y., Wang, G., Ma, Z.-L., Li, Y., Wang, X.-Y., Cheng, X., Chuai, M., Lee, K.K.H.* and Yang, X.* (2014). Adverse effects of high glucose levels on somite and limb development in avian embryos. Food and Chemical Toxicology, 71, 1-9.
  19. Lam, P.-L., Kok, S.H.L., Bian, Z.-X., Lam, K.-H., Gambari, R., Lee, K.K.H. and Chui, C.-H. (2014), Microencapsulation-protected L-ascorbic acid for the application of human epithelial HaCaT cell proliferation, Journal of Microencapsulation 31(8),754-758.
  20. Li, Y., Wang, G., Lao, P., Chuai, M., Lee, K.K.H., Liu, C. and Yang, X. (2014). Autophagy functions on EMT in gastrulation of avian embryo, Cell Cycle 13(17), 2752-2762
  21. Li, Y., Wang, X.-Y., Zhang, Z.-L., Cheng, X., Li, X.-D., Chuai, M., Lee, K.K.H., Kurihara, H. and Yang, X. (2014). Excess ROS induced by AAPH leads to myocardial hypertrophy during heart development, International Journal of Cardiology, 176(1), 62-73.
  22. Qi, C.-L., Zhou, Q., Li, B., Yang, Y., Cao, L., Ye, Y., Li, J.-C., Ding, Y., Wang, H., Wang, J., He, X.-D., Zhang, Q.-Q. , Lan, T., Lee, K.K.H., Li, W., Song, X., Zhou, J. and Yang, X. (2014). Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis, Oncotarget, 5(20),9966-9979. 
  23. Cheng, X., Chen, J.-L., Ma, Z.-L., Zhang, Z.-L., Lu, S., Mai, D.-M., Liu, J.-J., Chuai, M., Lee, K.K.H., Wan, C. and Yang, X. (2014), Biphasic influence of dexamethasone exposure on embryonic vertebrate skeleton development, Toxicology and Applied Pharmacology, 281(1):19-29.