TL Lee

Associate Professor

Telephone:  39434436

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.


Rm 622A, 6/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

 Head. Genomic platform development at CBIIT

 Vice Chairman. Hong Kong Biotechnology Organization

 Scientific consultant. BGI-Hong Kong


  1. Genomic regulations of non-coding RNAs in stem cell development
  2. Germline stem cell biology
  3. Nanotoxicology and nanomedicine
  4. System biology modeling and algorithm development
  1. Zhao, L. H., Liu, X., Yan, H. X., Li, W. Y., Zeng, X., Yang, Y., Zhao, J., Liu, S. P., Zhuang, X. H., Lin, C., Qin, C. J., Zhao, Y., Pan, Z. Y., Huang, G., Liu, H., Zhang, J., Wang, R. Y., Wen, W., Lv, G. S., Zhang, H. L., Wu, H., Huang, S., Wang, M. D., Tang, L., Cao, H. Z., Wang, L., Lee, T. L., Jiang, H., Tan, Y. X., Yuan, S. X., Hou, G. J., Tao, Q. F., Xu, Q. G., Zhang, X. Q., Wu, M. C., Xu, X., Wang, J., Yang, H. M., Zhou, W. P., & Wang, H. Y. (2016). Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun, 7, 12992.
  2. Tsang, D. P. F., Wu, W. K. K., Kang, W., Lee, Y.-Y., Wu, F., Yu, Z., Xiong, L., Chan, A. W., Tong, J. H., Yang, W., Li, M. S. M., Lau, S. S., Li, X., Lee, S.-D., Yang, Y., Lai, P. B. S., Yu, D.-Y., Xu, G., Lo, K.-W., Chan, M. T. V., Wang, H., Lee, T. L., Yu, J., Wong, N., Yip, K. Y., To, K. F., & Cheng, A. S. L. (2016). Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-B in hepatocellular carcinoma. Journal of Pathology, 238(5), 651-664.
  3. Cheung, H.-H., Yang, Y., Lee, T. L., Rennert, O., & Chan, W.Y. (2016). Hypermethylation of genes in testicular embryonal carcinomas. British Journal of Cancer, 114(2), 230-236.
  4. Tu, J. J., Ng, S. H., Luk, A. C. S., Liao, J. Y., Jiang, X. H., Feng, B., Mak, K. K. L., Rennert, O. M., Chan, W. Y., & Lee, T. L. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Research, 43(16), 7805-7822.
  5. Luk, A. C. S., Gao, H., Xiao, S., Liao, J. Y., Wang, D., Tu, J.J., Rennert, O. M., Chan, W. Y., & Lee, T. L. (2015). GermlncRNA: a unique catalogue of long non-coding RNAs and associated regulations in male germ cell development. Database (Oxford), bav044.
  6. Qian, Y., Tu, J. J., Tang, N. L. S., Kong, G., Chung, J. P., Chan, W. Y., & Lee, T. L. (2015). MicroRNAs mediated targeting on the Yin-yang dynamics of DNA methylation in disease and development. International Journal of Biochemistry & Cell Biology, 67, 121-127.
  7. Chen, X., Gu, S., Chen, B. F., Shen, W. L., Yin, Z., Xu, G. W., Hu, J. J., Zhu, T., Li, G., Wan, C., Ouyang, H. W., Lee, T. L.*, & Chan, W. Y. (2015). Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway. Biomaterials, 53, 239-250. (*co-corresponding author)
  8. Luk, A. C. S., Chan, W. Y., Rennert, O. M., & Lee, T. L. (2014). Long noncoding RNAs in spermatogenesis: insights from recent high-throughput transcriptome studies. Reproduction, 147(5), R131-R141.
  9. Li, P., Goecks, J., & Lee, T. L. (2012). Turning pipe dreams into reality. Genome Biology, 13(8).
  10. Lee, T. L., Raitano, J. M., Rennert, O. M., Chan, S. W., & Chan, W. Y. (2012). Accessing the genomic effects of naked nanoceria in murine neuronal cells. Nanomedicine-Nanotechnology Biology and Medicine, 8(5), 599-608.
  11. Zhu, R. X., Cheng, A. S., Lau, S. S., Chen, Y. C., Lee, T. L., Wong, V. W., Sung, J. J., & Chan, H. L. Y. (2011). Genome-Wide Binding Analysis of Carboxyl-Terminal Truncated HBx Reveals Direct Repression of a Negative Growth Regulator, GAS2, in Hepatucellular Carcinoma. Gastroenterology, 140(5), S144-S144.
  12. Cheung, H. H., Davis, A. J., Lee, T. L., Pang, A. L., Nagrani, S., Rennert, O. M., & Chan, W. Y. (2011). Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene, 30(31), 3404-3415.
  13. Lee, T. L., Li, Y. M., Cheung, H. H., Claus, J., Singh, S., Sastry, C., Rennert, O. M., Lau, Y. F. C., & Chan, W. Y. (2010). GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics, 26(4), 585-586.
  14. Kokkinaki, M., Lee, T. L.*, He, Z. P., Jiang, J. J., Golestaneh, N., Hofmann, M. C., Chan, W. Y., & Dym, M. (2010). Age affects gene expression in mouse spermatogonial stem/progenitor cells. Reproduction, 139(6), 1011-1020.
  15. Cheung, H. H., Lee, T. L., Davis, A. J., Taft, D. H., Rennert, O. M., & Chan, W. Y. (2010). Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. British Journal of Cancer, 102(2), 419-427.
  16. Lee, T. L., Cheung, H. H., Claus, J., Sastry, C., Singh, S., Vu, L., Rennert, O., & Chan, W. Y. (2009). GermSAGE: a comprehensive SAGE database for transcript discovery on male germ cell development. Nucleic Acids Research, 37, D891-D897.
  17. Lee, T. L., Yeh, J., Friedman, J., Yan, B., Yang, X. P., Yeh, N. T., Van Waes, C., & Chen, Z. (2008). A signal network involving coactivated NF-kappa B and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. International Journal of Cancer, 122(9), 1987-1998.
  18. Lee, T. L. (2008). Big data: open-source format needed to aid wiki collaboration. Nature, 455(7212), 461-461.
  19. Yan, B., Yang, X. P., Lee, T. L.*, Friedman, J., Tang, J., Van Waes, C., & Chen, Z. (2007). Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs of p53, NF-kappaB and other signal transcription factors in head and neck squamous cell carcinoma. Genome Biology, 8(5), R78.
  20. Lee, T. L.*, Yang, X. P., Yan, B., Friedman, J., Duggal, P., Bagain, L., Dong, G., Yeh, N.T., Wang, J., Zhou, J., Elkahloun, A., Van Waes, C., & Chen, Z. (2007). A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status.. Clinical Cancer Res, 13(19), 5680-5691. (Featured on cover page).