School of Biomedical Sciences
The Chinese University of Hong Kong 香港中文大學

MAK King Lun Kingston

Assistant Professor

B.Sc., Ph.D.

Telephone:  39434497

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.


 Rm 125A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, CUHK


  1. Study the roles of signaling pathways in cell fate determination of Mesenchymal Stem Cells (MSCs) for development of cartilage, bone and fat.
  2. Study the molecular mechanisms for the development of skeletal diseases and bone cancers.
  3. Investigate the roles of cancer stem cells/progenitor cells in the initiation and progression of skeletal related cancers.
  1. Wang, L., Luo, J. Y., Li, B., Tian, X. Y., Chen, L. J., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., Ai, D., Mak, K. K., Tong, K. K., Kwan, K. M., Wang, N., Chiu, J. J., Zhu, Y., Huang, Y. (2016). Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature, doi: 10.1038/nature20602.
  2. Zhang, X., Cheng, Q., Wang, Y., Leung, P. S., Mak, K. K. (2016). Hedgehog signaling in bone regulates whole body energy metabolism through a bone-adipose endocrine relay mediated by PTHrP and Adiponectin. Cell Death & Differentiation, doi: 10.1038/cdd.2016.113.
  3. Deng, Y., Wu, A., Li, PS., Li, G., Qin, L., Song, H., Mak, K. K. (2016). Yap1 regulates multiple steps of chondrocyte differentiation during skeletal development and repair, Cell Reports, 14(9), 2224-2237.
  4. Tu, J., Ng, S. H., Luk, A. C. S., Liao, J. J., Jiang, X., Feng, B., Mak, K. K., Rennert, O., Chan, W. Y., Lee, T. L. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modeulates mesendoderm differentiation in mouse embryonic stem cells, Nucleic Acids Research, 43(16), 7805-7822.
  5. Mak, K. K. (2015), White adipose tissue browning and cancer cachexia, Journal of Cancer Science, 2(1), 2.
  6. Chan, L. H., Wang, W., Yeung, W., Deng, Y., Yuan, P., Mak, K. K. (2014). Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression, Oncogene, 33(40), 4857-4866.
  7. Li, P., Chen, Y., Mak, K. K., Wong, C. K., Wang, C. C., Yuan, P. (2013). Functional role of Mst1/Mst2 in embryonic stem cell differentiation. PLoS One, 8(11), e79867.doi:10.1371/journal.pone.0079867.
  8. Mak, K. K. (2013). Differential effects of Hedgehog Signaling on postnatal bone remodeling. IBMS Bone Key, 10, 331.
  9. Yang, Y., Zhou, L., Jian, P., Wang, L., Hu, L., Li, X., Chan, L. K. Y., Yu, J., Kwong, J., Cheung, T. H., Chung, T. K. H., Mak, K. K., Sun, H., Wang, H. (2012). A Novel miR-193a-5p-yy1-APC Regulatory Axis in Human Endometrioid Endometrial Adenocarcinoma. Oncogene, 32(29), 3432-3442.
  10. Song, H.*, Mak, K. K.*, Topol, L., Yun, K., Hu, J., Garrett, L., Chen, Y., Park, O., Chang, J., Simpson, R. M., Wang, C. Y., Gao, B., Jiang, J. and Yang, Y. (2010). Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proceedings of the National Academy of Sciences, 107(4), 1431-1436.
  11. Guo, X., Mak, K. K., Maketo, M. M. and Yang, Y. (2009). The Wnt/ b-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation, PLoS One, 4(6), e6067.
  12. Nemeth, M. J., Mak, K. K., Yang, Y. and Bodine, D. M. (2009). b-catenin expression in the bone marrow microenvironment is required for long term maintenance of primitive haematopoitic cells. Stem Cells, 27(5), 1109-1119.
  13. Mak, K. K., Bi, Y., Wan, C., Chuang, P. T., Clemens, T., Young, M. and Yang, Y. (2008). Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression, Developmental Cell, 14(5), 674-678.
  14. Mak, K. K., Kronenberg, H. M., Chuang, P. T., Meckem, S. and Yang, Y. (2008). Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development, 135(11), 1947-1956.
  15. Mak, K. K., Chen, M., Day, T. F., Chuang, P. T. and Yang, Y. (2006). Wnt/b-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development, 133(18), 3695-3707.
  16. Mak, K. K. and Chan, S. Y. (2003). Epidermal growth factor as a biologic switch in hair growth cycle. Journal of Biological Chemistry, 278(28), 26120-26126.
  17. Wong, R. W., Kwan, R. W., Mak, P. H., Mak, K. K., Sham, M. H., Chan, S. Y. (2000). Overexpression of epidermal growth factor induced hypospermatogenesis in transgence mice Journal of Biological Chemistry, 275(24), 18297-18301.