Research Assistant Professor
B.S., M.S., Ph.D.
Telephone: 3943 9620
Room 323A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, The Chinese University of Hong Kong
Prof. PONOMAREV Eugene (龐佑信) is currently appointed to the School of Biomedical Sciences, The Chinese University of Hong Kong, and his research interest is related to the immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis, Alzheimer’s disease and traumatic brain injury. Particularly he is interested in (1) epigenetic and transcriptional control of microglia/macrophage activation during CNS inflammation and (2) the role of platelets in the initiation of neuroinflammation. Both directions of his research program are currently supported by RGC and HMRF grants. Dr. Ponomarev is well known scientist in field of neuroinflammation and neurodegeneration and he is an author of more than 40 publications in top academic journals such as Nature Medicine, Journal of Immunology, Journal of Neuroscience, Brain, Behavior and Immunity, Frontiers in Immunology, and Circulation Research. Dr. Ponomarev serves in the editorial boards of number of International academic journals such as Immunology & Cell Biology, Journal of Immunology, Journal of Neuroscience, Journal of Clinical Immunology, Annals of Neurology, Journal of Neuroinflammation, PLoS One, EMBO Reports etc. Before his relocation to Hong Kong, Eugene Ponomarev spent 12 years in the USA working as a scientist in top academic institutions such as Brigham and Women’s Hospital, Harvard Medical School (Boston) where he held the position of Assistant Professor and his work was supported by RO1 grant form National Institute of Health.
- Immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis, Alzheimer’s disease and traumatic brain injury.
- Epigenetic and transcriptional control of microglia/macrophage activation during CNS inflammation.
- The role of platelets in the initiation and propagation of neuroinflammation.
- Veremeyko, T., Yung, A.W.Y., Dukhinova, M., Strekalova, T., Ponomarev, E.D. (2019). The Role of Neuronal Factors in the Epigenetic Reprogramming of Microglia in the Normal and Diseased Central Nervous System. Frontiers in Cellular Neuroscience, 13, 453. doi: 10.3389/fncel.2019.00453.
- Dukhinova, M., Veremeyko, T., Yung, A.W.Y., Kuznetsova, I.S., Lau, T.Y.B., Kopeikina, E., Chan, A.M.L., & Ponomarev, E.D. (2019). Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease. Neurobiol Aging, 77, 128-143. doi: 10.1016/j.neurobiolaging.2019.01.020.
- Gorlova, A., Pavlov, D., Anthony, D.C., Ponomarev, E.D., Sambon, M., Proshin, A., Shafarevich, I., Babaevskaya, D., Lesсh, K.P., Bettendorff, L., & Strekalova, T. (2019). Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice. Neuropharmacology, 156, 107543. doi: 10.1016/j.neuropharm.2019.02.025.
- Pavlov, D., Bettendorff, L., Gorlova, A., Olkhovik, A., Kalueff, A., Ponomarev, E.D., Inozemtsev, A., Chekhonin, V., Lesсh, K.P., Anthony, D.C., & Strekalova, T. (2019). Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies. Progress in Neuro-psychopharmacology & Biological Psychiatry, 90(2), 104-116. doi: 10.1016/j.pnpbp.2018.11.014.
- Veremeyko, T., Kuznetsova, I.S., Dukhinova, M., Yung, A.W.Y., Kopeikina, E., Barteneva, N.S., & Ponomarev, E.D. (2019). Neuronal Extracellular MicroRNAs miR-124 and miR-9 Mediate Cell–Cell Communication between Neurons and Microglia. Journal of Neuroscience Research, 97(2), 162-184. doi: 10.1002/jnr.24344.
- Kholodenko, R.V., Kalinovsky, D.V., Doronin, I.I., Ponomarev, E.D., & Kholodenko, I.V. (2019). Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations. Current Medicinal Chemistry, 26(3), 396-426., doi: 10.2174/0929867324666170817152554.
- Veremeyko, T., Yung, A.W.Y., Anthony, D.C., Strekalova, T., & Ponomarev, E.D. (2018). Early growth response gene-2 is essential for M1 and M2 macrophage activation and plasticity by modulation of the transcription factor CEBPβ. Frontiers in Immunology, 9, 2515. doi: 10.3389/fimmu.2018.02515.
- Dukhinova, M., Kuznetsova, I., Kopeikina, E., Veniaminova, E., Yung, A.W.Y., Veremeyko, T., Levchuk, K., Barteneva, N.S., Wing-Ho, K.K., Yung, W.H., Liu, J.Y.H., Rudd, J., Yau, S.S.Y., Anthony, D.C, Strekalova T., & Ponomarev, E.D. (2018). Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury. Brain Behavior and Immunity, 74, 7-27. doi: 10.1016/j.bbi.2018.09.009.
- Pomytkin, I., Costa-Nunes, J.P., Kasatkin, V., Veniaminova, E., Demchenko, A., Lyundup, A., Lesh, K.P., Ponomarev, E.D.*, & Strekalova, T* (2018). Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment. CNS Neuroscience & Therapeutics. 24(9), 763-774. doi: 10.1111/cns.
- Ponomarev, E.D. (2018). Fresh evidence for platelets as neuronal and innate immune cells: their role in the activation, differentiation and deactivation of Th1, Th17 and Tregs during tissue inflammation. Frontiers in Immunology, 9, 406. doi: 10.3389/fimmu.2018.00406.
- Veremeyko, T., Yung, A.W.Y., Dukhinova, M., Kuznetsova, I.S., Pomytkin, I., Lyundup, A., Strekalova, T., Barteneva, N., & Ponomarev, E.D. (2018). Cyclic AMP pathway suppress autoimmune neuroinflammation by inhibiting functions of encephalitogenic CD4 T cells and enhancing M2 macrophage polarization at the site of inflammation. Frontiers in Immunology, 9, 50. doi: 10.3389/fimmu.2018.00050.
- Maksimova, N., Krasheninnikov, M., Zhang, Y., Ponomarev, E.D., Pomytkin, I., Melnichenko, G., & Lyundup, A. (2018). Early passage autologous mesenchymal stromal cells accelerate diabetic wound re-epithelialization: A clinical case study. Cytotherapy, 19(12), 1548-1550. doi: 10.1016/j.jcyt.2017.08.017.
- Strekalova, T., Pavlov, D., Markova, N., Bettendorff, L., Chekhonine, V., Pomytkin, I., Lioudynog, V., Svistunov, A., Ponomarev, E.D., & Lesch, K.P. (2017). Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour. Behavioural Brain Research, 335, 122-127.
- Barteneva, N.S., Baiken, Y., Fasler-Kan, E., Alibek, K., Wang, S., Maltsev, N., & Ponomarev, E.D. (2017). Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1868(2), 372-393.
- Starossom, S.C., Veremeyko, T., Dukhinova, M., Yung, A.W.Y., Au, C., Lau, A., Weiner, H.L., & Ponomarev, E.D. (2015). Platelets Play Differential Role in the Regulation of the Initiation and Progression of Autoimmune Neuroinflammation. Circulation Research, 117(9), 779-792.
- Barteneva, N.S., Ponomarev, E.D., Tsytsykova, A., Armant, M., & Vorobjev, I.A. (2014). Mitochondrial staining allows robust elimination of apoptotic and damaged cells during cell sorting. Journal of Histochemistry & Cytochemistry, 62(4),265-275.
- Starossom, S.C., Veremeyko, T., Dukhinova, M., Yung, A.W.Y., & Ponomarev, E.D. (2014). Glatiramer acetate (Copaxone) modulates platelet activation and inhibits thrombin-induced calcium influx: possible role of Copaxone in targeting platelets during autoimmune neuroinflammation. PloS one, 9(5), e96256.
- Doronin, I.I., Vishnyakova, P.A., Kholodenko, V.I., Ponomarev, E.D., Ryazantsev, D., Molotkovskaya, I.M., & Kholodenko, R.V. (2014). Ganglioside GD2 in reception and transduction of cell death signal in tumor cells. BMC Cancer, 14(1), 295.
- Barteneva, N.S., Fasler-Kan, E., Bernimoulin, M., Stern, J.N., Ponomarev, E.D., Duckett, L., & Vorobjev, I.A. (2013). Circulating microparticles: square the circle. BMC Cell Biology, 14(1), 23.
- Veremeyko, T., Siddiqui, S., Sotnikov, I., Yung, A, & Ponomarev, E.D. (2013). IL-4/IL-13-Dependent and Independent Expression of miR-124 and its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and During Allergic Inflammation. PloS one, 8(12), e81774.
- Sotnikov, I., Vermeyko, T., Starossom, S.C., Barteneva, N., Weiner, H.L., & Ponomarev, E.D. (2013). Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PloS one, 8(3), e58979.
* co-corresponding author
- RGC - General Research Fund [PI; 01-Sep-16 to 31-Aug-19]: "The Role of Interactions of Platelets with Brain-specific Neuronal Glycolipids in the Regulation of Neuroinflammation and Modulation of Neuronal Functions during Neurological Disorders" (HK$1,072,550).
- Health and Medical Research Fund [PI; 01-Mar-15 to 28-Feb-17]: "Role of Platelet-T Cell Interactions in Pathogenesis of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO)" (HK$785,000).
- RGC - General Research Fund ECS [PI; 01-Jul-14 to 30-Jun-17]: "The Role of microRNA-124 in Transcriptional Control of Macrophage Polarization and Suppression of Neuroinflammation" (HK$671,175).