B.S., M.S., Ph.D.
Room 323A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, The Chinese University of Hong Kong
- As a part of the big picture, I am interested in the immunological aspects of the regulation of inflammation. Inflammatory response can be viewed as a consequence of events when certain cell players act at a certain time. All events of the inflammation start with the trigger, which is known in some cases such as infection, or still unknown (e.g. most of autoimmune diseases). After trigger, initial damage of the tissue occurs followed by reaction of certain cell types within certain time frame. Platelets respond to damage within seconds, tissue resident macrophages within minutes, granulocytes within hours, peripheral macrophages within days, T and B cells within weeks, and memory T cells and antibodies can persists for years. My research focuses on a very early events of inflammation. Particularly I am interested in the role of tissue resident macrophages (microglia) in the regulation of autoimmune inflammation in the central nervous system (CNS) and the role of platelets in teh initiation of inflammatory response in the CNS.
- The role of microRNAs in adaptation of macrophages and microglia to CNS microenvironment.
- The role of brain-specific glycolipids in lipid rafts of astrocytes and neurons in the regulation of CNS inflammation.
- The role of platelet-lipid raft interactions in the regulation of neuroinflammation, neurodegeneration and development.
- Ponomarev E.D., Shriver L.P., Maresz K. and Dittel B.N. (2005) Microglial Cell Activation and Proliferation Precedes the Onset of CNS Autoimmunity. Journal of Neuroscience Research 81:374-389
- Ponomarev E.D., Shriver L.P. and Dittel B.N. (2006) CD40 Expression on Microglial Cells is Required for Their Completion of a Two-step Activation Process During CNS Autoimmune Inflammation. Journal of Immunology 176:1402-1410
- Ponomarev E.D., Shriver L.P. and Dittel B.N. (2007) GM-CSF Production by Autoreactive T Cells is Required for the Activation of Microglial Cells and the Onset of Experimental Autoimmune Encephalomyelitis. Journal of Immunology 181:39-48
- Ponomarev E.D., Maresz K., Tan Y., Dittel B.N. (2007) CNS-derived Interleukin-4 is Essential for the Regulation of Autoimmune Inflammation and Induces a State of Alternative Activation in Microglial Cells. Journal of Neuroscience 27:10714-10721
- Ponomarev E.D., Veremeyko T., Krichevsky A.K., Weiner H.L. (2011) MicroRNA-124 Promotes Microglia Quiescence and Suppresses EAE by Deactivating Macrophages via the CEBPalpha-PU.1 Pathway. Nature Medicine 17:64-70
- Ponomarev E.D., Veremeyko T., Barteneva N. (2011) Visualization and Quantitation of the Expression of MicroRNAs and their Target Genes in Neuroblastoma Single Cells Using Imaging Cytometry. BMC Research Notes 4:517
- Veremeyko T., Starossom S.C., Weiner H.L., Ponomarev E.D. (2012) Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation. Journal of Visualized Experiments (65)10.3791:4097
- Sotnikov I., Veremeyko T., Starossom S.C., Barteneva N., Weiner H.L. and Ponomarev E.D. (2013) Platelets Recognize Brain-specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation. PLoS One 8(3):e58979
- Veremeyko T., Siddiqui S., Sotnikov I., Yung A. and Ponomarev E.D. (2013) IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and During Allergic Inflammation. PLoS One 8(12):e81774
- Starossom S.C., Veremeyko T., Dukhinova M., Yung A.W.Y. and Ponomarev E.D. (2014) Glatiramer Acetate (Copaxone) Modulates Platelet Activation and Inhibits Thrombin-induced Calcium Influx: Possible Role of Copaxone in Targeting Platelets During Autoimmune Neuroinflammation. PLoS One (Accepted)