PONOMAREV Eugene D

Assistant Professor

B.S., M.S., Ph.D.

Telephone:  39439620

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Room 323A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, The Chinese University of Hong Kong

Website:  https://scholar.google.com/citations?user=SZDQ_oQAAAAJ&hl=en/citations?user=0jvjVzQAAAAJ&hl=en

 

  1. Our research interest is related to the immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis, Alzheimer’s disease and traumatic brain injury.
  2. Epigenetic and transcriptional control of microglia/macrophage activation and polarization during CNS inflammation.
  3. The role of platelets in the initiation and propagation of neuroinflammation.
  1. Veremeyko, T., Yung, A.W.Y., Anthony, D.C., Strekalova, T. & Ponomarev, E.D. (2018). Early growth response gene-2 is essential for M1 and M2 macrophage activation and plasticity by modulation of the transcription factor CEBPβ. Frontiers in Immunology. doi: 10.3389/fimmu.2018.02515.
  2. Veremeyko, T., Kuznetsova, I.S., Dukhinova, M., Yung, A.W.Y., Kopeikina, E., Barteneva, N.S & Ponomarev, E.D. (2018). Neuronal Extracellular MicroRNAs miR-124 and miR-9 Mediate Cell–Cell Communication between Neurons and Microglia. J Neurosci Res. doi: 10.1002/jnr.24344.
  3. Dukhinova, M., Kuznetsova, I., Kopeikina, E., Veniaminova, E., Yung, A.W.Y., Veremeyko, T., Levchuk, K., Barteneva, N.S., Wing-Ho, K.K., Yung, W.H., Liu, J.Y.H., Rudd, J., Yau, S.S.Y., Anthony, D.C, Strekalova, T. & Ponomarev, E.D. (2018). Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury. Brain Behav Immun. pii: S0889-1591(18)30578-6. doi: 10.1016/j.bbi.2018.09.009.
  4. Pomytkin, I., Costa-Nunes, J.P., Kasatkin, V., Veniaminova, E., Demchenko, A., Lyundup, A., Lesh, K.P., Ponomarev, E.* & Strekalova, T.* (2018) Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment. CNS Neuroscience & Therapeutics. doi: 10.1111/cns (*corresponding author).
  5. Ponomarev, E.D. (2018). Fresh evidence for platelets as neuronal and innate immune cells: their role in the activation, differentiation and deactivation of Th1, Th17 and Tregs during tissue inflammation. Frontiers in Immunology. doi: 10.3389/fimmu.2018.00406.
  6. Veremeyko, T., Yung, A.W.Y., Dukhinova, M., Kuznetsova, I.S., Pomytkin, I., Lyundup, A, Strekalova, T, Barteneva N & Ponomarev, E.D. (2018). Cyclic AMP pathway suppress autoimmune neuroinflammation by inhibiting functions of encephalitogenic CD4 T cells and enhancing M2 macrophage polarization at the site of inflammation. Frontiers in Immunology. doi: 10.3389/fimmu.2018.00050.
  7. Kopeikina, E., Dukhinova, M. & Ponomarev, E.D. (2018) Methods of Study of Neuron Structural Heterogeneity: Flow Cytometry vs. Laser Interferometry. Chapter in edited book: Cellular Heterogeneity. Methods and Protocols. Springer Nature, ISBN: 978-1-4939-7679-9. Methods Mol Biol. 1745:155-166. doi: 10.1007/978-1-4939-7680-5_9.
  8. Dukhinova, M., Kopeikina, E. & Ponomarev, E.D. (2018) Usage of Multiparameter Flow Cytometry to Study Microglia and Macrophage Heterogeneity in the Central Nervous System During Neuroinflammation and Neurodegeneration. Chapter in edited book: Cellular Heterogeneity. Methods and Protocols. Springer Nature, ISBN: 978-1-4939-7679-9. Methods Mol Biol. 1745:167-177. doi: 10.1007/978-1-4939-7680-5_10.
  9. Maksimova, N., Krasheninnikov, M., Zhang, Y., Ponomarev, E., Pomytkin, I., Melnichenko, G. & Lyundup, A. (2017). Early passage autologous mesenchymal stromal cells accelerate diabetic wound re-epithelialization: A clinical case study. Cytotherapy. pii: S1465-3249(17)30691-6: doi: 10.1016/j.jcyt.2017.08.017.
  10. Kholodenko, R.V., Kalinovsky, D.V., Doronin, I.I., Ponomarev, E.D. & Kholodenko, I.V. (2017). Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations. Curr Med Chem. 24 (42): doi:10.2174/0929867324666170817152554.
  11. Strekalova, T., Pavlov, D., Markova, N, Bettendorff, L., Chekhonine, V., Pomytkin, I., Lioudynog, V., Svistunov, A. Ponomarev, E.D. & Lesch, K.P. (2017). Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour. Behavioural Brain Research. 335: 122-127.
  12. Barteneva, N.S., Baiken, Y., Fasler-Kan, E., Alibek, K., Wang, S., Maltsev, N., Ponomarev, E.D., Kauanova, S., Moore, A., Beglinger, C. & Vorobjev, I.A. (2017). Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 1868 (2): 372-393.
  13. Starossom, S.C., Veremeyko, T, Dukhinova, M., Yung, A.W.Y., Au, C., Lau, A., Weiner, H.L. & Ponomarev, E.D. (2015). Platelets Play Differential Role in the Regulation of the Initiation and Progression of Autoimmune Neuroinflammation. Circulation Research. 117 (9): 779-792.
  14. Barteneva, N.S., Ponomarev, E.D., Tsytsykova, A., Armant, M. & Vorobjev, I. A. (2014). Mitochondrial staining allows robust elimination of apoptotic and damaged cells during cell sorting. J. Histochem. Cytochem. 62(4):265-275.
  15. Starossom, S.C., Veremeyko, T, Dukhinova, M., Yung, A.W.Y. & Ponomarev, E.D. (2014). Glatiramer acetate (Copaxone) modulates platelet activation and inhibits thrombin-induced calcium influx: possible role of Copaxone in targeting platelets during autoimmune neuroinflammation. PLOS ONE. 2014. 9(5): e96256.
  16. Doronin, I.I, Vishnyakova, P.A., Kholodenko V.I., Ponomarev E.D, Ryazantsev D., Molotkovskaya I.M, Kholodenko R.V. & Ponomarev, E.D. (2014). Ganglioside GD2 in reception and transduction of cell death signal in tumor cells. BMC Cancer. 14(1): 295.
  17. Barteneva, N.S., Fasler-Kan, E., Bernimoulin, M., Stern, J.N., Ponomarev, E.D., Duckett, L. & Vorobjev I.A. (2013). Circulating microparticles: square the circle. BMC Cell Biol. 14(1): 23.
  18. Veremeyko, T., Siddiqui, S., Sotnikov, I., Yung, A. & Ponomarev, E.D. (2013). IL-4/IL-13-Dependent and Independent Expression of miR-124 and its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and During Allergic Inflammation. PLOS ONE. 8(12): e81774.
  19. Sotnikov, I., Vermeyko, T., Starossom, S.C., Barteneva, N., Weiner, H.L. & Ponomarev, E.D. (2013). Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLOS ONE. 8(3): e58979.
  20. Veremeyko, T., Starossom, S.C., Weiner, H.L. & Ponomarev, E.D. (2012). Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J. Vis. Exp. 65: 10.3791/4097.