BSc, MPhil, PhD
326A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK
- Molecular biology of fluorescent proteins.
- Acetylcholinesterase and anti-cholinesterase inhibitors.
- Design of cell-based platforms to screen neuroprotective and antiviral drugs.
- Recombinant expression of antiviral and neuropeptides.
- Expression of therapeutic proteins and enzymes using baculovirus expression systems.
- LIN Huang Quan, Ho, M. T., Lau, L. S., Wong, K. K., Shaw, P. C., and WAN, D. C. (2008) Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease. Chemico-Biological Interactions 175: 352-354.
- WAN, Chi Cheong David and Ip, Denis Tsz Ming (2008) Fluorescent proteins. US patent No: US 7,335,488 B2 Feb 26,2008.
- IP Denis Tsz Ming; WONG Kam Bo and *WAN Chi Cheong David.* (2007) Characterization of Novel Orange Fluorescent Protein Cloned from Cnidarian Tube Anemone Cerianthus sp. Marine Biotechnology 9: 469-478.
- LAU Tat San; LI Yonggang; KAMEOKA Masanori; NG Tzi Bun and WAN Chi Cheong David. (2007) Suppression of HIV Replication Using RNA Interference Against HIV-1 Integrase. FEBS Letters 581(17):3253-3259.
- IP Denis Tsz Ming; WONG Kam Bo and WAN Chi Cheong David. (2007) Characterization of Novel Orange Fluorescent Protein Cloned from Cnidarian Tube Anemone Cerianthus sp. Marine Biotechnology 9: 469-478.
- Shaw, P.C, Ho, M.T; Fung, K.P. and Wan, D.C. (2004) Use of transhinone derivates as cholinesterase inhibitors in treating related diseases. US patent applicaton 20040191334.
- PUN Miu Kuen; WONG Chun Kwok; FUNG Kwok Pui; FONG Yuet Shim Carmen; WONG Ip D. T., Chan S. H., Allen M. D., Bycroft M., Wan D. C.* and Wong K. B. (2004) Crystallization and preliminary crystallographic analysis of a novel orange fluorescent protein from the Cnidaria tube anemone Cerianthus sp. Acta Crystallogr D Biol Crystallogr 60, 340-341. Acta Crystallographica Section D. Biological Crystallography 60: 340-341.
- Jiang J. X., Choi R. C., Siow N. L., Lee H. H., Wan D. C. and Tsim K. W. (2003) Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP-dependent signaling. Journal of Biological Chemistry 278: 45435-45444.
- Ng T. B., Au T. K., Lam T. L., Ye X. Y. and Wan D. C. (2002) Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase. Life Sci 70: 927-935.
- Yao, H. B., Shaw, P. C., Wong, C. C., and Wan, D. C. (2002) Expression of glycogen synthase kinase-3 isoforms in mouse tissues and their transcription in the brain. Journal of Chemical Neuroanatomy 23: 291-297.