School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

<strong>WAN Chi Cheong David</strong>

Associate Professor

BSc, MPhil, PhD

Telephone:  39436252

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 326A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Molecular biology of fluorescent proteins.
  2. Acetylcholinesterase and anti-cholinesterase inhibitors.
  3. Design of cell-based platforms to screen neuroprotective and antiviral drugs.
  4. Recombinant expression of antiviral and neuropeptides.
  5. Expression of therapeutic proteins and enzymes using baculovirus expression systems.
  1. LIN Huang Quan, Ho, M. T., Lau, L. S., Wong, K. K., Shaw, P. C., and WAN, D. C. (2008) Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease. Chemico-Biological Interactions 175: 352-354.
  2. WAN, Chi Cheong David and Ip, Denis Tsz Ming (2008) Fluorescent proteins. US patent No: US 7,335,488 B2 Feb 26,2008.
  3. IP Denis Tsz Ming; WONG Kam Bo and *WAN Chi Cheong David.* (2007) Characterization of Novel Orange Fluorescent Protein Cloned from Cnidarian Tube Anemone Cerianthus sp. Marine Biotechnology 9: 469-478.
  4. LAU Tat San; LI Yonggang; KAMEOKA Masanori; NG Tzi Bun and WAN Chi Cheong David. (2007) Suppression of HIV Replication Using RNA Interference Against HIV-1 Integrase. FEBS Letters 581(17):3253-3259.
  5. IP Denis Tsz Ming; WONG Kam Bo and WAN Chi Cheong David. (2007) Characterization of Novel Orange Fluorescent Protein Cloned from Cnidarian Tube Anemone Cerianthus sp. Marine Biotechnology 9: 469-478.
  6. Shaw, P.C, Ho, M.T; Fung, K.P. and Wan, D.C. (2004) Use of transhinone derivates as cholinesterase inhibitors in treating related diseases. US patent applicaton 20040191334.
  7. PUN Miu Kuen; WONG Chun Kwok; FUNG Kwok Pui; FONG Yuet Shim Carmen; WONG Ip D. T., Chan S. H., Allen M. D., Bycroft M., Wan D. C.* and Wong K. B. (2004) Crystallization and preliminary crystallographic analysis of a novel orange fluorescent protein from the Cnidaria tube anemone Cerianthus sp. Acta Crystallogr D Biol Crystallogr 60, 340-341. Acta Crystallographica Section D. Biological Crystallography 60: 340-341.
  8. Jiang J. X., Choi R. C., Siow N. L., Lee H. H., Wan D. C. and Tsim K. W. (2003) Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP-dependent signaling. Journal of Biological Chemistry 278: 45435-45444.
  9. Ng T. B., Au T. K., Lam T. L., Ye X. Y. and Wan D. C. (2002) Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase. Life Sci 70: 927-935.
  10. Yao, H. B., Shaw, P. C., Wong, C. C., and Wan, D. C. (2002) Expression of glycogen synthase kinase-3 isoforms in mouse tissues and their transcription in the brain. Journal of Chemical Neuroanatomy 23: 291-297.