<strong>WAN Chi Cheong David</strong>

Associate Professor

BSc, MPhil, PhD

Telephone:  39436252

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

326A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Molecular biology of fluorescent proteins.
  2. Acetylcholinesterase and anti-cholinesterase inhibitors.
  3. Design of cell-based platforms to screen neuroprotective and antiviral drugs.
  4. Recombinant expression of antiviral and neuropeptides.
  5. Expression of therapeutic proteins and enzymes using baculovirus expression systems.
  1. Zhao, S.J., Wang, D.H., Li, Y.W., Han, L., Xiao, X., Ma, M., WAN, D.C., Hong, A. & Ma, Y. (2017). A novel selective VPAC2 agonist peptide-conjugated chitosan modified selenium nanoparticles with enhanced anti-type 2 diabetes synergy effects. Int J Nanomedicine 12: 2143-2160.
  2. Wang, Y., Lin, H.Q., Xiao, C.Y., Law, W.K., Hu, J.S., Ip, T.M. & WAN, D.C.C. (2016). Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database. Journal of Functional Foods 20: 159-170.
  3. Wang, Y., Hu, J.S., Lin, H.Q., Ip, T.M. & WAN, D.C. (2016). Herbalog: A tool for target-based identification of herbal drug efficacy through molecular docking. Phytomedicine 23: 1469-1474.
  4. Wang, W.Y., Wong, J.H., Ip, D.T., WAN, D.C. & Cheung, R.C., Ng, T.B. (2016). Bovine Lactoferrampin, Human Lactoferricin, and Lactoferrin 1-11 Inhibit Nuclear Translocation of HIV Integrase. Appl Biochem Biotechnol 179: 1202-1212.
  5. Wang, Y., Lin, H.Q., Law, W.K., Liang, W.C., Zhang, J.F., Hu, J.S., Ip, T.M., Waye, M.M. & WAN, D.C. (2015). Pimozide, a novel fatty acid binding protein 4 inhibitor, promotes adipogenesis of 3T3-L1 cells by activating PPARgamma. ACS Chem Neurosci. 6:211-218.
  6. Wang, Y., Law, W.K., Hu, J.S., Lin, H.Q., Ip, T.M. & WAN, D.C. (2014). Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening. J Chem Inf Model 54: 3046-3050. (patent application filed U.S. Serial No. 62/068,625; US non-provisional patent applied filed on 26 Oct, 2015).
  7. Zhang, X., Huang, S.Z., Gu, W.G., Yang, L.M., Chen, H., Zheng, C.B., Zhao, Y.X., WAN, D.C. & Zheng YT (2014). Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation. Chin J Nat Med 12: 186-193.
  8. Wang, Y., Liang, W.C., Pan, W.L., Law, W.K., Hu, J.S., Ip, D.T., Waye, M.M., Ng, T.B. & WAN, D.C. (2014). Silibinin, a novel chemokine receptor type 4 antagonist, inhibits chemokine ligand 12-induced migration in breast cancer cells. Phytomedicine 21: 1310-1317.
  9. Lin, H.Q., Wang, Y., Chan, K.L., Ip, T.M. & WAN, D.C.C. (2014). Differential Regulation of Lipid Metabolism Genes in the Brain of Acetylcholinesterase Knockout Mice. J Mol Neurosci 53: 397-408.
  10. Gu, W.G., Zhang, X., Ip, D.T., Yang, L.M., Zheng, Y.T. & WAN, D.C. (2014). Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging. FEBS Lett 588: 3461-3468.
  11. Gu, O.W., Ip, D.T., Liu, S.J., Chan, J.H., Wang, Y, Zhang, X., Zheng, Y.T. & WAN, D.C.C. (2014). 1,4-Bis(5-naphthalen-1-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens-epithelium-derived growth factor. Chemico-Biological Interactions. 213C:23-27.
  12. Liang, W.C, Wang, Y., WAN, D.C., Yeung, V.S. & Waye, M.M. (2013). Characterization of miR-210 in 3T3-L1 adipogenesis. J Cell Biochem 114:2699-2707.
  13. Zhou, X.L., Wang, Y., Hu, T., Or, P.M.Y., Wong, J., Kwan. Y.W., WAN, D.C.C., Hoi, P.M., Lai, P.B.S., Yeung, J.H.K. (2013). Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes. Phytomedicine 20(3-4):367-374.
  14. Wang, Y., Pan, W.L., Liang, W.C., Law, W.K., Ip, D.T.M., Ng, T.B., Waye, M.M.Y. & WAN, D.C.C. (2013). Acetylshikonin, a novel AChE inhibitor, inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. Evid-Based Compl Alt.
  15. Chuck, C.P., Chen, C., Ke, Z.H., WAN, D.C.C., Chow, H.F. & Wong, K.B. (2013). Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases. Eur J Med Chem 59:1-6.
  16. Zhou, X.L., Wang, Y., Or, P.M.Y., WAN, D.C.C., Kwan, Y.W. & Yeung, J.H.K. (2012). Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes. Phytomedicine 19: 648-657.
  17. Chuck, C.P., Chow, H.F., WAN, D.C.C. & Wong, K.B. (2011). Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses. Plos One 6.
  18. Chuck, C.P., Chong, L.T., Chen, C., Chow, H.F., WAN, D.C. & Wong KB (2010) Profiling of substrate specificity of SARS-CoV 3CL. Plos One 5: e13197.
  19. Wong, K.K., Ngo, J.C., Liu, S., Lin, H.Q., Hu, C., Shaw, P.C. & WAN, D.C. (2010). Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Chem Biol Interact 187(1-3): 335-9.