School of Biomedical Sciences
The Chinese University of Hong Kong 香港中文大學

YU Siu Bun Sidney

Assistant Professor

B.A., Ph.D.

Telephone:  39436796

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.


 Rm 606a, 6/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK


  1. Metabolic diseases related to membrane trafficking
  2. Vesicular transport between the endoplasmic reticulum and the Golgi
  3. Regulation of lipid droplet homeostasis
  1. Zhao, S., Li, C., Luo, M.X., Siu, K.Y, Gan, W., Zhang, L., Wu, W.K.K., Chan, H.C., & Yu, S. (2017) Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles. Scientific Reports 7: 43207.
  2. Li, C., Luo, M.X., Zhao, S., Chan, H.C., Satoh, A., & Yu, S. (2017) Mammalian TRAPPII serves as a GEF for Rab18 and regulates its lipid droplet association. EMBO Journal 36: 441-457.
  3. Siu, K.Y., Zhou, F., Yu, M., Zhang, L., Wang, T., Liang, Y.H., Chen, Y., Chan, H.C., & Yu, S. (2016) Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondria fragmentation. Scientific Reports 6: 23464.
  4. Chen, Y., Zhou, F., Zou, S., Yu, S., Li, S., Li, D., Song, J., Li, H., He, Z., Hu B, Björn LO, Lipatova Z, Liang Y, Xie Z, Segev N. (2014). A Vps21 endocytic module regulates autophagy. Mol. Biol. of the Cell 25(20):3166-77.
  5. Koreishi, M., Yu, S., Oda, M., Honjo, Y., & Satoh, A. (2013) Casein kinase 2 phosphorylates Sec31 and regulates ER-to-Golgi trafficking. PLoS ONE 8(1): e54382.
  6. Zong, M., Satoh, A., Yu, M.K., Siu, K.Y., Ng, W.Y., Chan, HC, Tanner, T.A., & Yu, S. (2012)TRAPPC9 mediates the interaction between p150Glued and COPII vesicles at the target membrane. PLoS ONE 7(1):e29995.
  7. Yu, S., & Liang Y. (2012). A trapper keeper for TRAPP, its structures and functions.Cell & Molecular Life Sciences 69: 3933-44.
  8. Zong, M., Wu, X.G., Chan, C.W.L., Choi, M.Y., Chan, H.C., Tanner, J.A., & Yu, S. (2011) The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT and TRAPPC9-Associated Congenital Intellectual Disability. PLoS ONE 6(8): e23350.
  9. Cai, H., Yu, S., Menon, S., Cai, Y., Lazarova, D., Fu, C., Reinisch, K., Hay, J.C., & Ferro-Novick, S. (2007) TRAPP I tethers COP II vesicles by binding the coat subunit Sec23p. Nature 445, 941-944.
  10. Yu, S., Satoh, A., Pypaert, M., Mullen, K., Hay, J.C., & Ferro-Novick, S. (2006). mBet3p is required for homotypic COPII vesicle tethering in mammalian cells. Journal of Cell Biology 174, 359-368.
  11. Yu, S., & Roth, M.G. (2002) Casein kinase I regulates membrane-binding by ARF GAP1. Mol. Biol. of the Cell 13, 2559-2570.
  12. Yu, S., Avery, L., Baude, E., & Garbers, D. (1997) Guanylyl cyclase expression in specific sensory neurons: A new family of chemsensory receptors. PNAS 94, 3384-3387.