YU Siu Bun Sidney

Assistant Professor

B.A., Ph.D.

Telephone:  39436796

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Room 324, 3/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

 

  1. Early secretory pathway and mechanism of human diseases related to this process
  2. Regulation of lipid droplet homeostasis
  3. Mechanism of vesicle tethering
  4. Structural and functional study of the vesicle tethering complex TRAPP
  1. Luo, M.X., Li, C, Tan, R., Xu, X., Siu, G.K.Y., Wu, W.K.K., Satoh, A., Wang, T.* & Yu, S.* (2017). A RasGAP DAB2IP acts as Rab40C GAP and regulates its effect on lipid droplet homeostasis. Oncotarget 8(49), 85415-85427. *corresponding authors
  2. Gan, W., Zhang, C., Siu, K.Y., Satoh, A., Tanner, J.A. & Yu, S. (2107). ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic. BMC Cell Biology 18:22
  3. Zhao, S., Li, C, Luo, M.X. , Siu, K.Y., Gan, W., Zhang, L., Wu, W.K.K., Chan, H.C. & Yu, S. (2017). Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles. Scientific Reports 7: 43207.
  4. Li, C., Luo, M.X., Zhao, S., Siu, G.K.Y., Liang, Y., Chan, H.C., Satoh, A. & Yu, S. (2017). COPI-TRAPPII activates Rab18 and regulates its lipid droplet association. EMBO Journal 36: 441-457
  5. Siu, K.Y., Zhou, F., Yu, M., Zhang, L., Wang, T., Liang, Y.H., Chen, Y., Chan HC & Yu, S. (2016). Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondria fragmentation. Scientific Reports 6: 23464
  6. Luo, M.X., Wong, S.H., Chan, M.T., Yu, L., Yu, S., Wu, F., Xiao, Z., Wang, X., Zhang, L., Cheng, A.S, Ng, S., Chan, F.K., Cho, C.H., Yu, J., Sung, J.J. & Wu, W.K. (2015) Autophagy mediates HBx-induced Nuclear Factor-κB activation and release of IL-6, IL-8 and CXCL2 in hepatocytes. Journal of Cellular Physiology 230(10):2382-9
  7. Zou, S., Liu, Y., Zhang, C., Yu, S. & Liang, Y. (2015). Bet3 participates in autophagy through GTPase Ypt1 in Saccharomyces cerevisiae. Cell Biology International 39(4):466-74
  8. Chen, Y., Zhou, F., Zou, S., Yu, S., Li, S., Li, D., Song, J., Li, H., He, Z., Hu, B., Björn, L.O., Lipatova, Z., Liang, Y., Xie, Z. & Segev, N.(2014). A Vps21 endocytic module regulates autophagy. Mol. Biol. of the Cell 25(20):3166-77
  9. Xie, C.M., Liu, X.Y., Yu, S. & Cheng, C.H. (2013) Cardiac glycosides block cancer growth through HIF-1α and NF-κB-mediate PLK1. Carcinogenesis, 34(8):1870-1880
  10. Koreishi., M, Gniadek, T., Yu, S., Masuda, J., Honjo, Y. & Satoh, A. (2013). The golgin tether Giantin regulates the secretory pathway by controlling stack organization within Golgi apparatus. PLoS ONE 8(3): e59821
  11. Koreishi, M., Yu, S., Oda, M., Honjo, Y. & Satoh, A. (2013) Casein kinase 2 phosphorylates Sec31 and regulates ER-to-Golgi trafficking. PLoS ONE 8(1): e54382
  12. Zou, S., Chen, Y., Liu, Y., Segev, N., Yu, S., Liu, Y., Min, G., Ye, M., Zeng, Y., Zhu, X., Hong, B., Björn, L.O., Liang, Y., Li, S. & Xie, Z. (2013). Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae. Traffic 14(2):233-246
  13. Yu, S. & Liang, Y. (2012). A trapper keeper for TRAPP, its structures and functions. Cell & Molecular Life Sciences 69: 3933-44
  14. Tang, X.X., Fok, K.L., Chen, H., Chan, K.S., Tsang, L.L., Rowlands, D.K., Zhang, X.H., Dong, D.J., Ruan, Y.C., Jiang, X., Yu, S., Chung, Y.W. & Chan, H.C. (2012). Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing. Journal of Cellular Physiology 227(12): 3887-3894
  15. Zong, M., Satoh, A., Yu, M.K., Siu, K.Y., Ng. W.Y., Chan, H.C., Tanner, T.A., & Yu, S. (2012). TRAPPC9 mediates the interaction between p150 Glued and COPII vesicles at the target membrane. PLoS ONE 7(1): e29995
  16. Zhang, J.P., Dong, J.D., Gu, H., Yu, S., Zhang, X.H., Gou, Y.L., Xu, W.M., Burd, A., Huang, L., Miyado, K., Huang, Y.S. & Chan, H.C. (2012). CD9 is critical for cutaneous wound healing through JNK signalling. Journal of Investigative Dermatology 132(1): 226-236
  17. Zong, M., Wu, X.G., Chan, C.W.L, Choi, M.Y., Chan, H.C., Tanner, J.A., & Yu, S. (2011). The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT and TRAPPC9-Associated Congenital Intellectual Disability. PLoS ONE 6(8): e23350.
  18. Xie, C.M., Chan, W.Y., Yu, S., Zhao, J. & Cheng, C.H.K. (2011). Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. Free Radical Biology and Medicine 51: 1365-1375
  19. Siu, K.Y., Yu, M.K., Roth, M.G., Chan, H.C, & Yu, S. (2011). The non-catalytic carboxyl-terminus of ARFGAP1 inhibits cell spreading and antagonizes activation of Rac1. PLoS ONE 6(4): e18458
  20. Chen, H., Fok, K.L., Yu, S., Jiang, J.L., Chen, Z.N., Gui, Y.T., Cai, Z.M. & Chan, H.C. (2011). CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Molecular Human Reproduction 17(7): 405-414
  21. Tang, X.X., Chen, H., Yu, S., Zhang, L., Caplan, M. & Chan, H.C. (2010). Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK). PLoS ONE 5(8): e12343
  22. Yamasaki, A., Menon, S., Yu, S., Barrowman, J., Meerloo, T., Oorschot, V., Klumperman, J., Satoh, A., & Ferro-Novick S. (2009) mTrs130 is a component of a mammalian TRAPP complex, a Rab1 GEF that Binds to COPI Coated Vesicles. Mol. Biol. of the Cell 20, 4205-4215
  23. Moh, A., Zhang, W., Yu, S., Wang, J., Xu, X., Li, J. & Fu, X.Y. (2008). STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3beta. Diabetes 57,1227-1235
  24. Cai, H., Yu, S., Menon S, Cai Y, Lazarova D, Fu, C., Reinisch, K., Hay, J.C. & Ferro-Novick, S. (2007). TRAPP I tethers COP II vesicles by binding the coat subunit Sec23p. Nature 445, 941-944
  25. Yu, S., Satoh, A., Pypaert, M., Mullen, K., Hay, J.C. & Ferro-Novick, S. (2006). mBet3p is required for homotypic COPII vesicle tethering in mammalian cells. Journal of Cell Biology 174, 359-368
  26. Feng, Y, Yu, S., Lasell, T.K.R., Jadhav, A.P., Macia, E., Chardin, P., Melancon, P., Roth, M.G., Mitchitson, T. & Kirchausen, T. (2003). Exo1, a new chemical inhibitor of the secretory pathway. P.N.A.S. 100, 6469-6474
  27. Yu, S., & Roth, M.G. (2002). Casein kinase I regulates membrane-binding by ARF GAP1. Mol. Biol. of the Cell 13, 2559-2570.
  28. Baude, E.J., Arora, V.K., Yu, S., Garbers, D., & Wedel, B.I. (1997). The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor. Journal of Biological Chemistry 272, 16035-16039.
  29. Yu, S., Avery, L., Baude, E., & Garbers, D. (1997). Guanylyl cyclase expression in specific sensory neurons: A new family of chemsensory receptors. P.N.A.S. 94, 3384-3387.
  30. Mosig, G., Yu, S., Myung, H., Haggard-Ljungquist, E., Davenport, L., Carlson, K. & Calendar, R. (1997). A novel mechanism of virus-virus interactions: Bacteriophage P2 Tin protein inhibits phage T4 DNA synthesis by poisoning the T4 single-stranded DNA binding protein, gp32. Virology 230, 72-81.