Associate Professor

BSc, MPhil, PhD

Telephone:  3943 6104

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 404A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

  

Biography

Prof. CHEUNG Wing Tai (張榮泰) was trained initially in The Chinese University of Hong Kong as a biochemist and pharmacologist working on G protein-coupled receptor (GPCR)- regulated smooth muscle contraction and lipid metabolism. As a Croucher scholar, Dr. Cheung received his PhD degree in Cambridge University on molecular neurobiology studying orphan GPCRs. Postdoctoral training with Dr. John Rogers worked on calcium binding proteins. Dr. Cheung’s laboratory is built on his life-long pursuit of GPCR being a key regulator of life and therefore a valuable drug target, research themes are focused on pathophysiology of cancers and metabolic syndromes, and exploring protein engineering for therapeutic anti-GPCR antibody development.

  1. Antibody engineering and design.
  2. G protein-coupled receptors.
  3. Non-coding RNAs and repetitive sequences.
  4. Lipids in signaling and diseases.
  5. Cancer Biology.
  1. Jin, L., Li, Z.F., Wang, D.K., Sun, M., Qi, W., Ma, Q., Zhang, L., Chu, C., Chan, E.Y.M., Lee, S.S.T., Wise, H., To, K.F., Shi, Y., Zhou, N.* & Cheung W.T.* (2018). Molecular and functional characterization of tumor-induced factor (TIF): Hamster homolog of CXCL3 (GROγ) displays tumor suppressive activity. Cytokine, 102: 62-75. PMID: 29276973. DOI: 10.1016/j.cyto.2017.12.019
  2. Feng, L., Yuen, Y.L., Xu, J., Liu, X., Chan, M.Y.C., Wang, K., Fong, W.P., Cheung, W.T.* & Lee S.S.T.* (2017). Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8). J Lipid Res., 58: 1114-1131. (Paper is accompanied with an editorial Commentary by Paul Dawson and Kenneth Setchell). PMID: 28442498. DOI: 10.1194/jlr.M074302 
  3. Zhao, Q., Wong, P.F., Lee, S.S.T., Leung, S.O., Cheung, W.T.* & Wang, J.Z.* (2014). Generation of anti-idiotype scFv for pharmacokinetic measurement in lymphoma patients treated with chimera anti-CD22 antibody SM03. PLoS One, 9: e96697. PMID: 24816427. DOI: 10.1371/journal.pone.0096697
  4. Jiang, L.L., Teng, G.M.K., Chan, E.Y.M., Au, S.W.N., Wise, H., Lee, S.S.T. & Cheung, W.T. (2012). Impact of cell type and epitope tagging on heterologous expression of G protein-coupled receptor: A systematic study on angiotensin type II receptor. PLoS One, 7: e47016. PMID: 23056563. DOI: 10.1371/journal.pone.0047016
  5. Cheng, M., Chan, S.Y.W., Zhao, Q., Chan, E.Y.M., Au, S.W.N., Lee, S.S.T. & Cheung, W.T. (2011). Construction and characterization of single-chain variable fragment (scFv) antibody library derived from germline rearranged immunoglobulin variable genes. PLoS One, 6: e27406. PMID: 22096568. DOI:10.1371/journal.pone.0027406
  6. Lin, W.Z., Li, Z.F., Tsang, S.Y., Lung, L.K.W., Zhu, Y.K., Cheng, M., Chan, W.Y., Lee, S.S.T. & Cheung, W.T. (2009). Identification and characterization of a novel CXC chemokine in xenograft tumor induced by mas over-expressing cells. Int. J. Cancer, 125: 1316-1327. PMID: 19408311. DOI: 10.1002/ijc.24440
  7. Sun, Y., Ng, L., Lam, W., Lo, C.K.C., Chan, P.T., Yuen, Y.L. Wong, P.F., Tsang, D.S.T., Cheung, W.T. & Lee, S.S.T. (2008). Identification and characterization of a novel mouse peroxisome proliferator-activated receptor α-regulated and starvation-induced gene, Ppsig. Int. J. Biochem. Cell Biol., 40(9): 1775-1791. PMID: 18289917. DOI: 10.1016/j.biocel.2008.01.006.
  8. Cheng, M., Lee, S.S.T. & Cheung, W.T. (2007). Dual effect of endothelin I on angiotensin II-potentiated purinergic neurotransmission in prostatic rat vas deferens. Eur. J. Pharmacol., 557: 204-211. PMID: 17196586. DOI:10.1016/j.ejphar.2006.11.035.
  9. Bikkavilli, R.K., Tsang, S.Y., Tang, W.M., Sun, J.X., Ngai, S.M., Lee, S.S.T., Ko, W.H., Wise, H. & Cheung, W.T. (2006). Identification and characterization of surrogate peptide ligand for orphan G protein-coupled receptor mas using phage-displayed peptide library. Biochem. Pharmacol., 71: 319-337. PMID: 16336942. DOI: 10.1016/j.bcp.2005.10.050.
  10. Cheng, M., Chan, C.W.L., Cheung, R.C.F., Bikkavilli, R.K., Zhao, Q., Au, S.W.N., Chan, P.K.S., Lee, S.S.T., Cheng, G., Ho, W.K.K. & Cheung, W.T. (2005). Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11. Biochem. Biophys. Res. Commun., 338: 1654-1660. PMID: 16263078. DOI:10.1016/j.bbrc.2005.10.088
  11. Lee, S.S.T., Chan, W.Y., Lo, C.K.C., Wan, D.C.C., Tsang, D.S.C. & Cheung, W.T. (2004). Requirement of PPARα in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation. J. Lipid Res., 45: 2025-2037. PMID: 15342691. DOI:10.1194/jlr.M400078-JLR200.
  12. Wong, P.F., Lee, S.S.T. & Cheung, W.T. (2004). Immunohistochemical colocalization of type II angiotensin receptors with somatostatin in rat pancreas. Regul. Peptid., 117: 195-205. PMID: 14749040. DOI:10.1016/j.regpep.2003.10.019
  13. Lee, S.S.T., Li, T., Lee, W.S. & Cheung, W.T. (2002). Application of fluorescent differential display and PPARα-null mice to analyse PPAR target genes. Method Enzymol., 357: 214-240. PMID: 12424913.
  14. Cooper, A.C., Robinson, G., Vinson, G.P., Cheung, W.T. & Broughton, Pipkin F. (1999). The localization and expression of the renin-angiotensin system in the human placenta throughout pregnancy. Placenta, 20: 467-474. PMID: 10419812. DOI:10.1053/plac.1999.0404.
  15. Cheung, W.T., Yeung, S.Y., Yiu, A.K.L., Ip, T.M., Wan, D.C.C., Luk, S.K.S. & Ho, W.K.K. (1999). Characterization of a functional AT1A angiotensin receptor in pancreatoma AR4-2J cells. Peptides, 20: 829-836. PMID: 10477083. DOI:10.1016/S0196-9781(99)00069-8.
  16. Sum, C.S., Wan, C.C. & Cheung, W.T. (1996). Potentiation of purinergic transmission by angiotensin in prostatic rat vas deferens. Br. J. Pharmacol., 118: 1523-1529. PMID: 8832081.
  17. Cheung, W.T., Richards, D.E. & Rogers, J.H. (1993). Calcium binding by chick calretinin and rat calbindin-D28K synthesized in bacteria. Eur. J. Biochem., 215: 401-410. PMID: 8344307. DOI:10.1111/j.1432-1033.1993.tb18047.x.
  18. Hanley, M.R., Cheung, W.T., Hawkins, P., Poyner, D., Benton, H.P., Blair, L., Jackson, T.R. & Goedert, M. (1990). The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action. Ciba Foundation Symposium, 150: 23-46. PMID: 2197067.
  19. Cheung, W.T., Lee, C.M. & Ng, T.B. (1988). Potentiation of the anti-lipolytic effect of 2-chloroadenosine after chronic caffeine treatment. Pharmacol., 36: 331-339. PMID: 3406045. DOI:10.1159/000138403.
  20. Cheung, W.T., Shi, M.M., Young, J.D. & Lee, C.M. (1987). Inhibition of radioligand binding to A1 adenosine receptors by bay K8644 and nifedipine. Biochem. Pharmacol., 36: 2183-2186. PMID: 2440436. DOI: 10.1016/0006-2952(87)90148-1.

    * Corresponding / Co-corresponding author
  1. Health and Medical Research Fund [PI; 01-Jun-15 to 31-Aug-17]: "Exploring the Functional Roles of Stromal Leukotrienes in Cancer Development and Treatment" (HK$846,408).
  2. RGC - General Research Fund [PI; 01-Jan-15 to 30-Jun-18]: "Is Bile Acid a Metabolic Regulator Required for Maintaining Energy Homeostasis?" (HK$975,241).