LEE Ka Ho Kenneth

Professor

B.Sc., PhD., C.Biol., M.I.Biol.

Telephone:  3943 6785

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Rm 126A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, CUHK

  

Biography

Professor Lee Ka Ho Kenneth (李嘉豪) is the Chief of the Developmental and Regenerative Biology Thematic Research Program.  He is also the Director of the Joint CUHK-University of Southampton laboratory for Stem cell and Regenerative Medicine.  Educated in Scotland, he has over 35 years of research and teaching experiences, published 148 scientific papers and awarded 2 US patents.  His research interests, among which many have commercial values, include the discovery of small molecules that induce somatic cells into become pluripotent stem cells, molecular biology of embryo development, cardiac and skeletal muscles regeneration, BRE gene in stem cell and cancer biology, and drug discovery for the treatment of liver fibrosis.  In 2015, Professor Lee found a startup StapWorks Stem Cell Limited which markets a “Programin kit” for producing stem cells from human skin fibroblasts.  Stapworks’ performance was recognized by the Hong Kong Federation of Innovative Technologies and Manufacturing Industries (FITMI) and Bank of China and was a Bronze Award winner in 2015.  Professor Lee has also won many other awards including the prestigious Diamond Jubilee International Visiting Fellowship, University of Southampton.  In addition, he is a Prestigious Professor at the Chinese Academy of Science and a visiting Professor at Robert Gordon University. 

  1. Application of Small Molecules in Stem Cell Biology.
  2. Use of Small Molecules in the treatment of Liver fibrosis and heart diseases.
  3. Role of BRE gene in HUCPV stem cell biology.
  1. Milani, R., Brognara, E., Fabbri, E., Finotti, A., Borgatti, M., Lampronti, I, Marzaro, G., Chilin, A., Lee, K.K.H., Kok, S.H., Chui, C.H. and Gambari, R. (2017). Corilagin induces high levels of apoptosis in the temorzolomide-resistant T98G glioma cell line. Oncology Research, doi.org/10.3727/096504017X14928634401187.
  2. Zhang, P., Wang, G., Lin, Z.-L., Wu, Y., Zhang, J., Liu, M., Lee, K.K.H., Chuai, M., and Yang, X. (2017). Alcohol exposure induces chick crainiofacial bone defects by negatively affecting cranial neural crest development.  Toxicology Letters, 281, 53-64.
  3. Jin, Y.-M., Zhao, S.-Z., Zhang, Z.-L., Chen, Y., Cheng, X., Chuai, M., Liu, G.-S., Lee, K.K.H. and Yang, X. (2017). High glucose level induces cardiovascular dysplasia during early embryo development.  Experimental and Clincial Endocrinology & Diabetes, doi: 10.1055/s-0043-109696.
  4. He, Y.Q., Li, Y., Wang, X.Y., He, X.D., Li, J., Chuai, M., Lee, K.K.H., Wang, J., Wang, L.J. and Yang, X. (2014). Dimethyl phenyl piperazine iodide (DMPP) induces glioma regression by inhibiting angiogenesis, Experimental Cell Research, 320 (2), 354-364.
  5. Lam, K.H., Gambari, R., Lee, K.K.H., Chen, Y.X., Kok, S.H.L., Wong, R.S.M., Lau, F.Y.L., Cheng, C.H., Wong, W.Y., Bian, Z.A., Chan, S.C., Tang, J.O.C. and Chui, C.H. (2014). Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus, Bioorganic & Medicinal Chemistry Letters, 24(1), 367-370.
  6. Chui, Y.L., Ma, C.H., Li, W., Xu, Z., Yao, Y., Lin, K.Y., Chan, J.Y.H. and Lee, K.K.H. (2014). Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells, Apoptosis, 19(5), 829-840.
  7. Lam, P.L., Lu, G.L., Hon, K.M., Lee, K.W., Ho, C.L., Wang, X., Tang, J.C.O., Lam, K.H., Wong, R.S.M., Kok, S.H.L., Bian, Z., Li, H., Lee, K.K.H., Gambari, R., Chui, C.H. and Wong, R.W.Y. (2014). Development of ruthenium (II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus, Dalton Transactions, 43,3949-3957.
  8. Wang, X.Y., Li, Y., Wang, G., Wang, L.J., Münsterberg, A., Chuai, M., Lee, K.K.H., Geng, J.G. and Yang, X. (2014), Combinational electroporation and transplantation approach of studying gene functions in avian embryos, Chinese Science Bulletin, 59(7), 616-624.
  9. Lam, K.H., Lee, K.K.H., Gambari, R., Kok, S.H.L., Kok, T.W., Chan, A SC, Bian, Z.X., Wong, W.Y., Wong, R.S.M., Lau, F.Y., Tong, S.W., Chan, K.W., Cheng, C.H. and Chui, C.H. (2014). Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue, Phytomedicine, 21, 877-882.
  10. Lam, P.L., Lee, K.K.H., Ho, Y.W., Wong, R.S.M., Tong, -W., Cheng, C.H., Lam, K.H., Tang, J.C.O., Bain, Z.-X., Gambari, R., Kok, S.H.L. and Chui, C.H. (2014). Development of chitosan based microcapsules as a delivery vehicle for orally administered daunorubicin, RSC Advances, 4, 14109-14114.
  11. Cheng, X., Wang, G., Lee, K.K.H. and Yang, X. (2014). Dexamethasone use during pregnancy: potential adverse effects on embryonic skeletogenesis, Current Pharmaceutical Design, DOI: 10.2174/1381612820666140205144534 [Epub ahead of print].
  12. Li, Y., Pang, I., Wang, X.-Y., Chuai, M., Münsterberg, A., Lee, K.K.H. and Yang, X. (2014). Endoderm contributes to endocardial composition during cardiogenesis, Chinese Science Bulletin, 59(22), 2749–2755.
  13. Zhao, B.Y., Liao, Z.F., Chen, S., Yuan, Z.Q., Chen, Y.L., Lee, K.K.H., Qi, X.F., Shen, X.T., Zheng, X., Quinn, T. and Cai, D.Q. (2014). Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rat, Journal of Cellular and Molecular Medicine, 8(5), 780-789.
  14. Ma, Z.L., Wang, G., Cheng, X., Chuai, M., Kurihara, H., Lee, K.K.H. and Yang, X. (2014). Excess caffeine exposure impairs eye development during chick embryogenesis, Journal of Cellular and Molecular Medicine, 18(6), 1134-1143.
  15. Lam, P.L., Kok, S.H.L., Bian, Z.X., Lam, K.H., Tang, J.C.O., Lee, K.K.H.*, Gambari, R.* and Chui, C.H.* (2014), D-glucose as a modifying agent in gelatin/collagen matrix and reservoir nanoparticles for Calendula officinalis delivery, Colloids and Surfaces B: Biointerfaces, 117, 277-283 (*co-corresponding author)
  16. Chan, R.Y.K., Lee, K.K.H., Wong, W.Y., Tang, J.C.O., Lam, K.H., Cheng, C.H., Lau, F.Y., Kok, S.H.L., Gambari, R. and Chui, C.H. (2014). The puzzling issue of “vehicle-treated control” when using ethanol as drug carrier for MCF-7 cells. Phytotherapy Research, 28(11):1735-1736
  17. Tang, M.K., Lo, L.M., Shi, W.T., Yao, Y., Lee, H.S.S. and Lee, K.K.H. (2014). Transient acid treatment cannot induce neonatal somatic cells to become pluripotent stem cells, F1000Research, 3,102 (DOI: 10.12688/f1000research.4382).
  18. Chen, Y., Wang, G., Ma, Z.-L., Li, Y., Wang, X.-Y., Cheng, X., Chuai, M., Lee, K.K.H.* and Yang, X.* (2014). Adverse effects of high glucose levels on somite and limb development in avian embryos. Food and Chemical Toxicology, 71, 1-9.
  19. Lam, P.-L., Kok, S.H.L., Bian, Z.-X., Lam, K.-H., Gambari, R., Lee, K.K.H. and Chui, C.-H. (2014), Microencapsulation-protected L-ascorbic acid for the application of human epithelial HaCaT cell proliferation, Journal of Microencapsulation 31(8),754-758.
  20. Li, Y., Wang, G., Lao, P., Chuai, M., Lee, K.K.H., Liu, C. and Yang, X. (2014). Autophagy functions on EMT in gastrulation of avian embryo, Cell Cycle 13(17), 2752-2762
  21. Li, Y., Wang, X.-Y., Zhang, Z.-L., Cheng, X., Li, X.-D., Chuai, M., Lee, K.K.H., Kurihara, H. and Yang, X. (2014). Excess ROS induced by AAPH leads to myocardial hypertrophy during heart development, International Journal of Cardiology, 176(1), 62-73.
  22. Qi, C.-L., Zhou, Q., Li, B., Yang, Y., Cao, L., Ye, Y., Li, J.-C., Ding, Y., Wang, H., Wang, J., He, X.-D., Zhang, Q.-Q. , Lan, T., Lee, K.K.H., Li, W., Song, X., Zhou, J. and Yang, X. (2014). Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis, Oncotarget, 5(20),9966-9979. 
  23. Cheng, X., Chen, J.-L., Ma, Z.-L., Zhang, Z.-L., Lu, S., Mai, D.-M., Liu, J.-J., Chuai, M., Lee, K.K.H., Wan, C. and Yang, X. (2014), Biphasic influence of dexamethasone exposure on embryonic vertebrate skeleton development, Toxicology and Applied Pharmacology, 281(1):19-29.
  1. Pneumoconiosis Compensation Fund Board [PI; 01-Aug-17 to 31-Jan-19]: "Efficacy of Bioactive Tree Bark Extracts to Reverse Idiopathic Pulmonary Fibrosis" (HK$702,094).
  2. Hong Kong Cancer Fund [PI; 01-Jul-17 to 30-Jun-19]: "Translation Application of the Tree Bark Extract for the Treatment of Human Liver Fibrosis" (HK$2,280,000).
  3. Hong Kong Cancer Fund [PI; 01-Mar-16 to 28-Feb-17]: "Translation Application of the Tree Bark Extract for the Treatment of Human Liver Fibrosis" (HK$1,500,000).
  4. RGC - General Research Fund [PI; 01-Dec-15 to 30-Nov-18]: "Effects of Conditional Knockout of the Bcl-2-associated Athanogene-1 (Bag-1) Gene on Chondrogenesis and Osteogenesis in Murine Skeletal Development" (HK$1,324,987).
  5. RGC - General Research Fund [PI; 01-Jan-14 to 31-Dec-16]: "Functions of the Brain and Reproductive organ-Expressed (BRE) gene in mouse embryo development and gonadogenesis" (HK$848,712).