B.S., M.S., Ph.D.
電話: 3943 9620
Room 323A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, The Chinese University of Hong Kong
Prof. PONOMAREV Eugene (龐佑信) is currently appointed to the School of Biomedical Sciences, The Chinese University of Hong Kong, and his research interest is related to the immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis, Alzheimer’s disease, traumatic brain injury, and epilepsy. Previously, Prof. Ponomarev accomplished his postdoctoral training in neurology and immunology at Blood Center of Wisconsin (Medical College of Wisconsin) and Harvard Medical School (Harvard University and Brigham and Women’s Hospital) in the USA.
Here is the list of main ongoing research projects in Prof. Ponomarev’s laboratory: 1) the role of platelets and brain-specific glycolipids in the regulation of neuroinflammation and neuronal repair in the pathogenesis of Alzheimer’s disease and epilepsy, 2) transcriptional control of macrophage/microglia activation, 3) the role of B1a B cells and central nervous system immunoglobulins in neuronal repair, and 4) the role of HDLs in M2-like activation of microglia and macrophages. All directions of the research program are supported by prestigious NIH-RO1, RGC (ECS, GRF, CRF, and AoE schemes), and HMRF grants from the US and Hong Kong Governments, and by several competitive internal grants from the University.
Prof. Ponomarev’s laboratory is well-known around the world in the field of neuroinflammation and neurodegeneration, and he has 50 publications (19 as a last and corresponding author) in top international academic journals (and two PubMed indexed book chapters) such as Journal of Immunology (IF=5), Frontiers in Immunology (IF=7.5), Journal of Neuroscience (IF=7), Brain Behavior, and Immunity (IF=7.5), Frontiers in Cellular Neuroscience (IF=5.5), Neurobiology of Aging (IF=5), Circulation Research (IF=17), Nature Medicine (IF=25), etc. The last high-profile paper was published in Progress in Neurobiology (IF=12) in May of 2020. Prof. Ponomarev’s publications have been cited almost 5000 times with h-index 27/25/24 (Google Scholar/Scopus/WoS). Prof. Ponomarev is serving as an editorial board member for the Immunology & Cell Biology (journal of an Australian Immunological Society, (IF=5), Biomolecules (IF=5) journals, and as a reviewer for many top academic journals such as Nature Communications. Work from Prof. Ponomarev’s laboratory was presented at numerous international conferences and academic institutions.
- Immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis, Alzheimer’s disease and traumatic brain injury.
- Epigenetic and transcriptional control of microglia/macrophage activation during CNS inflammation.
- The role of platelets in the initiation and propagation of neuroinflammation.
- Strekalova, T., Svirin, E., Veniaminova, E., Kopeikina, E., Veremeyko, T., Yung, Amanda A.W.Y., Proshin, A., Walitza, S., Anthony, D., Lim, L.W., Lesch, K.P. & Ponomarev, E.D.* (2021). ASD-like behaviours, a dysregulated inflammatory response and decreased expression of PLP1 characterise mice deficient for sialyltransferase ST3GAL5. Brain, Behavior, and Immunity -Health., 16: 100306. doi: 10.1016/j.bbih.2021.100306.
- Strekalova, T., Veniaminova, T., Svirin, E., Kopeikina, E., Veremeyko, T., Yung, A.W.Y., Proshin, A., Tan, S.Z.K., Khairuddin, S., Lim, L.W., Lesch, K.P., Walitza, S., Anthony, D.C. & Ponomarev, E.D.* (2021). Sex-specific ADHD-like behaviour, altered metabolic functions, and altered EEG activity in sialyltransferase ST3GAL5-deficient mice. Biomolecules, 11(12): 1759. Doi: 10.3390/biom11121759.
- Kopeikina E. &Ponomarev, E.D.* (2021). The role of platelets in the stimulation of neuronal synaptic plasticity, electric activity, and oxidative phosphorylation: possibilities for new therapy of neurodegenerative diseases. Frontiers in Cellular Neuroscience., 15: 680126. doi: 10.3389/fncel.2021.680126.
- Kopeikina, E., Dukhinova, M., Yung, A.W.Y., Veremeyko, T., Kuznetsova, I.S., Lau, T.Y.B., Levchuk, K., & Ponomarev, E.D.* (2020). Platelets promote epileptic seizures by modulating brain serotonin level, enhancing neuronal electric activity, and contributing to neuroinflammation and oxidative stress. Prog Neurobiol., 188: 101783. doi: 10.1016/j.pneurobio.2020.101783.
- Veremeyko, T., Yung, A.W.Y., Dukhinova, M., Strekalova, T. & Ponomarev, E.D.* (2019). The Role of Neuronal Factors in the Epigenetic Reprogramming of Microglia in the Normal and Diseased Central Nervous System. Frontiers in Cellular Neuroscience, 13, 453. doi: 10.3389/fncel.2019.00453.
- Dukhinova, M., Veremeyko, T., Yung, A.W.Y., Kuznetsova, I.S., Lau, T.Y.B., Kopeikina, E., Chan, A.M.L. & Ponomarev, E.D.* (2019). Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease. Neurobiol Aging, 77, 128-143. doi: 10.1016/j.neurobiolaging.2019.01.020.
- Veremeyko, T., Kuznetsova, I.S., Dukhinova, M., Yung, A.W.Y., Kopeikina, E., Barteneva, N.S. & Ponomarev E.D.* (2019). Neuronal Extracellular MicroRNAs miR-124 and miR-9 Mediate Cell-Cell Communication between Neurons and Microglia. J Neurosci Res., 97 (2): 162-184. doi: 10.1002/jnr.24344.
- Veremeyko, T., Yung, A.W.Y., Anthony, D.C., Strekalova, T. & Ponomarev E.D.* (2018) Early growth response gene-2 is essential for M1 and M2 macrophage activation and plasticity by modulation of the transcription factor CEBPβ. Frontiers in Immunology, doi: 10.3389/fimmu.2018.02515.
- Dukhinova, M., Kuznetsova, I., Kopeikina, E., Veniaminova, E., Yung, A.W.Y., Veremeyko, T., Levchuk, K., Barteneva, N.S., Wing-Ho, K.K., Yung, W.H., Liu, J.Y.H., Rudd, J., Yau, S.S.Y., Anthony, D.C, Strekalova, T. & Ponomarev E.D.* (2018). Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury. Brain Behav Immun., 74: 7-27. doi: 10.1016/j.bbi.2018.09.009.
- Veremeyko, T., Yung, A.W.Y., Dukhinova, M., Kuznetsova, I.S., Pomytkin, I., Lyundup, A., Strekalova, T., Barteneva, N. & Ponomarev E.D.* ((2018). Cyclic AMP pathway suppress autoimmune neuroinflammation by inhibiting functions of encephalitogenic CD4 T cells and enhancing M2 macrophage polarization at the site of inflammation. Frontiers in Immunology., doi: 10.3389/fimmu.2018.00050.
- Pomytkin, I., Costa-Nunes, J.P., Kasatkin, V., Veniaminova, E., Demchenko, A., Lyundup, A., Lesh, K.P., Ponomarev E.D.* & Strekalova T. (2018). Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment. CNS Neuroscience & Therapeutics, 24 (9): 763-774. doi: 10.1111/cns. (*co-corresponding author).
- Ponomarev E.D.* (2018). Fresh evidence for platelets as neuronal and innate immune cells: their role in the activation, differentiation, and deactivation of Th1, Th17 and Tregs during tissue inflammation. Frontiers in Immunology, doi: 10.3389/fimmu.2018.00406.
- Kopeikina, E., Dukhinova, M. & Ponomarev, E.D.* ((2018). Methods of Study of Neuron Structural Heterogeneity: Flow Cytometry vs. Laser Interferometry. Methods Mol Biol., 1745:155-166. doi: 10.1007/978-1-4939-7680-5_9.
- Dukhinova, M., Kopeikina, E. & Ponomarev E.D.* (2018). Usage of Multiparameter Flow Cytometry to Study Microglia and Macrophage Heterogeneity in the Central Nervous System During Neuroinflammation and Neurodegeneration. Methods Mol Biol., 1745:167-177. doi: 10.1007/978-1-4939-7680-5_10.
- Starossom, S.C., Veremeyko, T., Dukhinova, M., Yung, A.W.Y., Weiner, H.L. & Ponomarev E.D.* (2015). Platelets Play Differential Role in the Regulation of the Initiation and Progression of Autoimmune Neuroinflammation. Circulation Research, 117 (9): 779-792.
- Starossom, S.C., Veremeyko, T., Dukhinova, M., Yung, A.W.Y. & Ponomarev E.D.* (2014). Glatiramer acetate (Copaxone) modulates platelet activation and inhibits thrombin-induced calcium influx: possible role of Copaxone in targeting platelets during autoimmune neuroinflammation. PLOS ONE, 9 (5): e96256.
- Veremeyko, T., Siddiqui, S., Sotnikov, I., Yung, A.W.Y. & Ponomarev E.D.* (2013). IL-4/IL-13-Dependent and Independent Expression of miR-124 and its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and During Allergic Inflammation. PLOS ONE, 8(12): e81774.
- Sotnikov, I., Vermeyko, T., Starossom, S.C., Barteneva, N., Weiner H.L. & Ponomarev E.D.* (2013). Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLOS ONE, 8 (3): e58979.
- Veremeyko, T., Starossom, S.C., Weiner, H.L. & Ponomarev E.D.* (2012). Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J. Vis. Exp., 65: 10.3791/4097.
* Corresponding author
- RGC – Area of Excellence [CUHK PI; 01-Sep-17 to 31-Aug-24] “Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases” (HK$885,000; amount allocated to CUHK PI from 2017 to 2022).
- RGC - General Research Fund [PI; 01-Sep-16 to 31-Aug-19]: "The Role of Interactions of Platelets with Brain-specific Neuronal Glycolipids in the Regulation of Neuroinflammation and Modulation of Neuronal Functions during Neurological Disorders" (HK$1,072,550).
- Health and Medical Research Fund [PI; 01-Mar-15 to 28-Feb-17]: "Role of Platelet-T Cell Interactions in Pathogenesis of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO)" (HK$785,000).
- RGC - General Research Fund ECS [PI; 01-Jul-14 to 30-Jun-17]: "The Role of microRNA-124 in Transcriptional Control of Macrophage Polarization and Suppression of Neuroinflammation" (HK$671,175).