B.Sc., M.Sc., Ph.D.
電話: 3943 6824
505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK
Prof. LIN Ge (林鴿) is currently working as a full professor at School of Biomedical Sciences, The Chinese University of Hong Kong (CUHK). She also serves as Director of Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and CUHK. Prof. Lin has a longstanding interest in pharmaceutical research including: 1) drug metabolism (DM) and pharmacokinetics (PK); 2) pharmacology and mechanisms of drug actions; 3) idiosyncratic adverse effect/toxicity; 4) herb-drug interactions; and 5) globalization of Chinese medicinal (CM) herbs. She is an expert in applying multidisciplinary studies for investigating TCM herbs. Her research in CM herbs integrates chemical analysis, PK, PD, and toxicology studies for the identification of bioactive ingredients with confirmed bioavailability and verified PK fates, safety assessment, and development of quality control of CM herbs and their beneficial interactions with orthodox drugs. Prof. Lin is also working on translational research. One of her on-going research projects is to develop biomarkers for the diagnosis and assessment of hepatotoxicity induced by pyrrolizidine alkaloids (PA)-containing herbs and PA-contaminated foods. Her team is one of the world leading groups in this field and has been well recognized internationally.
- Toxicology, in particular idiosyncratic hepatotoxicity and tumorigenicity.
- Herb-drug interactions, in particular chemopreventive and synergistic anticancer effects of CM herbs in the combinational therapy of anticancer drugs with CM herbs.
- Pharmacokinetics of therapeutic drugs and CM herbs.
- Integrative approach for the study of CM herbs, including chemical analysis, pharmacology, pharmacokinetics, safety and quality control of CM herbs.
- Yang, M., Ma, J., Ruan, J.Q., Ye, Y., Fu, P.P., & Lin, G.* (2019). Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids. Archives of Toxicology, 93, 2197-2209.
- Ma, J., Ruan, J.Q., Chen, X.M., Li, D.P., Yao, S., Fu, P.P., Ye, Y., Gao, H.*, Wang, J.Y., & Lin, G.* (2019). Pyrrole-hemoglobin adducts, A more feasible potential biomarker of pyrrolizidine alkaloid exposure. Chemical Research in Toxicology, 32, 1027-1039.
- Lu, Y., Ma, J., & Lin, G.* (2019). Development of a two-layer transwell co-culture model for the in vitro investigation of pyrrolizidine alkaloid-induced hepatic sinusoidal damage. Food and Chemical Toxicology, 129, 391-398.
- Lu, Y., Ma, J., Song, Z., Ye, Y., Fu, P.P., & Lin, G.* (2018). The role of formation of pyrrole-ATP synthase subunit beta adduct in pyrrolizidine alkaloid-induced hepatotoxicity. Archives of Toxicology, 92, 3403-3414.
- Li, Y.H., Tai, W.C.S., Khan, I., Lu, C., Lu, Y., Wong, W.Y., Chan, W.Y., Hsiao, W.L.W.*, & Lin, G.* (2018). Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats. Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 36, 65-83.
- Zhu, L., Wang, Z., Wong, L., He, Y., Zhao, Z., Ye, Y., Fu, P.P., & Lin, G.* (2018). Contamination of Hepatotoxic Pyrrolizidine Alkaloids in Retail Honey in China. Food Control, 85, 484-494.
- Yang, M.B., Ruan, J.Q., Gao, H., Li, N., Ma, J., Xue, J., Ye, Y., Fu, P.P., Wang, J.Y., & Lin, G.* (2017). First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans. Archives of Toxicology, 91, 3913-2915.
- Wu, X., Chan, S.W., Ma, J., Li, P., Shaw, P.C., & Lin, G.* (2017). Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species. Journal of Ethnopharmacology, 210, 39-46.
- Zhu, L., Xue, J., Xia, Q., Fu, P.P., & Lin, G.* (2017). The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice. Archives of Toxicology, 91, 949-965.
- Li, N., Zhang, F., Lian, W., Wang, H., Zheng, J.*, & Lin, G.* (2017). Immunoassay approach for diagnosis of exposure to pyrrolizidine alkaloids. Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 35, 127-139.
- Zhu, L., Ruan, J.Q., Li, N., Fu, P.P., Ye, Y., & Lin, G.* (2016). A novel ultra-performance liquid chromatography hyphenated with quadrupole time of flight mass spectrometry method for rapid estimation of total toxic retronecine-type of pyrrolizidine alkaloids in herbs without requiring corresponding standards. Food Chemistry, 194, 1320-1328.
- Yang, M.B., Ruan, J.Q., Fu, P.P., & Lin, G.* (2015). Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity. Chemico-Biological Interactions, 24, 119-126.
- Ruan, J.Q., Gao, H., Li, N., Xue, J.Y., Chen, J., Ke, C.Q., Ye, Y., Fu, P.P., Zheng, J., Wang, J.Y., & Lin, G.* (2015). Blood pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced liver injury in humans. Journal of Environmental Science and Health. Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 33, 404-421.
- Li, Y.H., Tai, W.C.S., Xue, J.Y., Wong, W.Y., Lu, C., Ruan, J.Q., Li, N., Wan, T.F., Chan, W.Y., Hsiao, W.L.W., & Lin, G.* (2015). Proteomic Study of Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome in Rats. Chemical Research in Toxicology, 28, 1715-1727.
- Ruan, J.Q., Yang, M.B., Fu, P., Ye, Y., & Lin, G.* (2014). Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis. Chemical Research in Toxicology, 27, 1030-1039.
- Zhan, S.L., Chu, Z.Q., Yin, C., Zhang, C.Y., Lin, G.*, & Li, Q.* (2013). Controllable drug release and simultaneously carrier decomposition of SiO2-drug composite nanoparticles. Journal of the American Chemical Society, 135, 5709-5716.
- Kan, W.L.T., Yin, C., Xu, H.X., Xu, G., To, K.K.W., Cho, C.H., Rudd, J.A., & Lin, G.* (2013). Anti-tumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1- mediated G0/G1 cell cycle arrest and apoptosis. International Journal of Cancer, 132, 707-716.
- Kan, W.L.T., Ma, B., & Lin, G.* (2011). Sulphur fumigation processing of traditional Chinese medicinal herbs: beneficial or detrimental? Frontiers in Pharmacology, 2(84), 1-7.
- Ma, B., Yang, D., Li, N., & Lin, G.* (2011). Effects of structural modification on intestinal absorption and transport mechanism of α–aminoxy peptides. Molecular Pharmaceutics, 8, 1073-1082.
- Lin, G.,* Wang, J.Y., Li, N., Li, M., Gao, H., Ji, Y., Zhang, F., Zhou, Y., Ye, Y., Xu, H.X., & Zheng, J. (2011). Hepatic sinusoidal obstruction syndrome associated with Gynura segetum. Journal of Hepatology, 54, 666-673.
* Corresponding / Co-corresponding author
- Six research projects supported by RGC - General Research Fund [PI; in 2015-2020]: with total of HK$6,539.272.
- Nin Jiom Medicine Mfy. (H.K.) Ltd. [PI; 01-Nov-17 to 31-Dec-18]: "Evaluation of Potential Contamination of Pyrrolizidine Alkaloids in Herbal Anti-cough Syrup".
- Sinoveda Canada Inc. [PI; 02-Jun-15 to 01-Jun-17]: "Development of Traditional Chinese Medicine (TCM)-Based Products".
- Centers for Disease Control and Prevention [PI; 01-Mar-14 to 30-Jun-15]: "Pyrrolizidine Alkaloid-induced Liver Disease (PAILD) Outbreak, Tigray, Ethiopia: Levels of Pyrrolizidine Alkaloids (PA) Biomarkers among Members of the Affected Community".