Chan_Hon_FaiAssistant Professor of the Institute for Tissue Engineering and Regenerative Medicine

 

Telephone:   3943 3032

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Address:

  Room 423A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

 

 

 

Biography

Prof. Hon Fai (陳漢輝) is an Assistant Professor at the Institute for Tissue Engineering and Regenerative Medicine and School of Biomedical Sciences at The Chinese University of Hong Kong (CUHK).  He received his B.Eng. in 2010 from The University of Hong Kong.  He then pursued his M.S. and Ph.D. degree at Duke University with the support of the Sir Edward Youde Memorial Fellowships for Overseas Studies.  During his Ph.D. training, he focused on developing several microfluidic technologies to perform 3D spheroid culture of mesenchymal stem cells and hepatocytes, and investigated the effect of supplementing extracellular matrix cues on spheroid functions.  After graduation in 2015, Hon Fai spent one year at Columbia University as a postdoctoral researcher.  He performed high-throughput screening of synthetic genes for optimization of protein expression using microfluidic droplets.  In 2016, Hon Fai joined Massachusetts Institute of Technology as a postdoctoral associate.  There he conducted organ-on-a-chip research and develop biomechanics-guided folded hydrogel to recapitulate morphogenesis of mucosal folding which is observed in many hollow or tubular organs in human body.

  1. Microfabrication approach for liver tissue engineering.
  2. Development of biomimetic biomaterial for tissue engineering and 3D microphysiological tissue model.
  3. Biomechanics of organ/tissue development.
  1. Liu, X., Steiger, C., Lin, S., Parada, G.A., Liu, J., Chan, H.F., Yuk, H., Phan, N.V., Collins, J., Tamang, S. & Traverso, G. (2019). Ingestible hydrogel device. Nature Communications, 10(1): 493.
  2. Chan, H.F., Zhao, R., Parada, G.A., Meng, H., Leong, K.W., Griffith, L.G. & Zhao, X. (2018). Folding artificial mucosa with cell-laden hydrogels guided by mechanics models. Proceedings of The National Academy of Sciences of The United States of America, 115(29): 7503-7508.
  3. Chan, H.F., Ma, S., Tian, J. & Leong, K.W. (2017). High-throughput screening of microchip-synthesized genes in programmable double-emulsion droplets. Nanoscale, 9(10): 3485-3495.
  4. Fang, X.B., Xu, Y.Q., Chan, H.F., Wang, C.M., Zheng, Q., Xiao, F. & Chen, M.W. (2016). A Redox-Sensitive and RAGE-Targeting Nanocarrier for Hepatocellular Carcinoma Therapy. Molecular Pharmacology, 13(11): 3613-3625.
  5. Chan, H.F., Ma, S. & Leong, K.W. (2016). Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies? Regenerative Biomaterials, 3(2): 87-98.
  6. Chan, H.F., Zhang, Y. & Leong, K.W. (2016). Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions. Small, 12(20): 2720-30.
  7. Zhang, J., Hu, J., Chan, H.F., Skibba, M., Liang, G. & Chen, M. (2016). iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy. Nanomedicine, 12(5): 1303-11.
  8. Jung, Y., Ji, H., Chen, Z., Chan, H.F., Atchison, L., Klitzman, B., Truskey, G. & Leong, K.W. (2015). Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. Scientific Reports, 5: 15116.
  9. Hong, S.#, Sycks, D.#, Chan, H.F.#, Lin, S., Lopez, G.P., Guilak, F., Leong, K.W. & Zhao, X. (2015). 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. Advanced Materials, 27(27): 4035-40. 
  10. Chiu, Y.L., Chan, H.F., Phua, K.K., Zhang, Y., Juul, S., Knudsen, B.R., Ho, Y.P. & Leong, K.W. (2014). Synthesis of fluorosurfactants for emulsion-based biological applications. ACS Nano, 8(4): 3913-20.
  11. Cao, C., Chan, H.F., Zang, J., Leong, K.W. & Zhao, X. (2014). Harnessing localized ridges for high-aspect-ratio hierarchical patterns with dynamic tunability and multifunctionality. Advanced Materials, 26(11): 1763-70.

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      Co-first author
  1. RGC - General Research Fund [PI; 01-Jan-20]: "Development of a microfluidic platform for biofabricating 3D spheroid entrapped in combinatorial microenvironment for optimized hepatocyte culture" (HK$343,034).
  2. Shun Hing Institute of Advanced Engineering Project Fund [PI; 01-Jul-19]: "Development of a bilayer folded scaffold for intestinal tissue engineering" (HK$800,000).