School of Biomedical Sciences
The Chinese University of Hong Kong 香港中文大學

Emeritus Professor

B.Sc., Ph.D.

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  1. Pancreatic islet cell biology and diabetes.
  2. Pancreatic progenitor cell and islet development.
  3. Novel agents/drugs for treating diabetes and pancreatic cancer.
  1. Yang, B.C., & Leung, P.S. (2020). Irisin is a positive regulator for ferroptosis in pancreatic cancer. Molecular Therapy: Oncolytics,18, 457- 466.
  2. Wu, S.Y., Liang, J., Yang, B., & Leung, P.S. (2019). SIRT1 activation promotes β-cell regeneration by activating endocrine progenitor cells via AMPK signalling-mediated fatty acid oxidation. Stem Cells, 37, 1416-1428.
  3. Wang, Y., Xie, T., Zhang, D., & Leung, P.S. (2019). GPR120 protects lipotoxicity-induced pancreatic beta-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation in mice. Clinical Science, 133, 101-116.
  4. Chan, K.Y., Wang, Y., Ng, K.W., & Leung, P.S. (2018). Na+/H+ exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of SGLT1-mediated glucose absorption in the small intestine. Diabetes, Obesity & Metabolism, 20, 709-717.
  5. Zhang, D., Xie, T., & Leung, P.S. (2018). Irisin ameliorates glucolipotoxicity-associated beta-cell dysfunction and apoptosis via AMPK sigaling and anti-inflammatory actions. Cellular Physiology & Biochemistry, 51, 924-937.
  6. Li, Y.T., Cheng, T.W., Zhang, D., & Leung, P.S. (2017). Identification and functional implications of sodium/myo-inositol cotransporter-1 in pancreatic beta-cells and type 2 diabetes mellitus. Diabetes, 66, 1258-1271.
  7. Zhang, D., So, W.Y., Wang, Y., Wu, S.Y., Cheng, Q., & Leung, P.S. (2017). Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states. Clinical Science, 131, 247-260.
  8. Liang, J., Wu, S.Y., Zhang, D., Wang, L., Leung, K.K., & Leung, P.S. (2016). NADPH oxidase-dependent reactive oxygen species stimulate beta-cell regeneration through differentiation of endocrine progenitors in murine pancreas. Antioxidants and Redox Signaling, 24, 419-433.
  9. Cheng, T.W., Chen, L., Li, Y.T., Mayoux E., & Leung, P.S. (2016). The effects of empagliflozin, an SGLT2 inhibitor, on pancreatic β-cell mass and glucose homeostasis in type 1 diabetes. PLoS One, 11, e0147391.
  10. So, W.Y., & Leung, P.S. (2016). Fibroblast growth factor 21 as an emerging therapeutic target for type 2 diabetes mellitus. Medicinal Research Reviews, 36, 672-704.
  11. So, W.Y., Cheng, Q., Xu, A., Lam, S.L., & Leung, P.S. (2015). Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. Cell Death and Disease, 6, e1707.
  12. Chen, L., So, W.Y., Li, S.Y.T., Cheng, Q., Boucher, B.J., & Leung, P.S. (2015). Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Molecular and Cellular Endocrinology, 404, 56-66.
  13. Wang, L., Liang, J., & Leung, P.S. (2015). The ACE2/Ang-(1-7)/Mas axis regulates the development of pancreatic endocrine cells in mouse embryos. PLoS One, 10, e0128216.
  14. Leung, K.K., Liang, J., Zhao, S., Chan, W.Y., & Leung, P.S. (2014). Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos. Developmental Dynamics, 243, 415-427.
  15. So, W.Y., Cheng, Q., Chen, L., Evans-Molina, E., Xu, A., Lam, S.L., & Leung, P.S. (2013). High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling. Diabetes, 62, 3751-3759.
  16. Cheng, Q., Boucher, B.J., & Leung, P.S. (2013). Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin-angiotensin system in mice. Diabetologia, 56, 553-562.
  17. Leung, K.K., Liang, J., Ma, M.T., & Leung, P.S. (2012). Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation. Stem Cells, 30, 525-536.
  18. Cheng, Q., Li, Y.C., Boucher, B.J., & Leung, P.S. (2011). A novel role for vitamin D: modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets. Diabetologia, 54, 2077-2081.
  19. Leung, P.S., & Chan, Y.C. (2009). Role of oxidative stress in pancreatic inflammation. Antioxidants and Redox Signaling, 11, 135-165.
  20. Wong, T.P., Debnam, E.S., & Leung, P.S. (2007). Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal border membrane. Journal of Physiology, 584, 613-623.
  21. Chu, K.Y., & Leung, P.S. (2007). Angiotensin II type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic β-cell function in young type 2 diabetic mice. Antioxidants and Redox Signaling, 9, 869-878.
  22. Chu, K.Y., Lau, T., Carlsson, P.O., & Leung, P.S. (2006). AT1 receptor blockade improves β-cell function and glucose tolerance in mouse model of type 2 diabetes. Diabetes, 55, 367-374.
  23. Leung, P.S., Srai, S.K., Mascarenhas, M., Churchill, L.J., & Debnam, E.S. (2005). Increased duodenal iron transport in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression. Gut, 54, 1391-1395.
  24. Lau, T., Carlsson, P.O., & Leung, P.S. (2004). Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia, 47, 240-248.