Au Chik Ko and Au Leung Shook Yin Professor of Biomedical Engineering
PhD CSci CEng MIMMM
Telephone: 3943 0509
Address: 622A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK
Prof. CHAN Pui Barbara （陳佩） obtained her Bachelor degree in Biochemistry and PhD degree in Surgical Science from the Chinese University of Hong Kong. She received Postdoctoral Fellowship in Laser Medicine from the Massachusetts General Hospital in US. Prof. Chan served the Biomedical Engineering programme of the University of Hong Kong since 2003. She joined the School of Biomedical Sciences, Department of Biomedical Engineering, and Institute of Tissue Engineering and Regenerative Medicine, of the Chinese University of Hong Kong since 2023.
Prof. Chan established the Tissue Engineering Laboratory with the vision to improve the quality of life in patients through bioengineering biomaterials- and stem cell-based tissues for personalized therapies. Her research interests centered around tissue engineering and regenerative medicine, natural and biomimetic biomaterials, multi-cellular organoids and tumoroids, mechano-regulation, multiphoton microfabrication and micropatterning, cell niche engineering and laser medicine.
Prof. Chan obtained her professional membership (Biomedical Engineering) and the status of Chartered Engineer and Chartered Scientist from the Institute of Materials, Minerals and Mining IMMM) since 2015. She has been a registered authorized person (AP) for advanced therapeutic products (ATPs) in Hong Kong since 2020. She has served the professional community in many areas, such as being an Associate Editor in Biomaterials since 2017, a panel member for the European Research Council since 2022, a member of the Task Force on Regulations of ATPs in Hong Kong. On knowledge exchange, together with her business partner, PhD students and Postdocs, she has co-founded a technology startup company in developing personalized tissue engineering therapies.
- Tissue engineering and regenerative medicine
- Enabling technologies
- Complex organoid and tumoroids
- Cell niche engineering
- Wang XN, Ou WJ, Feng D, Gao B, Chan BP* (2023) A Bio-Functional Wnt3a Gradient Microarray for Cell Niche Studies. Advanced Functional Materials, 33(33):2301941.
- Yang XX, Yip CH, Zhao SR, Ho YP, Chan BP* (2023) A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus. Biomaterials, 293:121991.
- Yip CH, Chen AD, Wong YH, Chan BP* (2022) Multiphoton microfabrication and micropatternining (MMM)-based screening of multiplex cell niche factors for phenotype maintenance - Bovine nucleus pulposus cell as an example. Biomaterials, 281:121367.
- Lam KL, Wong YH, Chew SY, Chan BP* (2021) Rac1-GTPase regulates compression-induced actin protrusions (CAPs) of mesenchymal stem cells in 3D collagen micro-tissues. Biomaterials, 274:120829.
- Wang XN, Gao B, Chan BP* (2021) Multiphoton microfabrication and micropatterning (MMM) – An all-in-one platform for engineering biomimetic soluble cell niches. Biomaterials, 269:120644.
- Li CW, Lau YT, Lam KL, Chan BP* (2020) Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells. Biomaterials, 258:120292.
- Li YY, Lam KL, Chen AD, Zhang W, Chan BP* (2019) Collagen microencapsulation recapitulates mesenchymal condensation and potentiates chondrogenesis of human mesenchymal stem cells–A matrix-driven in vitro model of early skeletogenesis. Biomaterials, 213:119210.
- Huang N, Li CW, Chan BP* (2018) Multiphoton 3D Microprinting of Protein Micropatterns with Spatially Controlled Heterogeneity – A Platform for Single Cell Matrix Niche Studies. Advanced Biosystems, 2(8):1800053.
- Yeung P, Zhang W, Wang XN, Yan CH, Chan BP* (2018) A human osteoarthritis osteochondral organ culture model for cartilage tissue engineering. Biomaterials, 162:1–21.
- Ho FC, Zhang W, Li YY, Chan BP* (2015) Mechanoresponsive, omni-directional and local matrix-degrading actin protrusions in human mesenchymal stem cells microencapsulated in a 3D collagen matrix. Biomaterials, 53:392–405.
- Li YY, Choy TH, Ho FC, Chan BP* (2015) Scaffold composition affects cytoskeleton organization, cell-matrix interaction and the cellular fate of human mesenchymal stem cells upon chondrogenic differentiation. Biomaterials, 52:208–220.
- Chik TK, Chooi WH, Li YY, Ho FC, Cheng HW, Choy TH, Sze KY, Luk KKD, Cheung KMC, Chan BP* (2015) Bioengineering a multicomponent spinal motion segment construct-a 3d model for complex tissue engineering. Advanced Healthcare Materials, 4(1):99–112.
- Chan BP*, Ma JN, Xu JY, Li CW, Cheng JP, Cheng SH (2014) Femto-Second Laser-Based Free Writing of 3D Protein Microstructures and Micropatterns with Sub-Micrometer Features: A Study on Voxels, Porosity, and Cytocompatibility. Advanced Functional Materials, 24(3):277–294.
- Yuan MT, Yeung CW, Li YY, Diao HJ, Cheung KMC, Chan D, Cheah K, Chan BP* (2013) Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells. Biomaterials, 34(16):3948–3961.
- Cheng HW, Luk KDK, Cheung KMC, Chan BP* (2011) In vitro generation of an osteochondral interface from mesenchymal stem cell-collagen microspheres. Biomaterials, 32(6):1526–1535.
- Lee M, Lo AC, Cheung PT, Wong D, Chan BP* (2009) Drug carrier systems based on collagen-alginate composite structures for improving the performance of GDNF-secreting HEK293 cells. Biomaterials, 30(6):1214–1221.
- Chan OCM, So KF, Chan BP* (2008) Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics. Journal of Controlled Release, 129(2):135–143.
- Hui TY, Cheung KMC, Cheung WL, Chan D, Chan BP* (2008) In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration. Biomaterials, 29(22):3201–3212.
- Wong HL, Wang MX, Cheung PT, Yao KM, Chan BP* (2007) A 3D collagen microsphere culture system for GDNF-secreting HEK293 cells with enhanced protein productivity. Biomaterials, 28(35):5369–5380.
- Chan BP*, Hui TY, Yeung CW, Li J, Mo I, Chan GCF (2007) Self-assembled collagen-human mesenchymal stem cell microspheres for regenerative medicine. Biomaterials, 28(31):4652–4666.