School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof WANG Dan Michelle


Wang_Dan_MichelleAssistant Professor

 

Telephone:   3943 0681

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

  Room 422A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

ORCID: https://orcid.org/0000-0002-5934-9085

 

 

 

Biography

Prof. WANG Dan (王丹) obtained her Ph.D. from the University of Pittsburgh and pursued postdoctoral training at Stanford University. In Aug 2022, she assumed the position of Assistant Professor at CUHK with appointments in the School of Biomedical Sciences (SBS), the Institute for Tissue Engineering and Regenerative Medicine (iTERM), and Department of Orthopaedics & Traumatology (ORT; by courtesy). She also serves as a Principal Investigator at CNRM, InnoHK center located at Hong Kong Science Park.

Prof. Wang has extensive training that spans across diverse disciplines, including basic and pre-clinical research, as well as her medical practice. In her current research program at CUHK, Prof. Wang and her team focus on elucidating the synergistical contributions of cell microenvironmental features, such as extracellular matrix (ECM), substrate stiffness, mechanical loading, during tendon development, regeneration, and the pathogenesis of diseases. This knowledge will be applied towards the development of innovative therapeutics and the engineering of novel biomaterials for musculoskeletal tissue regeneration. Prof. Wang has secured local and national research support and her research findings have been published as the first author or corresponding author in internationally renowned academic journals, including Advanced Materials, Bioactive Materials, Advanced Functional Materials, Biomaterials, NPG Asia Materials, as well as in book chapters. Prof. Wang also contributes to the academic community as an editorial board member for the esteemed journals Bioactive Materials and BMEMat. 

 

  1. Cell niche: Synergistic effects of biochemical and biophysical cues in tendon regeneration and pathogenesis.
  2. ECM biology and ECM-based biomaterial development: Investigating cell and ECM interactions and developing ECM-mimetic biomaterials for tendon repair.
  3. Exosome-based cell free therapy: Advancing large-scale production of stem cell-derived exosome technologies for tendon repair.
  1. Zhang, W., Rao, Y., Wong, S.H., Wu, Y., Zhang, Y., Yang, R., Tsui, S.K.W., Ker, D.F.E., Mao, C., Frith, J.E., Cao, Q., Tuan, R.S., and & Wang, D. (2024). Transcriptome-guided hydrogel design of a stem cell niche for enhanced tendon regeneration. Advanced Materials, e2313722, IF:27.4.
  2. Huang, S., Tam, M.Y., Ho, W.H., Wong, H.K., Zhou, M., Ker, D.F.E., Ling, S.K.K., Tuan, R.S., and & Wang, D. (2024). Model with Massive Supraspinatus Tendon Defect for Investigating Scaffold-Assisted Tendon Repair. Biological Procedures Online, 26(1):31, IF:3.7.
  3. Zhang, Y., RAO, Y., Lu, J., Wang, J., Ker, D.F.E., Zhou, J., and & Wang, D. (2024). The Influence of Biophysical Niche on Tumor-Associated Macrophages in Liver Cancer. Hepatology communications, 8(11):e0569, IF:5.7.
  4. Huang, S., Rao, Y., Zhou, M., Blocki, A.M., Chen, X., Wen, C., Ker, D.F.E., Tuan, R.S., and & Wang, D. (2024). Engineering an extracellular matrix-functionalized, load-bearing tendon substitute for effective repair of large-to-massive tendon defects. Bioactive Materials., 2024;36:221-237. doi: 10.1016/j.bioactmat. 02.032, IF:18.0.
  5. Huang, S., Rao, Y., Ju, A.L., Ker, D.F.E., Blocki, A.M., Wang, D., and & Tuan, R.S. (2023). Non-collagenous proteins, rather than the collagens, are key biochemical factors that mediate tenogenic bioactivity of tendon extracellular matrix. Acta Biomaterialia, S1742-7061(23)00745-6, IF:9.7.
  6. Kwan, K.Y.C, Ng, K.W.K., Zhu, C., Rao, Y., QI, S., TUAN, R.S., Ker, D. F.E., & Wang, D.* (2023). Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches. International Journal of Molecular Sciences. International Journal of Molecular Sciences , 24(20):15183, IF:6.208.
  7. Rao, Y., Zhu, C., Suen, H.C., Huang, S., Liao, J., Ker, D. F.E., TUAN, R.S., & Wang, D.* (2022). Tenogenic Induction of Human Adipose-derived Stem Cells by Soluble Tendon Extracellular Matrix: Composition and Transcriptomic Analyses. Stem Cell Research & Therapy, 13(1):380, IF:8.088.
  8. Wang, D., Zhang, X., Ng, K.W., Rao, Y., Wang, C., Gharaibeh, B., Lin, S., Abrams , G., Safran, M., Cheung, E., Campbell, P., Weiss L., & Yang, Y.P. (2022). Growth and Differentiation Factor-7 Immobilized, Mechanically Strong Quadrol-Hexamethylene Diisocyanate-Methacrylic Anhydride Polyurethane Polymer for Tendon Repair and Regeneration. Acta Biomaterialia, 154:108, IF:9.7.
  9. Liu, H.*, Shen, Y.*, Zhao, B., Poon, E.H., Qi, S., Ker, D.F.E., Billiar, T.R., Cooper, G.M., Xu, Y.*, & Wang, D.* (2022). Short-term Administration of the HIV Protease Inhibitor Saquinavir Improves Skull Bone Healing with Enhanced Osteoclastogenesis. Plastic and Reconstructive Surgery, 150(6):1264e-1274e, IF:5.169.
  10. Wang, D.*, Ker, D.F.E.*, Ng, K.W., L, K., Gharaibeh, B., Safran, M., Cheung, E., Campbell, P., Weiss .E, & Yang, Y.P. (2021). Combinatorial Mechanical-Gradation and Growth Factor-Biopatterning Strategy to Spatially Control Bone-Tendon-like Cell Differentiation and Tissue Formation. NPG Asia Materials, 13:26, IF:9.7.
  11. Wang, D.*, Zhang, X.*, Huang, S.T., Liu, Y., Fu, S.C., Mak, K.L., Blocki, A.M., Yung, S.H., Tuan, R.S., & Ker, D.F.E. (2021). Engineering Multi-Tissue Units for Regenerative Medicine: Bone-Tendon-Muscle Units of the Rotator Cuff. Biomaterials, 120789, IF:15.304.
  12. Wang, D., Pun, C.C.M., Huang, S., Tang, T.C.M., Ho, K.K.W., Rothrauff, B.B., Yung, P.S.H., Blocki, A.M., Ker, E.D.F., & Tuan, R.S. (2020). Tendon-derived extracellular matrix induces mesenchymal stem cell tenogenesis via an integrin/transforming growth factor-β crosstalk-mediated mechanism. Federation of American Societies for Experimental Biology Journal, 34(6):8172-8186, IF:5.834.
  13. Wang, D., Gilbert, J.R., Zhang, X., Zhao, B.K., Ker, D.F.E., & Cooper, G.M. (2020). Long Bone versus Calvarial Bone: Development, Structure, Healing and Tissue Engineering Strategies. Tissue Engineering Part B, 26(1):46-63, IF:7.376.
  14. Ker, D.F.E.*, Wang, D.*, Behn, A.W., Wang, E.T.H., Zhang, X., Zhou, B.Y., Mercado-Pagán, A.E., Kim, S., Kleimeyer, J., Gharaibeh, B., Shanjani, Y., Nelson, D., Safran, M., Cheung, E., Campbell, P., & Yang, Y.P. (2018). Functionally graded, bone- and tendon-like polyurethane for rotator cuff repair. Advanced Functional Materials , 28(20):1707107, IF:19.924.

    * Co-first author
  1. NSFC-RGC, N_CUHK409/23 [Principal Investigator]: “The development of tendon extracellular matrix-enriched, amino acid polymer hydrogel for functional tendon repair”.
  2. GRF, RGC 14118620 [Principal Investigator]: “Development of tendon extracellular matrix-based approach for functional tendon repair”.
  3. GRF, RGC 14121121 [Principal Investigator]: “Tendon extracellular matrix (ECM): identification of pro-tenogenic components and engineering of an ECM-mimetic biomaterial for tendon repair”.