TIAN XiaoyuAssistant Professor

B.Sc., Ph.D.

Telephone:  3943 3075

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 208A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  

Biography

Prof. TIAN Xiaoyu (田小雨) is an Assistant Professor of the School of Biomedical Sciences, The Chinese University of Hong Kong (CUHK).  She received PhD from CUHK Department of Physiology.  She studied the therapeutic effect of PPARs on vascular dysfunction in hypertension and type 2 diabetes, and mitochondrial oxidative stress in endothelial cell function.  After graduation, she continued as a postdoctoral fellow in the Cardiovascular Research Institute, the University of California San Francisco, studying macrophage dynamics in obesity-induced adipose tissue inflammation, and also in the atherosclerosis.  She later joined CUHK again as Research Assistant Professor in 2015, and is Assistant Professor since 2017.  Her current research interests include the regulation of macrophage function by molecular clock components in the vascular microenvironment of cardiovascular diseases.  She also works on adipose tissue inflammation and immune regulation of obesity and insulin resistance.

  1. Function of molecular clock in cardiovascular diseases.
  2. Macrophage function in metabolic syndrome.
  1. Cheang, W. S., Wong, W. T., Wang, L., Cheng, C. K., Lau, C. W., Ma, R. C. W., Xu, A., Wang, N., Huang, Y.*, Tian, X. Y.* (2019). Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacological Research, 139, 384-394.
  2. Zhang, L., Tian, X. Y., Chan, C. K. W., Bai, Q., Cheng, C. K., Chen, F. M., Cheung, M. S. H., Yin, B., Yang, H., Yung, W. Y., Chen, Z., Ding, F., Leung, K. C., Zhang, C., Huang, Y., Lau, J. Y. W. Choi, C. H. J.* (2019). Promoting the Delivery of Nanoparticles to Atherosclerotic Plaques by DNA Coating. ACS Appl Mater Interfaces, 11(15), 13888-13904. 
  3. Kho, J., Tian, X., Wong, W. T., Bertin, T., Jiang, M. M., Chen, S., Jin, Z., Shchelochkov, O. A., Burrage, L. C., Reddy, A. K., Jiang, H., Abo-Zahrah, R., Ma, S., Zhang, P., Bissig, K. D., Kim, J. J., Devaraj, S., Rodney, G. G., Erez, A., Bryan, N. S., Nagamani, S. C. S.*, Lee, B.H.* (2018). Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. American Journal of Human Genetics, 103(2), 276-287.
  4. Chan, K. W. C., Zhang, L., Cheng, C. K., Yang, H., Huang, Y., Tian, X. Y.*, Choi, C. H. J.* (2018). Recent advances in managing atherosclerosis via nanomedicine. Small, 14(4), 1702793
  5. Huo, M., Huang, Y. H., Qu, D., Zhang, H., Wong, W. T., Chawla, A., Huang, Y., Tian, X. Y.* (2017). Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB Journal, 31(3), 1097-1106.
  6. Cheang, W. S., Wong, W. T., Zhao, L., Xu, J., Wang, L., Lau, C. W., Chen, Z. Y., Ma, R. C. W, Xu, A., Wang, N., Tian, X. Y.*, Huang Y.* (2017). PPARδ is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes, 66(2), 519-528.
  7. Wong, W. T., Matrone, G., Tian, X., Tomoiaga, S. A., Au, K. F., Meng, S., Yamazoe, S., Sieveking, D., Chen, K., Burns, D. M., Chen, J. K., Blau, H. M., Cooke, J. P.* (2017). Discovery of Novel Determinants of Endothelial Lineage using Chimeric Heterokaryons. eLife, 6, e23588.
  8. Tian, X. Y.*, Wong, W. T., Lau, C. W., Wang, Y. X., Cheang, W. S., Liu, J., Lu, Y,, Huang, H., Xia, Y., Chen, Z. Y., Mok, C. S., Lau, C. M., Huang, Y. (2016). Melamine Impairs Renal and Vascular Function in Rats. Scientific Reports, 6, 28041.
  9. Ma, S.#, Tian, X. Y.#, Zhang, Y., Mu, C., Shen, H, Bismuth, J, Pownall, H. J., Huang, Y., Wong WT.* (2016). E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. Scientific Reports, 6, 22910.
  10. Tian, X. Y., Ganeshan, K., Hong, C., Nguyen, K. D., Qiu, Y., Kim, J., Tangirala, R. K., Tontonoz, P., Chawla, A.* (2016). Thermoneutral housing accelerates metabolic inflammation to potentiate atherosclerosis but not insulin resistance. Cell Metabolism, 23(1), 165–178.
  11. Zhang, Y., Liu, J., Tian, X. Y.*, Wong, W. T., Chen, Y., Wang, L., Luo, J., Cheang, W. S., Lau, C. W., Kwan, K. M., Wang, N., Yao, X., Huang, Y.* (2014). Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(1), 152-9.
  12. Cheang, W. S., Tian, X. Y.*, Wong, W. T., Lau, C. W., Lee, S. S., Chen, Z. Y., Yao, X., Wang, N., Huang, Y.* (2014). Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(4), 830-6.
  13. Qiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X., Tian, X., Locksley, R. M., Palmiter, R. D., Chawla, A.* (2014). Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell, 157(6), 1292-308.

    *  Corresponding / Co-corresponding author 
    #  Co-first author