School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof CHAN Wai Yee


CHAN Wai Yee 2024Li Ka Shing Professor of Biomedical Sciences

B.Sc., Ph.D.

Telephone:   3943 1383

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

  Room 123A, 1/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

Publons: https://publons.com/researcher/1858923/wai-yee-chan/

ORCID: https://orcid.org/0000-0002-9714-0936

 

 

 

Biography

Chan Wai-yee (陳偉儀) obtained his B.Sc. (Hon. 1st Class) in Chemistry from the Chinese University of Hong Kong in 1974 and Ph.D. in Biochemistry from the University of Florida, Gainesville, Florida, USA in 1977.  He served as tenured Assistant to Associate Professor at the Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA from 1979-1989, and tenured Professor, Department of Pediatrics and Department of Biochemistry, Cell & Molecular Biology at Georgetown University Medical Center, Washington, DC, USA from 1989-2009. He was jointly appointed at the Eunice Kennedy Shriver National of Child Health and Human Development (NICHD), National Institutes of Health (NIH), USA in 2001, and was later appointed as Head and Principal Investigator of the Section on Developmental Genomics and co-founded the Laboratory of Clinical Genomics, NICHD. In 2009, he established the School of Biomedical Sciences, Faculty of Medicine, CUHK, and served as the Founding Director and Chair Professor of Biomedical Sciences. He served as Master of CW Chu College from 2017-2021. He was appointed Pro-Vice-Chancellor (Strategic Developments)/ Vice President of CUHK in 2018 and Li Ka Shing Professor of Biomedical Sciences in 2020. He is also the Director of Institute for Tissue Engineering and Regenerative Medicine (iTERM). He has served as President of the Association of Chinese Geneticists in America, a Member of the Development Committee of the Society for the Study of Reproduction in the USA, and the immediate past President of Hong Kong Institution of Science. Besides being a Council Member of the Shaw Prize Foundation, he also serves as Member of the Hospital Authority Board, Chair of the Hospital Governing Committee of North District Hospital, Member of the Research Grant Council, Member of the Hong Kong Genome Institute Board of Directors, and a Specialist for the Hong Kong Council for Accreditation of Academic and Vocational Qualifications. He also serves in the Scientific Advisory Board of Hope for Rare Foundation, Shanghai, China. He received a number of awards including the Merrick Award for Outstanding Biomedical Research and the Presidential Award from the Association of Chinese Geneticists in America, USA.

  1. Functional genomics and epigenetic regulation of germ cell and gonad development in health and diseases.
  2. Functional genomics of developing male gonad.
  3. Molecular genetics of human endocrine disorders.
  4. Non-coding RNA, antisense transcript, and microRNA in normal and abnormal development.
  5. Genetics and genomics of fetal development.
  1. Tian, Y.Y., Wang, W., Lautrup, S., Zhao, H., Li, X., Law, P.W.N., Fang, E.F., Cheung, H.H., & Chan, W.Y. (2022). WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nature Communication, 13:5456. doi: 10.1038/s41467-022-33012-6. (IF: 17.69).
  2. Wu, Y., Chen, K., Li, L., Hao, Z., Wang, T., Liu, Y., Xing, G., Liu, Z., Li, H., Yuan, H., Lu, J., Zhang, C., Zhang, J., Zhao, D., Wang, J., Nie, J., Ye, D., Pan, G., & Chan, W.Y. (2022), Liu, X. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death and Differentiation, 29(11): 2316-2331. Springer,(356712132) (IF: 12.073).
  3. Lv, Y., Lu, G., Cai, Y., Su, R., Liang, L., Wang, X., Mu, W., He, X., Huang, T., Ma, J., Zhao, Y., Chen, Z.J., Xue, Y., Liu, H., & Chan, W.Y. (2022). RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits. Protein & Cell, 1–13, doi: 10.1093/procel/pwac040 (IF: 14.86).
  4. Li, W., Long, Q., Wu, H., Zhou, Y., Duan, L., Yuan, H., Ding, Y., Huang, Y., Wu, Y., Huang, J., Liu, D., Chen, B., Zhang, J., Qi, J., Du, S., Li, L., Liu, Y., Ruan, Z., Liu, Z., Liu, Z., Zhao, Y., Lu, J., Wang, J., & Chan, W.Y. (2022), Liu, X.. Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communication, 13(1):7414. doi: 10.1038/s41467-022-35199-0 (IF: 17.69).
  5. Wang, Z.T., Miu, K.K., Chan, S.W., Ou, F., Law, P.W.N., & Chan, W.Y. (2022). Genome-wide 5-hydroxymethylcytosine (5hmC) reassigned in Pten-depleted mESCs along neural differentiation. Front Cell Developmental Biology – Developmental Epigenetics, 10:956604. doi:10.3389/fcell.2022.956604. eCollection 2022. (IF: 6.684).
  6. Long, Q., Yan, K., Wang, C., Wen, Y., Qi, F., Wang, H., Shi, P., Liu, X., & Chan, W.Y. (2023), Lu, X., Zhao, H.. Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids. Science Advances. 9(14), eadd8343. (IF: 14.957).
  7. Huang, T., Wu, X., Wang, S., Bao, Z., Wan, Y., Wang, Z., Li, M., Yu, X., Lv, Y., Liu, Z., Chen, X., & Chan, W.Y. (2023), Gao, F., Lu, G., Chen, Z., Liu, H.. SPIDR is required for homologous recombination during mammalian meiosis. Nucleic Acid Res. 51(8), 3855-3868. (IF:19.16)
  8. Xu, K., Su, X., Fang, K., Lv, Y., Huang, L., Li, M., Wang, Z., Yin, Y., Muhammad, T., Liu, S., Chen, X., Jiang, J., Li, J., & Chan, W.Y. (2023), Ma, J., Lu, Gang., Chen, Z.J., Liu, H.. The slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice. eLife, 12, e83129, (doi:10.7554/eLife.83129) (IF: 8.713)
  9. Muhammad, T., Wan, Y., Lv, Y., Li, H., & Chan, W.Y. (2023), Lu, G., Chen, Z.J., Liu, H.. Maternal Obesity: a potential disruptor of female fertility and current 2 interventions to reduce associated risks. Obesity Reviews, 24(1), e13603, DOI: 10.1111/obr.13603; (IF:10.867; Ranking 9/148).
  10. Du, Y., Li, S., Zhai, J., Chu, W., Geng, X., Wang, D., Jiao, L., Lu, G., & Chan, W.Y. (2023), Sun, K., Sun, Y., Chen, Z.J.. Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling. Biofilms and Microbiomes; 9(1):47. doi: 10.1038/s41522-023-00415-2. (IF: 8.462)
  11. He, X., Mu, W., Wang, Z., Xu, K., Yin, Y., Lu, G., & Chan, W.Y. (2023), Liu, H., Lv, Y., Liu, S.. Deficiency of the Tmem232 gene causes male infertility with morphological abnormalities of the sperm flagellum in mice. Cells, 12(12):1614. doi: 10.3390/cells12121614 (IF: 7.666).
  12. Lu, G., Su, X., Wang, L.H., Leung, C.K., Zhou, J., Xiong, Z., Wang, W., Liu, H., & Chan, W.Y. (2023). Neuroprotective effects of human-induced pluripotent stem cell-derived mesenchymal stem cell extracellular vesicles in ischemic stroke models. Biomedicines, 2023, 2550. doi: 10.3390/biomedicines11092550 (IF: 4.757).
  13. Wan, Y., Yang, S., Li, T., Cai, Y., Wu, X., Zhang, M., Muhammad, T., Huang, T., Lv, Y., & Chan, W.Y. (2023), Lu, G., Li, J.. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Research, 51(21):11652-11667. doi: 10.1093/nar/gkad919. (IF: 19.16)
  14. Wang, C., Liu, Z., Zeng, Y., Zhou, L., Long, Q., Hassan, I.U., Zhang, Y., Qi, X.F., Cao, D.Q., Mao, B., Lu, G., Sun, J., Yao, Y.G., Deng, Y., Zhao, Q., Feng, B., Zhou, Q., & Chan, W.Y. (2024), Zhao, H.. ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation. EMBO Reports, 25(2):646-671. doi: 10.1038/s44319-023-00046-w. Epub 2024 Jan 2. (IF: 13.783)
  15. Yang, L., Ruan, Z., Lin, X., Wang, H., Xin, Y., Tang, H., Zhou, Y., Wu, Yi., Wang, J., Qin, D., Lu, G., Loomes, K.M., & Chan, W.Y. (2024), Liu, X.. NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. Nature Communications, 15(1):546. Doi: 10.1038/s41467-024-44808-z. (IF: 17.69)
  16. Tian, Y., Lautrup, S., Law, W.N., Dinh, N.D., Fang, E.F., & Chan, W.Y. (2024). WRN loss accelerates abnormal adipocyte metabolism in Werner Syndrome. Cell & Biosciences, DOI:10.1186/s13578-023-01183-4. (IF: 9.597)
  17. Suen, H-C, Ou, F., Miu, K.K., Wang, Z., & Chan, W.Y. (2024), Liao, J.. The single-cell chromatin landscape in gonadal cell lineage specification and sex fate determination. BMC Genomics, (IF: 4.4)
  18. Hu, Z., Yang, L., Zhang, M., Tang, H., Huang, Y., Su, Y., Ding, Y., Li, C., Wang, M., Zhou, Y., Zhang, Q., Guo, L., Wu, Y., Wang, Q., Liu, N., Kang, H., Wu, Y., Yao, D., Li, Y., Ruan, Z., Wang, H., Bao, F., Liu, G., Wang, J., Wang, Y., Wang, W., Lu, G., Qin, D., Pei, D., & Chan, W.Y. (2024), Liu, X.. A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. Cell Metabolism. doi.:10.1016/j.cmet.2024.04.012 (IF: 29.0)
  1. RGC/NSFC Joint Grant Scheme 2022/2023. Reference Code: N_CUHK 428/22; CU Project Code: 2900424 [PI; 01-Jan-23 to 31-Dec-26]: "Study the roles of mitochondrial DNA methylation in regulating nucleoid phase separation and transcription modulation." (HK$1,125,254).
  2. CUHK Direct Grant for Research 2022/2023. Reference Code: 2022.082. [PI; 30-Jun-23 to 29-Jun-24]: "WRN loss accelerates abnormal adipocyte metabolism in Werner Syndrome." (HK$50,000).
  3. 广东省基础与应用基础研究重大项目(基石项目). 广东省科学技术厅, Project Code: 8326203. [PI; 01-Mar-23 to 31-Feb-28]: "能量代谢调控细胞全能性与多能性转变的机制与转化研究" (RMB500,000).
  4. ITF – MHKJFS 2023 Program. Reference: MHP/005/23. [PI; 01-Mar-23 to 28-Feb-26]: " Establishment of mitochondrial disease model and drug screening by using induced pluripotent stem cells." (HK$1,115,200).
  5. : 粤港干细胞与再生医学联合实验室. 广东省科学技术厅粤港澳大湾区国际科技创新中心建设 [PI; 01-Apr-23 to 31-Mar-26]: (RMB600,000).
  6. ITC, General Support Program. Reference Code: GSP/003/24. [PI; 1-Feb-24 to 1-Jul-24]: " Global Conference on Climate Change." (HK$2,026,880).