B.Sc., M.Phil. (CUHK), D.Phil. (Oxon)
Telephone: 3943 6880
304A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK
Prof. YUNG Wing Ho (容永豪) graduated from The Chinese University of Hong Kong (CUHK) in biology and biochemistry with first class honors. He was a recipient of the Commonwealth Scholarship and the Croucher Foundation Fellowship that supported his DPhil study and post-doctoral training in the University of Oxford, under the supervision of Prof. Julian Jack, FRS. He is currently Professor in the School of Biomedical Sciences and the Director of the Gerald Choa Neuroscience Centre, CUHK. He had received the Master Teacher of the Year award, Faculty of Medicine and the Research Excellence Award, CUHK. He has broad research interests in understanding the functions and mechanisms of the nervous system in health and in disease, emphasizing the underlying neural circuits and the roles of neuroplasticity. This is achieved by employing a multitude of cutting-edge neuroscience and computational techniques.
- Neural mechanism of motor learning. The capability to learn novel, complex motor skills is a remarkable ability, and essential for daily lives and survival. By applying multi-array electrophysiological recording, 2-photon imaging and machine-learning algorithms in novel motor paradigms, we probe the mechanisms underlying the emergence of neural circuits in the brain encoding motor memory.
- Neural circuits underlying cognitive functions. We aim to decipher the neural circuits and mechanisms underlying important cognitive functions. Especially we are interested in cognitive flexibility, which underlies adaptive behaviours like switching of strategy to solve a problem. Impairment of cognitive flexibility is related to various conditions such as compulsive behaviour and anxiety. Techniques including neuronal tract tracing, optogenetics and network analysis are employed to tackle the questions.
- Parkinson’s and other degenerative diseases. Both motor and non-motor (emotional, cognitive) malfunctions are common in Parkinsonism and other neurodegenerative diseases. We are interested in the origin of these deficits, especially at the network level, and exploration of their treatments including interventional approach such as brain stimulation techniques.
- Mu, M.D., Geng, H.Y., Rong, K.L., Peng, R.C., Wang, S.T., Geng, L.T., Qian, Z,M, Yung, W.H. & Ke, Y. (2020). A limbic circuitry involved in emotional stress-induced grooming. Nature Communications, 11, 2261. doi: 10.1038/s41467-020-16203-x. (Editor’s highlight)
- Li, C., Chan, D.C.W., Yang, X., Ke, Y. & Yung, W.H. (2019). Prediction of forelimb reach results from motor cortex activities based on calcium imaging and deep learning. Frontiers in Cellular Neuroscience, 13, 88 doi: 10.3389/fncel.2019.00088.
- Cui, Q., Li, Q., Geng, H., Chen, L., Ip, N.Y., Ke, Y. & Yung, W.H. (2018). Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex-nucleus accumbens pathway in mice. Proceedings of the National Academy of Science USA, 115(21), E4890-E4899.
- Li, Q., Ko, H., Qian, Z.M., Yan, L.Y.C., Chan, D.C.W., Arbuthnott, G., Ke, Y. & Yung, W.H. (2017). Refinement of learned skilled movement representation in motor cortex deep output layer. Nature Communications, 8, 15834. doi: 10.1038/ncomms15834
- Leong, A.T., Chan, R.W., Gao, P.P., Chan, Y.S., Tsia, K.K., Yung, W.H. & Wu, E.X. (2016). Long-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile. Proceedings of the National Academy of Science USA, 113(51), E8306-E8315.
- Xu, L.H., Xie, H., Shi, Z.H., Du, L.D., Wing, Y.K., Li, A.M., Ke, Y. & Yung, W.H.(2015). Critical role of endoplasmic reticulum stress in chronic intermittent hypoxia-induced deficits in synaptic plasticity and long-term memory. Antioxidants & Redox Signaling, 23, 695-710.
- Li, Q., Qian, Z.M., Arbuthnott, G.W., Ke, Y. & Yung, W.H. (2014). Cortical effects of deep brain stimulation: implications for pathogenesis and treatment of Parkinson disease. JAMA Neurology, 71, 100-103(Editorial Highlight).
- Sun, X.R., Chen, L., Chen, W.F., Xue, Y. & Yung, W.H. (2013). Electrophysiological and behavioral effects of group III metabotropic glutamate receptors on pallidal neurons in normal and parkinsonian rats. Synapse, 67(12), 831-838. doi: 10.1002/syn.21694.
- Huang, Y., Wang, J.J., & Yung, W.H. (2013). Coupling between GABA-A receptor and chloride transporter underlies ionic plasticity in cerebellar Purkinje neurons. The Cerebellum, 12, 328-330.
- Lai, K.O., Wong, A.S., Cheung, M.C., Xu, P., Liang, Z., Lok, K.C., Xie, H., Palko, M.E., Yung, W.H., Tessarollo, L., Cheung, Z.H. & Ip, N.Y. (2012). Serine phosphorylation of TrkB by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nature Neuroscience, 15, 1506-1515 (editorial highlight).
- Li, Q., Ke, Y., Chan, D.C.W., Qian, Z.M., Yung, K.K.L., Ko, H., Arbuthnott, G. & Yung, W.H. (2012). Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex. Neuron, 76, 1030-1041 (Highlighted in 'Nature Reviews Neuroscience' and 'Nature China').
- Huang, Y., Ko, H., Cheung, Z.H., Yung, K.K.L., Yao, T., Wang, J.J., Morozov, A., Ke, Y., Ip, N.Y. & Yung, W.H. (2012). Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental Neurology, 233, 791-798.
- Xie, H., Leung, K.L., Chen, L., Chan, Y.S., Ng, P.C., Fok, T.F., Wing, Y.K., Ke, Y., Li, A.M. & Yung, W.H. (2010). Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity. Neurobiology of Disease, 40, 155-162.
- Chu, J.Y.S., Lee, L.T.O., Lai, C.H., Vaudry, H., Chan, Y.S. Yung, W.H. & Chow, B.K.C. (2009). Secretin as a neurohypophysial factor regulating body water homeostasis.Proceedings of the National Academy of Science USA, 106, 15961-15966.
- Chen, L., Yung, K.K.L., Chan, Y.S. & Yung, W.H. (2008). 5-hydroxytryptamine excites globus pallidus neurons by multiple receptor mechanisms. Neuroscience, 151, 439-451.
- Cui, Q.L., Chen, L., & Yung, W.H. (2007). Substance P excites globus pallidus neurons in vivo. European Journal of Neuroscience, 26, 1853-1861.
- Xue, Y., Chen, L., Xie, J.X. & Yung, W.H. (2007). Electrophysiological and behavioral effects of neurotensin in rat globus pallidus: an in vivo study. Experimental Neurology, 205, 108-115.
- Chen, L., Yung, K.K.L. & Yung, W.H. (2006). Neurotensin selectively facilitates glutamatergic transmission in rat globus pallidus. Neuroscience, 141, 1871-1878.
- Fu, A.K.Y., Ip, F.C.F., Fu, W.Y., Cheung, J., Wang, J.H. Yung, W.H. & Ip, N.Y. (2005). Aberrant motor axon projection, AChR clustering and neurotransmission in Cyclin-dependent kinase 5 null mice. Proceedings of the National Academy of Science USA, 102, 15224-15229.
- Pang, P., Teng, H., Zaitsev, E., Woo, N.T., Sakata, K., Zhen, S., Teng, K.K., Yung, W.H., Hempstead, B., & Lu, B. (2004). Proteolytic conversion from pro- to mature BDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science, 305, 487-491.
- RGC - General Research Fund [PI; 01-Jan-20 to 31-Dec-2022]: "Anomalous synaptic representations of locomotive states in the motor cortex in Parkinson’s disease: origin and significance" (HK$928,156).
- RGC – NSFC-RGC Joint Research Scheme [PI; 01-Jan-2020 to 31-Dec-2024]: “ The synaptic, cellular and circuit plasticity mechanisms underlying the role of the small-molecule neuropeptide orexin in central vestibular compensation” (HK$1,177,667).
- RGC – Collaborative Research Fund [Co-PI; 01-Feb-18 to 31-Jan-2021]: “Reconstitution of Postsynaptic Densities of Excitatory Synapses’ (HK$8,559,029).
- ITC – ITF Midstream Research Programme [Co-PI; 01-02-2019 to 31-Jan-2021]: “Development of an Ultrasonic Deep Brain Stimulation Method for Non-invasive Parkinson's Disease Treatment” (HK$8,000,000).
- UGC – Area of Excellence Scheme [Co-PI; 01-Jun-2017 to 31-May-2025]: “Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases” (HK$77,516,000).
- UGC – Theme-Based Research Scheme [Co-PI; 01-Jan-2019 to 31-Dec-2023]: “A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases” (HK$37,973,000).