B.Sc., M.Phil. (CUHK), D.Phil. (Oxon)
Telephone: 3943 6880
304A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK
Prof. YUNG Wing Ho (容永豪) graduated from The Chinese University of Hong Kong (CUHK) in biology and biochemistry with first class honors. He was a recipient of the Commonwealth Scholarship and the Croucher Foundation Fellowship that supported his DPhil study and post-doctoral training in the University of Oxford, under the supervision of Prof. Julian Jack, FRS. He is currently Professor in the School of Biomedical Sciences and the Director of the Gerald Choa Neuroscience Centre, CUHK. He received the Master Teacher of the Year award, Faculty of Medicine in 2007 and the Research Excellence Award, CUHK in 2013. He has major research interests in neuroplasticity, neural circuitry and neurodegenerative diseases
- Neural circuits are the building blocks of the brain. A major line of my research is to decipher the neural circuits underlying animal behaviors and cognitive functions. We aim to untangle the neuron types and synaptic connections shaping these circuits and the computational principles underlying the operation of the circuits.
- An important property of the brain is its remarkable plasticity. Neuroplasticity underlies experience-dependent modification of all nervous system functions, and participates in the pathophysiology and functional adaptation in brain trauma. Another line of my research aims at understanding the nature of neuroplasticity and its involvement in both health and disease.
- To meet the challenges, a multidisciplinary approach is employed to address the research questions, including in vitro and in vivo electrophysiology, optogenetics, behavioral analysis and different types of brain imaging technology.
- Li, C., Chan, D.C.W., Yang, X., Ke, Y. & Yung, W.H. (2019). Prediction of forelimb reach results from motor cortex activities based on calcium imaging and deep learning. Frontiers in Cellular Neuroscience, 13: 88 doi: 10.3389/fncel.2019.00088.
- Cui, Q., Li, Q., Geng, H., Chen, L., Ip, N.Y., Ke, Y. & Yung, W.H. (2018). Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex-nucleus accumbens pathway in mice. Proceedings of the National Academy of Science USA, 115(21): E4890-E4899
- Li, Q., Ko, H., Qian, Z.M., Yan, L.Y.C., Chan, D.C.W., Arbuthnott, G., Ke, Y. & Yung, W.H. (2017). Refinement of learned skilled movement representation in motor cortex deep output layer. Nature Communications, 9; 8: 15834. doi: 10.1038/ncomms15834
- Leong, A.T., Chan, R.W., Gao, P.P., Chan, Y.S., Tsia, K.K., Yung, W.H. & Wu, E.X. (2016). Long-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile. Proceedings of the National Academy of Science USA, 113(51): E8306-E8315.
- Xu, L.H., Xie, H., Shi, Z.H., Du, L.D., Wing, Y.K., Li, A.M., Ke, Y. & Yung, W.H. (2015). Critical role of endoplasmic reticulum stress in chronic intermittent hypoxia-induced deficits in synaptic plasticity and long-term memory. Antioxidants & Redox Signaling, 23: 695-710.
- Li, Q., Qian, Z.M., Arbuthnott, G.W., Ke, Y. & Yung, W.H. (2014). Cortical effects of deep brain stimulation: implications for pathogenesis and treatment of Parkinson disease. JAMA Neurology, 71: 100-103(Editorial Highlight).
- Sun, X.R., Chen, L., Chen, W.F., Xue, Y. & Yung, W.H. (2013). Electrophysiological and behavioral effects of group III metabotropic glutamate receptors on pallidal neurons in normal and parkinsonian rats. Synapse, 67(12): 831-838. doi: 10.1002/syn.21694
- Huang, Y., Wang, J.J. & Yung, W.H. (2013). Coupling between GABA-A receptor and chloride transporter underlies ionic plasticity in cerebellar Purkinje neurons. The Cerebellum, 12: 328-330.
- Lai, K.O., Wong, A.S., Cheung, M.C., Xu, P., Liang, Z., Lok, K.C., Xie, H., Palko, M.E., Yung, W.H., Tessarollo, L., Cheung, Z.H. & Ip, N.Y. (2012). Serine phosphorylation of TrkB by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nature Neuroscience, 15: 1506-1515 (editorial highlight).
- Li, Q., Ke, Y., Chan, D.C.W., Qian, Z.M., Yung, K.K.L., Ko, H., Arbuthnott, G. & Yung, W.H. (2012). Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex. Neuron, 76: 1030-1041 (Highlighted in 'Nature Reviews Neuroscience' and 'Nature China').
- Huang, Y., Ko, H., Cheung, Z.H., Yung, K.K.L., Yao, T., Wang, J.J., Morozov, A., Ke, Y., Ip, N.Y. & Yung, W.H. (2012). Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental Neurology, 233: 791-798.
- Xie, H., Leung, K.L., Chen, L., Chan, Y.S., Ng, P.C., Fok, T.F., Wing, Y.K., Ke, Y., Li, A.M. & Yung, W.H. (2010). Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity. Neurobiology of Disease, 40: 155-162.
- Chu, J.Y.S., Lee, L.T.O., Lai, C.H., Vaudry, H., Chan, Y.S., Yung, W.H. & Chow, B.K.C. (2009). Secretin as a neurohypophysial factor regulating body water homeostasis. Proceedings of the National Academy of Science USA, 106: 15961-15966.
- Chen, L., Yung, K.K.L., Chan, Y.S. & Yung, W.H. (2008). 5-hydroxytryptamine excites globus pallidus neurons by multiple receptor mechanisms. Neuroscience, 151: 439-451.
- Cui, Q.L., Chen, L. & Yung, W.H. (2007). Substance P excites globus pallidus neurons in vivo. European Journal of Neuroscience, 26: 1853-1861.
- Xue, Y., Chen, L., Xie, J.X. & Yung, W.H. (2007). Electrophysiological and behavioral effects of neurotensin in rat globus pallidus: an in vivo study. Experimental Neurology, 205: 108-115.
- Chen, L., Yung, K.K.L. & Yung, W.H. (2006). Neurotensin selectively facilitates glutamatergic transmission in rat globus pallidus. Neuroscience, 141: 1871-1878
- Fu, A.K.Y., Ip, F.C.F., Fu, W.Y., Cheung, J., Wang, J.H., Yung, W.H. & Ip, N.Y. (2005). Aberrant motor axon projection, AChR clustering and neurotransmission in Cyclin-dependent kinase 5 null mice. Proceedings of the National Academy of Science USA, 102: 15224-15229.
- Chan, S.C., Surmeier, D.J. & Yung, W.H. (2005). Neuronal integration of striatopallidal signals: timing matters. NeuroSignals, 14: 281-289.
- Pang, P., Teng, H., Zaitsev, E., Woo, N.T., Sakata, K., Zhen, S., Teng, K.K., Yung, W.H., Hempstead, B. & Lu, B. (2004). Proteolytic conversion from pro- to mature BDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science, 305: 487-491.
- RGC - General Research Fund [PI; 01-Jan-20]: "Anomalous synaptic representations of locomotive states in the motor cortex in Parkinson’s disease: origin and significance" (HK$928,156).
- Health and Medical Research Fund [PI; 01-Jul-17 to 30-Jun-19]: "Targeting Endoplasmic Reticulum Stress in Obstructive Sleep Apnea-aggravated Neurocognitive Decline in Alzheimer's Disease" (HK$1,186,736).
- RGC - General Research Fund [PI; 01-Jan-16 to 31-Dec-18]: "Functional Dissection of the Neuronal Circuitry Underlying Cognitive Inflexibility in Parkinsonism" (HK$974,280).
- Health and Medical Research Fund [PI; 01-Jul-15 to 30-Jun-17]: "Treatment of Parkinsonian Symptoms via Stochastic Stimulation of the Motor Cortex: A Proof-of-principle Study" (HK$999,379).
- RGC - General Research Fund [PI; 01-Sep-14 to 31-Aug-17]: "Investigating the Dynamic Neuronal Network in the Motor Cortex Underlying Motor Engram Formation and Consolidation" (HK$819,000).
- Specialized Research Fund for the Doctoral Prgram of Higher Education (SPRDP) and Research Grants Council Earmarked Research Grants (RGC ERG) Joint Research Scheme [PI; 01-Jan-14 to 31-Dec-16]: "Elucidating the Therapeutic Mechanisms of Deep Brain Stimulation in Parkinson's Disease by Selective in vivo Optogenetic Maipulation Strategy" (HK$398,800).
- National Natural Science Foundation of China (NSFC) [PI; 01-Jan-14 to 31-Dec-17]: "Mechanisms of Deep Brain Stimulation Mediated Antidromic Activation in Alleviating Parkinsonian Motor Symptoms and Motor Learning Deficit (Project Awarded: RMB700,000; no funding transferred to Hong Kong)" (RMB700,000).