JIANG Yangzi1Research Assistant Professor of the Institute for Tissue Engineering and Regenerative Medicine

 

Telephone:   3943 5153

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Room 421A, 4/F, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

 

Biography

Prof. JIANG Yangzi (姜洋子) received Bachelor (2007) and PhD (2012) in Zhejiang University, Hangzhou, China, and did her postdoctoral training (2012-18) at University of Pittsburgh, PA, USA.  Prof. Jiang joined The Chinese University of Hong Kong in 2018.  Prof. Jiang’s previous research work has focused on creating tissue regeneration strategies of musculoskeletal system, particularly in bone and cartilage.  Her publications cover the topics of stem cells, tissue engineering, cell transplantation, biomaterials, pathology of osteoarthritis, and translational medicine.  Prof. Jiang’s lab has sought to understand the stem/progenitor cell origin (Nat Rev Rheum, 2015) and signaling pathways (Arthritis Res Therapy, 2015) of human articular cartilage in both healthy and disease conditions, and apply these knowledges to instruct the production of functional tissue replacements for clinical use.  Prof. Jiang’s work of taking the cartilage derived stem/progenitor cells for repair large-size of osteochondral defect (6-13 cm2, ave 8.5 cm2) in 15 young patients (Stem Cells Transl Med, 2016) has also paved a way for the autologous cell-based Tissue Engineering Techniques as Class III Therapeutics in China (J Ortho Transl, 2014), and many patients had been benefited from Prof. Jiang’s work.

  1. Development of therapeutic strategies for musculoskeletal tissue regeneration.
  2. The mechanism for degenerative and inflammatory diseases.
  3. Cell based therapy and translational medicine.
  1. Jiang, Y.* & Tuan, R.S.*. (2019). Role of NGF/TrkA Signaling in Calcification of Articular Chondrocytes. The FASEB Journal, 33(9): 10231-10239. doi: 10.1096/fj.201900970.
  2. He, J.#, Jiang, Y.#, Alexander, P.G., Ulici, V., Zhu, Y., Wu, S. & Tuan, R.S. (2017). Infrapatellar Fat Pad Aggravates Degeneration of Acute Traumatized Cartilage: A Possible Role for Interleukin-6. Osteoarthritis and Cartilage, 25(1): 138-145.
  3. Jiang, Y., Cai, Y., Zhang, W., Hu, C., Tong, T., Lu, P., Zhang, S., Neculai, D., Tuan, R. & Ouyang, H.W. (2016). Human Cartilage Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Stem Cells Translational Medicine, 5: 1-12.
  4. Jiang, Y. & Tuan, R. (2015). Origin and Function of Cartilage Stem/Progenitor Cells in Osteoarthritis. Nature Reviews Rheumatology, 11(4): 206-12.
  5. Jiang, Y., Hu, C., Yu, S., Yan, J., Peng, H., Ouyang, H.W. & Tuan, R.S. (2015). Cartilage Stem/Progenitor Cells are Activated in Osteoarthritis via Interleukin-1β/Nerve Growth Factor Signaling. Arthritis Research and Therapy, 17: 327.
  6. Zhang, W., Heng, B.C., Jiang, Y.* & Ouyang, H.W.* (2014). Clinical Translation of Autologous Cell-based Tissue Engineering Techniques as Class III Therapeutics in China: Taking Cartilage Tissue Engineering as An Example. Journal of Orthopaedic Translation, 2(2): 56-65.
  7. Jiang, Y., Chen, L., Zhang, S., Tong, T., Zhang, W., Liu, W., Xu, G., Tuan, R.S., Heng, B.C., Crawford, R., Xiao, Y. & Ouyang H.W. (2013). Incorporation of Bioactive Polyvinylpyrrolidone-iodine within Bilayered Collagen Scaffolds Enhances the Differentiation and Subchondral Osteogenesis of Mesenchymal Stem Cells. Acta Biomaterialia, 9(9): 8089-98.
  8. Zhang, S., Jiang, Y., Zhang, W., Chen, L., Tong, T., Liu, W., Mu, Q., Liu, H., Ji, J., Ouyang, H.W. & Zou, X. (2013). Neonatal Desensitization Supports Long-term Survival and Functional Integration of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression. Stem Cells and Development, 22(1): 90-101.
  9. Zhang, W., Chen, J., Tao, J., Jiang, Y., Hu, C., Huang, L., Ji, J. & Ouyang, H.W. (2013). The Use of Type 1 Collagen Scaffold Containing Stromal Cell-Derived Factor-1 to Create a Matrix Environment Conducive to Partial-thickness Cartilage Defects Repair. Biomaterials, 34(3): 713-23.
  10. Jiang, Y., Zhang, S., Wang, L. & Ouyang, H.W. (2010). Cell Transplantation for Articular Cartilage Defects: Principles of Past, Present and Future Practice. Cell Transplantation, 20(5): 593-607.
  11. Jiang, Y., Chen, L.K., Zhu, D.C., Zhang, G.R., Qi, Y.Y. & Ouyang, H.W. (2010). The Inductive Effect of Bone Morphogenetic Protein-4 on Chondral-lineage Differentiation and In Situ Cartilage Repair. Tissue Engineering Part A, 16(5): 1621-32.

    * Corresponding / Co-corresponding author 
    # Co-first author

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