School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof KER Dai Fei Elmer


Dai_Fei_Elmer_KerAssistant Professor of the Institute for Tissue Engineering and Regenerative Medicine

 

Telephone:   3943 4497

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

  Room 425D, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

ORCID: https://orcid.org/0000-0003-3434-8390

 

 

 

Biography

Prof. KER Dai Fei Elmer (柯岱飞) completed his Ph.D. in Biological Sciences from Carnegie Mellon University and postdoctoral training from the Department of Orthopaedic Surgery at Stanford University.  He is an Assistant Professor at The Chinese University of Hong Kong with appointments in the School of Biomedical Sciences and the Institute for Tissue Engineering and Regenerative Medicine.  His research interests include developing biomaterials and computer vision-based approaches for repairing injured bone-tendon and bone-ligament tissue units.  His lab webpage is https://ker-lab.weebly.com/.

  1. Biomaterials for Multi-Tissue Regeneration and Tissue Engineering.
  2. Functional Genomic Approaches to Study Musculoskeletal Biology and Regeneration.
  3. Computer-Vision-based Approaches for Cell Detection and Tracking.

Musculoskeletal Biology and Tissue Engineering

  1. Zhang, X., Li, K., Wang, C.Y., Rao, Y., Tuan, R.S., Wang, D., Ker, D.F.E.# (2024) Facile and Rapid Fabrication of a Novel 3D-Printable, Visible Light-Crosslinkable and Bioactive Polythiourethane for Large-to-Massive Rotator Cuff Tendon Repair. Bioactive Materials (2022 JIF 18.9) 37, pg. 439. doi.org/10.1016/j.bioactmat.2024.03.036.
  2. Wang, C.Y., Zhang, X., Wang, D, Yung, P.S.H., Tuan, R.S., Ker, D.F.E.# (2024) Optimized design of an enthesis-mimicking suture anchor-tendon hybrid graft for mechanically robust bone-tendon repair. Acta Biomaterialia (2022 5-year JIF 9.9) 176, pg. 277. doi.org/10.1016/j.actbio.2024.01.011.
  3. Wang, D.*, Zhang, X., Ng, K.W., Rao, Y., Wang, C.Y., Gharaibeh, B., Lin, S., Abrams, G., Safran, M., Cheung, E., Campbell, P., Weiss, L., Ker, D.F.E.*#, Yang, Y.P. # (2022) Growth and Differentiation Factor-7 Immobilized, Mechanically Strong Quadrol-Hexamethylene Diisocyanate-Methacrylic Anhydride Polyurethane Polymer for Tendon Repair and Regeneration. Acta Biomaterialia (2022 5-year JIF 9.9) 154, pg. 108. *Co-first authors. doi.org/10.1016/j.actbio.2022.10.029.
  4. Wang, D., Zhang, X., Huang, S., Liu, Y., Fu, B.S., Mak, K.K., Blocki, A.M., Yung, P.S., Tuan, R.S., & Ker, D.F.E.#, (2021) Engineering Multi-Tissue Units for Regenerative Medicine: Bone-Tendon-Muscle Units of the Rotator Cuff. Biomaterials (2022 JIF 14.0) 272, 120789, doi.org/10.1016/j.biomaterials.2021.120789 .
  5. Wang, D., Ker, D.F.E.#*, Ng, K.W., Li, K., Gharaibeh, B., Safran, M., Cheung, E., Campbell, P.G., Weiss, L.E., & Yang, Y.P. (2021) Combinatorial Mechanical-Gradation and Growth Factor-Biopatterning Strategy to Spatially Control Bone-Tendon-like Cell Differentiation and Tissue Formation. NPG Asia Materials (2022 5-year JIF 10.5) 13, 26, doi.org/10.1038/s41427-021-00294-z .
  6. Shanjani, Y., Siebert, S.M., Ker, D.F.E., Mercado-Pagan, A.E., & Yang, Y.P. (2020) Acoustic Patterning of Growth Factor for 3D Tissue Engineering. Tissue Engineering Part A, 26 (11-12), 602-612, doi.org/10.1089/ten.tea.2019.0271 .
  7. Ker, D.F.E. & Yang, Y.P. (2019). Ruminants: Evolutionary past and future impact. Science (Perspective) (2022 JIF 56.9) 364(6446), 1130-1131. doi.org/10.1126/science.aax5182.
  8. Ker, D.F.E.#*, Wang, D.#, Behn, A.W., Wang, E.T.H., Zhang, X., Zhou, B.Y., Mercado-Pagan, A.E., Kim, S., Kleimeyer, J., Gharaibeh, B., Shanjani, Y., Nelson, D., Safran, M., Cheung E., Campbell, P., & Yang, Y.P.* (2018). Functionally Graded, Bone- and Tendon-Like Polyurethane for Rotator Cuff Repair. Advanced Functional Materials (2022 JIF 19.0) 28(20), 1707107, doi.org/10.1002/adfm.201707107 .
  9. Ker, D.F.E., Chu, B., Phillippi, J.A., Gharaibeh, B., Huard, J., Weiss, L.E., & Campbell, P.G. (2011). Engineering spatial control of multiple differentiation fates within a stem cell population. Biomaterials (2022 JIF 14.0) 32(13), 3413-3422, doi.org/10.1016/j.biomaterials.2011.01.036 .
  10. Ker, D.F.E., Nain, A., Weiss, L.E., Wang, J., Suhan, J., Amon, C., & Campbell, P.G. (2011). Bioprinting of Growth Factors onto Aligned Sub-micron Fibrous Scaffolds for Simultaneous Control of Cell Differentiation and Alignment. Biomaterials (2022 JIF 14.0) 32(32), 8097-8107, doi.org/10.1016/j.biomaterials.2011.07.025 .

Computer Vision-Aided Study and Expansion of Stem Cells

  1. Cheng, C.T., Wang, D., Wang, H.#, Ker, D.F.E.# (2022) Application of neural networks on in vitro-generated Raman spectra for label-free, ex vivo skeletal muscle detection. Measurement (Q1 Journal) 204, pg. 112172. doi.org/10.1016/j.measurement.2022.112172.
  2. Nishimura, K., Wang, C., Wantanabe, K., Ker, D.F.E., Bise, R. (2021) Weakly Supervised Cell Instance Segmentation under Various Conditions. Medical Image Analysis (2022 JIF 10.9) 73, 102182, doi.org/10.1016/j.media.2021.102182
  3. Ker, D.F.E., Eom, S., Sanami, S., Bise, R., Pascale, C., Yin, Z., Huh, S., Osuna-Highley, E., Junkers, S.N., Helfrich, C.J., Liang, P.W., Pan, J., Jeong, S., Kang, S.S., Liu, J., Nicholson, R., Sandbothe, M.F., Van, P.T., Liu, A., Chen, M., Kanade, T., Weiss, L.E., & Campbell, P.G. (2018). Phase contrast time-lapse microscopy datasets with automated and manual cell tracking annotations. Scientific Data (2022 JIF 9.8) 5, 180237, doi.org/10.1038/sdata.2018.237.
  4. Ker, D.F.E., Weiss, L.E., Junkers, S.N., Chen, M., Yin, Z., Sandboth, M.F., Huh, S., Eom, S., Bise, R., Osuna-Highley, E., Kanade, T., & Campbell, P.G. (2011). An Engineered Approach to Stem Cell Culture: Automating the Decision Process for Real-Time Adaptive Subculture of Stem Cells. PLoS ONE, 6(11), e27672, doi.org/10.1371/journal.pone.0027672 .


    5. * Corresponding / Co-corresponding author 
    # Co-first author

  1. General Research Fund [PI; 2023-2025]: "Facile Connective Tissue Engineering: A 3D-Printed Monolithic Scaffold with Compliant and Growth Factor-Immobilized Regions to Reduce Stress and Induce Multi-Tissue Formation".
  2. Health@InnoHK [PI; 2022-2027]: "Engineering Vascularized Muscle Flaps for Skeletal Muscle Repair".
  3. Health Medical Research Fund [PI; 2021-2024]: "3D-printed, mechanically-graded and growth factor-biopatterned polyurethane for rotator cuff repair".
  4. Early Career Scheme [PI; 2021]: "A semi-automated computer vision-based pipeline for label-free cell instance segmentation in musculoskeletal tissue engineering".
  5. Innovation Technology Fund Tier 3 [PI; 2019-2020]: "Repairing tendon injuries with tissue mimetic biomaterials".
  6. CUHK - Faculty Innovation Award [PI; 2019-2023]: "Multi-tissue engineering of myotendinous graft for rotator cuff repair".
  7. Stanford University Spectrum MedTech [PI; 2017]: "Development of a hybrid suture anchor-tendon graft for rotator cuff repair".
  8. AO Foundation Start-up Grant [PI; 2014-2017]: "Development of a functionally graded polyurethane biomaterial for rotator cuff injury".