CHAN Man Lok Andrew resize Professor


Telephone:   39433771

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.


  705A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK


  1. Cancer cell signaling 
  2. PTEN tumor suppressor
  3. Ras-related small GTPases
  4. Tumor microenvironment
  5. Tumor Immunity
  6. Neurodevelopmental and Neurodegenerative disorders
  7. Mouse models of human diseases
  1. Wong, C.W., Or, P.M.-Y., Wang, Y., Li, L., Li, J., Yan, M., Cao, Y., Luk, H.M., Tong, T.M.F., Leslie, N.R., Lo, I.F.-M., Choy, R.K.W. & Chan, A.M. (2018). Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays and macrocephaly. Autism Research, In press.
  2. Zhou, X., Yue, G.G., Chan, A.M., Tsui, S.K., Fung, K.P., Sun, H., Pu, J. & Lau, C.B. (2017). Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer. Biochem. Pharmacol. 142, 58-70.
  3. Liu, W.N., Yan, M. & Chan, A.M. (2017). A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase. Cancer Lett. 430, 59-65.
  4. Ni, J., Bao, S., Johnson, R.I., Zhu, B, Li, J., Vadaparampil, J., Smith C.M., Cambell, K.N., Grahammer, F., Huber, T.B., He, J.C., D'Agati, V.D., Chan, A.M. & Kaufman, L. (2016). MAGI-1 interacts with nephrin to maintain slit diaphragm structure through enhanced Rap1 activation in podocytes. J. Biol. Chem., 291, 24406-24417.
  5. Knafo, S., Sanchez-Puelles, C., Palomer, E., Delgado, I., Draffin, J.E., Mingo, J., Wahle, T., Kaleka, K., Mou, L., Pereda-Perez, I., Klosi, E., Faber, E.B., Chapman, H.M., Lozano-Montes, L., Ortega-Molina, A., Ordonez-Guiterrez, L., Wandosell, F., Vina, J., Dotti, C.G., Hall, R.A., Pulido, R., Gerges, N.Z., Chan, A.M., Spaller, M.R., Serrano, M., Venero, C. & Esteban, J.A. (2016). PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nature Neuroscience, 19, 443-453.
  6. Yan, X., He, Y., Chen, Y., Yu, M., Singh, G., Wang, D., Hillery, C.A. & Chan, A.M. (2015). R-Ras regulates Murine T cell migration to peripheral lymph nodes and chemokine-induced activation of lymphocyte function-associated antigen-1. Plos One, 10, e0145218.
  7. Feng, H., Yu, Z., Lee, Y.-Y., Li, M.S., Go, M.Y.Y., Cheung, Y.-S., Lai, P.B.S., Chan, A.M., To, K.-F., Sung, J.J.Y. & Cheng, A.S.L. (2015). A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients. J. Hepatology. 62, 1100-1111.
  8. Ray, A., Basu, S., Miller, N.M., Chan, A.M. & Dittel, B.N. (2014). An increase in tolerogenic Dendritic Cell and natural T Regulatory Cell Numbers during EAE in Rras-/- mice results in attenuated disease. J. Immunology, 192, 5109-5117.
  9. Worzfeld, T., Swiercz, J.M., Sentürk, A., Genz, B., Korostylev, A., Deng, S., Hoshino, M., Epstein, J.A., Ruoslahti, E., Chan, A.M., Vollmar, B., Acker-Palmer, A., Kuner, R. & Offermanns, S. (2014). Genetic dissection of plexin signalling in vivo. PNAS, 1111, 2194-2199.
  10. Kennedy, C.R., Tilkens, S.B., Guan, H. & Chan, A.M. (2013). Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions. Cancer Letters, 336, 299-306.
  11. Singh, G., Hashimoto, D., Yan, X., Helft, J., Ma, G., Qiao, R.F., Kennedy, C.R., Chen, S.-H., Merad, M., & Chan, A.M. (2012). R-Ras is required for Murine Dendritic cell maturation and CD4+ T-cell priming. Blood. 119, 1693-1701.
  12. Singh, G., Odriozola, Guan, H., Hoang, T., Kennedy, C.R. & Chan, A.M. (2011). Characterizing a novel PTEN mutation in MDA-MB-453 breast carcinoma. BMC-Cancer, 11, 490.
  13. Odriozola, L., Singh, G., Hoang, T., & Chan, A.M. (2007). Regulation of PTEN Activity by its Carboxyl-terminal Autoinhibitory domain. J. Biol. Chem., 282, 23306-23315.
  14. Rodriguez, N.N., Lee, I.N., Banno, A., Qiao, H.F., Qiao, R.F., Hoang, T., Kimmelman, A.C. & Chan, A.M. (2006) Characterization of R-Ras3/M-Ras null mice reveals a potential role in trophic factor signaling. Mol. Cell. Biol. 26, 7145-7154.
  15. Kimmelman, A.C., Nuñez-Rodriguez, N., & Chan, A.M. (2002). R-Ras3/M-Ras induces Differentiation of PC12 cells through a Cell-Type Specific Activation of the Mitogen-Activated Protein Kinase. Mol. Cell. Biol. 22, 5946-5961.
  16. Chan, T.O., Rodeck, U., Chan, A.M., Kimmelman, A.C., Rittenhouse, S.E., Panayotou, G. & Tsichlis, P.N. (2002). Small GTPases and tyrosine kinases co-regulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell, 1, 181-191.
  17. Goutham N., Heath, K.E., Reeves, H.L., Li, D., Giono, L.E., Kimmelman, A.C., Glucksman, M.J., Narla, J., Eng, F.J., Chan, A.M., Ferrari, A.C., Martignetti, J.A. & Friedman, S.L. (2001). KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer. Science, 294, 2563-2566.
  18. Tolkacehva, T., Boddapati, M., Sanfiz, A., Tsuchida, K., Kimmelman, A.C. & Chan, A.M. (2001). Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at Threonine codon 382 & 383. Cancer Research, 61, 4985-4989.
  19. Kimmelman, A.C., Osada, M. & Chan, A.M. (2000.) R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells. Oncogene 19, 2014-2022.
  20. Tolkacheva, T. & Chan, A.M. (2000). Inhibition of H-ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene, 19, 680-689.
  21. Osada, M., Tolkacheva, T., Li, W., Chan, T.O., Tsichlis, P.N., Saez, R., Kimmelman, A.C. & Chan, A.M. (1999). Differential Roles of Akt, Rac, and Ral in R-Ras-Mediated Cellular Transformation, Adhesion, and Survival. Mol. Cell. Biol., 19, 3336-3344.
  22. Kimmelman, A., Tolkacheva, T., Lorenzi, M.V., Osada, M. & Chan, A.M. (1997). Identification and characterization of R-ras3 : a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. Oncogene, 15, 2675 – 2686.
  23. Tolkacheva, T., Feuer, B., Lorenzi, M.V., Saez, R. & Chan, A.M. (1997). Cooperative transformation of NIH/3T3 cells by Ga12 and Rac1. Oncogene, 15, 727-736.
  24. Kruh, G.D., Gaughan, K.T., Godwin, A. & Chan, A.M. (1995). Expression pattern of MRP in human tissues and adult solid tumor cell lines. JNCI 87, 1256-1258.
  25. Saez, R., Chan, A.M., Miki, T. & Aaronson, S.A. (1994). Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes. Oncogene, 9, 2977-2982.
  26. Clark, J., Rocques, P.J., Crew, A.J., Gill, S., Shipley, J., Chan, A.M., Gusterson, B.A. & Cooper, C.S. (1994). Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genetics, 7, 502-508.
  27. Chan, A.M., Miki, T., Meyers, K.A., & Aaronson, S.A. (1994). A new human oncogene of the ras superfamily unmasked by expression cDNA cloning. Proc. Natl. Acad. Sci. U.S.A., 91, 7558-7562.
  28. Chan, A.M., Fleming, T.P., McGovern, E.S., Chedid, M., Miki, T. & Aaronson, S.A. (1993). Expression cDNA cloning of a transforming gene encoding the wild-type Ga12 gene product. Mol. Cell. Biol. 13, 762-768.
  29. Chan, A.M., Rubin, J.S., Bottaro, D.P., Hirschfield, D.W., Chedid, M. & Aaronson, S.A. (1991). Identification of a competitive HGF Antagonist Encoded by an Alternative Transcript. Science 254, 1382-1385.
  30. Bottaro, D.P., Rubin, J.S., Falletto, D.L., Chan, A.M., Kmiecik, T.E., Vande Woude, G.F. & Aaronson, S.A. (1991). Identification of the HGF receptor as the c-met protooncogene product. Science 251, 802-804.