School of Biomedical Sciences
The Chinese University of Hong Kong 香港中文大學

CHAN Man Lok Andrew resize Professor


Telephone:   39433771

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.


  705A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK


  1. Cancer cell signaling - Ras-related oncogenes and PTEN tumor suppressor
  2. Tumor microenvironment
  3. Ras-related GTPase in anti-tumor immunity
  4. Mouse model of human cancer
  1. Ni, J., Bao, S., Johnson, R.I., Zhu, B, Li, J., Vadaparampil, J., Smith C.M., Cambell, K.N., Grahammer, F., Huber, T.B., He, J.C., D'Agati, V.D., Chan, A.M. & Kaufman, L. (2016). MAGI-1 interacts with nephrin to maintain slit diaphragm structure through enhanced Rap1 activation in podocytes. J. Biol. Chem., In press.
  2. Knafo, S., Sanchez-Puelles, C., Palomer, E., Delgado, I., Draffin, J.E., Mingo, J., Wahle, T., Kaleka, K., Mou, L., Pereda-Perez, I., Klosi, E., Faber, E.B., Chapman, H.M., Lozano-Montes, L., Ortega-Molina, A., Ordonez-Guiterrez, L., Wandosell, F., Vina, J., Dotti, C.G., Hall, R.A., Pulido, R., Gerges, N.Z., Chan, A.M., Spaller, M.R., Serrano, M., Venero, C. & Esteban, J.A. (2016). PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nature Neuroscience, 19, 443-453.
  3. Yan, X., Yan, M.F., Guo, Y.H., Singh, G., Chen, Y.H., Yu, M., Wang, D.M., Hillery, C.A. & Chan, A.M. (2015). R-Ras regulates murine T cell migration and Intercellular Adhesion Molecule-1 binding. PLoS ONE, 10, e0145218.
  4. Feng, H., Yu, Z., Lee, Y.-Y., Li, M.S., Go, M.Y.Y., Cheung, Y.-S., Lai, P.B.S., Chan, A.M., To, K.-F., Sung, J.J.Y. & Cheng, A.S.L. (2015). An androgen receptor-regulated kinase CCRK activates an epigenetic circuitry in hepatocarcinogenesis through dual regulation of EZH2. J. Hepatology, 62, 1100-1111.
  5. Ray, A., Basu, S., Miller, N.M., Chan, A.M. & Dittel, B.N. (2014). An increase in tolerogenic Dendritic Cell and natural T Regulatory Cell Numbers during EAE in Rras-/- mice results in attenuated disease. J. Immunology, 192, 5109-5117.
  6. Worzfeld, T., Swiercz, J.M., Sentürk, A., Genz, B., Korostylev, A., Deng, S., Hoshino, M., Epstein, J.A., Ruoslahti, E., Chan, A.M., Vollmar, B., Acker-Palmer, A., Kuner, R. & Offermanns, S. (2014). Genetic dissection of plexin signalling in vivo. PNAS, 1111, 2194-2199.
  7. Kennedy, C.R., Tilkens, S.B., Guan, H. & Chan, A.M. (2013). Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions. Cancer Letters, 336, 299-306.
  8. Singh, G., Odriozola, Guan, H., Hoang, T., Kennedy, C.R. & Chan, A.M. (2011). Characterizing a novel PTEN mutation in MDA-MB-453 breast carcinoma. BMC-Cancer, 11, 490.
  9. Yan, X., Kennedy, C.R., Tilkens, S.B., Wiedemeier, O., Guan, H., Park, J.-I. & Chan, A.M. (2011). Cooperative cross-talk between neuroblastoma subtypes confers resistance to Anaplastic Lymphoma Kinase inhibition. Genes and Cancer, 2, 523-537.
  10. Odriozola, L., Singh, G., Hoang, T., & Chan, A.M. (2007). Regulation of PTEN Activity by its Carboxyl-terminal Autoinhibitory domain. J. Biol. Chem., 282:23306-23315.
  11. Rodriguez, N.N., Lee, I.N., Banno, A., Qiao, H.F., Qiao, R.F., Hoang, T., Kimmelman, A.C. & Chan, A.M. (2006). Characterization of R-Ras3/M-Ras null mice reveals a potential role in trophic factor signaling. Mol. Cell. Biol., 26, 7145-7154.
  12. Kimmelman, A.C., Nuñez-Rodriguez, N., & Chan, A.M. (2002). R-Ras3/M-Ras induces Differentiation of PC12 cells through a Cell-Type Specific Activation of the Mitogen-Activated Protein Kinase. Mol. Cell. Biol., 22, 5946-5961.
  13. Chan, T.O., Rodeck, U., Chan, A.M., Kimmelman, A.C., Rittenhouse, S.E., Panayotou, G. & Tsichlis, P.N. (2002). Small GTPases and tyrosine kinases co-regulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell, 1, 181-191.
  14. Goutham N., Heath, K.E., Reeves, H.L., Li, D., Giono, L.E., Kimmelman, A.C., Glucksman, M.J., Narla, J., Eng, F.J., Chan, A.M., Ferrari, A.C., Martignetti, J.A. & Friedman, S.L. (2001). KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer. Science, 294, 2563-2566.
  15. Tolkacehva, T., Boddapati, M., Sanfiz, A., Tsuchida, K., Kimmelman, A.C. & Chan, A.M. (2001). Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at Threonine codon 382 & 383. Cancer Research, 61, 4985-4989.
  16. Tolkacheva, T. & Chan, A.M. (2000). Inhibition of H-ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene, 19:680-689.
  17. Osada, M., Tolkacheva, T., Li, W., Chan, T.O., Tsichlis, P.N., Saez, R., Kimmelman, A.C. & Chan, A.M. (1999). Differential Roles of Akt, Rac, and Ral in R-Ras-Mediated Cellular Transformation, Adhesion, and Survival. Mol. Cell. Biol., 19, 3336-3344.
  18. Clark, J., Rocques, P.J., Crew, A.J., Gill, S., Shipley, J., Chan, A.M., Gusterson, B.A. & Cooper, C.S. (1994). Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genetics, 7, 502-508.
  19. Chan, A.M., Miki, T., Meyers, K.A., & Aaronson, S.A. (1994). A new human oncogene of the ras superfamily unmasked by expression cDNA cloning. Proc. Natl. Acad. Sci. U.S.A., 91, 7558-7562.
  20. Chan, A.M., Rubin, J.S., Bottaro, D.P., Hirschfield, D.W., Chedid, M. & Aaronson, S.A. (1991). Identification of a competitive HGF Antagonist Encoded by an Alternative Transcript. Science, 254,1382-1385.