CHAN Wood YeeProfessor

B.Sc., M.Phil., Ph.D., C.Biol., M.I.Biol.,

Telephone:   39436895

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.


  Rm 621A, 6/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK



  1. Formation, migration and differentiation of neural crest cells and neural crest stem cells
  2. Development of the nervous systems in experimental animals and human fetuses
  3. Genetic and epigenetic controls of cellular migration, proliferation and differentiation in embryos and cancers
  4. Early organogenesis in post-implantation embryos
  5. Embryotoxicity and teratogenicity of various bioactive compounds
  1. Burns, A. J., Goldstein, A. M., Newgreen, D. F., Stamp, L., Schafer, K. H., Metzger, M., Hotta, R., Young, H. M., Andrews, P. W., Thapar, N., Belkind-Gerson, J., Bondurand, N., Bornstein, J. C., Chan, W. Y., Cheah, K., Gershon, M. D., Heuckeroth, R. O., Hofstra, R. M., Just, L., Kapur, R. P., King, S. K., McCann, C. J., Nagy, N., Ngan, E., Obermayr, F., Pachnis, V., Pasricha, P. J., Sham, M. H., Tam, P., & Vanden Berghe, P. (2016). White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology, 417(2), 229-251.
  2. Wang, B., Chen, Y. C., Jiang, G., Ning, Q., Ma, L., Chan, W. Y., Wu, S., Zhou, G. Q., Bao, R., Zheng, Z. C., Yang, X., Luo, J. X., Zheng, W., Guo, H. W., Zeng, C., Zeng, Q. Y., & Shu, S. Y. (2016). New learning and memory related pathways among the hippocampus, the amygdala and the ventromedial region of the striatum in rats. Journal of Chemical Neuroanatomy, 71, 13-19.
  3. Wang, C., Kam, R. K., Shi, W., Xia, Y., Chen, X., Cao, Y., Sun, J., Du, Y., Lu, G., Chen, Z., Chan, W. Y., Chan, S. O., Deng, Y., & Zhao, H. (2015). The proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 to mediate output of bone morphogenetic protein signaling. The Journal of Biological Chemistry, 290(36), 21925-21938.
  4. Shu, S. Y., Jiang, G., Zeng, Q. Y., Wang, B., Li, H., Ma, L., Steinbusch, H., Song, C., Chan, W. Y., Chen, X. H., Wu, Y. M., Bao, R., Chen, Y. C., & Wu, J. Y. (2015). The marginal division of the striatum and hippocampus has different role and mechanism in learning and memory. Molecular Neurobiology, 51(2), 827-839.
  5. Chan, W. Y., Wong, J. H., & Ng, T. B. (2014). Embryotoxic and abortifacient activities of ribosome-inactivating proteins. In F. Stirpe, & D. A. Lappi (Eds.), Ribosome-inactivating proteins: Ricin and related proteins (pp. 270-280). Iowa USA: John Wiley & Sons.
  6. Wong, C. H., Nguyen, L., Peh, J., Luu, L. M., Sanchez, J. S., Richardson, S. L., Tuccinardi, T., Tsoi, H., Chan, W. Y., Chan, H. Y., Baranger, A. M., Hergenrother, P. J., & Zimmerman, S. C. (2014). Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor. Journal of the American Chemical Society, 136(17), 6355-6361.
  7. Kam, R. K., Shi, W., Chan, S. O., Chen, Y., Xu, G., Lau, C. B., Fung, K. P., Chan, W. Y., & Zhao, H. (2013). Dhrs3 protein attenuates retinoic acid signaling and is required for early embryonic patterning. The Journal of Biological Chemistry, 288(44), 31477-31487.
  8. Qu, Z. Q., Zhou, Y., Zeng, Y. S., Lin, Y. K., Li, Y., Zhong, Z. Q., & Chan, W. Y. (2012). Protective effects of a rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat. PLoS One, 7(1), e29641.
  9. Wang, X., Chan, A. K., Sham, M. H., Burns, A. J., & Chan, W. Y. (2011). Analysis of the sacral neural crest cell contribution to the hindgut enteric nervous system in the mouse embryo. Gastroenterology, 141(3), 992-1002.e1-6.
  10. Chan, K. Y., Xiang, P., Zhou, L., Li, K., Ng, P. C., Wang, C. C., Zhang, L., Deng, H. Y., Pong, N. H., Zhao, H., Chan, W. Y., & Sung, R. Y. (2011). Thrombopoietin protects against doxorubicin-induced cardiomyopathy, improves cardiac function, and reversely alters specific signalling networks. European Journal of Heart Failure, 13(4), 366-376.
  11. Xie, C. M., Chan, W. Y., Yu, S., Zhao, J., & Cheng, C. H. (2011). Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. Free Radical Biology & Medicine, 51(7), 1365-1375.
  12. Zeng, X., Zeng, Y. S., Ma, Y. H., Lu, L. Y., Du, B. L., Zhang, W., Li, Y., & Chan, W. Y. (2011). Bone marrow mesenchymal stem cells in a three-dimensional gelatin sponge scaffold attenuate inflammation, promote angiogenesis, and reduce cavity formation in experimental spinal cord injury. Cell Transplantation, 20(11-12), 1881-1899.
  13. Ni, Y., Shu, S., Guo, Z., Liu, S., Bao, Y., Liu, S., & Chan, W. Y. (2011). Dissociated brain organization for two-digit addition and subtraction: An fMRI investigation. Brain Research Bulletin, 86(5-6), 395-402.
  14. Chan, W. Y., Ng, T. B., Lam, J. S., Wong, J. H., Chu, K. T., Ngai, P. H., Lam, S. K., & Wang, H. X. (2010). The mushroom ribosome-inactivating protein lyophyllin exerts deleterious effects on mouse embryonic development in vitro. Applied Microbiology and Biotechnology, 85(4), 985-993.
  15. Ng, T. B., Lam, J. S., Wong, J. H., Lam, S. K., Ngai, P. H., Wang, H. X., Chu, K. T., & Chan, W. Y. (2010). Differential abilities of the mushroom ribosome-inactivating proteins hypsin and velutin to perturb normal development of cultured mouse embryos. Toxicology in Vitro, 24(4), 1250-1257.
  16. Cheung, K. K., Mok, S. C., Rezaie, P., & Chan, W. Y. (2008). Dynamic expression of Dab2 in the mouse embryonic central nervous system. BMC Developmental Biology, 8, 76-213X-8-76.
  17. Ng, A. K., Zhang, H., Tan, K., Li, Z., Liu, J. H., Chan, P. K., Li, S. M., Chan, W. Y., Au, S. W., Joachimiak, A., Walz, T., Wang, J. H., & Shaw, P. C. (2008). Structure of the influenza virus A H5N1 nucleoprotein: Implications for RNA binding, oligomerization, and vaccine design. FASEB Journal, 22(10), 3638-3647.
  18. Chan, W. Y., Kohsaka, S., & Rezaie, P. (2007). The origin and cell lineage of microglia: New concepts. Brain Research Reviews, 53(2), 344-354.
  19. Ackermann, G. E., Marenholz, I., Wolfer, D. P., Chan, W. Y., Schafer, B., Erne, P., & Heizmann, C. W. (2006). S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses. Biochimica et Biophysica Acta - Molecular Cell Research, 1763(11), 1307-1319.
  20. Chan, W. Y., Cheung, C. S., Yung, K. M., & Copp, A. J. (2004). Cardiac neural crest of the mouse embryo: Axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect. Development, 131(14), 3367-3379.