School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


KO Wing HungAssociate Professor

B.Sc., Ph.D., C. Biol., M.I. Biol.

Telephone:  39436781

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Rm 607A, 6/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

Website:   http://ihome.sbs.cuhk.edu.hk/kowinghung/

 

  1. Cellular signalling mechanisms and ion transport regulation in the mammalian epithelia, such as sweat gland, intestinal and airway epithelia
  2. Purinergic receptors and signaling pathways in epithelia
  3. Pathophysiological mechanisms of epithelial-related inflammatory diseases, such as asthma and ulcerative colitis
  4. Effect of Traditional Chinese Medicines and natural flavonoids on epithelial functions
  5. Development of a “trimultaneous” measurement technique for real-time monitoring of bioelectric properties, intracellular cAMP and Ca2+ in polarized epithelia
  1. Hao, Y., Chow, A. W., Yip, W. C., Li, C. H., Wan, T. F., Tong, B. C., Cheung, K. H., Chan, W. Y., Chen, Y., Cheng, C. H. & Ko, W. H. (2016). G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca2+ signaling pathway in human airway epithelia. Pflugers Archiv European Journal of Physiology, 468(8), 1489-1503.
  2. Liu, P. Y., Li, S. T., Shen, F. F., Ko, W. H.*, Yao, X. Q., & Yang, D. (2016). A small synthetic molecule functions as a chloride-bicarbonate dual-transporter and induces chloride secretion in cells. Chemical Communications, 52(46), 7380-7383. (*co-corresponding author)
  3. Hao, Y., Cheung, C. S., Yip, W. C., & Ko, W. H. (2015). Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway. Cellular Physiology and Biochemistry, 37(1), 306-320.
  4. Hao, Y. & Ko, W. H. (2014). Purinergic P2Y receptors in airway epithelia: from ion transport to immune functions. Sheng Li Xue Bao, 66(1), 16-22.
  5. Hao, Y., Liang, J. F., Chow, A. W., Cheung, W. T., & Ko, W. H. (2014). P2Y6 Receptor-Mediated Proinflammatory Signaling in Human Bronchial Epithelia. PLoS ONE, 9(9), e106235.
  6. Bovell, D. L., Riggs, C. M., Sidlow, G., Troester, S., MacLaren, W., Yip, W. & Ko, W. H. (2013). Evidence of purinergic neurotransmission in isolated, intact horse sweat glands. Veterinary Dermatology, 24(4), 398-6.
  7. Alzamora, R., O'Mahony, F., Ko, W. H., Yip, T.W., Carter, D., Irnaten, M., & Harvey, B.J. (2011). Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1 channels. Frontiers in Physiology, 2:33.
  8. Fung, J. C., Yue, G. G., Fung, K. P., Ma, X., Yao, X., & Ko, W. H. (2011). Cordyceps militaris extract stimulates Cl- secretion across human bronchial epithelia by both Ca2+- and cAMP- dependent pathways. Journal of Ethnopharmacology, 138(1), 201-211.
  9. Lau, W. K., Chow, A. W., Au, S. C., & Ko, W. H. (2011). Differential Inhibitory Effects of CysLT1 Receptor Antagonists on P2Y6 Receptor-Mediated Signaling and Ion Transport in Human Bronchial Epithelia. PLoS ONE, 6(7), e22363.
  10. Chow, A. W., Liang, J. F., Wong, J. S., Fu, Y., Tang, N. L., & Ko, W. H. (2010). Polarized Secretion of Interleukin (IL)-6 and IL-8 by Human Airway Epithelia 16HBE14o- Cells in Response to Cationic Polypeptide Challenge. PLoS ONE, 5(8), e12091.
  11. Wong, A. M., Chow, A. W., Au, S. C., Wong, C. C., & Ko, W. H. (2009). Apical versus basolateral P2Y6 receptor-mediated Cl- secretion in immortalized bronchial epithelia. American Journal of Respiratory Cell and Molecular Biology, 40(6), 733-745.
  12. Yue, G. G., Lau, C. B., Fung, K. P., Leung, P. C., & Ko, W. H. (2008). Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells. Journal of Ethnopharmacology 117(1), 92-101.
  13. Chung, H. L., Yue, G. G., To, K. F., Su, Y. L., Huang, Y., & Ko, W. H. (2007). Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats. World Journal of Gastroenterology, 13(42), 5605-5611.
  14. Ko, W. H., Law, V. W., Yip, W. C., Yue, G. G., Lau, C. W., Chen, Z. Y. & Huang, Y. (2002). Stimulation of chloride secretion by baicalein in isolated rat distal colon. Amerian Journal of Physiology - Gastrointestestinal and Liver Physiology, 282(3), G508-G518.
  15. Yue, G. G., Yip, T. W., Huang, Y., & Ko, W. H. (2004). Cellular mechanism for potentiation of Ca2+-mediated Cl--secretion by the flavonoid baicalein in intestinal epithelia. Journal of Biological Chemistry, 279(38), 39310-39316.
  16. Wong, C. H. & Ko, W. H. (2002). Stimulation of Cl- secretion via membrane-restricted Ca2+ signaling mediated by P2Y receptors in polarized epithelia. Journal of Biological Chemistry, 277(11), 9016-9021.
  17. Ko, W. H., Law, V. W., Wong, H. Y., & Wilson, S. M. (1999). The simultaneous measurement of epithelial ion transport and intracellular free Ca2+ in cultured equine sweat gland secretory epithelium. Journal of Membrane Biology, 170(3), 205-211.
  18. Wilson, S. M., Law, V. W., Pediani, J. D., Allen, E. A., Wilson, G., Khan, Z. E. & Ko, W. H. (1998). Nucleotide-evoked calcium signals and anion secretion in equine cultured epithelia that express apical P2Y2 receptors and pyrimidine nucleotide receptors. British Journal of Pharmacology, 124(4), 832-838.
  19. Ko, W. H., Chan, H. C., Chew, S. B. C., & Wong, P. Y. D. (1996). Ionic mechanisms of Ca2+-dependent electrolyte transport across equine sweat gland epithelium. Journal of Physiology, 493(Pt 3), 885–894.
  20. Ko, W. H., Chan, H. C., & Wong, P. Y. (1996). Anion secretion induced by capacitative Ca2+ entry through apical and basolateral membranes of cultured equine sweat gland epithelium. Journal of Physiology, 497(Pt 1), 19-29.