- To investigate the contributions and mechanisms of actions of various endogenous mediators in the development of arthritis, stroke, and allergic contact dermatitis.
- To evaluate the efficacies and mechanisms of actions of some traditional Chinese medicines in the treatment of inflammatory and cardiovascular diseases.
Zhen X, Ng ESK, Lam FFY (2016). Suppression of ischaemia-induced injuries in rat brain by protease-activated receptor-1 (PAR-1) activating peptide. Eur. J. Pharmacol., 786, 36-46.
Deng Y, Ng ESK, Kwan YW, Lau CBS, Cheung DWS, Koon JC., Zhang Z, Zuo Z, Leung, PC, Fung KP, Lam FFY (2014). Cerebral vasodilator properties of Danshen and Gegen: A study of their combined efficacy and mechanisms of actions. Phytomedicine, 21, 391-399.
Ma X, Du J, Zhang P, Deng J, Liu J, Lam FFY, Li RA, Huang Y, Jin J, Yao X (2013). Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension, 62(1), 134-139.
Li M, He J, Jiang LL, Ng ESK, Wang H, Lam FFY, Zhang YM, Tan NH, Shaw PC (2013). The anti-arthritic effects of Aconitum vilmorinianum, a folk herbal medicine in Southwestern China. J. Ethnopharmacol., 147, 122-127.
Zhou XL, Chan SW, Tseng HL, Deng Y, Hoi PM, Choi PS, Or PMY, Yang JM, Lam FFY, Lee SMY, Leung GPH, Kong SK, Ho HP, Kwan YW, Yeung JHK (2012). Danshensu is the major marker for the antioxidant and vasorelaxant effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions. Phytomedicine, 19, 1263-1269.
Ho JCY, Lai WH, Li MF, Au KW, Yip MC, Wong NLY, Ng ESK, Lam FFY, Siu CW, Tse HF (2012). Reversal of endothelial progenitor cell dysfunction in patients with type 2 diabetes using a conditioned medium of human embryonic stem cell-derived endothelial cells. Diabetes/Metabolism Research and Reviews, 28, 462-473.
Or PMY, Lam FFY, Kwan YW, Cho CH, Lau CBS, Fung KP, Leung PC, Yeung JHK (2012). Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms. Phytomedicine, 19, 535-544.
Lam FFY, Deng SY, Ng ESK, Yeung JHK, Kwan YW, Lau CBS, Koon JCM, Zhou L, Zuo Z, Leung PC, Fung KP (2010). Mechanisms of the relaxant effect of a Danshen and Gegen formulation on rat isolated cerebral basilar artery. J. Ethnopharmacol., 132, 186-192.
Deng Y, NG ESK, Yeung JHK, Kwan YW, Lau CBS, Koon JCM, Zhou L, Zuo Z, Leung PC, Fung KP, Lam FFY (2011). Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated cerebral basilar artery. J. Ethnopharmacol., 139, 294-304.
Lian QZ, Zhang YL, Zhang JQ, Zhang HK, Wu XG, Zhang Y, Lam FFY, Kang S, Xia JC, Lai WH, Au KW, Chow YY, Siu CW, Lee CN, Tse HF (2010). Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation, 121, 1113-1123.
Lam FFY, NG ESK (2010). Substance P and glutamate receptor antagonists improve anti-arthritis actions of dexamethasone in rats. Br. J. Pharmacol., 159, 958-969.
Lau TWD, Lam FFY, Lau KM, Cha YW, Lee KM, Sahota DS, Ho YY, Fung KP, Leung PC, Lau CBS (2009). Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer. J. Ethnopharmacol., 123, 155-162.
Lam FFY, Ko IWM, Ng ESK, Tam LS, Leung PC, Li EKM (2008). Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund’s complete adjuvant. J. Ethnopharmacol., 120, 44-50.
Lam FFY, Yeung JHK, Chan KM, Or PMY (2008). Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J. Ethnopharmacol., 119, 318-321.
Lam FFY, Yeung JHK, Chan KM, Or PMY (2008). Mechanisms of the dilator action of cryptotanshinone on rat coronary artery. Eur. J. Pharmacol., 578, 253-260.
Lam FFY, Luk PWS, Ng ESK (2007). Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. Life Sci., 80, 1495-1502.
Lam FFY, Yeung JHK, Kwan YW, Chan KM, Or PMY (2006). Salvianolic acid B, an aqueous extract of Danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. Eur. J. Pharmacol., 553, 240-245.
Lam FFY, Seto SW, Kwan YW, Yeung JHK, Chan P (2006). Activation of iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells. Eur. J. Pharmacol., 546, 28-35.
Lam FFY, Yeung JHK, Cheung JHY (2005). Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol., 46, 361-368.
Lam FFY, Wong HHL, Ng ESK (2004). Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats. Int. Immunopharmacol., 4, 299-310.