School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


LAM Fu Yuen FrancisAssociate Professor

B.Sc., Ph.D.

Telephone:   39436790

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 226A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Neuroprotective efficacies of some Traditional Chinese Medicines
  2. Proteinase-activated receptors in cerebrovascular and inflammatory joint diseases
  3. The vanilloid TRPV1 receptor and allergic contact dermatitis
  1. Zhen, X., Ng, E.S.K., & Lam, F.F.Y. (2017). Protease activated receptor-3 on in vivo and in vitro rat models of ischemic stroke. Central South Pharmacy, 15 (6), 780-785.
  2. Zhen, X., Ng, E.S.K., & Lam, F.F.Y. (2017). Role of protease activated receptor-2 in in vivo and in vitro rat models of ischemic stroke. Central South Pharmacy, 15 (5), 595-600.
  3. Yui, C.O.L., Leung, K.S., Fung, K.P., Lam, F.F.Y., Ng, E.S.K., Lau,K.M., Chow, S.K.H. & Cheung, W.H. (2017). The characterization of a full-thickness excision open foot wound model in n5-streptozotocin (STZ)-induced type 2 diabetic rats that mimics diabetic foot ulcer in terms of reduced blood circulation, higher C-reactive protein, elevated inflammation, and reduced cell proliferation. Exp. Anim. 66, 259-269.
  4. Zhen, X., Ng, E.S.K. & Lam, F.F.Y. (2016). Suppression of ischaemia-induced injuries in rat brain by protease-activated receptor-1 (PAR-1) activating peptide. Eur. J. Pharmacol., 786, 36-46.
  5. Deng, Y., Ng, E.S.K., Kwan, Y.W., Lau, C.B.S., Cheung, D.W.S., Koon, J.C.M., Zhang, Z., Zuo, Z., Leung, P.C., Fung, K.P. & Lam, F.F.Y. (2014). Cerebral vasodilator properties of Danshen and Gegen: A study of their combined efficacy and mechanisms of actions. Phytomedicine, 21, 391-399.
  6. Ma, X., Du, J., Zhang, P., Deng, J., Liu J, Lam, F.F.Y., Li, R.A., Huang, Y., Jin, J. & YAO, X. (2013) Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension, 62(1), 134-139.
  7. Li, M., He, J., Jiang, L.L., Ng, E.S.K., Wang, H., Lam, F.F.Y., Zhang, Y.M., Tan, N.H. & Shaw, P.C. (2013). The anti-arthritic effects of Aconitum vilmorinianum, a folk herbal medicine in Southwestern China. J. Ethnopharmacol., 147, 122-127.
  8. Zhou, X.L., Chan, S.W., Tseng, H.L., Deng, Y., Hoi, P.M., Choi, P.S., Or, P.M.Y., Yang, J.M., Lam, F.F.Y., Lee, S.M.Y., Leung, G.P.H., Kong, S.K., Ho, H.P., Kwan, Y.W. & Yeung, J.H.K., (2012). Danshensu is the major marker for the antioxidant and vasorelaxant effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions. Phytomedicine, 19, 1263-1269.
  9. Ho, J.C.Y., Lai, W.H., Li, M.F., Au K.W., Yip, M.C., Wong, N.L.Y., Ng, E.S.K., Lam, F.F.Y., Siu, C.W. & Tse, H.F. (2012). Reversal of endothelial progenitor cell dysfunction in patients with type 2 diabetes using a conditioned medium of human embryonic stem cell-derived endothelial cells. Diabetes/Metabolism Research and Reviews, 28, 462-473.
  10. Or, P.M.Y., Lam, F.F.Y., Kwan, Y.W., Cho, C.H., Lau, C.B.S., Fung, K.P., Leung, P.C. & Yeung, J.H.K. (2012). Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms. Phytomedicine, 19, 535-544.
  11. Deng Y., Ng, E.S.K., Yeung, J.H.K., Kwan, Y.W., Lau, C.B.S., Koon, J.C.M., Zhou, L., Zuo, Z., Leung, P.C., Fung, K.P. & Lam, F.F.Y. (2012). Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated cerebral basilar artery. J. Ethnopharmacol., 139, 294-304.
  12. Lam, F.F.Y., Deng S.Y., Ng, E.S.K., Yeung, J.H.K., Kwan, Y.W., Lau, C.B.S., Koon, J.C.M., Zhou, L., Zuo, Z., Leung, P.C. & Fung, K.P. (2010). Mechanisms of the relaxant effect of a Danshen and Gegen formulation on rat isolated cerebral basilar artery. J. Ethnopharmacol., 132, 186-192.
  13. Lian, Q.Z, Zhang, Y.L., Zhang, J.Q., Zhang H.K., Wu, X.G., Zhang, Y., Lam, F.F.Y., Kang, S., Xia, J.C., Lai, W.H., Au, K.W., Siu, C.W., Lee, C.N. & Tse, H.F. (2010). Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation, 121, 1113-1123.
  14. Lam, F.F.Y. & NG, E.S.K. (2010). Substance P and glutamate receptor antagonists improve anti-arthritis actions of dexamethasone in rats. Br. J. Pharmacol. 159, 958-969.
  15. Lau, T.W.D., Lam, F.F.Y., Lau, K.M., Chan, Y.W., Lee, K.M., Sahota, D.S., Ho, Y.Y., Fung, K.P., Leung, P.C. & Lau, C.B.S. (2009). Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer. J. Ethnopharmacol., 123, 155-162.
  16. Lam, F.F.Y., Ko, I.W.M., Ng, E.S.K., Tam, L.S., Leung, P.C. & Li, E.K.M. (2008). Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund’s complete adjuvant. J. Ethnopharmacol., 120, 44-50.
  17. Lam, F.F.Y., Yeung, J.H.K., Chan, K.M., & OR, P.M.Y. (2008). Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J. Ethnopharmacol., 119, 318-321.
  18. Lam, F.F.Y., Yeung, J.H.K., Chan, K.M., & Or, P.M.Y. (2008). Mechanisms of the dilator action of cryptotanshinone on rat coronary artery. Eur. J. Pharmacol., 578, 253-260.
  19. Lam, F.F.Y. (2007). Role of protease-activated receptor 2 in joint inflammation. Arthritis Rheum., 56, 3514-3517.
  20. Lam, F.F.Y., Luk, P.W.S. & Ng, E.S.K. (2007). Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. Life Sci., 80, 1495-1502.
  21. Lam, F.F.Y., Yeung, J.H.K., Chan, K.M., & OR, P.M.Y. (2007). Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vas. Pharmacol., 46, 271-277.
  22. Lam, F.F.Y., Yeung, J.H.K., Kwan, Y.W., Chan, K.M., & Or, P.M.Y. (2006). Salvianolic acid B, an aqueous extract of Danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels.Eur. J. Pharmacol., 553, 240-245.
  23. Lam, F.F.Y., Seto, S.W., Kwan, Y.W., Yeung, J.H.K. & Chan, P. (2006). Activation of iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells. Eur. J. Pharmacol., 546, 28-35.
  24. Hung, G.H.Y., Jones, R.L., Lam, F.F.Y., Chan K.M. & Sasaki, Y. (2006). Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery. Prost Leukot Essential Fatty Acids, 74, 401-415.
  25. Lam, F.F.Y., Ng, S.C.W., Cheung, J.H.Y. & Yeung, J.H.K. (2006). Mechanisms of the vasorelaxant effect of Danshen (Salvia miltiorrhiza) in rat knee joints. J. Ethnopharmacol., 104, 336-344.
  26. Lam, F.F.Y., Yeung, J.H.K., Cheung, J.H.Y. & OR, P.M.Y. (2006). Pharmacological evidence for calcium channel inhibition by Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol., 47, 139-145.
  27. Lam, F.F.Y., Yeung, J.H.K. & Cheung, J.H.Y. (2005). Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol., 46, 361-368.
  28. Lam, F.F.Y., Wong, H.H.L. & Ng, E.S.K. (2004). Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats. Int. Immunopharmacol., 4, 299-310
  29. Lam, F.F.Y. & NG, E.S.K. (2003). Characterisation of somatostatin actions on knee joint blood vessels of the rat. Eur. J. Pharmacol., 474, 295-301.
  30. Lam, F.F.Y. & YIP, A.L.M. (2000). Unique gradual and sustained vasodilator response to substance P in the rabbit knee joint. Eur. J. Pharmacol., 400, 327-335.