Assistant Professor

B.Sc., M.Sc, Ph.D.

Telephone: 39431344

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  Rm 620a, 6/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK


  1. Genetic and epigenetic regulation in the neural crest formation.
  2. Molecular mechanisms of germ layer formation during early embryonic development.
  3. Gene regulation and functional genomics in neuroblastoma.
  4. Genome editing in Xenopus embryos and stem cells.
  5. Molecular mechanisms of tissue regeneration and repair.
  1. Liu, Z. Z., Cheng, T. T. K., Shi, Z. Y., Liu, Z. R., Lei, Y., Wang, C. D., Shi, W. L., Chen, X. F., Qi, X. F., Cai, D. Q., Feng, B., Deng, Y., Chen, Y. L., and Zhao, H. (2016). Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos. Cell and Bioscience, 6: 22, s13578-016-0088-4.
  2. He, X., Tan, C., Wang, F., Wang, Y., Zhou, R., Cui, D., You, W., Zhao, H., Ren, J., Feng, B. (2016). Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair. Nucleic Acids Res. [Epub ahead of print].
  3. Wang, C. D., Kam, R. T. K., Shi, W. L., Xia, Y., Chen, X. F., Cao, Y., Sun, J., Du, Y., Lu, G., Chen, Z. J., Chan, W. Y., Chan, S. O., Deng, Y., and Zhao, H. (2015). The proto-oncogene transcription factor Ets1 regulates neural crest development through Histone Deacetylase 1 to mediate output of bone morphogenetic protein signaling. J Biol Chem, 290(36), 21925-21938.
  4. Shi, Z., Wang, F., Cui, Y., Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., and Chen, Y. (2015). Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis. FASEB J, 29(12), 4914-4923.
  5. Shi, W. L., Xu, G., Wang, C. D., Sperber, S. M., Chen, Y. L., Zhou, Q., Deng, Y., and Zhao, H. (2015). Heat shock 70kDa protein 5 (Hspa5) is essential for pronephros formation by mediating retinoic acid signaling. J Biol Chem, 290(1), 577-589.
  6. Wang, L., Lam, J. S., Zhao, H., Wang, J., Chan, S. O. (2014). Localization of protein kinase C isoforms in the optic pathway of mouse embryos and their role in axon routing at the optic chiasm. Brain Res., 1575, 22-32.
  7. Liu, Y., Luo, D. Y., Lei, Y., Hu, W., Zhao, H., and Cheng, C. H. K. (2014). A highly effective TALEN-mediated approach for targeted gene disruption in Xenopus tropicalis and zebrafish. Methods, 69(1), 58-66, S1046-2023.
  8. Hu, J., Lei, Y., Wong, W. K., Liu, S., Lee, K. C., He, X., You, W., Zhou, R., Guo, J. T., Chen, X., Peng, X., Sun, H., Huang, H., Zhao, H., Feng, B. (2014). Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Res., 42(7), 4375-4390.
  9. Guo, X. G., Zhang, T. J., Hu, Z., Zhang, Y. Q., Shi, Z. Y., Wang, Q. H., Cui, Y., Wang, F. Q., Zhao, H. and Chen, Y. L. (2014). Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development, 141, 1-8.
  10. Kam, R. K. T., Shi, W., Chan, S. O., Chen, Y., Xu, G., Lau, C. B. S., Fung, K. P., Chan, W. Y., Zhao, H. (2013). dhrs3 attenuates the retinoic acid signaling and is required for early embryonic patterning. J Biol Chem, 288(44), 31477-31487.
  11. Lei, Y., Guo, X., Deng, Y., Chen, Y. L., Zhao, H. (2013). Generation of gene disruptions by transcription activator-like effector nucleases (TALENs) in Xenopus tropicalis embryos. Cell & Bioscience, 3, 21.
  12. Tsang, W. H., Wang, B., Wong, W. K., Shi, S., Chen, X., He, X., Gu, S., Hu, J., Wang, C., Liu, P. C., Lu, G., Chen, X., Zhao, H., Poon, W. S., Chan, W. Y., Feng, B. (2013). LIF-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment. Stem Cell Res. 2, 11, 1091-1102.
  13. Lei, Y., Guo, X. G., Liu, Y., Cao, Y., Deng, Y., Chen, X. F., Cheng, H. K. C., Dawid, I. B., Chen, Y. L. and Zhao, H. (2012). Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc Natl Acad Sci USA, 109(43), 17484-17489.
  14. Zhao, H., Han, D., Pieler, T. and Chen, Y. (2012). Hhex induced conversion of intestinal to ventral pancreatic precursor cells results in the formation of giant pancreata in Xenopus embryos. Proc Natl Acad Sci USA, 109, 8594-8599.
  15. Kam, K. T., Deng, Y., Chen, Y. L., and Zhao, H. (2012). Retinoic acid synthesis and functions in early embryonic development. Cell and BioSci, 2, 11.
  16. Wang, C. D., Liu, Y., Chan, W. Y., Chan, S. O., Grunz, H. and Zhao, H. (2011). Characterization of three synuclein genes in Xenopus laevis. Dev. Dyn., 240(8), 2028-2033.
  17. Tanegashima, K., Zhao, H., Rebbert, M. and Dawid, I. B. (2009). Notochord differentiation requires activation of the unfolded protein response. Development, 136, 3543-3548.
  18. Zhao, H., Tanegashima, K., Ro, H. and Dawid, I. (2008). Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways. Development, 135(7), 1283-1293.
  19. Tanegashima, K., Zhao, H. and Dawid, I. (2008). WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation. EMBO. J., 27(4), 606-617.
  20. Zhao, H., Cao, Y. and Grunz, H. (2003). XXBP-1, a leucine zipper transcription factor, is involved in the BMP-4 signaling pathway. Dev Biol, 257, 278-291.