LIN Ge

Professor

B.Sc., M.Sc., Ph.D.

Telephone:  39436824

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

Address:505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Publicity:  公示證明

 

  1. Toxicology, in particular idiosyncratic hepatotoxicity and tumorigenicity
  2. Herb-drug interactions, in particular chemopreventive and synergistic anticancer effects of Chinese medicinal (CM) herbs in the combinational therapy of anticancer drugs with CM herbs
  3. Pharmacokinetics of therapeutic drugs and CM herbs
  4. Integrative approach for the study of CM herbs, including chemical analysis, pharmacology, pharmacokinetics, safety and quality control of CM herbs
  1. Lu, Y., Ma, J., Song, Z., Ye, Y., Fu, P.P. and Lin G.* (2018). The role of formation of pyrrole-ATP synthase subunit beta adduct in pyrrolizidine alkaloid-induced hepatotoxicity. Archives of Toxicology, 92, 3403-3414.
  2. Li, Y.H., Tai, W.C.S., Khan, I., Lu, C., Lu, Y., Wong, W.Y., Chan, W.Y., Hsiao, W.L.W.* and Lin, G.* (2018). Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats. Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 36, 65-83.
  3. Zhu, L., Wang, Z., Wong, L., He, Y., Zhao, Z., Ye, Y., Fu, P.P. and Lin, G.* (2018). Contamination of Hepatotoxic Pyrrolizidine Alkaloids in Retail Honey in China. Food Control, 85, 484-494.
  4. Yang, M.B., Ruan, J.Q., Gao, H., Li, N., Ma, J., Xue, J., Ye, Y., Fu, P.P., Wang, J.Y. and Lin, G.* (2017). First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans, Archives of Toxicology, 91, 3913-2915.
  5. Wu, X., Chan, S.W., Ma, J., Li, P., Shaw, P.C. and Lin, G.* (2017). Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species, Journal of Ethnopharmacology, 210, 39-46.
  6. Zhu, L., Xue, J., Xia, Q., Fu, P.P., and Lin, G.* (2017). The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice, Archives of Toxicology, 91, 949-965.
  7. Li, N., Zhang, F., Lian, W., Wang, H., Zheng, J.* and Lin, G.* (2017). Immunoassay approach for diagnosis of exposure to pyrrolizidine alkaloids. Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 35, 127-139.
  8. To, K.K.W., Wu, X., Yin, C., Chai, S., Yao, S., Kadioglu, O., Efferth, T., Ye, Y.* and Lin, G.* (2017). Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes, Journal of Ethnopharmacology, 203, 110-119.
  9. Zhu, L., Ruan, J.Q., Li, N., Fu, P.P., Ye, Y. and Lin, G.* (2016). A novel ultra-performance liquid chromatography hyphenated with quadrupole time of flight mass spectrometry method for rapid estimation of total toxic retronecine-type of pyrrolizidine alkaloids in herbs without requiring corresponding standards, Food Chemistry, 194, 1320-1328.
  10. Yang, M.B., Ruan, J.Q., Fu, P.P.  and Lin, G. (2015). Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity. Chemico-Biological Interactions, 24, 119-126.
  11. Ruan, J.Q., Gao, H., Li, N., Xue, J.Y., Chen, J., Ke, C.Q., Ye, Y., Fu, P.P., Zheng, J., Wang, J.Y.  and Lin, G. (2015). Blood pyrrole-protein adducts – A biomarker of pyrrolizidine alkaloid-induced liver injury in humans. Journal of Environmental Science and Health. Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 33, 404-421.
  12. Li, Y.H., Tai, W.C.S., Xue, J.Y., Wong, W.Y., Lu, C., Ruan, J.Q., Li, N., Wan, T.F., Chan, W.Y., Hsiao, W.L.W. and Lin, G. (2015). Proteomic Study of Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome in Rats. Chemical Research in Toxicology, 28, 1715-1727.
  13. Gao, H., Ruan, J.Q., Chen, J., Li, N., Ke, C.Q., Ye, Y., Lin, G. and Wang, J.Y. (2015). Blood Pyrrole-protein Adducts as Diagnostic and Prognostic Index in Pyrrolizidine Alkaloids-Hepatic Sinusoidal Obstruction Syndrome. Drug Design. Development and Therapy, 9, 4861-4868.
  14. Ruan,J.Q., Yang, M.B., Fu, P., Ye, Y. and Lin, G.* (2014). Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis, Chemical Research in Toxicology, 27, 1030-1039.
  15. Zhan, S.L., Chu, Z.Q., Yin, C., Zhang, C.Y., Lin, G. and Li, Q. (2013). Controllable drug release and simultaneously carrier decomposition of SiO2-drug composite nanoparticles. Journal of the American Chemical Society, 135, 5709-5716.
  16. Kan, W.L.T., Yin, C., Xu, H.X., Xu, G., To, K.K.W., Cho, C.H., Rudd, J.A. and Lin, G. (2013). Anti-tumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1- mediated G0/G1 cell cycle arrest and apoptosis. International Journal of Cancer, 132, 707-716.
  17. Yan, R., Ko, N.L., Ma, B., Tam, Y.K. and Lin, G. (2012). Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma, in rat. Current Drug Metabolism, 13, 524-534.
  18. Kan, W.L.T., Ma, B., and Lin, G.* (2011). Sulphur fumigation processing of traditional Chinese medicinal herbs: beneficial or detrimental? Frontiers in Pharmacology, 2(84), 1-7.
  19. Ma, B., Yang, D., Li, N. and Lin, G. (2011). Effects of structural modification on intestinal absorption and transport mechanism of α–aminoxy peptides. Molecular Pharmaceutics, 8, 1073-1082.
  20. Lin, G., Wang, J.Y., Li, N., Li, M., Gao, H., Ji, Y., Zhang, F., Zhou, Y., Ye, Y., Xu, H.X. and Zheng, J. (2011). Hepatic sinusoidal obstruction syndrome associated with Gynura segetum. Journal of Hepatology, 54, 666-673.