School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

LIN Ge

Professor

B.Sc., M.Sc., Ph.D.

Telephone:  39436824

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

Address:505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Toxicology, in particular idiosyncratic hepatotoxicity and tumorigenicity
  2. Herb-drug interactions, in particular chemopreventive and synergistic anticancer effects of Chinese medicinal (CM) herbs in the combinational therapy of anticancer drugs with CM herbs
  3. Pharmacokinetics of therapeutic drugs and CM herbs
  4. Integrative approach for the study of CM herbs, including chemical analysis, pharmacology, pharmacokinetics, safety and quality control of CM herbs
  1. Zhu, L., Xue, J., Xia, Q., Fu, P.P. and Lin, G. (2016). The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice. Archives of Toxicology. In Press. DOI 10.1007/s00204-016-1713-z.
  2. Ma, B.L., Yin, C., Zhang, B.K., Dai, Y., Jia, Y.Q., Yang, Y., Li, Q., Shi, R., Wang, T.M., Wu, J.S., Li, Y.Y., Lin, G. and Ma, Y.M.  (2016). Naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption. Scientific Reports 6, 20110.
  3. Yao, S., To, K.K.W., Ma, L., Yin, C., Tang, C.P., Chai, S., Ke, C.Q., Lin, G. and Ye, Y. (2016). Polyoxypregane steroids with open-chain sugar moiety from marsdenia tenacissima and their chemoresistance reversal activity. Phytochemistry, 126, 47-58.
  4. Yang, M.B., Ruan, J.Q., Fu, P.P.  and Lin, G. (2015). Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity. Chemico-Biological Interactions, 24, 119-126.
  5. Ruan, J.Q., Gao, H., Li, N., Xue, J.Y., Chen, J., Ke, C.Q., Ye, Y., Fu, P.P., Zheng, J., Wang, J.Y.  and Lin, G. (2015). Blood pyrrole-protein adducts – A biomarker of pyrrolizidine alkaloid-induced liver injury in humans. Journal of Environmental Science and Health. Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 33, 404-421.
  6. Li, Y.H., Tai, W.C.S., Xue, J.Y., Wong, W.Y., Lu, C., Ruan, J.Q., Li, N., Wan, T.F., Chan, W.Y., Hsiao, W.L.W. and Lin, G. (2015). Proteomic Study of Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome in Rats. Chemical Research in Toxicology, 28, 1715-1727.
  7. Gao, H., Ruan, J.Q., Chen, J., Li, N., Ke, C.Q., Ye, Y., Lin, G. and Wang, J.Y. (2015). Blood Pyrrole-protein Adducts as Diagnostic and Prognostic Index in Pyrrolizidine Alkaloids-Hepatic Sinusoidal Obstruction Syndrome. Drug Design. Development and Therapy, 9, 4861-4868.
  8. To, K.K., Poon, D.C., Wei, Y., Wang, F., Lin, G. and Fu, L. (2015). Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer. British Journal of Pharmacology, 172, 4089-4016.
  9. Chu, Z.Q., Miu, K.K., Lung, P.S., Zhan, S.L., Zhao, S.S., Chang, H.C., Lin, G. and Li, Q. (2015). Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery. Scientific Reports, 5, 11661.
  10. Ruan, J.Q., Yang, M.B., Fu, P., Ye, Y. and Lin, G. (2014). Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis. Chemical Research in Toxicology, 27, 1030-1039.
  11. Xia, Q., Zhao, Y., Von Tungeln, L.S., Doerge, D.R., Lin, G., Cai, L. and Fu, P.P. (2013). Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity. Chemical Research in Toxicology, 26, 1384-1396.
  12. Zhan, S.L., Chu, Z.Q., Yin, C., Zhang, C.Y., Lin, G. and Li, Q. (2013). Controllable drug release and simultaneously carrier decomposition of SiO2-drug composite nanoparticles. Journal of the American Chemical Society, 135, 5709-5716.
  13. Chu, Z.Q., Yin, C. ,Zhan, S.L., Lin, G. and Li, Q. (2013). Surface plasmon enhanced drug efficacy using core shell Au@SiO2 nanoparticle carrier. Nanoscale, 5, 3406-3411.
  14. Kan, W.L.T., Yin, C., Xu, H.X., Xu, G., To, K.K.W., Cho, C.H., Rudd, J.A. and Lin, G. (2013). Anti-tumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1- mediated G0/G1 cell cycle arrest and apoptosis. International Journal of Cancer, 132, 707-716.
  15. Yan, R., Ko, N.L., Ma, B., Tam, Y.K. and Lin, G. (2012). Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma, in rat. Current Drug Metabolism, 13, 524-534.
  16. Li, N., Xia, Q.S., Ruan, J.Q., Fu, P.P. and Lin, G. (2011). Hepatotoxicity and tumorigenicity induced by metabolic activation of pyrrolizidine alkaloids in herbs. Current Drug Metabolism. 12, 823-834.
  17. Ma, B., Yang, D., Li, N. and Lin, G. (2011). Effects of structural modification on intestinal absorption and transport mechanism of α–aminoxy peptides. Molecular Pharmaceutics, 8, 1073-1082.
  18. Lin, G., Wang, J.Y., Li, N., Li, M., Gao, H., Ji, Y., Zhang, F., Zhou, Y., Ye, Y., Xu, H.X. and Zheng, J. (2011). Hepatic sinusoidal obstruction syndrome associated with Gynura segetum. Journal of Hepatology, 54, 666-673.
  19. Yan, R., Ko, N.L., Li, S.L., Tam, Y.K. and Lin, G. (2008). Pharmacokinetics and metabolism of ligustilide, a major bioactive component in rhizoma chuanxiong, in the rat. Drug Metabolism and Disposition, 36, 400-408.
  20. Zhang, L., Zuo, Z. and Lin, G. (2007). Intestinal and hepatic glucuronidation of flavonoids. Molecular Pharmaceutics, 4, 833-845.