CHAN Wai YeeProfessor of Biomedical Sciences

B.Sc., Ph.D.

Telephone:   39431383

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.


  Room G03A, G/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK


  1. Functional genomics and epigenetic regulation of germ cell development in health and diseases
  2. Functional genomics of developing male gonad
  3. Molecular genetics of human endocrine disorders
  4. Non-coding RNA, antisense transcript, and microRNA in normal and abnormal development
  5. Genetics and genomics of fetal development
  1. Cheung, H. H., Lee, T. L., Davis, A. J., Taft, D. H., Rennert, O. M., & Chan, W. Y. (2010). Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. British Journal of Cancer, 102(2), 419-427.
  2. Cheung, H. H., Davis, A. J., Lee T. L., Pang, A. L., Nagrani, S., Rennert, O. M., & Chan, W. Y. (2011). Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene, 30(31), 3405-3415.
  3. Lee, T. L., Raitano, J. M., Rennert, O. M., Chan, S. W., & Chan, W. Y. (2012). Accessing the genomic effects of naked nanoceria in murine neuronal cells. Nanomedicine, 8(5), 599-608.
  4. Kaipparettu, B. A., Ma, Y., Park, J. H., Lee, T. L., Zhang, Y., Yotnda, P., Creighton, C. J., Chan, W. Y., & Wong, L. J. (2013). Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. PLoS One, 8(5), e61747.
  5. Gu, S., Cheung, H. H., Lee, T. L., Lu, G., Poon, W. S., & Chan, W. Y. (2013). Molecular mechanisms of regulation and action of microRNA-199a in testicular germ cell tumor and glioblastomas. PLoS One, 8(12), e83980.
  6. Tsang, W. H., Wang, B., Wong, W. K., Shi, S., Chen, X., He, X. J., Gu, S., Hu, J. B., Wang, C.D., Liu, P.C., Lu, G., Chen, X. F., Zhao, H., Poon, W. S., Chan, W. Y., & Feng, B. (2013). LIF-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment. Stem Cell Research, 11(3), 1091-1102.
  7. Chen, B. F., Gu, S., Suen, Y. K., Li, L., & Chan, W. Y. (2014). MicroRNA-199a-3p, DNMT3A and aberrant DNA methylation in testicular cancer. Epigenetics, 9(1), 119-128.
  8. Chen, B., & Chan, W. Y. (2014). The de novo DNA methyltransferase DNMT3A in development and cancer. Epigenetics, 9(5), 669-677.
  9. Chen, B. F., Suen, Y. K., Gu, S., Li, L., & Chan, W. Y. (2014). A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. Scientific Reports, 4, 6413.
  10. Chen, X., Gu, S., Chen, B. F., Shen, W. L., Yin, Z., Xu, G. W., Hu, J.J., Zhu, T., Li, G., Wan, C., Ouyang, H. W. , Lee, T. L., & Chan, W. Y. (2015). Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway. Biomaterials, 53, 239-250.
  11. Wu, Y., Li, Y., Zhang, H., Huang, Y., Zhao, P., Tang, Y., Qiu, X., Ying, Y., Li, W., Ni, S., Zhang, M., Liu, L., Xu, Y., Zhuang, Q., Luo, Z., Benda, C., Song, H., Liu, B., Lai, L., Liu, X., Tse, H. F., Bao, X., Chan, W. Y., Esteban, M. A., Qin, B., & Pei, D. (2015). Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nature Cell Biology, 17(6), 715-725.
  12. Luk, A. C. S., Gao, H., Xiao, S., Liao, J., Wang, D., Tu, J., Rennert, O. M., Chan, W. Y., & Lee, T. L. (2015). GermlncRNA: a unique catalog of long noncoding RNAs and associated regulations in male germ cell development. Database – The Journal of Biological Databases and Curation (Oxford), doi: 10.1093/database/bav044.
  13. Tu, J., Ng, S. H., Luk, A. C. S., Liao, J. Y., Jiang, X. H., Feng, B., Mak, K. K. L., Rennert, O. M., Chan, W. Y., & Lee, T. L. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Research, 43(16), 7805-7822.
  14. Culty, M., Liu, Y., Manku, G., & Chan, W. Y., & Papadopoulos, V. (2015). Expression of steroidogenesis-related genes in murine male germ cells. Steroids, 103, 105-114.
  15. Cheung, H. H., Pei, D. Q., & Chan, W. Y. (2015). Stem cell aging in adult progeria. Cell Regeneration (London), 4, 6.
  16. Cheung, H. H., Yang, Y., Lee, T.L., Rennert O., & Chan, W. Y. (2016). Hypmethylation of genes in testicular embryonal carcinomas. British Journal of Cancer, 114(2), 230-236.
  17. Cao, D. D., Li, L., & Chan, W. Y. (2016). MicroRNAs: Key regulators in the central nervous system and their implication in neurological diseases. International Journal of Molecular Sciences, 17(6), E842.
  18. Dan, X., Ng, T. B., Wong, J. H., Chan, Y. S., Cheung, R. C. F., & Chan, W. Y. (2016). A hemagglutinin isolated from Northeast China black beans induced mitochondrial dysfunction and apoptosis in colorectal cancer cells. Biochimica et Biophysica Acta, 1863(9), 2201-2211.
  19. Yang, Y., Cheung, H. H., Tu, J. J., Mui, K. K., & Chan, W. Y. (2016). New insights into the unfolded protein response in stem cells. Oncotarget, doi: 10.18632/oncotarget.9833. [Epub ahead of print]
  20. Liu, X. Z., Campanac, E., Cheung, H. H., Ziats, M. N., Canterel-Thouennon, L., Raygada, M., Baxendale ,V., Pang, A. L. Y., Yang, L., Swedo, S., Thurm, A., Lee, T. L., Fung, K. P., Chan, W. Y., Hoffman, D., & Rennert, O. M. (2016). Idiopathic autism: cellular and molecular phenotypes in pluripotent stem cell-derived neurons. Molecular Neurobiology, doi:10.1007/s12035-016-9961-8. [Epub ahead of print]