School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


headphotoAssociate Professor

Ph.D.

Tel:   39431100

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

  508A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Identification of novel diagnostic markers and therapeutic targets for digestive cancers including pancreatic cancer and liver cancer
  2. Identification and characterization of long and short non-coding RNAs with critic roles in cancer
  3. Identification of cancer associated genes using large scale genetic perturbation screen such as CRISPR/CAS9
  4. Functional roles of EZH2 in cancer
  5. Development of novel therapeutics for cancer
  1. Xiao, Z. & Chen, Y. (2017). Identification of Small Molecule Modulators of MicroRNA by Library Screening. Methods Mol. Biol., 1517, 169-178.
  2. Li, C.H., Xiao, Z., Tong, J., To, K.F., Fang, X., Cheng, A.S.L. & Chen, Y. (2017). EZH2 Coupled with HOTAIR to Silence MicroRNA-34a by the induction of heterochromatin formation in Human Pancreatic Ductal Adenocarcinoma. Int. J. Cancer, 140, 120-129.
  3. Lau, O.C., Shen, B., Wong, C.O., Tjong, Y.W., Lo, C.Y., Wang, H.C., Huang, Y., Yung, W.H. & Chen, Y., Fung, M.L., Rudd, J.A. & Yao, X. (2016). TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nat. Commun., 7, 11947.
  4. Li, C.H. & Chen, Y. (2015). Small and Long Non-Coding RNAs: Novel Targets in Perspective Cancer Therapy. Current Genomics, 16, 319-326.
  5. Xiao, Z., Li, C.H., Chan, S.L., Xu, F., Feng, L., Wang, Y., Jiang, J.D., Sung, J.J.Y., Cheng, C.H.K. & Chen, Y. (2014). A small molecule modulator of the tumor suppressor miRNA-34a inhibits the growth of hepatocellular carcinoma. Cancer Res., 74(21), 6236-6247.
  6. Li, C.H., Xu, F., Chow, S.C., Feng, L., Yin, D., Ng, T.B. & Chen, Y. (2014). Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interlukin-6 activation of microRNA-21 expression. Eur. J. Cancer, 50, 2560-2569.
  7. He, C.Y., Fu, J., Ma, J.Y., Feng, R., Tan, X.S., Huang, M., Shou, J.W., Zhao, Z.X., Li, X.Y., Zhang, X.F. & Chen, Y.*, Wang, Y. (2014). Biotransformation and metabolic profile of extracts with potential anti-tumor activity from a traditional Miao-nationality herbal medicine, Polygonum capitatum in vitro. Molecules, 19(7),10291-10308.
  8. Tang, S.C. & Chen, Y. (2014). Novel Therapeutic Targets for Pancreatic Cancer. World J. Gastroenterol., 20, 10825-10844.
  9. Xiao, Z.G., Chow, S.C., Li, C.H., Tang, S.C., Tsui, S.K.W., Lin, Z.X. & Chen, Y. (2014). Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma. Eur. J. Pharmacol., 728, 141-150.
  10. Wang, Y., Ma, J.Y., Chow, S.C., Li, C.H., Xiao, Z.G., Feng, R., Fu, J. & Chen, Y. (2014). A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2. Tumor Biology, 35, 205-212.
  11. Li, C.H. & Chen, Y. (2013). Targeting long non-coding RNAs in cancer: progress and perspective. Int. J. Biochem. Cell Biol., 45, 1895-1910.
  12. Li, C.H., To, K.F., Tong, J.H., Xiao, Z., Xia, T., Lai, P.B., Chow, S.C., Zhu, Y.X., Chan, S.L., Marquez, V.E. & Chen, Y. (2013). Enhancer of Zeste Homolog 2 Silences microRNA-218 in Human Pancreatic Ductal Adenocarcinoma Cells by Inducing Formation of Heterochromatin. Gastroenterology, 144, 1086-1097.
  13. Cheng, A.S.L., Lau, S.S., Chen, Y., Kondo, Y., Li, M.S., Feng, H., Ching, A.K., Cheung, P.K., Wong, K.H., Jin, H., Choy, R., Yu, J., To, K.F., Wong, N., Huang, T.H. & Sung, J.J.Y. (2011). EZH2–mediated concordant repression of Wnt antagonists promotes β- catenin –dependent hepatocarcinogenesisi. Cancer Res., 71, 4028-4039.
  14. Diao, S., Zhang, J.F., Wang, H., Chen, Y.* & Kung, H.F. (2010) Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma. Proteomics, 10, 3723-3731.
  15. Wong, W.T., Tian, X.Y., Chen, Y., Leung, F.P., Wong, S.L., Lee, H.K., Ng, C.F., Yao, X., Vanhoutte, Tipoe G. & Huang, Y. (2010). COX-2 up-regulation and prostaglandin F2α mediate bone morphogenic protein 4-induced endothelial dysfunction in hypertension. Circ. Res., 107, 984-991.
  16. Chen, Y., Lin, M.C., Yao, H., Wang, H., Zhang, A.Q., Yu, J., Hui, C.K., Lau, G.K., He, M.L., Sung, J. & Kung, H.F. (2007). Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. Hepatology, 46, 200-208
  17. Chen, Y., Lin, M.C., Wang, H., Chan, C.Y., Jiang, L., Ngai, S.M., Yu, J., He, M.L., Shaw, P.C., Yew, D.T., Sung, J.J. & Kung, H.F. (2007). Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma. Proteomics, 7, 3097-3104.
  18. Ng, S.S., Cheung, Y.T., An, X.M., Chen, Y., Li, M., Li, G., Cheung, W., Sze, J., Lai, L., He, M.L., Peng, Y., Xia, H., Wong, B.C.Y., Leung, S.Y., Kung, H.F., Lin, M.C. (2007) Cell cycle related kinase (CCRK): a novel candidate oncogene in human glioblastoma. J. Natl. Cancer. Inst., 99, 936- 948.
  19. Chen, Y., Stamatoyannopoulos G & Song CZ. (2003). Down-regulation of CXCR4 by inducible expression of siRNAs inhibited breast cancer cell invasion in vitro. Cancer Res., 63, 4801-4804.
  20. Song, C.Z., Keller, K. Chen, Y. & Stamatoyannopoulos, G. (2003). Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity, J. Mol. Biol., 329, 207-215.