School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

RUDD John Anthony

Professor

B.Sc., Ph.D.

Telephone:  39436789

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Website:  http://jar-labs.vomifix.com

Address:

 704A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Characterizing the pharmacology of drugs to prevent chemotherapy-induced acute and delayed emesis using animal models with proven translational value; connection with the pharmaceutical industry to make discoveries a reality.
  2. Understanding mechanisms of gastric dysrhythmia following anticancer treatment; interstitial cells of Cajal (ICC); value of prokinetic drugs.
  3. Understanding mechanisms of cancer cachexia; development of meaningful animal models.
  4. Role of forebrain to brainstem mechanisms controlling feeding and homeostasis and behaviors indicative of nausea; emetic liability mechanisms.
  5. Mechanisms of taste and smell alterations during chemotherapy.
  1. Rudd, J.A., Ngan, M.P., Lu, Z., Higgins, G., Giuliano, C., Lovati, E., and Pietra, C. (2016). Profile of antiemetic activity of netupitant alone or in combination with palonosetron and dexamethasone in ferrets and Suncus murinus (house musk shrew). Frontiers in Pharmacology, 7, 236. DOI: 10.3389/fphar.2016.00263.
  2. Guimaraes, D.D., Andrews, P.L.R., Rudd, J.A., Braga, V.A., and Nalivaiko, E. (2016). Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats. Temperature, 2, 543-553.
  3. Rudd, J.A., Nalivaiko E., Matsuki, N., Wan C. and Andrews, P.L.R. (2015). The involvement of TRPV1 in emesis and anti-emesis. Temperature, 2, 258-276.
  4. Sin T.K., Tam B.T., Yung B.Y., Yip S.P., Chan L.W., Wong C.S., Ying M., Rudd J.A., and Siu P.M. (2015). Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis. Journal of Physiology, 593, 1887-1899.
  5. Lu, Z., Percie du Sert, N, Chan, S.W., Yeung, C.K., Lin, G., Yew, D.T.W., Andrews, P.L.R., and Rudd, J.A. (2015). Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret. Journal of Translational Medicine, 12, 1-13.
  6. Nalivaiko, E., Rudd, J.A., and So, R. (2014). Motion sickness, nausea and thermoregulation: the "toxic" hypothesis. Temperature, 1, 164-171.
  7. Ullah, I., Subhan, F., Rudd, J.A., Rauf, K., Alam, J., Shahid, M., and Sewll, R.D.E. (2014). Attenuation of cisplatin-induced emetogenesis by standardized Bacopa monnieri extracts in the pigeon: behavioral and neurochemical correlations. Planta Medica., 80, 1569-1579.
  8. Chan, S.W., Lu, Z., Lin, G., Yew, D.T.W., Yeung, C.K., and Rudd, J.A. The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9-39) in Suncus murinus (house musk shrew). Neuropharmacology, 83, 71-78.
  9. Ngampramuan, S., Cerri, M., Vecchio, F.D., Corrigan, J.J., Kamphee, A., Dragic, A.S., Rudd, J.A., Romanovsky, A.A., Nalivaiko, E. (2014). Thermoregulatory correlates of nausea in rats and musk shrews. Oncotarget, 5, 1565-1575.
  10. Johnston, K.D., Lu, Z., & Rudd, J.A. (2014). Looking beyond 5-HT3 receptors: a review of the wider role of serotonin in the pharmacology of nausea and vomiting. Eur. J. Pharmacol., 722, 13-25.
  11. Chan, S.W., Lu, Z., Lin, G., Yew, D.T.W., Yeung, C.K., & Rudd, J.A. (2014). The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9-39) in Suncus murinus (house musk shrew). Neuropharmacology, 83, 71-78.
  12. Chan, S.W., Lin, G., Yew, D.T.W., Yeung, C.K., and Rudd, J.A. (2013). Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus (house musk shrew). Neuropharmacology, 70, 141-147.
  13. Percie du Sert, N., Rudd, J.A., Apfel, C.C. and Andrews, P.L.R. (2011). Systematic review and meta-analysis of the efficacy of 5-HT3 receptor antagonists in the ferret model of cisplatin-induced emesis. Cancer Chemotherapy and Pharmacology, 67, 667-686.
  14. Percie du Sert, N., Ho, W.S.V., Rudd, J.A. and Andrews, P.L.R. (2010). Cannabinoid-induced reduction in antral pacemaker frequency: a telemetric study in the ferret. Neurogastroenterol. Motil., 22, 1257-e324.
  15. Percie du Sert, N., Chu, K.M., Wai, M.K., Rudd, J.A. and Andrews, P.L.R. (2010). Telemetry in a motion-sickness model implicates the abdominal vagus in motion-induced gastric dysrhythmia. Expt. Physiol., 95(7), 768-773.
  16. Chu, K.M., Ngan, M.P., Wai, M.K., Yeung, C.K., Andrews, P.L.R., Percie du Sert, N., Lin, G. & Rudd, J.A. (2010). Olvanil, a non-pungent vanilloid enhances the gastrointestinal toxicity of cisplatin in the ferret. Toxicology Letters, 192, 402-407.
  17. Chu, K.M., Yeung, C.K., Ngan, M.P., Wai, M.K., Andrews, P.L.R., Percie du Sert, N., and Rudd, J.A. (2010). Olvanil: a non-pungent TRPV1 activator has anti-emetic properties in the ferret. Neuropharmacology, 58, 383-391.
  18. Percie du Sert, N., Rudd, J.A., Apfel, C.C. and Andrews, P.L.R. (2011). Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists. Cancer Chemother. Pharmacol., 67, 667-686.
  19. Percie du Sert, N., Chu, K.M., Wai, M.K., Rudd, J.A. and Andrews, P.L.R. (2009). Reduced normogastric electrical activity associated with emesis: a telemetric study in ferrets. World J. Gastroenterol., 15, 6034-6043.
  20. Percie du Sert, N., Rudd, J.A., Moss, R. and Andrews, P.L.R. (2009). The delayed phase of cisplatin-induced emesis is mediated by the area postrema and not the abdominal visceral innervation in the ferret. Neuroscience Letters, 465, 16-20.
Yu S, Wang X, Ng CF, Chen S and Chan FL (2007) ERRg suppresses cell proliferation and tumor growth of androgen-sensitive and -insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Research 67(10): 4904-4914.