School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


Ellis FokAssistant Professor

Telephone:  39439986 

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Notice:

Dr. Fok’s lab is seeking an enthusiastic postgraduate student to work on projects related to reproductive biology and male infertility. The candidate will join a vibrant school that offers state-of-the-art facilities for research and all-round training for different career paths. Interested candidate should send a CV to This email address is being protected from spambots. You need JavaScript enabled to view it..

  1. Biology of spermatogonial stem cells, spermatogenesis and sperm functions
  2. Etiology and therapeutic regimen of male infertility and related diseases
  3. Male contraception
  1. Fok, K.L.#, Bose, R.#, Sheng, K., Chang, C.W., Katz-Egorov, M., Culty, M., Su, S., Yang, M., Ruan, Y.C., Chan, H.C., Iavarone, A., Lasorella, A., Cencic, R., Pelletier, J., Nagano, M., Xu, W., Wing, S.S. (Equal contributions) (2017). Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Endocrinology, doi: 10.1210/en.2017-00396. PMID:28938460.
  2. Wang, C., Fok, K.L., Cai, Z., Chen, H., Chan, H.C. (2017). CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways. Oncotarget, 8(2),3132-3143. PMID:27902973.
  3. Diao, R.#, Fok, K.L.#, Chen, H., Yu, M.K., Duan, Y., Chung, C.M., Li, Z., Wu, H., Li, Z., Zhang, H., Ji, Z., Zhen, W., Ng, C.F., Gui, Y., Cai, Z., Chan, H.C. (Equal contributions) (2014). Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. Science Translational Medicine. 6(249),249ra108. PMID:25122636.
  4. Guo, J.H., Chen, H., Ruan, Y.C., Zhang, X.L., Zhang, X.H., Fok, K.L., Tsang, L.L., Yu, M.K., Huang, W.Q., Sun, X., Chung, Y.W., Jiang, X., Sohma, Y., Chan, H.C. (2014). Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature Communications, 5,4420. PMID:25025956.
  5. Fok, K.L., Chen, H., Ruan, Y.C., Chan, H.C. (2014). Novel regulators of spermatogenesis (Review). Seminars in Cell & Developmental Biology, 29,31-42. PMID:24594193.
  6. Fok, K.L.#, Chung, C.M.#, Yi, S.Q., Jiang, X., Sun, X., Chen, H., Chen, Y.C., Kung, H.F., Tao, Q., Diao, R., Chan, H., Zhang, X.H., Chung, Y.W., Cai, Z., Chang, Chan H. (Equal contributions) (2012). STK31 maintains the undifferentiated state of colon cancer cells. Carcinogenesis, 33(11),2044-2053. PMID:22828137.
  7. Chen, J., Fok, K.L., Chen, H., Zhang, X.H., Xu, W.M., Chan, H.C. (2012). Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2. Human Reproduction, 27(9),2585-2597. PMID:22777528.
  8. Ruan, Y.C., Guo, J.H., Liu, X., Zhang, R., Tsang, L.L., Dong, J.D., Chen, H., Yu, M.K., Jiang, X., Zhang, X.H., Fok, K.L., Chung, Y.W., Huang, H., Zhou, W.L., Chan, H.C. (2012). Activation of the epithelial Na+ channel triggers prostaglandin E₂ release and production required for embryo implantation. Nature Medicine, 18(7), 1112-1117. PMID:22729284.
  9. Lu, Y.C.#, Chen, H.#, Fok, K.L.#, Tsang, L.L., Yu, M.K., Zhang, X.H., Chen, J., Jiang, X., Chung, Y.W., Ma, A.C., Leung, A.Y., Huang, H.F., Chan, H.C. (Equal contributions) (2012). CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Research, 22(10), 1453-1466. PMID:22664907.
  10. Tang, X.X.#, Fok, K.L.#, Chen, H., Chan, K.S., Tsang, L.L., Rowlands, D.K., Zhang, X.H., Dong, J.D., Ruan, Y.C., Jiang, X., Yu, S.S., Chung, Y.W., Chan, H.C. (Equal contributions) (2012). Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing. Journal of Cellular Physiology, 227(12),3887-3894. PMID:22552906.
  11. Chen, H.#, Fok, K.L.#, Jiang, X., Jiang, J., Chen, Z., Gui, Y., Chan, H.C., Cai, Z.. (Equal contributions) (2012). CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia. Human Reproduction, 27(6), 1568-1576. PMID:22451502.
  12. Chen, H., Fok, K.L., Yu, S., Jiang, J., Chen, Z., Gui, Y., Cai, Z., Chan, H.C. (2011). CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Molecular Human Reproduction, 17(7),405-414. PMID:21343160.
Yu S, Wang X, Ng CF, Chen S and Chan FL (2007) ERRg suppresses cell proliferation and tumor growth of androgen-sensitive and -insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Research 67(10): 4904-4914.