School of Biomedical Sciences
The Chinese University of Hong Kong 香港中文大學

SO Hon CheongAssistant Professor


Telephone:   39439255

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  Rm 624A, 6/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK


  1. Bioinformatics; statistical/computational methodologies for “omics” studies; applications to cancer/neuropsychiatric/cardio-metabolic phenotypes
  2. Disease risk prediction methodologies, particularly with the use of genomic profiles
  3. Genetic architecture of complex diseases
  4. Genetic epidemiological studies, especially on neuro-psychiatric disorders
  5. High dimensional data analysis, multiple testing, machine learning
  1. So, H.C., Chen, R.Y., Chen, E.Y., Cheung, E.F., Li T., et al. (2008). An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 147B, 77-85.
  2. Zhang, F., Sham, P.C., Fan, H., Xu, Y., Huang, X., So, H., Song, Y. and Liu, P. (2008). An association study of ADSS gene polymorphisms with schizophrenia. Behav Brain Funct 4: 39.
  3. So, H.C., Chen, E.Y. and Sham, P.C. (2009), Genetics of schizophrenia spectrum disorders: looking back and peering ahead. Ann. Acad. Med. Singapore, 38, 436-434.
  4. So, H.C., Fong, P.Y., Chen, R.Y., Hui, T.C., Ng, M.Y., et al. (2010). Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 153B, 103-113.
  5. So, H.C. and Sham, P.C. (2010). A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained. PLoS Genet, 6, e1001230.
  6. So, H.C., Sham, P.C. (2010). Effect size measures in genetic association studies and age-conditional risk prediction. Hum. Hered., 70, 205-218.
  7. So, H.C., Yip, B.H. and Sham, P.C. (2010). Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies. PLoS One, 5, e13898.
  8. So, H.C., Gui, A.H., Cherny, S.S. and Sham, P.C. (2011) Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genet Epidemiol., 35, 310-317. [listed as one of 5 top downloaded articles in the year, cited 119 times as at 30/3/2015 according to Google Scholar]
  9. So, H.C., Kwan, J.S., Cherny, S.S. and Sham, P.C. (2011). Risk prediction of complex diseases from family history and known susceptibility loci, with applications to cancer screening. American Journal of Human Genetics, 88(5), 548-565
  10. So, H.C. and Sham, P.C. (2011), Robust Association Tests Under Different Genetic Models, Allowing for Binary or Quantitative Traits and Covariates. Behav Genet., 41, 768-775.
  11. So, H.C. and Sham, P.C. (2011). Multiple testing and power calculations in genetic association studies. Cold Spring Harb Protoc, 2011, pdb top95.
  12. Garcia-Barcelo, M.M., Miao, X., Tang, CS, So HC, Tang W, et al. (2011). No NRG1 V266L in Chinese patients with schizophrenia. Psychiatr Genet, 21, 47-49.
  13. So, H.C., Li, M.X. and Sham, PC. (2011). Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genetic Epidem., 35, 447-456.
  14. Wong, E.H.*, So, H.C.*, Li, M., Wang, Q., Butler, A.W., Paul, B., Wu, H.M., Hui, T.C., Choi, S.C., So, M.T. et al. (2014), Common variants on Xq28 conferring risk of schizophrenia in Han Chinese. Schizophr Bull, 40(4), 777-778 (*equal first authors)
  15. Falchi, M., Moustafa, J.S.E., Takousis, P., Pesce, F., Bonnefond, A., Andersson-Assarsson, J.C., Sudmant, P.H., Al-Shafai, M.N., Bottolo, L., So, H.C. et al. (2014). Low number of copies of the salivary amylase gene predisposes to obesity. Nat. Genet., 46(5), 492-497.
  16. Chan, S.K., So, H.C., Hui, C.L., Chang, W.C., Lee, E.H., Chung, D.W., Tso, S., Hung, S.F., Yip, K.C., Dunn, E. et al. (2014). 10-year outcome study of an early intervention program for psychosis compared with standard care service. Psychol. Med., 1-13.
  17. Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature 511(7510), 421-427.
  18. Gusev, A., Lee, S.H., Trynka, G., Finucane, H., Vilhjalmsson, B.J., Xu, H., Zang, C., Ripke, S., Bulik-Sullivan, B., Stahl, E., Schizophrenia Working Group of the Psychiatric Genomics Consortium et al. (2014). Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am. J. Hum. Genet., 95(5), 535-552.
  19. Bulik-Sullivan, B.K., Loh, P.R., Finucane, H.K., Ripke, S., Yang, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson, N., Daly, M.J., Price, A.L., Neale, B.M. (2015). LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet., 47(3), 291-295.