SO Hon CheongAssistant Professor


Telephone:   3943 9255

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  Rm 520A, 5/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK


  1. Bioinformatics; statistical/computational methodologies for “omics” studies; applications to cancer/neuropsychiatric/cardio-metabolic phenotypes
  2. Disease risk prediction methodologies, particularly with the use of genomic profiles
  3. Genetic architecture of complex diseases
  4. Genetic epidemiological studies, especially on neuro-psychiatric disorders
  5. High dimensional data analysis, multiple testing, machine learning
  1. So, H.C.*, Chau, C.K., Chiu, W.T., Ho, K.S., Lo, C.P., Yim, S.H., and Sham, P.C. (2017). Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry. Nature Neuroscience 20, 1342-1349. (*Corresponding author)
  2. So, H.C.* and Sham, P. C. (2017). Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits.
    Bioinformatics, 33(6), 886-892. (*Corresponding author)
  3. So, H.C.* and Sham, P.C. (2017). Improving polygenic risk prediction from summary statistics by an empirical Bayes approach. Sci Rep, 7, 41262. (*Corresponding author)
  4. Lee, E.H., So, H.C., and Chen, E.Y. (2016). Admission Rates and Psychiatric Beds in Hong Kong, 1999-2014: A Population-Based Study. Psychiatric services 67, 579.
  5. Chan, S. K., So, H.C., Hui, C.L., Chang, W.C., Lee, E.H., Chung, D.W., Tso, S., Hung, S.F., Yip, K.C., Dunn, E., Chen E.Y. (2015). 10-year outcome study of an early intervention program for psychosis compared with standard care service. Psychol Med 45(6), 1181-1193.
  6. Wong, E.H.*, So, H.C.*, Li, M., Wang, Q., Butler, A.W., Paul, B., Wu, H.M., Hui, T.C., Choi, S.C., So, M.T., Garcia-Barcelo, M. M., McAlonan, G. M., Chen, E. Y., Cheung,E. F., Chan, R. C., Purcell, S. M., Cherny, S. S., Chen, R. R., Li, T. and Sham, P. C. (2014). Common variants on Xq28 conferring risk of schizophrenia in Han Chinese. Schizophr Bull 40, 777-786. (*equal first authors)
  7. Falchi, M., Moustafa, J.S.E., Takousis, P., Pesce, F., Bonnefond, A., Andersson-Assarsson, J.C., Sudmant, P.H., Al-Shafai, M.N., Bottolo, L., So, H.C. et al. (2014). Low number of copies of the salivary amylase gene predisposes to obesity. Nat. Genet., 46(5), 492-497.
  8. So, H.C., Gui, A.H., Cherny, S.S., and Sham, P.C. (2011). Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genet Epidemiol 35, 310-317. (cited 201 times as at 5/10/2017 according to Google Scholar)
  9. So, H.C., and Sham, P.C. (2011). Robust association tests under different genetic models, allowing for binary or quantitative traits and covariates. Behav Genet 41, 768-775.
  10. So, H.C., Li, M., and Sham, P.C. (2011). Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genet Epidemiol 35, 447-456.
  11. So, H.C., Kwan, J.S., Cherny, S.S., and Sham, P.C. (2011). Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. Am J Hum Genet 88, 548-565.
  12. So, H.C., Yip, B.H., and Sham, P.C. (2010). Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies. PLoS One 5, e13898.
  13. So, H.C., and Sham, P.C. (2010). Effect size measures in genetic association studies and age-conditional risk prediction. Hum Hered 70, 205-218
  14. So, H.C., and Sham, P.C. (2010). A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained. PLoS Genet 6, e1001230.
  15. So, H.C., Fong, P.Y., Chen, R.Y., Hui, T.C., Ng, M.Y., Cherny, S.S., Mak, W.W., Cheung, E.F., Chan, R.C., Chen, E.Y. and Sham P.C. (2010). Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. Am J Med Genet B Neuropsychiatr Genet 153B, 103-113.
  16. So, H.C., Chen, E.Y. and Sham, P.C. (2009), Genetics of schizophrenia spectrum disorders: looking back and peering ahead. Ann. Acad. Med. Singapore, 38, 436-434.
  17. So, H.C., Chen, R.Y., Chen, E.Y., Cheung, E.F., Li, T., and Sham, P.C. (2008). An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population. Am J Med Genet B Neuropsychiatr Genet 147B, 77-85.