WAN Chao

Associate Professor


Telephone: 39434494

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.


Rm 128A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, CUHK


  1. Molecular and cellular mechanisms of skeletal development, metabolism and regeneration
  2. Molecular control of stem cell self-renewal and mesenchymal lineage differentiation
  3. Tissue engineering for skeletal tissue repair
  4. Efficacy and novel therapeutics of Chinese medicines for skeletal tissue repair
  1. Wang, J., Zhang, F,, Tsang, W. P., Wan, C., Wu, C. (2017). Fabrication of injectable high strength hydrogel based on 4-arm star PEG for cartilage tissue engineering. Biomaterials, 120, 11-21.
  2. Tsang, W. P., Zhang, F., He, Q., Cai, W., Huang, J., Chan, W. Y., Shen, Z., Wan, C. (2017). Icaritin enhances mESC self-renewal through upregulating core pluripotency transcription factors mediated by ERα. Sci Rep, 7, 40894.
  3. He, Q., Swindle, C. S., Wan, C., Flynn, R. J., Oster, R. A., Chen, D., Zhang, F., Shu, Y., Klug, C. A. (2017). Enhanced hematopoietic stem cell self-renewal-promoting ability of clonal primary MSC versus their osteogenic progeny. Stem Cells, 35(2), 473-484.
  4. Wang, P. Z., Zhang, F., Shu, Y., Shiu, H. T., He, Q., Tsang, W. P., Wan, C. (2016). Flavonoid compound Icariin activates hypoxia inducible factor-1α in chondrocytes and promotes articular cartilage repair. PLoS One, 11(2), e0148372.
  5. Chen, X., Gu, S., Chen, B. F., Shen, W. L., Yin, Z., Xu, G. W., Hu, J. J., Zhu, T., Li, G., Ouyang, H. W., Wan, C., Lee, T. L., Chan, W. Y. (2015). Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway. Biomaterials, 53, 239-250.
  6. Tian, Y., Xu, Y., Fu, Q., Chang, M., Wang, Y., Shang, X., Wan, C., Marymont, J. V., Dong, Y. (2015). Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1. Mol Cell Endocrinol, 403C, 30-38.
  7. Su, X., Zuo, W., Wu, Z., Chen, J., Wu, N., Ma, P., Xia, Z., Jiang, C., Ye, Z., Liu, S., Liu, J., Zhou, G., Wan, C., Qiu, G. (2015). CD146 as a new marker for an increased chondroprogenitor cell sub-population in the later stages of osteoarthritis. J Orthop Res, 33(1), 84-91.
  8. Zhang, F., He, Q., Tsang, W. P., Garvey, W. T., Chan, W. Y., Wan, C. (2014). Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes. Bone Research, 2(2), 14012.
  9. Wan, L., Zhang, F., He, Q., Tsang, W. P., Lu, L., Li, Q., Liu, Z., Qiu, G., Zhou, G., Wan, C. (2014). EPO promotes bone repair through enhanced cartilaginous callus formation and angiogenesis. PLoS One, 9(7), e102010.
  10. Tsang, W. P., Shu, Y., Kwok, P. L., Zhang, F., Lee, K. K. H., Tang, M. K., Li, G., Chan, K. M., Chan, W. Y., Wan, C. (2013). CD146 human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration. PLoS One, 8(10), e76153.
  11. Yao, D., Xie, X. H., Wang, X. L., Wan, C., Lee, Y. W., Chen, S. H., Pei, D. Q., Wang, Y. X., Li, G., Qin, L. (2012). Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis - an in vitro efficacy study. PLoS One, 7(8), e41264.
  12. Wan, C., Shao, J., Gilbert, S. R., Riddle, R. C., Long, F., Johnson, R. S., Schipani, E., Clemens, T. L. (2010). Role of HIF-1a in skeletal development. Ann N Y Acad Sci, 1192(1), 322-326.
  13. Fulzele, K., Riddle, R. C., Digirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M. A., Brüning, J. C., Clemens, T. L. (2010). Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell, 142(2), 309-319.
  14. Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., Feng, X., Van Hul W., Wan, M., Cao, X. (2009). TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med, 15(7), 757-765.
  15. Mak, K. K., Bi, Y., Wan, C., Chuang, P. T., Clemens, T., Young, M., Yang, Y. (2008). Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell, 14(5), 674-688.
  16. Jacobsen, K. A., Alaql, Z. S., Wan, C., Jennifer, L., Fitch, B. S., Mason, Z. D., Cole, R. M., Gilbert, S. R., Clemens, T. L., Morgan, E. F., Einhorn, T. A., Gerstenfeld, L. C. (2008). Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling. J Bone Miner Res, 23(5), 596-609.
  17. Wan, C., Gilbert, S. R., Wang, Y., Cao, X. M., Shen, X., Ramaswamy, G., Jacobsen, K. A., Alaql, Z. S., Gerstenfeld, L. C., Einhorn, T. A., Guldberg, R. E., Deng, L., Clemens, T. L. (2008). Activation of the hypoxia inducible factor pathway accelerates bone regeneration. Proc Natl Acad Sci USA, 105(2), 686-691.
  18. Wang, Y., Wan, C., Deng, L., Liu, X., Cao, X., Gilbert, S. R., Bouxsein, M. L., Faugere, M. C., Guldberg, R. E., Gerstenfeld, L. C., Haase, V. H., Johnson, R. S., Schipani, E., Clemens, T. L. (2007). The hypoxia inducible factor pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest, 117(6), 1616-1626.
  19. Liu, X., Bruxvoort, K., Zylstra, C. R., Liu, J., Cichowski, R., Faugere, M. C., Bouxsein, M. L., Wan, C., Williams, B. O., Clemens, T. L. (2007). Lifelong accumulation of bone in mice lacking PTEN in osteoblasts. Proc Natl Acad Sci USA, 104(7), 2259-2264.
  20. Wan, C., He, Q., McCaige, M., Marsh, D., Li, G. (2006). Nonadherent cell population of human marrow culture is a complementary source of mesenchymal stem cells (MSCs). J Orthop Res, 24(1), 21-28.