School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


FENG Bo Associate Professor

Ph.D.

Telephone:  39431455

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:  Rm 105A, Lo Kwee Seong Integrated Biomedical Sci. Bldg, CUHK

Website:  http://ihome.sbs.cuhk.edu.hk/FengBo/

 

  1. Generation of iPS cells and mechanistic study of reprogramming process
  2. Molecular mechanisms that control stem cell self-renewal and differentiation
  3. Stem cell and molecular tools for disease modeling and treatment
  4. Tissue regeneration
  1. He, X., Tan, C., Wang, F., Wang, Y., Zhou, R., Cui, D., You, W., Zhao, H., Ren, J., & Feng, B.# (2016). Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair. Nucleic Acids Res, 44(9), e85.
  2. Wang, Y., Qin, J., Wang, S., Zhang, W., Duan, J., Zhang, J., Wang, X., Yan, F., Chang, M., Liu, X., Feng, B., Liu, J., & Pei, X. (2016). Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules. Cell Stem Cell, 19(4), 449-461.
  3. Wang, X. W., He, X. J., Lee, K. C., Huang, C., Hu, J. B., Zhou, R., Xiang, X. Y., Feng, B.#, & Lu, Z. Q.# (2016). MicroRNA-221 sponge therapy attenuates neointimal hyperplasia and improves blood flows in vein grafts. Int J Cardiol, 208, 79-86. (#co-correspondence)
  4. Liu, S., Xu, Y., Zhou, Z., Feng, B.#, & Huang, H#. (2015). Progress and challenges in generating functional hematopoietic stem/progenitor cells from human pluripotent stem cells. Cytotherapy, 17(4), 344-358. (#co-correspondence)
  5. Tu, J., Ng, S. H., Luk, A. C., Liao, J., Jiang, X., Feng, B., Lun Mak, K. K., Rennert, O. M., Chan, W. Y., & Lee, T. L. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res, 43(16), 7805-7822.
  6. Hu, J., Lei, Y., Wong, W. K., Liu, S., Lee, K. C., He, X., You, W., Zhou, R., Guo, J. T., Chen, X., Peng, X., Sun, H., Huang, H., Zhao, H., & Feng, B.# (2014). Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Res, 42(7), 4375-4390.
  7. Ma, H., Ng, H. M., Teh, X., Li, H., Lee, Y. H., Chong, Y. M., Loh, Y. H., Collins, J. J., Feng, B., Yang, H., & Wu, Q. (2014). Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency. PLoS Genet, 10(2), e1004038.
  8. Ma, H., Ow, J. R., Tan, B. C., Goh, Z., Feng, B., Loh, Y. H., Fedele, M., Li, H., & Wu, Q. (2014). The dosage of Patz1 modulates reprogramming process. Sci Rep, 4, 7519.
  9. Lu, X., Goke, J., Sachs, F., Jacques, P. E., Liang, H., Feng, B., Bourque, G., Bubulya, P. A., & Ng, H. H. (2013). SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells. Nat Cell Biol, 15(10), 1141-1152.
  10. Do, D. V., Ueda, J., Messerschmidt, D. M., Lorthongpanich, C., Zhou, Y., Feng, B., Guo, G., Lin, P. J., Hossain, M. Z., Zhang, W., Moh, A., Wu, Q., Robson, P., Ng, H. H., Poellinger, L., Knowles, B. B., Solter, D., & Fu, X. Y. (2013). A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev, 27(12), 1378-1390.
  11. Tsang, W. H., Wang, B., Wong, W. K., Shi, S., Chen, X., He, X., Gu, S., Hu, J., Wang, C., Liu, P. C., Lu, G., Zhao, H., Poon, W. S., Chan, W. Y., & Feng, B.# (2013). LIF-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment. Stem Cell Res, 11(3), 1091-1102.
  12. Chan, Y. S., Goke, J., Lu, X., Venkatesan, N., Feng, B., Su, I. H., & Ng, H. H. (2012). A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells, 31(4), 682-692.
  13. Xu, Y., Liu, L., Zhang, L., Fu, S., Hu, Y., Wang, Y., Fu, H., Wu, K., Xiao, H., Liu, S., Yu, X., Zheng, W., Feng, B., & Huang, H. (2012). Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells. PLoS One, 7(4), e34321.
  14. Chia, N. Y., Chan, Y. S., Feng, B.*, Lu, X., Orlov, Y. L., Moreau, D., Kumar, P., Yang, L., Jiang, J., Lau, M. S., Huss, M., Soh, B. S., Kraus, P., Li, P., Lufkin, T., Lim, B., Clarke, N. D., Bard, F., & Ng, H. H. (2010). A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature, 468(7321), 316-320. (*co-first authors)
  15. Heng, J. C., Feng, B.*, Han, J., Jiang, J., Kraus, P., Ng, J. H., Orlov, Y. L., Huss, M., Yang, L., Lufkin, T., Lim, B., & Ng, H. H. (2010). The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell, 6(2), 167-174. (*co-first authors)
  16. Im, C. N., Kang, N. Y., Ha, H. H., Bi, X., Lee, J. J., Park, S. J., Lee, S. Y., Vendrell, M., Kim, Y. K., Lee, J. S., Li, J., Ahn, Y. H., Feng, B., Ng, H. H., Yun, S. W., & Chang, Y. T. (2010). A fluorescent rosamine compound selectively stains pluripotent stem cells. Angew Chem Int Ed Engl, 49(41), 7497-7500.
  17. Feng, B., Jiang, J., Kraus, P., Ng, J. H., Heng, J. C., Chan, Y. S., Yaw, L. P., Zhang, W., Loh, Y. H., Han, J., Vega, V. B., Cacheux-Rataboul, V., Lim, B., Lufkin, T., & Ng, H. H. (2009). Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol, 11(2), 197-203.
  18. Feng, B., Ng, J. H., Heng, J. C., & Ng, H. H. (2009). Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell, 4(4), 301-312.
  19. Feng, B., Bulchand, S., Yaksi, E., Friedrich, R. W., & Jesuthasan, S. (2005). The recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection. BMC Neurosci, 6, 46.
  20. Feng, B., Schwarz, H., & Jesuthasan, S. (2002). Furrow-specific endocytosis during cytokinesis of zebrafish blastomeres. Exp Cell Res, 279(1), 14-20.