KWAN Yiu Wa Professor

B.Sc., Ph.D.

Telephone:  39436884

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 207A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

 

 

Biography

Prof. KWAN Yiu Wa (關耀華) obtained his Bachelor degree (Hons) from the Department of Pharmacology and Experimental Therapeutics of The Liverpool University (UK), and his PhD degree in the Department of Pharmacology and Physiology of The Strathclyde University (Glasgow, Scotland) after he received a scholarship from the Croucher Foundation.  He went on to have his post-doctoral training, with the supports of the American Heart Association (USA), under Professor R.S. Kass (University of Rochester New York, New York, USA) prior to joining The Chinese University of Hong Kong.  He is a pharmacologist by training, and his main research interests are related to the pharmacology of different drugs in treating metabolic and vascular diseases e.g. type 2 diabetes mellitus, osteoporosis and pulmonary hypertension. He also has research interests in the utilization of alternative / un-conventional approaches such as recombinant probiotics in treating various diseases. 

  1. Diabetes Mellitus: Development and treatments (Western medicines and Natural / herbal Products).
  2. Osteoporosis: Development and treatments (Western medicines and Natural / herbal Products).
  3. Cardiovascular diseases: Drug treatments (Western medicines and Natural / herbal Products).
  4. Cancers Biology: Development and treatments (Western medicines and Natural / herbal Products).
  5. Development of recombinant probiotics for therapeutic uses.
  1. Tseng, H.H.L., Vong, C.T., Kwan, Y.W., Lee, S.M. & Hoi, M.P.M. (2017). Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells. Front Immunol, 8: 1161.
  2. Li, S., Ai, N., Shen, M., Dang, Y., Chong, C.M., Pan, P., Kwan, Y.W., Chan, S.W., Leung, G.P.H, Hoi, M.P.M., Hou, T. & Lee, S.M. (2017). Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin. Cell Death Discov, 3: 17051.
  3. Chan, J.Y., Zhou, H., Kwan, Y.W., Chan, S.W., Radis-Baptista, G. & Lee, S.M. (2017). Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics. J Biochem Mol Toxicol, 31(11).
  4. Steiner, G.Z., Seto, S.W., Kwan, Y.W., Haskell-Ramsay, C. & Camfield D.A. (2017). Complementary Medicine for the Modification of Risk Factors for Cognitive Impairment. Evid Based Complement Alternat Med, 2017: 9472859.
  5. Zhou, X., Cui, G., Tseng, H.H., Lee, S.M., Leung, G.P., Chan, S.W., Kwan, Y.W. & Hoi, M.P. (2016). Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine. Evid Based Complement Alternat Med, 2016: 9627258.
  6. Tseng, H.H., Vong, C.T., Leung, G.P., Seto, S.W., Kwan, Y.W., Lee, S.M. & Hoi, M.P. (2016). Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca2+-Activated K+-Channels (BKCa). Evid Based Complement Alternat Med, 2016: 5272531.
  7. Tang, P.C., Yang, C., Li, R.W., Lee, S.M., Hoi, M.P., Chan, S.W., Kwan, Y.W., Tse, C.M. & Leung, G.P. (2016). Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine. Eur J Pharmacol, 791: 544-551.
  8. Tseng, H.H., Vong, C.T., Kwan, Y.W., Lee, S.M. & Hoi, M.P. (2016). TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep, 6: 35016.
  9. Zhou, X., Choi, P.S., Yang, J.M., Or, P.M., Hoi, P.M., Lee, S.M., Leung, G.P., Ngai, S.M., Kong, S.K., Ho, H.P., Wong, M.Y., Chan, S.W., Yeung, J.H. & Kwan, Y.W. (2016). Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods. Springerplus, 5(1): 1438.
  10. Vong, C.T., Tseng, H.H., Kwan, Y.W., Lee, S.M. & Hoi, M.P. (2016). Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Front Pharmacol, 7: 67.
  11. Li, S., Dang, Y., Zhou, X., Huang, B., Huang, X., Zhang, Z., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M. & Hoi, M.P. (2015). Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Sci Rep, 5: 16815.
  12. Poon, C.C., Li, R.W., Seto, S.W., Kong, S.K., Ho, H.P., Hoi, M.P., Lee, S.M, Ngai, S.M., Chan, S.W., Leung, G.P. & Kwan, Y.W. (2015). In vitro vitamin K2 and 1a,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice. Eur J Pharmacol, 767: 30-40.
  13. Zhou, X., Wang, Y., Lee, W.Y., Or, P.M., Wan, D.C., Kwan, Y.W. & Yeung, J.H. (2015). Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in oxorubicin-Resistant HepG2 Cells. J Nat Prod, 78(9): 2266-75.
  14. Seto, S.W., Yang, G.Y., Kiat, H., Bensoussan, A., Kwan, Y.W. & Chang, D. (2015). Diabetes Mellitus, Cognitive Impairment, and Traditional Chinese Medicine. Int J Endocrinol, 2015: 810439.
  15. Li, R.W., Yang, C., Shan, L., Zhang, Z., Wang, Y., Kwan, Y.W., Lee, S.M., Hoi, M.P., Chan, S.W., Cheung, A.C., Cheung, K.H. & Leung, G.P. (2015). Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. Eur J Pharmacol, 761: 153-60.
  16. Li, R.W., Yang, C., Chan, S.W., Hoi, M.P., Lee, S.M., Kwan, Y.W. & Leung, G.P. (2015). Relaxation effect of abacavir on rat basilar arteries. PLoS One, 10(4): e0123043.
  17. Hu, T., Zhou, X., Wang, L., Or, P.M., Yeung, J.H., Kwan, Y.W. & Cho C.H. (2015). Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies. Chem Biol Interact, 230: 1-8.
  18. Li, S., Zhou, X.L., Dang, Y.Y., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M. & Hoi, M.P. (2015). Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta, 850(2): 373-84.
  19. Hoi, P.M., Li, S., Vong, C.T., Tseng, H.H., Kwan, Y.W. & Lee, S.M. (2015). Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors. Methods, 71: 85-91.
  20. Li, S., Dang, Y.Y., Oi, Lam, Che, G., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M. & Hoi MP. (2014). VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol, 280(3): 408-20.
  21. Ho, H.P., Lau, P.M., Kwok, H.C., Wu, S.Y., Gao, M., Cheung, A.K., Chen, Q., Wang, G., Kwan, Y.W., Wong, C.K. & Kong, S.K. (2014). Allergen screening bioassays: recent developments in lab-on-a-chip and lab-on-a-disc systems. Bioanalysis, 6(14): 2005-18.
  22. Li, R.W., Yang, C., Sit, A.S., Kwan, Y.W., Lee, S.M., Hoi, M.P., Chan, S.W., Hausman, M., Vanhoutte, P.M. & Leung GP. (2014). Uptake and protective effects of ergothioneine in human endothelial cells. J Pharmacol Exp Ther, 350(3): 691-700.
  23. Chan, J.Y., Tsui, H.T., Chung, I.Y., Chan, R.Y., Kwan, Y.W. & Chan SW. (2014). Allicin protects rat cardiomyoblasts (H9c2 cells) from hydrogen peroxide-induced oxidative injury through inhibiting the generation of intracellular reactive oxygen species. Int J Food Sci Nutr, 65(7): 868-73.
  24. Deng, Y., Ng, E.S., Kwan, Y.W., Lau, C.B., Cheung, D.W., Koon, JC, Zhang, Z., Zuo, Z., Leung, P.C., Fung, K.P. & Lam, F.F. (2014). Cerebral vasodilator properties of Danshen and Gegen: a study of their combined efficacy and mechanisms of actions. Phytomedicine, 21(4): 391-9.
  25. Li, W.Y., Ng, Y.F., Zhang, H., Guo, Z.D, Guo, D.J., Kwan, Y.W., Leung, G.P., Lee, S.M., Yu, P.H. & Chan, S.W. (2014). Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. Inflammopharmacology, 22(2): 127-34.
  26. Wang, G., Ho, H.P., Chen, Q., Yang, A.K., Kwok, H.C., Wu, S.Y., Kong, S.K., Kwan, Y.W. & Zhang, X. (2013). A lab-in-a-droplet bioassay strategy for centrifugal microfluidics with density difference pumping, power to disc and bidirectional flow control. Lab Chip, 13(18): 3698-706.
  27. Seto, S.W., Au, A.L., Poon, C.C., Zhang, Q., Li, R.W., Yeung, J.H., Kong, S.K., Ngai, S.M., Wan, S., Ho, H.P., Lee, S.M., Hoi, M.P., Chan, S.W., Leung, G.P. & Kwan, Y.W. (2013). Acute simvastatin inhibits KATP channels of porcine coronary artery myocytes. PLoS One, 8(6): e66404.
  28. Li, R.W., Yang, C., Kwan, Y.W., Chan, S.W., Lee, S.M. & Leung, G.P. (2013). Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Front Pharmacol, 4: 14.
  29. Zhou, X., Wang, Y., Hu, T., Or, P.M., Wong, J., Kwan, Y.W., Wan, D.C., Hoi, P.M., Lai, P.B. & Yeung, J.H. (2013). Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes. Phytomedicine, 20(3-4): 367-74.
  30. Zhou, X., Chan, S.W., Tseng, H.L., Deng, Y., Hoi, P.M., Choi, P.S, Or, P.M., Yang, J.M., Lam, F.F., Lee, S.M., Leung, G.P., Kong, S.K., Ho, H.P., Kwan, Y.W. & Yeung, J.H. (2012). Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions. Phytomedicine, 19(14): 1263-9.
  1. RGC - General Research Fund [PI; 01-Jan-14 to 31-Dec-16]: "A Novel Combination Therapy for Treating Osteoporosis - A Mechanistic Study on the Synergistic Bone Anabolic Effects of HMG CoA Reductase Inhibitor and Vitamin D" (HK$770,769).