KWAN Yiu Wa Professor

B.Sc., Ph.D.

Telephone:  39436884

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 207A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Diabetes Mellitus: Development and treatments (Western medicines and Natural / herbal Products).
  2. Osteoporosis: Development and treatments (Western medicines and Natural / herbal Products).
  3. Cardiovascular diseases: Drug treatments (Western medicines and Natural / herbal Products).
  4. Cancers Biology: Development and treatments (Western medicines and Natural / herbal Products).
  1. Tseng, H.H.L., Vong, C.T., Kwan, Y.W., Lee, S.M. & Hoi, M.P.M. (2017). Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells. Front Immunol. 8:1161.
  2. Li, S., Ai, N., Shen, M., Dang, Y., Chong, C.M., Pan, P., Kwan, Y.W., Chan, S.W., Leung, G.P.H, Hoi, M.P.M., Hou, T. & Lee, S.M. (2017). Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin. Cell Death Discov. 3:17051.
  3. Chan, J.Y., Zhou, H., Kwan, Y.W., Chan, S.W., Radis-Baptista, G. & Lee, S.M. (2017). Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics. J Biochem Mol Toxicol. 31(11).
  4. Steiner, G.Z., Seto, S.W., Kwan, Y.W., Haskell-Ramsay C, Camfield DA. (2017). Complementary Medicine for the Modification of Risk Factors for Cognitive Impairment. Evid Based Complement Alternat Med. 2017:9472859.
  5. Zhou, X., Cui, G., Tseng, H.H., Lee, S.M., Leung, G.P., Chan, S.W., Kwan, Y.W., Hoi, M.P. (2016). Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2016:9627258.
  6. Tseng, H,H., Vong, C,T., Leung, G.P., Seto, S.W., Kwan, Y.W. Lee, S.M. & Hoi, M.P. (2016). Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca2+-Activated K+-Channels (BKCa). Evid Based Complement Alternat Med. 2016:5272531.
  7. Tang, P.C., Yang, C., Li, R.W., Lee, S.M., Hoi, M.P., Chan, S.W., Kwan, Y.W., Tse, C.M. & Leung, G.P. (2016). Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine. Eur J Pharmacol. 791:544-551.
  8. Tseng, H.H., Vong, C.T., Kwan, Y.W., Lee, S.M. & Hoi, M.P. (2016). TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep. 6:35016.
  9. Zhou, X., Choi, P.S., Yang, J.M., Or, P.M., Hoi, P.M., Lee, S.M., Leung, G.P., Ngai, S.M., Kong, S.K., Ho, H.P., Wong, M.Y., Chan, S.W., Yeung, J.H. & Kwan, Y.W.. (2016). Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods. Springerplus. 5(1):1438.
  10. Vong, C.T., Tseng, H.H., Kwan, Y.W., Lee, S.M. & Hoi, M.P. (2016). Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Front Pharmacol. 7:67.
  11. Li, S., Dang, Y., Zhou, X., Huang, B., Huang, X., Zhang, Z., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M. & Hoi, M.P. (2015). Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Sci Rep. 5:16815.
  12. Poon, C.C., Li, R.W., Seto, S.W., Kong, S.K., Ho, H.P., Hoi, M.P., Lee, S.M, Ngai, S.M., Chan, S.W., Leung, G.P. & Kwan, Y.W.. (2015). In vitro vitamin K2 and 1a,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice. Eur J Pharmacol. 767:30-40.
  13. Zhou, X., Wang, Y., Lee, W.Y., Or, P.M., Wan, D.C., Kwan, Y.W. & Yeung, J.H. (2015). Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in oxorubicin-Resistant HepG2 Cells. J Nat Prod. 78(9):2266-75.
  14. Seto, S.W., Yang, G.Y., Kiat, H., Bensoussan, A., Kwan, Y.W. & Chang, D. (2015) Diabetes Mellitus, Cognitive Impairment, and Traditional Chinese Medicine. Int J Endocrinol. 2015:810439.
  15. Li, R.W., Yang, C., Shan, L., Zhang, Z., Wang, Y., Kwan, Y.W., Lee, S.M., Hoi, M.P., Chan, S.W., Cheung, A.C., Cheung, K.H. & Leung, G.P. (2015). Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. Eur J Pharmacol. 761:153-60.
  16. Li, R.W., Yang, C., Chan, S.W., Hoi, M.P., Lee, S.M., Kwan, Y.W. & Leung, G.P. (2015). Relaxation effect of abacavir on rat basilar arteries. PLoS One. 10(4):e0123043.
  17. Hu, T., Zhou, X., Wang, L., Or, P.M., Yeung, J.H., Kwan, Y.W. & Cho CH. (2015). Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies. Chem Biol Interact. 25;230:1-8.
  18. Li, S., Zhou, X.L., Dang, Y.Y., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M. & Hoi, M.P. (2015). Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta. 850(2):373-84.
  19. Hoi, P.M., Li, S., Vong, C.T., Tseng, H.H., Kwan, Y.W. & Lee, S.M. (2015). Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors. Methods. 71:85-91.
  20. Li, S., Dang, Y.Y., Oi, Lam, Che, G., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M. & Hoi MP. (2014). VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol. 280(3):408-20.
  21. Ho, H.P., Lau, P.M., Kwok, H.C., Wu, S.Y., Gao, M., Cheung, A.K., Chen, Q., Wang, G., Kwan, Y.W., Wong, C.K. & Kong, S.K. (2014). Allergen screening bioassays: recent developments in lab-on-a-chip and lab-on-a-disc systems. Bioanalysis. 6(14):2005-18.
  22. Li, R.W., Yang, C., Sit, A.S., Kwan, Y.W., Lee, S.M., Hoi, M.P., Chan, S.W., Hausman, M., Vanhoutte, P.M. & Leung GP. (2014). Uptake and protective effects of ergothioneine in human endothelial cells. J Pharmacol Exp Ther. 350(3):691-700.
  23. Chan, J.Y., Tsui, H.T., Chung, I.Y., Chan, R.Y., Kwan, Y.W. & Chan SW. (2014). Allicin protects rat cardiomyoblasts (H9c2 cells) from hydrogen peroxide-induced oxidative injury through inhibiting the generation of intracellular reactive oxygen species. Int J Food Sci Nutr. 65(7):868-73.
  24. Deng, Y., Ng, E.S., Kwan, Y.W., Lau, C.B., Cheung, D.W., Koon, JC, Zhang, Z., Zuo, Z., Leung, P.C., Fung, K.P. & Lam, F.F. (2014). Cerebral vasodilator properties of Danshen and Gegen: a study of their combined efficacy and mechanisms of actions. Phytomedicine. 15;21(4):391-9.
  25. Li, W.Y., Ng, Y.F., Zhang, H., Guo, Z.D, Guo, D.J., Kwan, Y.W., Leung, G.P., Lee, S.M., Yu, P.H. & Chan, S.W. (2014). Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. Inflammopharmacology. 22(2):127-34.
  26. Wang, G., Ho, H.P., Chen, Q., Yang, A.K., Kwok, H.C., Wu, S.Y., Kong, S.K., Kwan, Y.W. & Zhang, X. (2013). A lab-in-a-droplet bioassay strategy for centrifugal microfluidics with density difference pumping, power to disc and bidirectional flow control. Lab Chip. 13(18):3698-706.
  27. Seto, S.W., Au, A.L., Poon, C.C., Zhang, Q., Li, R.W., Yeung, J.H., Kong, S.K., Ngai, S.M., Wan, S., Ho, H.P., Lee, S.M., Hoi, M.P., Chan, S.W., Leung, G.P. & Kwan, Y.W.. (2013). Acute simvastatin inhibits KATP channels of porcine coronary artery myocytes. PLoS One. 8(6):e66404.
  28. Li, R.W., Yang, C., Kwan, Y.W., Chan, S.W., Lee, S.M. & Leung, G.P. (2013). Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Front Pharmacol. 4:14.
  29. Zhou, X., Wang, Y., Hu, T., Or, P.M., Wong, J., Kwan, Y.W., Wan, D.C., Hoi, P.M., Lai, P.B. & Yeung, J.H. (2013). Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes. Phytomedicine. 20(3-4):367-74.
  30. Zhou, X., Chan, S.W., Tseng, H.L., Deng, Y., Hoi, P.M., Choi, P.S, Or, P.M., Yang, J.M., Lam, F.F., Lee, S.M., Leung, G.P., Kong, S.K., Ho, H.P., Kwan, Y.W. & Yeung, J.H. (2012). Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions. Phytomedicine. 19(14):1263-9.