School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

SHUM Sau Wun Alisa

Associate Professor

B.Sc. (Glas.), D.Phil. (Oxon)

Telephone:  39436840

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 308A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

  1. Normal and abnormal embryonic development of the central nervous system
  2. Using animal models to study the pathogenic mechanism of various types of birth defects, including neural tube defects, eye defects, renal malformations and caudal regression
  3. Cellular and molecular mechanisms underlying the increased susceptibility to birth defects in diabetic pregnancy
  4. The effect of diabetes mellitus on female reproduction
  5. The teratogenic mechanism of retinoic acid embryopathy
  1. Lee LMY, Leung CY, Tang WWC, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS andShum ASW (2012), A paradoxical teratogenic mechanism for retinoic acid, Proceedings of the National Academy of Sciences of the United States of America 109:13668-13673
  2. Shum ASW, Tang LSC, Copp AJ and Roelink H (2010), Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube, Developmental Dynamics 239:3192-3203
  3. Wang CC, Chu KO, Chong WS, Li WY, Pang CP, Shum ASW, Lau TK and Rogers MS (2007), Tea epigallocatechin-3-gallate increases 8-isoprostane level and induces caudal regression in developing rat embryos, Free Radical Biology & Medicine 43: 519-527
  4. Tse HKW, Leung MBW, Woolf AS, Menke AL, Hastie ND, Gosling JA, Pang CP and Shum ASW(2005), Implication of Wt1 in the pathogenesis of nephrogenic failure in a mouse model of retinoic acid-induced caudal regression syndrome, American Journal of Pathology 166: 1295-1307
  5. Leung MBW, Choy KW, Copp AJ, Pang CP and Shum ASW (2004), Hyperglycemia potentiates the teratogenicity of retinoic acid in maternal diabetes, Diabetologia 47: 515-522
  6. Chan BWH, Chan KS, Koide T, Yeung SM, Leung MBW, Copp AJ, Loeken MR, Shiroishi T andShum ASW (2002), Maternal diabetes increases the risk of caudal regression caused by retinoic acid, Diabetes 51: 2811-2816
  7. Shum ASW, Poon LLM, Tang WWT, Koide T, Chan BWH, Leung YC, Shiroishi T and Copp AJ (1999), Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo, Mechanisms of Development 84: 17-30
  8. Shum ASW and Copp AJ (1996), Regional differences in morphogenesis of the neuroepithelium suggest multiple mechanisms of spinal neurulation in the mouse, Anatomy and Embryology 194: 65-73
  9. Sasaki H, Ferguson-Smith AC, Shum ASW, Barton SC and Azim Surani M (1995), Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos, Development 121: 4195-4202
  10. Brook FA, Shum ASW, Van Straaten HWM and Copp AJ (1991), Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo, Development 113: 671-678