School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

SHUM Sau Wun Alisa

Associate Professor

B.Sc. (University of Glasgow), D.Phil. (University of Oxford)

Telephone:  39436840

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 308A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

  1. Development of drugs for prevention and treatment of metabesity (obesity, type 2 diabetes and related metabolic disorders) and neurodegenerative diseases
  2. Mechanisms underlying fetal programming of obesity, diabetes, hypertension and neurologic disorders
  3. In utero therapeutic interventions to combat against the adverse effects of maternal diabetes and obesity on embryo development
  4. Mechanisms underlying abnormal development of the central nervous system
  1. Lee, L.M.Y., Leung, M.B.W., Kwok, R.C.Y., Leung, Y.C., Wang, C.C., McCaffery, P.J., Copp, A.J. & Shum, A.S.W. (2017). Perturbation of retinoid homeostasis increases malformation risk in embryos exposed to pregestational diabetes. Diabetes 66: 1041-1051.
  2. Lee, L.M.Y., Leung, C.Y., Tang, W.W.C., Choi, H.L., Leung, Y.C., McCaffery, P.J., Wang, C.C., Woolf, A.S. & Shum, A.S.W. (2012). A paradoxical teratogenic mechanism for retinoic acid. Proceedings of the National Academy of Sciences of the United States of America, 109, 13668-13673.
  3. Shum, A.S.W., Tang, L.S.C., Copp, A.J. & Roelink, H. (2010). Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube. Developmental Dynamics, 239, 3192-3203.
  4. Tse, H.K.W., Leung, M.B.W., Woolf, A.S., Menke, A.L., Hastie, N.D., Gosling, J.A., Pang, C.P. & Shum, A.S.W.(2005). Implication of Wt1 in the pathogenesis of nephrogenic failure in a mouse model of retinoic acid-induced caudal regression syndrome. American Journal of Pathology, 166, 1295-1307.
  5. Leung, M.B.W., Choy, K.W., Copp, A.J., Pang, C.P., & Shum, A.S.W. (2004). Hyperglycemia potentiates the teratogenicity of retinoic acid in maternal diabetes. Diabetologia, 47, 515-522.
  6. Chan, B.W.H., Chan, K.S., Koide, T., Yeung, S.M., Leung, M.B.W., Copp, A.J., Loeken, M.R., Shiroishi, T., & Shum, A.S.W. (2002). Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes, 51, 2811-2816.
  7. Shum, A.S.W., Poon, L.L.M., Tang, W.W.T., Koide, T., Chan, B.W.H., Leung, Y.C., Shiroishi, T., & Copp, A.J. (1999). Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. Mechanisms of Development, 84, 17-30.
  8. Shum A.S.W., & Copp, A.J. (1996). Regional differences in morphogenesis of the neuroepithelium suggest multiple mechanisms of spinal neurulation in the mouse. Anatomy and Embryology, 194, 65-73.
  9. Sasaki, H., Ferguson-Smith, A.C., Shum, A.S.W., Barton, S.C. & Azim Surani, M. (1995). Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos. Development 121, 4195-4202.
  10. Brook, F.A., Shum, A.S.W., Van Straaten, H.W.M., & Copp, A.J. (1991). Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo. Development, 113, 671-678.