CHENG Sze Lok AlfredAssociate Professor

Telephone:  39439842

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Rm 405A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Epigenetic regulation of tumor cells and tumor microenvironment
  2. Transcriptional enhancers in carcinogenesis
  3. Molecular mechanisms underlying male predominance of liver cancer
  1. Yuan, T., Yang, B., Qiu, W., Hao, Y., Zhang, Z., Yang, B., Li, N., Cheng, S., Lin, Z., Rui, Y.C., Cheung, O.K., Wu, W.K., Yang, W., Cheung, Y., Lai, P.B., Luo, J., Sung, J.J., Chen, R., Wang, H., Cheng, A.S.L.*, Yang P* (2019). ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. Nature Communications, accepted.
  2. Liu, M., Zhou, J., Liu, X., Feng, Y., Yang, W., Wu, F., Cheung, O.K., Sun, H., Zeng, X., Tang, W., Mok, M.T., Wong, J., Yeung, P.C., Lai, P.B., Jin, H., Chen, J., Chan, S.L., Chan, A.W., To, K.F., Chen, Z., Sung, J.J., Chen, M., Cheng, A.S.L.* (2019). Targeting Monocyte-intrinsic Enhancer Reprogramming Improves Immunotherapy Efficacy in Hepatocellular Carcinoma. Gut, doi: 10.1136/gutjnl-2018-317257. [Epub ahead of print].
  3. Li, L., Gao, Y., Wu, Q., Cheng, A.S.L.*, Yip, K.Y.* (2019). New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation. Genome Research, 29(4), 543-555.
  4. Xiong, L., Wu, F., Wu, Q., Xu, L., Cheung, O.K., Kang, W., Mok, M.T., Szeto, L.L.M., Lun, C.Y., Lung, R.W., Zhang, J., Yu, K.H., Lee, S.D,, Huang, G., Wang, C.M., Liu, J., Yu, Z., Yu, D.Y., Chou, J.L., Huang, W.H., Feng, B., Cheung, Y.S., Lai, P.B., Tan, P., Wong, N., Chan, M.W., Huang, T.H., Yip, K.Y.*, Cheng, A.S.L.*, To, K.F.* (2019). Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. Nature Communications, 10(1), 335.
  5. Sun, H., Yang, W., Tian, Y., Zeng, X., Zhou, J., Mok, M.T.S., Tang, W., Feng, Y., Xu, L., Chan, A.W.H., Tong, J.H., Cheung, Y.S., Lai, P.B.S., Wang, H.K.S., Tsang, S.W., Chow, K.L., Hu, M., Liu, R., Huang, L., Yang, B., Yang, P., To, K.F., Sung, J.J.Y., Wong, G.L.H.*, Wong, V.W.S.*, Cheng, A.S.L.* (2018). An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. Nature Communications, 9(1), 5214.
  6. Lee, Y., Mok, M.T.S., Kang, W., Yang, W., Tang, W., Wu, F., Xu, L., Yan, M., Yu, Z., Lee, S.D., Tong, J.H., Cheung, Y.S., Lai, P.B., Yu, D.Y., Wang, Q., Wong, G.L., Chan, A.M., Yip, K.Y., To, K.F., Cheng, A.S.L.* (2018). Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. Nucleic Acids Research, 46, 8832-8847.
  7. Zhou, J., Liu, M., Sun, H., Feng, Y., Xu, L., Chan, A.W.H., Tong, J.H., Wong, J., Chong, C.C.N., Lai, P.B.S., Wang, H.K., Tsang, S.W., Goodwin, T., Liu, R., Huang, L., Chen, Z., Sung, J.J., Chow, K.L., To, K.F., Cheng, A.S.L* (2018). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut, 67, 931-944.
  8. Cao, Q., Anyansi, C., Hu, X., Xu, L., Xiong, L., Tang, W., Mok, M.T.S., Cheng, C., Fan, X., Gerstein, M., Cheng, A.S.L., Yip, KY. (2017). Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines. Nature Genetics, 49,1428-1436.
  9. Yang, W., Mok, M.T., Li, M.S., Kang, W., Wang, H., Chan, A.W., Chou, J.L., Chen, J., Ng, E.K., To, K.F., Yu, J., Chan, M.W., Chan, F.K., Sung, J.J., Cheng, A.S.L.* (2016). Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development. Oncogene, 35(16), 2133-2144
  10. Tian, Y., Wong, V.W., Wong, G.L., Yang, W., Sun, H., Shen, J., Tong, J.H., Go, M.Y., Cheung, Y.S., Lai, P.B., Zhou, M., Xu, G., Huang, T.H., Yu, J., To, K.F., Cheng, A.S.L.*, Chan, H.L.* (2015). Histone deacetylase HDAC8 promotes insulin resistance and ß-catenin activation in NAFLD-associated hepatocellular carcinoma. Cancer Research, 75(22), 4803-4816.
  11. Feng, H., Yu, Z., Tian, Y., Lee, Y.Y., Li, M.S., Go, M.Y., Cheung, Y.S., Lai, P.B., Chan, A.M., To, K.F., Chan, H.L., Sung, J.J., Cheng, A.S.L.* (2015). A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients. Journal of Hepatology, 62(5), 1100-1111
  12. Yu, Z., Gao, Y.Q., Feng, H., Lee, Y.Y., Li, M.S., Tian, Y., Go, M.Y., Yu, D.Y., Cheung, Y.S., Lai P.B., Yu, J., Wong, V.W., Sung, J.J., Chan, H.L.*, Cheng, A.S.L. (2014). Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis.  Gut, 63(11), 1793-1804.
  13. Cheng, A.S.L.*, Li, M.S., Kang, W., Cheng, V.Y., Chou, J.L., Lau, S.S., Go, M.Y., Lee, C.C., Ling, T.K., Ng, E.K., Yu, J., Huang, T.H., To, K.F., Chan, M.W., Sung, J.J., Chan, F.K.* (2013). Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology, 144(1), 122-133.e9.
  14. Ren, S.X.#, Cheng, A.S.L.#, To, K.F., Tong, J.H., Li, M.S., Shen, J., Wong, C.C., Zhang, L., Chan, R.L., Wang, X.J., Ng, S.S., Chiu, L.C., Marquez, V.E., Gallo, R., Chan, F.K., Yu, J., Sung, J.J., Wu, W.K., Cho, C.H. (2012). Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Research, 72(24), 6512-6523. (#Co-first author)
  15. Feng, H., Cheng, A.S.L.*, Tsang, D.P., Li, M.S., Go, M.Y., Cheung, Y.S., Zhao, G.J., Ng, S.S., Lin, M.C., Yu, J., Lai, P.B., To, K.F., Sung, J.J.* (2011). Cell cycle–related kinase is a direct androgen receptor-regulated gene driving ß-catenin/T-cell factor-dependent hepatocarcinogenesis. Journal of Clinical Investigation, 121(8), 3159-3175.
  16. Cheng, A.S.L.*, Lau, S.S., Chen, Y., Kondo, Y., Li, M.S., Feng, H., Ching, A.K., Cheung, P.K., Wong, K.H., Tong, J.H., Jin, H., Choy, R., Yu, J., To, K.F., Wong, N., Huang, T.H., Sung, J.J. (2011). EZH2-mediated concordant repression of Wnt antagonists promotes ß-catenin-dependent hepatocarcinogenesis. Cancer Research, 71(11), 4028-4039. (*Corresponding author)
  17. Wang, H., Garzon R., Sun, H., Ladner, K.J. Singh, R., Dahlman, J., Cheng, A.S.L., Hall, B.M., Qualman, S.J., Chandler, D.S., Croce, C.M., Guttridge, D.C. (2008) NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell, 14(5), 369-381.
  18. Kondo, Y., Shen, L., Cheng, A.S.L., Ahmed, S., Boumber, Y., Charo, C., Yamochi, T., Urano, T., Furukawa, K., Huang, T.H.M., Issa, J.P. (2008). Gene silencing in cancer by histone H3 lysine 27 tri-methylation independent of promoter DNA methylation, Nature Genetics, 40(6), 741-750.
  19. Cheng, A.S.L., Culhane, A.C., Chan, M.W., Venkataramu, C.R., Ehrich, M., Nasir, A., Rodriguez, B.A., Liu, J., Yan, P.S., Quackenbush, J., Nephew, K.P., Yeatman, T.J., Huang, T.H. (2008). Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome, Cancer Research, 68(6), 1786-1796.
  20. Cheng, A.S.L., Jin, V.X., Fan, M.Y., Smith, L.T., Liyanarachchi, S., Yan, P.S., Leu, Y.W., Chan, M.W.Y., Plass, C., Nephew, K.P., Davuluri, R.V., Huang, T.H.M. (2006). Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor α-responsive promoters, Molecular Cell, 21(3), 393-404.