School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


Assistant Professor

B.Sc., Ph.D.

Telephone:  39436814

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 222, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. Molecular circadian clock in cardiovascular diseases
  2. Macrophage dysfunction in metabolic syndrome
  1. Chan, K.W.C., Zhang, L., Cheng, C.K., Yang, H., Huang, Y., Tian, X.Y.* & Choi, C.H.J.* (2017). Recent advances in managing atherosclerosis via nanomedicine. Small, in press.
  2. Huo, M., Huang, Y.H., Qu, D., Zhang, H., Wong, W.T., Chawla, A., Huang, Y. & Tian, X.Y.* (2017). Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB Journal 31(3):1097-1106.
  3. Cheang, W.S., Wong, W.T., Zhao, L., Xu, J., Wang, L., Lau, C.W., Chen, Z.Y., Ma, R.C.W, Xu, A., Wang, N., Tian, X.Y.,* & Huang Y.* (2017) PPARδ is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes 66(2): 519-528.
  4. Wong, W.T., Matrone, G., Tian, X., Tomoiaga, S.A., Au, K.F., Meng, S., Yamazoe, S., Sieveking, D., Chen, K., Burns, D.M., Chen, J.K., Blau, H.M. & Cooke, J.P.* (2017). Discovery of Novel Determinants of Endothelial Lineage using Chimeric Heterokaryons. eLife. 6:e23588.
  5. Xiang, L., Wei, J., Tian, X.Y., Wang, B., Chan, W., Li, S., Tang, Z., Zhang, H., Cheang, W.S., Zhao, Q., Zhao, H., Yang. Z., Hong, Y., Huang, Y. & Cai, Z.* (2017). Comprehensive Analysis of Acylcarnitine Species in db/db Mouse Using a Novel Method of High-Resolution Parallel Reaction Monitoring Reveals Widespread Metabolic Dysfunction Induced by Diabetes. Analytical Chemistry. 89(19):10368-10375.
  6. Tian, X.Y.,* Wong, W.T., Lau, C.W., Wang, Y.X., Cheang, W.S., Liu, J., Lu, Y,, Huang, H., Xia, Y., Chen, Z.Y., Mok, C.S., Lau, C.M. & Huang, Y. (2016) Melamine Impairs Renal and Vascular Function in Rats. Scientific Reports 6:28041.
  7. Ma, S.,# Tian, X.Y.,# Zhang, Y., Mu, C., Shen, H, Bismuth, J, Pownall, H.J., Huang, Y. & Wong WT.* (2016) E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. Scientific Reports 6:22910.
  8. Tian, X.Y., Ganeshan, K., Hong, C., Nguyen, K.D., Qiu, Y., Kim, J., Tangirala, R.K., Tontonoz, P. & Chawla, A.* (2016). Thermoneutral housing accelerates metabolic inflammation to potentiate atherosclerosis but not insulin resistance. Cell Metabolism 23(1):165–178.
  9. Zhang, Y., Liu, J., Tian, X.Y.,* Wong, W.T., Chen, Y., Wang, L., Luo, J., Cheang, W.S., Lau, C.W., Kwan, K.M., Wang, N., Yao, X. & Huang, Y.* (2014). Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis, and Vascular Biology 34(1):152-9.
  10. Cheang, W.S., Tian, X.Y.,* Wong, W.T., Lau, C.W., Lee, S.S., Chen, Z.Y., Yao, X., Wang, N. & Huang, Y.* (2014). Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis, and Vascular Biology 34(4):830-6.
  11. Qiu, Y., Nguyen, K.D., Odegaard, J.I., Cui, X., Tian, X., Locksley, R.M., Palmiter, R.D. & Chawla, A.* (2014). Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157(6):1292-308.
  12. Cheang, W.S., Fang, X. & Tian, X.Y.* (2013). Pleiotropic effects of peroxisome proliferator-activated receptor gamma and delta in vascular diseases. Circulation Journal 77(11):2664-71.
  13. Tian, X.Y., Wong, W.T., Wang, N., Lu, Y., Liu, J., Cheang, W.S., Liu, L., Liu, Y., Lee, S.S.T., Chen, Z.Y., Yao, X., Cooke, J.P. & Huang, Y.* (2012). PPARdelta activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-93.
  14. Tian, X.Y., Wong, W.T., Xu, A., Lu, Y., Wang, L., Zhang, Y., Cheang, W.S., Wang, Y., Yao, X. & Huang, Y.* (2012). Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circulation Research 110(9):1211-6.
  15. Tian, X.Y., Yung, L.H., Wong, W.T., Liu, J., Leung, F.P., Liu, L., Chen, Y., Kong, S.K., Kwan, K.M., Ng, S.M., Lai, P.B., Yung, L.M., Yao, X. & Huang, Y.* (2012). Bone morphogenic Protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-44.
  16. Tian, X.Y., Wong, W.T., Wang, Y.X., Lee, H.K., Ng, C.F., Chen, Z.Y., Yao, X., Au, C.L., Leung, F.P., Lau, C.W., Vanhoutte, P.M., Cooke, J.C. & Huang Y* (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2α impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling 16(4):363-73.
  17. Wong, W.T.,# Tian, X.Y.,# Xu, A., Yu, J., Lau, C.W., Hoo, R.C.L., Wang, Y., Lee, V.W.Y., Lam, K.S.L., Vanhoutte, P.M. & Huang Y (2011). Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 14(1):104-15.
  18. Tian, X.Y., Wong, W.T., Xu, A., Chen, Z.Y., Lu, Y., Liu, L.M., Lee, V.W., Lau, C.W., Yao, X. & Huang Y# (2011). Rosuvastatin improves endothelial function of db/db mice: role of angiotensin II type 1 receptors and oxidative stress. British Journal of Pharmacology 164(2b):598-606.
  19. Wong, W.T.,# Tian, X.Y.,# Chen, Y., Leung, F.P., Liu, L., Lee, H.K., Ng, C.F., Xu, A., Yao, X., Vanhoutte, P.M., Tipoe, G.L. & Huang Y (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circulation Research 107(8): 984-991.
  20. Wong, W.T.,# Tian, X.Y.,# Xu, A., Ng, C.F., Lee, H.K., Chen, Z.Y., Au, C.L., Yao, X. & Huang Y# (2010). Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice. Antioxidants & Redox Signaling 13(6): 757-768.