School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

XIA Yin

Assistant Professor

Telephone:  39434480

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Rm 619a, 6/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

 

  1. Metabolic signaling pathways in the liver
  2. Kidney injury and repair
  3. Follicle development and spermatogenesis
  1. Xia, Y., O’Shea, T., Murison, R., & McFarlane, J. R. (2003). Concentrations of follistatins and follicle-stimulating hormone (FSH) and progesterone in peripheral plasma across the estrous cycle and pregnancy in Merino ewes that are homozygous or non-carriers of Booroola gene. Biology of Reproduction, 69, 1079-84.
  2. Xia, Y., Sidis, Y., & Schneyer, A. (2004). Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice. Molecular Endocrinology, 18, 979-994.
  3. Xia, Y., Sidis, Y., Mukherjee, A., Samad, T. A., Brenner, G., Woolf, C. J., Lin, H. Y., & Schneyer, A. (2005). Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology, 146, 3614-21.
  4. Babitt, J. L., Huang, F. W.*, Wrighting, D. M.*, Xia, Y.*, Sidis, Y.*, Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., Andrews, N. C., Lin, H. Y. (2006). Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nature Genetics, 38, 531-539. (*Contributed equally).
  5. Xia, Y., Yu, P. B., Sidis, Y., Beppu, H., Bloch, K. D., Schneyer, A. L., & Lin, H. Y. (2007). Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem, 282, 18129-40.
  6. Mukherjee, A., Sidis, Y., Mahan, A., Raher, M. J., Xia, Y., Rosen, E. D., Bloch, K. D., Thomas, M. K., & Schneyer, A. L. (2007). FSTL3 deletion reveals roles for TGF-b family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci USA, 104, 1348-1353.
  7. Babitt, J. L., Huang, F. W., Xia, Y., Sidis, Y., Andrews, N. C., & Lin, H. Y. (2007). Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. Journal of Clinical Investigation, 117, 1933-1939.
  8. Xia, Y., Babitt, J. L., Sidis, Y., Chung, R. T., & Lin, H. Y. (2008). Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood, 111, 5195-04.
  9. Andriopoulos, B. Jr.*, Corradini, E.*, Xia, Y.*, Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y., & Babitt, J. L. (2009). BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nature Genetics, 41, 482-487. (*Co-first authors).
  10. Xia, Y., & Schneyer, A. L. (2009). The biology of activin, Recent advances in structure, regulation and function. Journal of Endocrinology, 202, 1-12. (Review).
  11. Xia, Y., Babitt, J. L., Bouley, R., Zhang, Y., Da Silva, N., Chen, S., Zhuang, Z., Samad, T. A., Brenner, G. J., Anderson, J. L., Hong, C. C., Schneyer, A. L., Brown, D., Lin, H. Y. (2010). Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol, 21(4),666-77.
  12. Xia, Y.*, Cortez-Retamozo, V., Niederkofler, V., Salie, R., Chen, S., Samad, T. A., Hong, C. C., Arber, S., Vyas, J. M., Weissleder, R., Pittet, M. J., & Lin, H. Y.* (2011). Dragon (RGMb) inhibits interleckin (IL)-6 expression in macrophages. Journal of Immunology, 186, 1369-76. (*Corresponding authors).
  13. Wu, X., Yung, L. M., Cheng, W. H., Yu, P. B., Babitt, J. L., Lin, H. Y., & Xia, Y. (2012). Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. PLoS One, 7(9), e44622.
  14. Liu, W., Li, X., Zhao, Y., Meng, X. M., Wan, C., Yang, B., Lan, H. Y., Lin, H. Y., & Xia, Y. (2013). Dragon (RGMb) inhibits E-Cadherin expression and induces apoptosis in renal tubular epithelial cells. J Biol Chem, 288, 31528-39.
  15. Zhao, Y., Xiao, X., Frank, S. J., Lin, H. Y., & Xia, Y. (2014). Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α and IL-1β. Am J Physiol Endocrinol Metab, 307, E186-98.
  16. Wu, X.G., Wang, Y., Wu, Q., Cheng, W.H., Liu, W., Zhao, Y., Mayeur, C., Schmidt, P.J., Yu, P.B., Wang, F., & Xia, Y. (2014). HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood, 124, 1335-43. With an inside Blood commentary.
  17. Shi, Y., Chen, G. B., Huang, X. X., Xiao, C. X., Wang, H. H., Li, Y. S., Zhang, J. F., Li, S., Xia, Y.*, Ren, J. L.*, Guleng, B.* (2015). Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth. Oncotarget, 6, 20540-54 (*Corresponding authors).
  18. Zhao, Y., Meng, C., Wang, Y., Huang, H., Liu, W., Zhang, J. F., Zhao, H., Feng, B., Leung, P. S., & Xia, Y.* (2016). Interleukin (IL)-1β inhibits β-Klotho expression and FGF19 signaling in hepatocytes. Am J Physiol Endocrinol Metab, 310, E289-300.
  19. Meng, C., Liu, W., Huang, H., Wang, Y., Chen, B., Freeman, G. J., Schneyer, A., Lin, H. Y., & Xia, Y. (2016). Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice. Biol Reprod, 94(4), 78.
  20. Shi, Y.*, Huang, X. X., Chen, G. B., Wang, Y., Zhi, Q., Liu, Y. S., Wu, X. L., Wang, L. F., Yang, B., Xiao, C. X., Xing, H. Q., Ren, J. L., Xia, Y.*, & Guleng, B.* (2016). Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells. Oncotarget, (in press). (Corresponding authors).