School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

YUNG Wing Ho

Professor

B.Sc., M.Phil. (CUHK), D.Phil. (Oxon)

Telephone:  39436880

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it. 

Address:

304A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 

  1. One of the most fascinating and important properties of the brain is its remarkable plasticity, which underlies experience-dependent modification of all nervous system functions including development, learning, memory, sensory perception, motor functions and others. Neuroplasticity also participates in the pathophysiology and functional adaptation in brain trauma. My research aims at understanding the nature of neuroplasticity and its involvement in both health and disease conditions.
  2. Current projects include the cortical mechanisms of motor learning, synaptic plastic changes underlying motor and non-motor impairments in Parkinsonism, neural mechanism of therapeutic deep brain stimulation and the origin of neurocognitive deficits in obstructive sleep apnea.
  3. A multidisciplinary approach is employed to address the research questions, including in vitro and in vivo electrophysiology, optogenetics, behavioral analysis and in vivo deep brain imaging.
  1. Li, Q., Ko, H., Qian, Z.M., Yan, L.Y.C., Chan, D.C.W., Arbuthnott, G., Ke, Y. & Yung, W.H. (2017). Refinement of learned skilled movement representation in motor cortex deep output layer. Nat Commun 9; 8, 15834. doi: 10.1038/ncomms15834
  2. Lui, N.G., Tam, W.Y., Gao, C., Huang, J.D., Wang, C.C., Jiang, L.W., Yung, W.H. & Kwan, K.M. (2017). Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin. Nat Commun 8, 15079. doi: 10.1038/ncomms15079
  3. Leong, A.T., Chan, R.W., Gao, P.P., Chan, Y.S., Tsia, K.K., Yung, W.H. & Wu E.X. (2016). Long-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile. Proc Natl Acad Sci U S A. 113(51), E8306-E8315. doi: 10.1073/pnas.1616361113
  4. Xu, L.H., Xie, H., Shi, Z.H., Du, L.D., Wing, Y.K., Li, A.M., Ke Y. & Yung, W.H. (2015). Critical role of endoplasmic reticulum stress in chronic intermittent hypoxia-induced deficits in synaptic plasticity and long-term memory. Antioxidants & Redox Signaling 23, 695-710
  5. Li Q., Qian, Z.M., Arbuthnott, G.W., Ke, Y. & Yung, W.H. (2014). Cortical effects of deep brain stimulation: implications for pathogenesis and treatment of Parkinson disease. JAMA Neurology 71, 100-103(Editorial Highlight)
  6. Sun, X.R., Chen, L., Chen, W.F., Xue, Y. & Yung, W.H. (2013) Electrophysiological and behavioral effects of group III metabotropic glutamate receptors on pallidal neurons in normal and parkinsonian rats. Synapse. Jun 29. doi: 10.1002/syn.21694
  7. Huang, Y., Wang, J.J. & Yung, W.H. (2013). Coupling between GABA-A receptor and chloride transporter underlies ionic plasticity in cerebellar Purkinje neurons. The Cerebellum 12, 328-330.
  8. Li, Q., Ke, Y., Chan, D.C.W., Qian, Z.M., Yung, K.K.L., Ko, H., Arbuthnott G. & Yung, W.H. (2012). Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex. Neuron 76, 1030-1041 (Highlighted in 'Nature Reviews Neuroscience' and 'Nature China').
  9. Huang, Y., Ko, H., Cheung, Z.H., Yung, K.K.L., Yao, T., Wang, J.J., Morozov, A., Ke, Y., Ip, N.Y. & Yung, W.H.(2012). Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental Neurology 233, 791-798.
  10. Ip, J.P.K., Shi, L., Chen, Y., Itoh, Y., Fu, W.Y. Yung, W.H., Gotoh, Y., Fu, A.K.Y. & Ip N.Y. (2012). alpha2-chimaerin-mediated neuronal migration regulates cerebral cortical lamination and seizure susceptibility. Nature Neuroscience 15, 39-47.
  11. Xie, H., Leung, K.L., Chen, L., Chan, Y.S., Ng, P.C., Fok, T.F., Wing, Y.K., Ke, Y., Li, A.M. & Yung, W.H. (2010). Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity. Neurobiology of Disease 40, 155-162.
  12. Chu, J.Y.S., Lee, L.T.O., Lai, C.H., Vaudry, H. Chan, Y.S., Yung, W.H. & Chow B.K.C. (2009). Secretin as a neurohypophysial factor regulating body water homeostasis. Proceedings of the National Academy of Science USA 106, 15961-15966.
  13. Chen, L., Yung, K.K.L., Chan, Y.S. & Yung, W.H. (2008). 5-hydroxytryptamine excites globus pallidus neurons by multiple receptor mechanisms. Neuroscience 151, 439-451.
  14. Zhao, L., Qian, Z.M., Zhang, C., Yung, W.H., Du, F., & Ke, Y. (2008). Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase A activation. Aging Cell 7, 47-57.
  15. Cui, Q.L., Chen, L. & Yung, W.H. (2007). Substance P excites globus pallidus neurons in vivo. European Journal of Neuroscience 26, 1853-1861.
  16. Zhu, J.N., Yung, W.H., Chow, B.K.C., Chan, Y.S. & Wang, J.J. (2006). The cerebellar-hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic-visceral integration. Brain Research Review 52, 93-106.
  17. Fu, A.K.Y., Ip, F.C.F., Fu, W.Y., Cheung, J., Wang, J.H., Yung, W.H., & Ip, N.Y. (2005). Aberrant motor axon projection, AChR clustering and neurotransmission in Cyclin-dependent kinase 5 null mice Proceedings of the National Academy of Science USA 102, 15224-15229.
  18. Chan, S.C., Surmeier, D.J. & Yung, W.H. (2005). Neuronal integration of striatopallidal signals: timing matters. NeuroSignals 14, 281-289
  19. Pang, P., Teng, H., Zaitsev, E., Woo, N.T., Sakata, K., Zhen, S., Teng, K.K. & Yung, W.H. Hempstead, B., & Lu, B. (2004). Proteolytic conversion from pro- to mature BDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 305, 487-491.
  20. Yung, W.H., Leung, P.S., Ng, S.S.M., Zhang, J., Chan, S.C.Y., & Chow, B.K.C. (2001). Secretin facilitates GABA transmission in the rat cerebellum. Journal of Neuroscience 21, 7063-7068.