YAO Xiao Qiang


BB.S., M.S., Ph.D.

Telephone:  39436877

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.


224A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 Website:  http://ihome.sbs.cuhk.edu.hk/YAOXiaoQiang/


  1. Ca2+ signaling in autophagy and ER stress in cardiovascular system
  2. Ca2+ signaling in cancer progression and multidrug resistance
  3. Mechanosensation, cytoskeleton and TRP channels
  4. Oxidative stress and atherosclerosis
  5. Disease modeling using stem cell-derived cardiomyocytes
  1. Zhu, Y., Xie, M., Meng, Z., Leung, L.K., Chan, F.L., Hu, X., Chi, K., Liu, C.L., & Yao, X. (2019). Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells. Oncogene (in print).
  2. Sun, L., Meng, Z., Zhu, Y., Lu, J., Li, Z., Zhao, Q., Huang, Y., Jiang, L.W., & Yao, X. (2018). TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death Differ 25(2):368-379.
  3. Lu, J., Boheler, K.R., Jiang, L.W., Chan, C.W., Tse, W.W., Keung, W., Poon, E.N.Y., Li, R.A. & Yao, X. (2018). Polycystin-2 plays an essential role in glucose starvation induced autophagy in human embryonic stem cell derived cardiomyocytes. Stem Cells 36(4):501-513.
  4. Lu, J., Lee, Y.K., Ran, X., Lai, W.H., Li, R.A., Keung, W., Tse, K., Tse, H.F., & Yao, X. (2017). An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. Biochim Biophys Acta - Mol Basis Disease 1863:2964-2972.
  5. Lau, O.C., Shen, B., Wong, C.O., Tjong, Y.W., Lo, C.Y., Wang, H.C., Huang, Y., Yung, W.H., Chen, Y.C., Fung, M.L., Rudd, J.A., & Yao, X. (2016). TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nature Commun, 7, 11947.
  6. Wang, Y., Li, Z.C., Zhang, P., Poon, E., Kong, C.W., Boheler, K.R., Huang, Y., Li, R.A., & Yao, X. (2015). Nitric oxide-cGMP-PKG pathway acts on Orai1 to inhibit the hypertrophy of human embryonic stem cell-derived cardiomyocytes. Stem Cells, 33(10), 2973-84.
  7. Ru, X., Zheng, Z.B., Zhao, Q., Lan, H.Y., Huang, Y., Wan, S., Mori, Y., & Yao, X. (2015). Transient receptor potential channel M2 contributes to neointimal hyperplasia in vascular walls. Biochim Biophys Acta - Mol Basis Disease, 1852, 1360-1371.
  8. Ma, Y., Zhang, P., Li, J., Lu, J., Ge, J, Zhao, Z., Ma, X., Wan, S., Yao, X.* & Shen, B.*. (2015). Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries. Biochim Biophys Acta - Mol Basis Dis. 1852(3):552-9 (*co-corresponding authors).
  9. Qi, Y., Li, Z.C., Kong, C.W., Tang, N,L., Huang, Y., Li, R.A. & Yao, X. (2015). Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes. J Mol Cell Cardiol 87:65-73.
  10. Ma, X., Chen, Z., Hua, D., He, D., Wang, L, Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X., Zhang, F., Wang, T., Hong, T., Jin, L., Qi, X., Chen, S., Gu, X., Yang, D., Pan, Q., Zhu, Y., Chen, Y., Chen, D., Jiang, L., Han, X., Zhang, Y., Jin, J., & Yao, X. (2014) Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci USA, 111, 6389-6394.
  11. Zhang, P., Ma, Y., Wang, Y., Ma, X., Huang, Y., Li, R.A., Wan, S., & Yao, X. (2014). Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation. Cardiovasc Res, 104(1), 138-46.
  12. Du, J., Ma, X., Shen, B., Huang, Y., Birnbaumer, L., & Yao, X. (2014). TRPV4, TRPC1 and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J, 28(11), 4677-85.
  13. Ma, X., Du, J., Zhang, P., Deng, J., Liu, J., Lam, F.F.Y., Li, R.A., Huang, Y., Jin, J., & Yao, X. (2013). Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension, 62(1), 134-9.
  14. Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C.Y., Xu, Z., Chan, F.L., Yu, S., Chen, Y., Zhu, R., Lei, J., Jin, J., & Yao, X. (2012) Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc Natl Acad Sci USA, 109(40), 16282-7.
  15. Du, J., Wong, W.Y., Sun, L., Huang, Y., Yao, X. (2012) Protein kinase G regulates flow-induced Ca2+ entry in M1-CCD cells. J Ame Soc Nephrol, 23, 1172-80.
  16. Shen, B., Kwan, H.Y., Ma, X., Wong, C.O., Du, J., Huang, Y. & Yao, X. (2011) Cyclic AMP activates TRPC6 channels via PI3K-PKB-MEK-ERK1/2 signaling pathway. J Biol Chem 286(22):19439-45.
  17. Ma, X., Cao, J.Y., Luo, J.H., Nilius, B., Huang, Y., Ambudkar, I.S., & Yao, X.. (2010) Depletion of intracellular Ca2+ stores stimulates the translocation of TRPV4-C1 heteromers to the plasma membrane. Arterioscler Thromb Vasc Biol, 30(11), 2249-55.
  18. Ma, X., Qiu, S., Luo, J.H., Ma, Y., Ngai, C.Y., Shen, B., Wong, C.O., Huang, Y., & Yao, X. (2010). Functional role of TRPV4-TRPC1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol, 30(4), 851-8.
  19. Kwan, H.Y., Shen, B., Ma, X., Kwok, Y.C., Huang, Y., Man YB, Yu S, & Yao, X. (2009). TRPC1 Associates With BKCa Channel to Form a Signal Complex in Vascular Smooth Muscle Cells. Circ Res, 104, 670-678.
  20. Li, X., Shen, B., Yao, X.*, & Yang, D.* (2009). A synthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels. J Am Chem Soc, 131, 13676-80. (*, co-corresponding authors)
  21. Cheng, K.T., Leung, Y.K., Shen, B., Kwan, H.Y., Kwok, Y.C., Wong, C.O., Ma, X., Huang, Y. & Yao, X. (2008). CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Arterioscler Throm Vasc Biol. 28:913-918.
  22. Yao, X., & Garland, C.J. (2005). Recent development in endothelial cell TRP channels. Circ Res (Invited Review) 97:853-863.
  23. Kwan, H.Y., Huang, Y., & Yao, X. (2004). Regulation of canonical transient receptor potential channel isoforms 3 (TRPC3) by protein kinase G. Proc Natl Acad Sci USA, 101, 2625-2630.
  24. Yao, X., & Huang, Y. (2003) From nitric oxide to endothelial cytosolic Ca, a negative feedback control. Trends Pharmacol Sci (review), 24, 263-266.
  25. Kwan, H.Y., Leung, P.C., Huang, Y., & Yao, X. (2003). Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells. Circ Res, 92, 286-292.
  26. Yao, X., Tian, S., & Chan, H.Y., Biemesderfer, D., Desir, G.V. (2002). Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J Am Soc Nephrol, 13, 2831-2839 (One Figure was chosen as Cover page of the Journal).
  27. Kwan, H.Y., Huang, Y. & Yao, X. (2000). Store-operated Ca++ entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism. J Biol Chem 275:6758-6773.
  28. Yao, X., Kwan, H.Y., Chan, F.L., Chan, N.W.K. & Huang, Y. (2000). A protein kinase G-sensitive channel mediates flow-induced Ca2+ entry in endothelial cells. FASEB J 14:932-938.
  29. Yao, X., Chang, A., Boulpaep, E.L., Segal, A.S. & Desir, G.V. (1996). Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel preferentially expressed in rabbit kidney medulla. J Clin Invest 97:2525-2533.
  30. Yao, X., Segal, A.S., Welling, P., Zhang, X., Engel, D., Boulpaep, E.L. & Desir, G.V. (1995). Primary structure and functional expression of a cGMP-gated potassium channel. Proc Natl Acad Sci USA 92:11711-11715.