School of Biomedical Sciences
The Chinese University of Hong Kong 香港中文大學

YAO Xiao Qiang


BB.S., M.S., Ph.D.

Telephone:  39436877

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.



224A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK


  1. Ca2+ signaling in cardiac hypertrophy and autophagy
  2. Ca2+ signaling in cancer progression and multidrug resistance
  3. Cytoskeleton, mechanosensation and TRP channels
  4. Cardiac stem cell differentiation and regeneration
  5. Neuronal synaptic plasticity, long-term potentiation, memory and learning
  1. Sun, L., Meng, Z., Zhu, Y., Lu, J., Li, Z., Zhao, Q., Huang, Y., Jiang, L.W. & Yao, X. (2017). TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death Differ (in print).
  2. Lu, J., Lee, Y.K., Ran, X., Lai, W.H., Li, R.A., Keung, W., Tse, K., Tse, H.F. & Yao, X. (2017). An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. Biochim Biophys Acta - Mol Basis Disease 1863:2964-2972.
  3. Lau, O.C., Shen, B., Wong, C.O., Tjong, Y.W., Lo, C.Y., Wang, H.C., Huang, Y., Yung, W.H., Chen, Y.C., Fung, M.L., Rudd, J.A. & Yao, X. (2016) TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nature Commun 7:11947.
  4. Wang, Y., Li, Z.C., Zhang, P., Poon, E., Kong, C.W., Boheler, K.R., Huang, Y., Li, R.A. & Yao, X. (2015). Nitric oxide-cGMP-PKG pathway acts on Orai1 to inhibit the hypertrophy of human embryonic stem cell-derived cardiomyocytes. Stem Cells 33(10):2973-84.
  5. Ru, X., Zheng, Z.B., Zhao, Q., Lan, H.Y., Huang, Y., Wan, S., Mori, Y. & Yao, X. (2015) Transient receptor potential channel M2 contributes to neointimal hyperplasia in vascular walls. Biochim Biophys Acta - Mol Basis Disease. 1852:1360-1371.
  6. Ma, X., Chen, Z., Hua, D., He, D., Wang, L., Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X., Zhang, F., Wang, T., Hong, T., Jin, L., Qi, X., Chen, S., Gu, X., Yang, D., Pan, Q., Zhu, Y., Chen, Y., Chen, D., Jiang, L., Han, X., Zhang, Y., Jin, J. & Yao. X. (2014) Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci USA 111:6389-94.
  7. Du, J., Ma, X., Shen, B., Huang, Y., Birnbaumer, L. & Yao, X. (2014) TRPV4, TRPC1 and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J 28(11):4677-85.
  8. Zhang, P., Ma, Y., Wang, Y., Ma, X., Huang, Y., Li, R.A., Wan, S. & Yao, X. (2014) Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation. Cardiovasc Res 104(1):138-46.
  9. Ma, X., Du, J., Zhang, P., Deng, J., Liu, J., Lam, F.F.Y., Li, R.A., Huang, Y., Jin, J. & Yao, X. (2013) Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension 62(1):134-9.
  10. Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C.Y., Xu, Z., Chan, F.L., Yu, S., Chen, Y., Zhu, R., Lei, J., Jin, J. & Yao X (2012) Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc Natl Acad Sci USA 109(40):16282-7.
  11. Du, J., Wong, W.Y., Sun, L., Huang, Y. & Yao, X. (2012) Protein kinase G regulates flow-induced Ca2+ entry in M1-CCD cells. J Ame Soc Nephrol 23:1172-80.
  12. Ma, X., Cao, J.Y., Luo, J.H., Nilius, B., Huang, Y., Ambudkar, I.S. & Yao, X.. (2010) Depletion of intracellular Ca2+ stores stimulates the translocation of TRPV4-C1 heteromers to the plasma membrane. Arterioscler Thromb Vasc Biol 30(11):2249-55.
  13. Ma, X., Qiu, S., Luo, J.H., Ma, Y., Ngai, C.Y., Shen, B., Wong, C.O., Huang, Y. & Yao, X. (2010) Functional role of TRPV4-TRPC1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol 30(4):851-8.
  14. Kwan, H.Y., Shen, B., Ma, X., Kwok, Y.C., Huang, Y., Man, Y.B., Yu, S. & Yao, X.. (2009) TRPC1 Associates With BKCa Channel to Form a Signal Complex in Vascular Smooth Muscle Cells. Circ Res 104:670-8.
  15. Li, X., Shen, B., Yao, X.* & Yang, D.* (2009) A synthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels. J Am Chem Soc 131:13676-80 (*, co-corresponding authors).
  16. Yao, X. & Garland, C.J. (2005) Recent development in endothelial cell TRP channels. Circ Res (Invited Review) 97:853-63.
  17. Kwan, H.Y., Huang, Y. & Yao, X. (2004) Regulation of canonical transient receptor potential channel isoforms 3 (TRPC3) by protein kinase G. Proc Natl Acad Sci USA 101:2625-30.
  18. Yao, X., & Huang, Y. (2003) From nitric oxide to endothelial cytosolic Ca, a negative feedback control. Trends Pharmacol Sci (review) 24:263-6.
  19. Kwan, H.Y., Leung, P.C., Huang, Y. & Yao, X. (2003) Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells. Circ Res 92:286-92.
  20. Yao, X., Tian, S., Chan, H.Y. Biemesderfer, D. & Desir, G.V. (2002) Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J Am Soc Nephrol 13:2831-9 (One Figure was chosen as Cover page of the Journal).