YAO Xiao Qiang


BB.S., M.S., Ph.D.

Telephone:  39436877

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.


224A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 Website:  http://ihome.sbs.cuhk.edu.hk/YAOXiaoQiang/


  1. Ca2+ signaling in autophagy and ER stress in cardiovascular system
  2. Ca2+ signaling in cancer progression and multidrug resistance
  3. Mechanosensation, cytoskeleton and TRP channels
  4. Oxidative stress and atherosclerosis
  5. Disease modeling using stem cell-derived cardiomyocytes
  1. Sun, L., Meng, Z., Zhu, Y., Lu, J., Li, Z., Zhao, Q., Huang, Y., Jiang, L.W., & Yao, X. (2018). TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death Differ 25(2):368-379.
  2. Lu, J., Boheler, K.R., Jiang, L.W., Chan, C.W., Tse, W.W., Keung, W., Poon, E.N.Y., Li, R.A. & Yao, X. (2018). Polycystin-2 plays an essential role in glucose starvation induced autophagy in human embryonic stem cell derived cardiomyocytes. Stem Cells 36(4):501-513.
  3. Lu, J., Lee, Y.K., Ran, X., Lai, W.H., Li, R.A., Keung, W., Tse, K., Tse, H.F., & Yao, X. (2017). An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. Biochim Biophys Acta - Mol Basis Disease 1863:2964-2972.
  4. Lau, O.C., Shen, B., Wong, C.O., Tjong, Y.W., Lo, C.Y., Wang, H.C., Huang, Y., Yung, W.H., Chen, Y.C., Fung, M.L., Rudd, J.A., & Yao, X. (2016). TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nature Commun, 7, 11947.
  5. Wang, Y., Li, Z.C., Zhang, P., Poon, E., Kong, C.W., Boheler, K.R., Huang, Y., Li, R.A., & Yao, X. (2015). Nitric oxide-cGMP-PKG pathway acts on Orai1 to inhibit the hypertrophy of human embryonic stem cell-derived cardiomyocytes. Stem Cells, 33(10), 2973-84.
  6. Ru, X., Zheng, Z.B., Zhao, Q., Lan, H.Y., Huang, Y., Wan, S., Mori, Y., & Yao, X. (2015). Transient receptor potential channel M2 contributes to neointimal hyperplasia in vascular walls. Biochim Biophys Acta - Mol Basis Disease, 1852, 1360-1371.
  7. Ma, Y., Zhang, P., Li, J., Lu, J., Ge, J, Zhao, Z., Ma, X., Wan, S., Yao, X.* & Shen, B.*. (2015). Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries. Biochim Biophys Acta - Mol Basis Dis. 1852(3):552-9 (*co-corresponding authors).
  8. Qi, Y., Li, Z.C., Kong, C.W., Tang, N,L., Huang, Y., Li, R.A. & Yao, X. (2015). Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes. J Mol Cell Cardiol 87:65-73.
  9. Ma, X., Chen, Z., Hua, D., He, D., Wang, L, Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X., Zhang, F., Wang, T., Hong, T., Jin, L., Qi, X., Chen, S., Gu, X., Yang, D., Pan, Q., Zhu, Y., Chen, Y., Chen, D., Jiang, L., Han, X., Zhang, Y., Jin, J., & Yao, X. (2014) Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci USA, 111, 6389-6394.
  10. Zhang, P., Ma, Y., Wang, Y., Ma, X., Huang, Y., Li, R.A., Wan, S., & Yao, X. (2014). Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation. Cardiovasc Res, 104(1), 138-46.
  11. Du, J., Ma, X., Shen, B., Huang, Y., Birnbaumer, L., & Yao, X. (2014). TRPV4, TRPC1 and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J, 28(11), 4677-85.
  12. Ma, X., Du, J., Zhang, P., Deng, J., Liu, J., Lam, F.F.Y., Li, R.A., Huang, Y., Jin, J., & Yao, X. (2013). Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension, 62(1), 134-9.
  13. Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C.Y., Xu, Z., Chan, F.L., Yu, S., Chen, Y., Zhu, R., Lei, J., Jin, J., & Yao, X. (2012) Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc Natl Acad Sci USA, 109(40), 16282-7.
  14. Du, J., Wong, W.Y., Sun, L., Huang, Y., Yao, X. (2012) Protein kinase G regulates flow-induced Ca2+ entry in M1-CCD cells. J Ame Soc Nephrol, 23, 1172-80.
  15. Shen, B., Kwan, H.Y., Ma, X., Wong, C.O., Du, J., Huang, Y. & Yao, X. (2011) Cyclic AMP activates TRPC6 channels via PI3K-PKB-MEK-ERK1/2 signaling pathway. J Biol Chem 286(22):19439-45.
  16. Ma, X., Cheng, K.T., Wong, C.O., O'Neil RG, Birnbaumer, L., Ambudkar, I.S. & Yao, X. (2011) Heteromeric TRPV4-C1 channels contribute to store-operated Ca2+ entry in vascular endothelial cells. Cell Calcium 50:502-9.
  17. Ma, X., Cao, J.Y., Luo, J.H., Nilius, B., Huang, Y., Ambudkar, I.S., & Yao, X.. (2010) Depletion of intracellular Ca2+ stores stimulates the translocation of TRPV4-C1 heteromers to the plasma membrane. Arterioscler Thromb Vasc Biol, 30(11), 2249-55.
  18. Ma, X., Qiu, S., Luo, J.H., Ma, Y., Ngai, C.Y., Shen, B., Wong, C.O., Huang, Y., & Yao, X. (2010). Functional role of TRPV4-TRPC1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol, 30(4), 851-8.
  19. Kwan, H.Y., Shen, B., Ma, X., Kwok, Y.C., Huang, Y., Man YB, Yu S, & Yao, X. (2009). TRPC1 Associates With BKCa Channel to Form a Signal Complex in Vascular Smooth Muscle Cells. Circ Res, 104, 670-678.
  20. Li, X., Shen, B., Yao, X.*, & Yang, D.* (2009). A synthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels. J Am Chem Soc, 131, 13676-80. (*, co-corresponding authors)
  21. Cheng, K.T., Leung, Y.K., Shen, B., Kwan, H.Y., Kwok, Y.C., Wong, C.O., Ma, X., Huang, Y. & Yao, X. (2008). CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Arterioscler Throm Vasc Biol. 28:913-918.
  22. Yao, X., & Garland, C.J. (2005). Recent development in endothelial cell TRP channels. Circ Res (Invited Review) 97:853-863.
  23. Kwan, H.Y., Huang, Y., & Yao, X. (2004). Regulation of canonical transient receptor potential channel isoforms 3 (TRPC3) by protein kinase G. Proc Natl Acad Sci USA, 101, 2625-2630.
  24. Yao, X., & Huang, Y. (2003) From nitric oxide to endothelial cytosolic Ca, a negative feedback control. Trends Pharmacol Sci (review), 24, 263-266.
  25. Kwan, H.Y., Leung, P.C., Huang, Y., & Yao, X. (2003). Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells. Circ Res, 92, 286-292.
  26. Yao, X., Tian, S., & Chan, H.Y., Biemesderfer, D., Desir, G.V. (2002). Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J Am Soc Nephrol, 13, 2831-2839 (One Figure was chosen as Cover page of the Journal).
  27. Kwan, H.Y., Huang, Y. & Yao, X. (2000). Store-operated Ca++ entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism. J Biol Chem 275:6758-6773.
  28. Yao, X., Kwan, H.Y., Chan, F.L., Chan, N.W.K. & Huang, Y. (2000). A protein kinase G-sensitive channel mediates flow-induced Ca2+ entry in endothelial cells. FASEB J 14:932-938.
  29. Yao, X., Chang, A., Boulpaep, E.L., Segal, A.S. & Desir, G.V. (1996). Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel preferentially expressed in rabbit kidney medulla. J Clin Invest 97:2525-2533.
  30. Yao, X., Segal, A.S., Welling, P., Zhang, X., Engel, D., Boulpaep, E.L. & Desir, G.V. (1995). Primary structure and functional expression of a cGMP-gated potassium channel. Proc Natl Acad Sci USA 92:11711-11715.