YAO Xiao Qiang

Professor

BB.S., M.S., Ph.D.

Telephone:  3943 6877

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

224A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

 Website:  http://ihome.sbs.cuhk.edu.hk/YAOXiaoQiang/

https://scholar.google.com.hk/citations?user=U3ztQhQAAAAJ&hl=zh-TW&oi=ao

 

 

Biography

Prof. YAO Xiaoqiang (姚曉強) obtained his degree of Bachelor of Science in Biology in 1981 from Department of Biology, Hangzhou University, Zhejiang, China. In 1984, he obtained his Master of Philosophy degree from Chinese Academy of Sciences.  He then obtained his Ph.D. degree in 1991 from Department of Biological Sciences, The State University of New York at Buffalo, USA.  After that, he had postdoctoral training in Department of Internal Medicine, Yale University School of Medicine, USA.  In 1996, he became an Assistant Professor in Department of Physiology, The Chinese University of Hong Kong, and later was promoted to Associate Professor in 1999 and Professor in 2002.  He is now the Chief of Neural, Vascular, and Metabolic Biology Thematic Research Program in the School of Biomedical Sciences, The Chinese University of Hong Kong.  His research interest is mostly on ion channels in cardiovascular system and cancer cells.  These include TRP channels and K+ channels. He has published more than 220 original articles with total citation of >9000 with h-factor of 53, including those in Proc Natl Acad Sci USA, Nature Communications, Circulation Research, Journal of Clinical Investigation and Trends in Pharmacological Sciences.

  1. Ca2+ signaling in autophagy, ER stress and vascular tone control in cardiovascular system. 
  2. Ca2+ signaling in cancer progression and multidrug resistance.
  3. Mechanosensation, cytoskeleton and TRP channels.
  4. Oxidative stress and atherosclerosis.
  5. Disease modeling using stem cell-derived cardiomyocytes.
  1. Zhu, Y., Xie, M., Meng, Z., Leung, L.K., Chan, F.L., Hu, X., Chi, K., Liu, C.L. & Yao, X. (2019). Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells. Oncogene, 38(29): 5778-5791.
  2. Sun, L., Meng, Z., Zhu, Y., Lu, J., Li, Z., Zhao, Q., Huang, Y., Jiang, L.W. & Yao, X. (2018). TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death Differ, 25(2): 368-379.
  3. Lu, J., Boheler, K.R., Jiang, L.W., Chan, C.W., Tse, W.W., Keung, W., Poon, E.N.Y., Li, R.A. & Yao, X. (2018). Polycystin-2 plays an essential role in glucose starvation induced autophagy in human embryonic stem cell derived cardiomyocytes. Stem Cells, 36(4): 501-513.
  4. Li, Z.C., Meng, Z., Lu, J., Chen, F.M., Wong, W.T., Tse, G., Zheng, C., Keung, W., Tse, K., Li, R.A., Jiang, L.W. & Yao, X. (2018). TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes. J Mol Cell Cardiol, 120: 1-11.
  5. Lu, J., Lee, Y.K., Ran, X., Lai, W.H., Li, R.A., Keung, W., Tse, K., Tse, H.F. & Yao, X. (2017). An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. Biochim Biophys Acta - Mol Basis Disease, 1863: 2964-2972.
  6. Lau, O.C., Shen, B., Wong, C.O., Tjong, Y.W., Lo, C.Y., Wang, H.C., Huang, Y., Yung, W.H., Chen, Y.C., Fung, M.L., Rudd, J.A. & Yao, X. (2016). TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nature Commun, 7: 11947.
  7. Wang, Y., Li, Z.C., Zhang, P., Poon, E., Kong, C.W., Boheler, K.R., Huang, Y., Li, R.A. & Yao, X. (2015). Nitric oxide-cGMP-PKG pathway acts on Orai1 to inhibit the hypertrophy of human embryonic stem cell-derived cardiomyocytes. Stem Cells, 33(10): 2973-84.
  8. Ma, Y., Zhang, P., Li, J., Lu, J., Ge, J, Zhao, Z., Ma, X., Wan, S., Yao, X.* & Shen, B.* (2015). Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries. Biochim Biophys Acta - Mol Basis Dis, 1852(3): 552-9.
  9. Qi, Y., Li, Z.C., Kong, C.W., Tang, N.L., Huang, Y., Li, R.A. & Yao, X. (2015). Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes. J Mol Cell Cardiol, 87: 65-73. 
  10. Ma, X., Chen, Z., Hua, D., He, D., Wang, L, Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X., Zhang, F., Wang, T., Hong, T., Jin, L., Qi, X., Chen, S., Gu, X., Yang, D., Pan, Q., Zhu, Y., Chen, Y., Chen, D., Jiang, L., Han, X., Zhang, Y., Jin, J. & Yao, X. (2014). Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci USA, 111: 6389-6394.
  11. Zhang, P., Ma, Y., Wang, Y., Ma, X., Huang, Y., Li, R.A., Wan, S. & Yao, X. (2014). Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation. Cardiovasc Res, 104(1): 138-46.
  12. Du, J., Ma, X., Shen, B., Huang, Y., Birnbaumer, L. & Yao, X. (2014). TRPV4, TRPC1 and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J, 28(11): 4677-85.
  13. Ma, X., Du, J., Zhang, P., Deng, J., Liu, J., Lam, F.F.Y., Li, R.A., Huang, Y., Jin, J. & Yao, X. (2013). Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension, 62(1): 134-9.
  14. Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C.Y., Xu, Z., Chan, F.L., Yu, S., Chen, Y., Zhu, R., Lei, J., Jin, J. & Yao, X. (2012). Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc Natl Acad Sci USA, 109(40): 16282-7.
  15. Du, J., Wong, W.Y., Sun, L., Huang, Y. & Yao, X. (2012). Protein kinase G regulates flow-induced Ca2+ entry in M1-CCD cells. J Ame Soc Nephrol, 23: 1172-80.
  16. Shen, B., Kwan, H.Y., Ma, X., Wong, C.O., Du, J., Huang, Y. & Yao, X. (2011). Cyclic AMP activates TRPC6 channels via PI3K-PKB-MEK-ERK1/2 signaling pathway. J Biol Chem 286(22): 19439-45.
  17. Ma, X., Cao, J.Y., Luo, J.H., Nilius, B., Huang, Y., Ambudkar, I.S. & Yao, X. (2010). Depletion of intracellular Ca2+ stores stimulates the translocation of TRPV4-C1 heteromers to the plasma membrane. Arterioscler Thromb Vasc Biol, 30(11): 2249-55.
  18. Ma, X., Qiu, S., Luo, J.H., Ma, Y., Ngai, C.Y., Shen, B., Wong, C.O., Huang, Y. & Yao, X. (2010). Functional role of TRPV4-TRPC1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol, 30(4): 851-8.
  19. Kwan, H.Y., Shen, B., Ma, X., Kwok, Y.C., Huang, Y., Man, Y.B., Yu, S. & Yao, X. (2009). TRPC1 Associates With BKCa Channel to Form a Signal Complex in Vascular Smooth Muscle Cells. Circ Res, 104: 670-678.
  20. Li, X., Shen, B., Yao, X.* & Yang, D.* (2009). A synthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels. J Am Chem Soc, 131: 13676-80. 
  21. Cheng, K.T., Leung, Y.K., Shen, B., Kwan, H.Y., Kwok, Y.C., Wong, C.O., Ma, X., Huang, Y. & Yao, X. (2008). CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Arterioscler Throm Vasc Biol, 28: 913-918.
  22. Yao, X. & Garland, C.J. (2005). Recent development in endothelial cell TRP channels. Circ Res (Invited Review), 97: 853-863.
  23. Kwan, H.Y., Huang, Y. & Yao, X. (2004). Regulation of canonical transient receptor potential channel isoforms 3 (TRPC3) by protein kinase G. Proc Natl Acad Sci USA, 101: 2625-2630.
  24. Yao, X. & Huang, Y. (2003). From nitric oxide to endothelial cytosolic Ca, a negative feedback control. Trends Pharmacol Sci (review), 24: 263-266.
  25. Kwan, H.Y., Leung, P.C., Huang, Y. & Yao, X. (2003). Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells. Circ Res, 92: 286-292.
  26. Yao, X., Tian, S. & Chan, H.Y., Biemesderfer, D. & Desir, G.V. (2002). Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J Am Soc Nephrol, 13: 2831-2839 (One Figure was chosen as Cover page of the Journal).
  27. Kwan, H.Y., Huang, Y. & Yao, X. (2000). Store-operated Ca++ entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism. J Biol Chem, 275: 6758-6773.
  28. Yao, X., Kwan, H.Y., Chan, F.L., Chan, N.W.K. & Huang, Y. (2000). A protein kinase G-sensitive channel mediates flow-induced Ca2+ entry in endothelial cells. FASEB J, 14: 932-938.
  29. Yao, X., Chang, A., Boulpaep, E.L., Segal, A.S. & Desir, G.V. (1996). Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel preferentially expressed in rabbit kidney medulla. J Clin Invest, 97: 2525-2533.
  30. Yao, X., Segal, A.S., Welling, P., Zhang, X., Engel, D., Boulpaep, E.L. & Desir, G.V. (1995). Primary structure and functional expression of a cGMP-gated potassium channel. Proc Natl Acad Sci USA, 92: 11711-11715.

    * Co-corresponding author
  1. RGC - General Research Fund [PI; 01-Jan-20 to 31-Dec-22]: "Role of TRPC5 in endothelium-dependent contraction in hypertensive model of mice" (HK$1,042,225).
  2. Health and Medical Research Fund [PI; 1-Sept-19 – 31-Aug-2022]: "Targeting TRPM2 as a Potential Therapeutic Strategy for Spontaneous Atherosclerosis" (HK$1,181,050).
  3. Innovation & Technology Commission-Tier 3 [PI; 01-Feb-19 to 31-Jul-20]: "Active immunization with TRPM2 peptide antigens as a potential treatment strategy for atherosclerotic progression in a mouse model" (HK$1,400,000).
  4. Research Committee Group Research Scheme [co-PI; 30-Jun-17 to 29-Jun-20]: "The First Integrated cryo-EM and cryo-ET Shared Facility for Life Sciences Research in Hong Kong" (HK$1,000,000).
  5. RGC - General Research Fund [PI; 01-Jan-17 to 31-Dec-19]: "TM9SF4 as a Novel K+ Channel and Its Role in Autophagy" (HK$1,000,387).
  6. National Natural Science Foundation of China (NSFC) [PI; 01-Jan-15 to 31-Dec-18]: "Role of TRP Channels in Stretch-induced Differentiation and Maturation of Human Embryonic Stem Cell-derived Cardiomyocytes (Project Awarded: RMB 900,000; no funding transferred to Hong Kong)" (RMB900,000).
  7. SZ Science & Technology Innovation Commission - SZ R & D Funds of Science and Technology [PI; 09-Jan-14 to 31-Dec-15]: "Functional Role of TRPM2 Channels in Neointima Hyperplasia of Vascular Walls (Project Awarded: RMB130,000; no funding transferred to Hong Kong)" (RMB130,000).
  8. RGC - NSFC/RGC Joint Research Scheme [PI; 01-Jan-14 to 31-Dec-17]: "Role of TRPC5 Channels in Multidrug Resistance in Adriamycini-resistant Breast Cancer Cells" (HK$1,000,000).
  9. RGC - General Research Fund [PI; 01-Jan-14 to 31-Dec-16]: "Role of Transient Receptor Potential Channel Isoform M2 in the Pathological Progression of Arteriosclerosis" (HK$952,636).