School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學


Jiang Xiaohua Assistant Professor

Telephone:  39431229

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Room 409A, 4/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg., Area 39, CUHK

 

  1. Molecular regulation of adult stem cells
  2. Stem cell therapy in tissue regeneration and cancer targeting
  3. Crosstalk between stem cells and microenvironment during tissue repair and regeneration
  4. Application of embryonic stem cells in embryonic development and disease modeling
  1. Chen, K., Liu, Q., Tsang, L.L., Ye, Q., Chan, H.C., Sun, Y., Jiang, X. (2017). Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/β-catenin/Slug pathway. Cell Death Dis, 8(5), e2819.
  2. Chen, R., Lee, W.Y.W., Zhang, X.H., Zhang, J.T., Lin, S., Xu, L.L., Huang, B., Yang, F.Y., Liu, H.L., Wang, B., Tsang, L.L., Willaime-Morawek, S., Li, G., Chan, H.C., Jiang, X. (2017). Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs. Stem Cell Reports, 8(3), 743-757.
  3. Liu, Z., Guo, J., Wang, Y., Weng, Z., Huang, B., Mei, K.Y., Zhang, X., Yuan, P., Zhao, H., Chan, W.Y., Jiang, X.#, Chan, H.C.# (2017). CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Diff, 24(1), 98-110. (#Co-corresponding authors)
  4. Wang, B, Lee, Y.W., Huang, B., Zhang, J., Wu, T., Jiang, X., Wang, R., Li, G. Secretome of human fetal mesenchymal stem cell ameliorates replicative senescence. Stem Cells Dev, 25(22), 1755-1766.
  5. Meng, F., Xu, L., Huang, S., Liu, Y., Hou, Y., Wang, K., Jiang, X.#, Li, G.# (2016). Small nuclear ribonucleoprotein polypeptide N (Sm51) promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating Runx2. Cell Tissue Res, 366(1), 155-62. (#Co-correspondence)
  6. Liu, K., Zhang, X., Zhang, J.T., Tsang, L.L., Jiang, X.#, Chan, H.C.# (2016). Defective CFTR-beta-catenin interaction promotes NF-kappaB nuclear translocation and intestinal inflammation in cystic fibrosis. Oncotarget, 7(39):64030-64042. (#Co-corresponding authors)
  7. Fu, X., Yang, H., Zhang, H., Wang, G., Liu, K., Gu, Q., Tao, Y., Chen, G., Jiang, X., Li, G., Gu, Y., Shi, Q. (2016). Improved osteogenesis and upregulated immunogenicity in human placenta-derived mesenchymal stem cells primed with osteogenic induction medium. Stem Cell Res Ther, 7(1), 138.
  8. Zhang, J., Weng, Z., Tsang, K., Tsang, L., Chan, H.C., Jiang, X. (2016). MycN is critical for the maintenance of human embryonic stem cell-derived neural crest stem cells. PLoS One, 11(1), e0148062.
  9. Chen, K., Huang, B., Liu, Q., Sun, Y., Jiang, X. (2015). Mesenchymal stem cell therapy for inflammatory bowel diseases: promise and challenge. Curr Stem Cell Res Ther, 10(6), 499-508.
  10. Tu, J., Ng, S.H., Shui Luk, A.C., Liao, J., Jiang, X., Feng, B., Lun Mak, K.K., Rennert, O.M., Chan, W.Y., Lee, T.L. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res, 43(16), 7805-7822.
  11. Rui, Y., Xu, L., Chen, R., Zhang, T., Lin, S., Hou, Y., Liu, Y., Meng, F., Liu, Z., Ni, M., Tsang, K.S., Yang, F., Wang, C., Chan, H.C., Jiang, X.#, Li, G.# (2015). Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells. Sci Reports, 5, 11056. (#Co-corresponding authors)
  12. Huang, B., Li, G., Jiang, X. (2015). Fate determination in mesenchymal stem cells: a perspective from histone-modifying enzymes. Stem Cell Res Ther, 6, 35.
  13. Xu, L., Huang, S., Hou, Y., Liu, Y., Ni, M., Meng, F., Wang, K., Rui, Y., Jiang, X., Li, G. (2015). Sox11-modified mesenchymal stem cells (MSCs) accelerate bone fracture healing: Sox11 regulates differentiation and migration of MSCs. FASEB J, 29(4), 1143-1152.
  14. Guo, J.H., Chen, H., Ruan, Y.C., Zhang, X.L., Fok, K.L., Tsang, L.L., Yu, M.K., Huang, W.Q., Sun, X., Chung, Y.W., Jiang, X., Sohma, Y., Chan, H.C. (2014). Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature Communications, 5, 4420.
  15. Meng, F., Rui, Y., Xu, L., Wan, C., Jiang, X., Li, G. (2014). Aqp1 enhances migration of bone marrow mesenchymal stem cells through regulation of FAK and β-catenin. Stem Cells and Dev, 23(1), 66-75.
  16. Zhang, T., Lee, Y.W., Rui, Y.F., Cheng, T.Y., Jiang, X., Li, G. (2013). Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. Stem Cell Res Ther, 4(3), 70.
  17. Xie, C.*, Jiang, X.* , Zhang, J.T., Sun, T.T., Sanders, A.J., Diao, R.Y., Wang, Y., Tsang, L.L., Yu, M.K., Fok, K.L., Zhang, X.H., Chung, Y.W., Ye, L., Dong, J.D., Zhao, M.Y., Guo, J.H., Lan, H.Y., Ng, C.F., Cai, Z.M., Jiang, W.G., Chan, H.C. (2013). CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene, 32(18), 2282-2291. (*First authors)
  18. Ruan, Y.C., Guo, J.H., Zhang, R.J., Tsang, L.L., Dong, J.D., Chen, H., Yu, M.K., Jiang, X., Zhang, X.H., Chung, Y.W., Huang, H.F., Zhou, W.L., Chan, H.C. (2012). Activation of the epithelial Na+ channel triggers PGE2 release and production required for embryo implantation. Nature Med, 18(7), 1112-1117.
  19. Lu, Y.C., Chen, H., Fok, K.L., Tsang, L.L., Yu, M.K., Zhang, X.H., Chen, J., Jiang, X., Chung, Y.W., Ma, A.C., Leung, A.Y., Huang, H.F., Chan, H.C. (2012). CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Res, 22(10), 1453-1466.
  20. Liu, Y.*, Jiang, X.*, Zhang, X.H.*, Chen, R., Sun, T.T., Fok, K.L., Dong, J.D., Ruan, Y.C., Guo, J.H., Yi, S.Q., Yu, M.K., Tsang, L.L., Tian, Y.M., Chung, Y.W., Yang, M., Xu, W.M., Chung, C.M., Li, T.Y., Chan, H.C. (2011). Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential. Stem Cells, 29(12), 2077-2089.