Jiang Xiaohua Assistant Professor

Telephone:  39431229

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

 Room 409A, 4/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg., Area 39, CUHK

 

  1. Molecular regulation of adult stem cells
  2. Stem cell therapy in tissue regeneration and cancer targeting
  3. Crosstalk between stem cells and microenvironment during tissue repair and regeneration
  4. Disease modeling using pluripotent stem cells
  1. Liu S, U KP, Zhang J, Tsang LL, Huang J, Tu SP, Jiang X. (2018). R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells. Cancer Cell Int, 18, 156.
  2. Sun X, Guo JH, Zhang D, Chen JJ, Lin WY, Huang Y, Chen H, Huang WQ, Liu Y, Tsang LL, Yu MK, Chung YW, Jiang X, Huang H, Chan HC, Ruan YC. (2018). Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. EMBO Mol Med, 10(10).
  3. Yang FY, Chen R, Zhang X, Huang B, Tsang LL, Li X, Jiang X. (2018). Preconditioning Enhances the Therapeutic Effects of Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation. Cell Transplant, 27(9), 1352-1367.
  4. Sun H, Wang Y, Zhang J, Chen Y, Liu Y, Lin Z, Liu M, Sheng K, Liao H, Tsang KS, Zhang X, Jiang X, Xu W, Mao M, Chan HC. (2018). CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis. Cell Death Dis, 9(3), 275.
  5. Zhang J, Wang Y, Jiang X#, Chan HC#. (2018). Cystic fibrosis transmembrane conductance regulator-emerging regulator of cancer. Cell Mol Life Sci, 75(10), 1737-1756.
  6. Li X, Fok KL, Guo J, Wang Y, Liu Z, Chen Z, Wang C, Ruan YC, Yu SS, Zhao H, Wu J, Jiang X#, Chan HC#. (2018). Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR. Biochim Biophys Acta Mol Cell Res, 1865(4), 605-615.
  7. Lin S, Lee WYW, Feng Q, Xu L, Wang B, Man GCW, Chen Y, Jiang X, Bian L, Cui L, Wei B, Li G. (2017). Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation. Stem Cell Res Ther, 8(1), 221.
  8. Chen K, Liu Q, Tsang LL, Ye Q, Chan HC, Sun Y, Jiang X. (2017). Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/β-catenin/Slug pathway. Cell Death Dis, 8(5), e2819.
  9. Chen R, Lee WYW, Zhang XH, Zhang JT, Lin S, Xu LL, Huang B, Yang FY, Liu HL, Wang B, Tsang LL, Willaime-Morawek S, Li G, Chan HC, Jiang X. (2017). Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs. Stem Cell Reports, 8(3), 743-757.
  10. Liu Z, Guo J, Wang Y, Weng Z, Huang B, Mei KY, Zhang X, Yuan P, Zhao H, Chan WY, Jiang X#, Chan HC#. (2017). CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Diff, 24(1), 98-110.
  11. Wang B, Lee YW, Huang B, Zhang J, Wu T, Jiang X, Wang R, Li G. (2016). Secretome of human fetal mesenchymal stem cell ameliorates replicative senescence. Stem Cells Dev, 25(22), 1755-1766.
  12. Meng F, Xu L, Huang S, Liu Y, Hou Y, Wang K, Jiang X#, Li G#. (2016). Small nuclear ribonucleoprotein polypeptide N (Sm51) promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating Runx2. Cell and Tissue Research, 366(1), 155-162.
  13. Fu X, Yang H, Zhang H, Wang G, Liu K, Gu Q, Tao Y, Chen G, Jiang X, Li G, Gu Y, Shi Q. (2016). Improved osteogenesis and upregulated immunogenicity in human placenta-derived mesenchymal stem cells primed with osteogenic induction medium. Stem Cell Res Ther, 7(1), 138.
  14. Zhang J, Weng Z, Tsang K, Tsang L, Chan HC, Jiang X. (2016). MycN is critical for the maintenance of human embryonic stem cell-derived neural crest stem cells. Plos One, 11(1), e0148062.
  15. Chen K, Huang B, Liu Q, Sun Y, Jiang X. (2015). Mesenchymal stem cell therapy for inflammatory bowel diseases: promise and challenge. Curr Stem Cell Res Ther, 10(6), 499-508.
  16. Tu J, Ng SH, Luk ACS, Liao J, Jiang X, Feng B, Mak KKL, Rennert OM, Chan WY, Lee TL. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res, 43(16), 7805-22.
  17. Rui Y, Xu L, Chen R, Zhang T, Lin S, Hou Y, Liu Y, Meng F, Liu Z, Ni M, Tsang KS, Yang F, Wang C, Chan HC, Jiang X#, Li G#. (2015). Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells. Sci Reports, 5, 11056.
  18. Huang B, Li G, Jiang X. (2015). Fate determination in Mesenchymal Stem Cells: a perspective from histone modifying enzymes. Stem Cell Res Ther, 6(1), 35.
  19. Xu L, Huang S, Hou Y, Liu Y, Ni M, Meng F, Wang K, Rui Y, Jiang X, Li G. (2015). Sox11-modified mesenchymal stem cells (MSCs) accelerate bone fracture healing: Sox11 regulates differentiation and migration of MSCs. FASEB J, 29(4), 1143-52.
  20. Xie C*, Jiang X*, Zhang JT, Sun TT, Sanders AJ, Diao RY, Wang Y, Tsang LL, Yu MK, Fok KL, Zhang XH, Chung YW, Ye L, Dong JD, Zhao MY, Guo JH, Lan HY, Ng CF, Cai ZM, Jiang WG, Chan HC. (2013). CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene, 32(18), 2282-91. (*First authors)